Fan Laboratory

Overview

The long-term goal of our research is to explore the molecular basis of vascular disease and the intersection of vascular disease and cancer. We aim to uncover novel therapeutic targets and approaches to prevent and treat cardiovascular disease and cancer. 

We recently demonstrated that transcription factor EB (TFEB), a master regulator of autophagy and lysosome biogenesis, is critical to maintain vascular wall homeostasis.  The overall goal of the Fan laboratory is to identify novel therapeutic targets for the treatment of a variety of vascular-related human diseases.