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Plas Laboratory

Group photo lab

Innovative Therapy

Our group investigates the effects of oncogenic signal transduction on tumor cell metabolism and apoptosis control. In PTEN-deficient cancer cells, signal transduction activates the protein kinase S6K1, which in turn primes cell metabolism to growth and survival in cancer cells. By counteracting oncogenic signal transduction and cancer cell metabolism, we aim to restore normal cell death control in cancer cells.

The lab uses genetic and biochemical approaches to identify and validate novel therapeutic targets in brain cancers and leukemia. We join with outstanding clinical and research colleagues to pursue answers for the biggest obstacles in cancer therapy.

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Department of
Cancer Biology

Vontz Center for Molecular Studies
3125 Eden Avenue
PO Box 670521
Cincinnati, OH 45267-0521

Mail Location: 0521
Phone: 513-558-5323
Fax: 513-558-1190