Fan Laboratory

Most Recent Publications

2023

Ren, Lu; Du, Wa; Song, Dan; Lu, Haocheng; Hamblin, Milton H; Wang, Chenran; Du, Chunying; Fan, Guo-Chang; Becker, Richard C; Fan, Yanbo 2023. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. iScience, 26 1, 105769

Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Wang, Cheng; Hong, Wanzi; Morgan, Hannah; Wang, Mingyang; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim 2023. BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma. Gastroenterology, ,

Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway. Cardiovascular research, 119 10, 1981-1996

Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Wu, Shihong; Deng, Siwei; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim 2023. BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma. bioRxiv : the preprint server for biology, ,

2022

Li, Qianqian; Li, Yutian; Huang, Wei; Wang, Xiaohong; Liu, Zhenling; Chen, Jing; Fan, Yanbo; Peng, Tianqing; Sadayappan, Sakthivel; Wang, Yigang; Fan, Guo-Chang 2022. Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. Frontiers in immunology, 13 , 930397

2021

Zhao, Guizhen; Chang, Ziyi; Zhao, Yang; Guo, Yanhong; Lu, Haocheng; Liang, Wenying; Rom, Oren; Wang, Huilun; Sun, Jinjian; Zhu, Tianqing; Fan, Yanbo; Chang, Lin; Yang, Bo; Garcia-Barrio, Minerva T; Chen, Y Eugene; Zhang, Jifeng 2021. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI insight, 6 5,

Lu, Haocheng; Sun, Jinjian; Hamblin, Milton H; Chen, Y Eugene; Fan, Yanbo 2021. Transcription factor EB regulates cardiovascular homeostasis. EBioMedicine, 63 , 103207

Liu, Yuhao; Zhao, Ying; Shukha, Yousef; Lu, Haocheng; Wang, Lu; Liu, Zhipeng; Liu, Cai; Zhao, Yang; Wang, Huilun; Zhao, Guizhen; Liang, Wenying; Fan, Yanbo; Chang, Lin; Yurdagul, Arif; Pattillo, Christopher B; Orr, A Wayne; Aviram, Michael; Wen, Bo; Garcia-Barrio, Minerva T; Zhang, Jifeng; Liu, Wanqing; Sun, Duxin; Hayek, Tony; Chen, Y Eugene; Rom, Oren 2021. Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis. Cell reports, 36 4, 109420

Liang, Wenying; Lu, Haocheng; Sun, Jinjian; Zhao, Guizhen; Wang, Huilun; Guo, Yanhong; Eitzman, Daniel; Chen, Y Eugene; Fan, Yanbo#; Zhang, Jifeng 2021. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. Thrombosis and haemostasis, ,

Du, Wa; Ren, Lu; Hamblin, Milton H; Fan, Yanbo 2021. Endothelial Cell Glucose Metabolism and Angiogenesis. Biomedicines, 9 2,

Lu, Haocheng; Du, Wa; Ren, Lu; Hamblin, Milton H; Becker, Richard C; Chen, Y Eugene; Fan, Yanbo 2021. Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms. Journal of the American Heart Association, , e023601

Fan, Yanbo; Wolford, Brooke N; Lu, Haocheng; Liang, Wenying; Sun, Jinjian; Zhou, Wei; Rom, Oren; Mahajan, Anubha; Surakka, Ida; Graham, Sarah E; Liu, Zhipeng; Kim, Hyunbae; Ramdas, Shweta; Fritsche, Lars G; Nielsen, Jonas B; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Yang, Dongshan; Song, Jun; Garcia-Barrio, Minerva T; Zhang, Jifeng; Liu, Wanqing; Zhang, Kezhong; Willer, Cristen J; Chen, Y Eugene 2021. Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2. iScience, 24 11, 103196

Liang, Wenying; Lu, Haocheng; Sun, Jinjian; Zhao, Guizhen; Wang, Huilun; Guo, Yanhong; Eitzman, Daniel; Chen, Y Eugene; Fan, Yanbo; Zhang, Jifeng 2021. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression. Thrombosis and haemostasis, ,

2020

Lu, Haocheng; Sun, Jinjian; Liang, Wenying; Chang, Ziyi; Rom, Oren; Zhao, Yang; Zhao, Guizhen; Xiong, Wenhao; Wang, Huilun; Zhu, Tianqing; Guo, Yanhong; Chang, Lin; Garcia-Barrio, Minerva T; Zhang, Jifeng; Chen, Y Eugene; Fan, Yanbo 2020. Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell TFEB. Circulation, ,

