Wasylishen Lab

Recent Publications

2022

Sun C, Estrella JS, Whitley EM, Lozano G^#, Wasylishen AR^#. Context matters – Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas. Dis Model Mech.  2022 Aug 1;15(8):dmm049552. doi: 10.1242/dmm.049552. Epub 2022 Aug 26. PMID: 35976056 (^#Co-corresponding)

Ding J, Li X, Khan S, Zhang C, Gao F, Sen S, Wasylishen AR, Zhao Y, Lozano G, Koul D, Yung WK. EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a non-canonical regulatory axis between EGFR and wild-type p53 in glioblastoma. Neuro-Oncology. 2022 Apr 26:noac105. doi: 10.1093/neuonc/noac105. Online ahead of print. PMID: 35474131

2021

Fahrmann JF*, Wasylishen AR*, Pieterman CRC*, Irajizad E, Vykoukal J, Murage E, Wu R, Dennison JB, Krishna H, Peterson CB, Lozano G, Zhao H, Do K, Halperin DM, Agarwal SK, Blau JE, Del Rivero J, Nilubol N, Walter MF, Welch JM, Weinstein LS, Vriens MR, van Leeuwaarde RS, van Treijen MJC, Valk GD, Perrier ND, Hanash SM. A blood-based polyamine signature associated with MEN1 duodenopancreatic neuroendocrine tumor progression. J Clin Endocrinol Metab, 106(12): e4969-e4980, 11/2021. PMID: 34318891 (*equal contribution)

Kim MP, Li X, Deng J, Zhang Y, Dai B, Alton K, Hughes TG, Siangco C, Augustine J, Kang Y, McDaniel JM, Xiong SX, Koay E, McAllister F, Bristow C, Heffernan TP, Maitra A, Liu B, Barton MC, Wasylishen AR, Fleming JB, Lozano G. Oncogenic KRAS recruits an expansive transcriptional network through mutant p53 to drive pancreatic cancer metastases. Cancer Discovery, 11(8): 2094-2111, 8/2021. Epub 4/2021. PMID: 33839689

2020

Moyer SM, Wasylishen AR, Qi Y, Fowlkes N, Su X, Lozano G. p53 drives a transcriptional program that elicits a non-cell autonomous response and alters cell state in vivo. Proc Natl Acad Sci USA 117(38): 23663-23673, 9/2020. PMID: 32900967

Wasylishen AR#, Sun C, Moyer SM, Chau GP, Qi Y, Aryal N, McAllister F, Kim MP, Barton MC, Estrella JS, Su X, Lozano G#. Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo. Science Advances, 6(32): eaba8415, 8/2020. PMID: 32821827 (#co-corresponding)

Wasylishen AR, Sun C, Chau GP, Qi Y, Su X, Kim MP, Estrella JS, Lozano G. Men1 maintains homeostasis in response to pancreatitis and oncogenic stress. Proc Natl Acad Sci USA 117(12):6622-6629, 3/2020. PMID: 32156729

El Beaino M, Liu J, Wasylishen AR, Pourebrahim R, Migut A, Bessellieu B, Huang K, Lin P. Loss of Stag2 Cooperates with EWS-FLI1 to Transform Murine Mesenchymal Stem Cells. BMC Cancer. 20(1):3, 1/2020. PMID: 31409715

2019

Pant V, Xiong S, Wasylishen AR, Larsson CA, Aryal NK, Chau G, Tailor RC, Lozano G. Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity. Proc Natl Acad Sci USA 116(35):17429-17437, 8/2019. PMID: 31409715

Samdani RT, Wasylishen AR, Halperin DM, Dasari A, Yao J, Rashid A, Estrella JS. Loss of Menin Expression by Immunohistochemistry in Pancreatic Neuroendocrine Tumors: Comparison Between Primary and Metastastatic Tumors. Pancreas 48(4):510-513, 4/2019. PMID: 30946241

Aryal NK, Pant V, Wasylishen AR, Rimel BJ, Baseler L, El-Naggar AK, Mutch DG, Goodfellow PJ, Arur S, Lozano G. Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination. Cancer Res. 79(10):2662-2668, 5/2019. e-Pub 3/2019. PMID: 30914430

Aryal NK, Pant V, Wasylishen AR, Parker-Thornburg J, Baseler L, El-Naggar AK, Liu B, Kalia A, Lozano G, Arur S. Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo. Proc Natl Acad Sci USA 116(3):960-969, 1/2019. e-Pub 12/2018. PMID: 30593561

2018

Wasylishen AR, Estrella JS, Pant V, Chau GP, Lozano G. Daxx Functions Are p53-Independent In Vivo. Mol Cancer Res 16(10):1523-1529, 10/2018. e-Pub 6/2018. NIHMSID: NIHM973854

Aryal NK, Wasylishen AR, Lozano G. CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo. Cell Death Dis 9(11):1099, 10/2018. e-Pub 10/2018. PMCID: PMC6204134

Tonnessen-Murray C, Ungerleider NA, Rao SG, Wasylishen AR, Frey WD, Jackson JG. p53 Mediates Vast Gene Expression Changes That Contribute to Poor Chemotherapeutic Response in a Mouse Model of Breast Cancer. Transl Oncol 11(4):930-940, 8/2018. e-Pub 5/2018. PMCID: PMC6041561