Zhao, Yang; Chang, Ziyi; Zhao, Guizhen; Lu, Haocheng; Xiong, Wenhao; Liang, Wenying; Wang, Huilun; Villacorta, Luis; Garcia-Barrio, Minerva T; Zhu, Tianqing; Guo, Yanhong; Fan, Yanbo; Chang, Lin; Schopfer, Francisco J; Freeman, Bruce A; Zhang, Jifeng; Chen, Y Eugene 2020. Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy. Cardiovascular drugs and therapy, ,

Chang, Ziyi; Zhao, Guizhen; Zhao, Yang; Lu, Haocheng; Xiong, Wenhao; Liang, Wenying; Sun, Jinjian; Wang, Huilun; Zhu, Tianqing; Rom, Oren; Guo, Yanhong; Fan, Yanbo; Chang, Lin; Yang, Bo; Garcia-Barrio, Minerva T; Lin, Jiandie D; Chen, Y Eugene; Zhang, Jifeng 2020. BAF60a Deficiency in Vascular Smooth Muscle Cells Prevents Abdominal Aortic Aneurysm by Reducing Inflammation and Extracellular Matrix Degradation. Arteriosclerosis, thrombosis, and vascular biology, 40 10, 2494-2507

Sun, Yifang; Venugopal, Jessica; Guo, Chiao; Fan, Yanbo; Li, Jianping; Gong, Yanjun; Chen, Y Eugene; Zhang, Haoming; Eitzman, Daniel T 2020. Clopidogrel Resistance in a Murine Model of Diet-Induced Obesity Is Mediated by the Interleukin-1 Receptor and Overcome With DT-678. Arteriosclerosis, thrombosis, and vascular biology, , ATVBAHA120314146

Zhang, Xuejing; Tang, Xuelian; Ma, Feifei; Fan, Yanbo; Sun, Ping; Zhu, Tianqing; Zhang, Jifeng; Hamblin, Milton H; Chen, Y Eugene; Yin, Ke-Jie 2020. Endothelium-targeted overexpression of Krüppel-like factor 11 protects the blood-brain barrier function after ischemic brain injury. Brain pathology (Zurich, Switzerland), ,

Sun, Jinjian; Lu, Haocheng; Liang, Wenying; Zhao, Guizhen; Ren, Lu; Hu, Die; Chang, Ziyi; Liu, Yuhao; Garcia-Barrio, Minerva T; Zhang, Jifeng; Chen, Y Eugene; Fan, Yanbo 2020. Endothelial TFEB (Transcription Factor EB) Improves Glucose Tolerance via Upregulation of IRS (Insulin Receptor Substrate) 1 and IRS2. Arteriosclerosis, thrombosis, and vascular biology, , ATVBAHA120315310

Rom, Oren; Liu, Yuhao; Liu, Zhipeng; Zhao, Ying; Wu, Jianfeng; Ghrayeb, Alia; Villacorta, Luis; Fan, Yanbo; Chang, Lin; Wang, Lu; Liu, Cai; Yang, Dongshan; Song, Jun; Rech, Jason C; Guo, Yanhong; Wang, Huilun; Zhao, Guizhen; Liang, Wenying; Koike, Yui; Lu, Haocheng; Koike, Tomonari; Hayek, Tony; Pennathur, Subramaniam; Xi, Chuanwu; Wen, Bo; Sun, Duxin; Garcia-Barrio, Minerva T; Aviram, Michael; Gottlieb, Eyal; Mor, Inbal; Liu, Wanqing; Zhang, Jifeng; Chen, Y Eugene 2020. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome. Science translational medicine, 12 572,

2019

Lu, Haocheng; Sun, Jinjian; Liang, Wenying; Zhang, Jifeng; Rom, Oren; Garcia-Barrio, Minerva T; Li, Shengdi; Villacorta, Luis; Schopfer, Francisco J; Freeman, Bruce A; Chen, Y Eugene; Fan, Yanbo 2019. Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells. Physiological genomics, 51 6, 224-233

Liang, Wenying*; Fan, Yanbo*,#; Lu, Haocheng; Chang, Ziyi; Hu, Wenting; Sun, Jinjian; Wang, Huilun; Zhu, Tianqing; Wang, Jintao; Adili, Reheman; Garcia-Barrio, Minerva T; Holinstat, Michael; Eitzman, Daniel; Zhang, Jifeng; Chen, Y Eugene 2019. KLF11 (Krüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall. Arteriosclerosis, thrombosis, and vascular biology, 39 3, 402-412

Rom, Oren; Xu, Guan; Guo, Yanhong; Zhu, Yunhao; Wang, Huilun; Zhang, Jifeng; Fan, Yanbo; Liang, Wenying; Lu, Haocheng; Liu, Yuhao; Aviram, Michael; Liu, Zhipeng; Kim, Seongho; Liu, Wanqing; Wang, Xueding; Chen, Y Eugene; Villacorta, Luis 2019. Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice. EBioMedicine, 41 , 62-72