Today is Monday, Aug. 26, 2019

Department of

Cancer Biology

  • Jensen Symposium
  • State-of-the-Art Labs and Facilities
  • Competitive National Graduate Program

About Cancer Biology

Cancer Biology Faculty and Students

The Cancer Biology Department is the home of a dynamic, collaborative and highly interactive faculty with cutting-edge research programs that span a wide range of cancer-related topics.

Every new discovery and success in our laboratories—big and small—is putting our dreams of eradicating (or controlling) cancer closer than ever to reality. We hope you will join us in our fight against cancer through basic and translational research at this most opportune and exciting time.

We invite you to learn more about:

Recent Publications

Graduate Students

The following publications have been recently published by Cancer Biology faculty:

  • Kofuji, Satoshi; Hirayama, Akiyoshi; Eberhardt, Alexander O; Kawaguchi, Risa; Sugiura, Yuki; Sampetrean, Oltea; Ikeda, Yoshiki; Warren, Mikako; Sakamoto, Naoya; Kitahara, Shuji; Yoshino, Hirofumi; Yamashita, Daisuke; Sumita, Kazutaka; Wolfe, Kara; Lange, Lisa; Ikeda, Satsuki; Shimada, Hiroko; Minami, Norialo; Malhotra, Akshiv; Morioka, Shin; Ban, Yuki; Asano, Maya; Flanary, Victoria L; Ramkissoon, Annmarie; Chow, Lionel M L; Kiyokawa, Juri; Mashimo, Tomoyuki; Lucey, Greg; Mareninov, Sergey; Ozawa, Tatsuya; Onishi, Nobuyuki; Okumura, Koichi; Terakawa, Jumpei; Daikoku, Takiko; Wise-Draper, Trisha; Majd, Nazanin; Kofuji, Kaori; Sasaki, Mika; Mori, Masaru; Kanemura, Yonehiro; Smith, Eric P; Anastasiou, Dimitrios; Wakimoto, Hiroaki; Holland, Eric C; Yong, William H; Horbinski, Craig; Nakano, Ichiro; DeBerardinis, Ralph J; Bachoo, Robert M; Mischel, Paul S; Yasui, Wataru; Suematsu, Makoto; Saya, Hideyuki; Soga, Tomoyoshi; Grummt, Ingrid; Bierhoff, Holger; Sasaki, Atsuo, T. 2019. IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma. Nature Cell Biology. 21(8):1003-1014
  • Sliz, Anna; Locker, Kathryn C S; Lampe, Kristin; Godarova, Alzbeta; Plas, David R; Janssen, Edith M; Jones, Helen; Herr, Andrew B; Hoebe, Kasper 2019. Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy. Science Immunology, 4, 38.
  • Brose, Nils; Brunger, Axel; Cafiso, David; Chapman, Edwin R; Diao, Jiajie; Hughson, Frederick M; Jackson, Meyer B; Jahn, Reinhard; Lindau, Manfred; Ma, Cong; Rizo, Josep; Shin, Yeon-Kyun; Söllner, Thomas H; Tamm, Lukas; Yoon, Tae-Young; Zhang, Yongli 2019. Synaptic vesicle fusion: today and beyondNature Structural & Molecular Biology, 26 8, 663-668
  • Smith, Molly A; Choudhary, Gaurav S; Pellagatti, Andrea; Choi, Kwangmin; Bolanos, Lyndsey C; Bhagat, Tushar D; Gordon-Mitchell, Shanisha; Von Ahrens, Dagny; Pradhan, Kith; Steeples, Violetta; Kim, Sanghyun; Steidl, Ulrich; Walter, Matthew; Fraser, Iain D C; Kulkarni, Aishwarya; Salomonis, Nathan; Komurov, Kakajan; Boultwood, Jacqueline; Verma, Amit; Starczynowski, Daniel T. 2019. U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignanciesNature Cell Biology.
  • Huang, Huilin; Weng, Hengyou; Zhou, Keren; Wu, Tong; Zhao, Boxuan Simen; Sun, Mingli; Chen, Zhenhua; Deng, Xiaolan; Xiao, Gang; Auer, Franziska; Klemm, Lars; Wu, Huizhe; Zuo, Zhixiang; Qin, Xi; Dong, Yunzhu; Zhou, Yile; Qin, Hanjun; Tao, Shu; Du, Juan; Liu, Jun; Lu, Zhike; Yin, Hang; Mesquita, Ana; Yuan, Celvie L; Hu, Yueh-Chiang; Sun, Wenju; Su, Rui; Dong, Lei; Shen, Chao; Li, Chenying; Qing, Ying; Jiang, Xi; Wu, Xiwei; Sun, Miao; Guan, Jun-Lin; Qu, Lianghu; Wei, Minjie; Müschen, Markus; Huang, Gang; He, Chuan; Yang, Jianhua; Chen, Jianjun 2019. Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally. Nature, 567 7748, 414-419
  • Xu, Yichen; Poggio, Mauro; Jin, Hyun Yong; Shi, Zhen; Forester, Craig M; Wang, Ying; Stumpf, Craig R; Xue, Lingru; Devericks, Emily; So, Lomon; Nguyen, Hao G; Griselin, Alice; Gordan, John D; Umetsu, Sarah E; Reich, Siegfried H; Worland, Stephen T; Asthana, Saurabh; Barna, Maria; Webster, Kevin R; Cunningham, John T; Ruggero, Davide 2019. Translation control of the immune checkpoint in cancer and its therapeutic targeting. Nature Medicine.

SEE MORE

Latest News/Events

Welcome Krushna Patra, PhD!

Effective 8/5/19:  Dr. Krushna Patra will join the University of Cincinnati as an assistant professor in the Department of Cancer Biology. Dr. Patra’s research will focus on the interplay of cellular signaling and metabolism in the tumorigenesis processes related to the development and treatment of pancreatic and other gastrointestinal cancers, with emphasis on the study of oncogenic roles of mutant GNAS in pancreatic cancer, using genetically engineered mouse models and human patient derived models of pancreatic cancer harboring mutant GNAS (PDXs, Organoids, cell lines).

Congratulations to Ken Greis, PhD!

7/25/19: Dr. Greis, Associate Dean for Research Core Facilities and Cancer Biology professor, has been awarded an NIH S10 grant for "An Orbitrap Mass Spectrometry System for the University of Cincinnati Proteomics".

Congratulations to Tom Cunningham, PhD!

7/5/19: Dr. Cunningham, Cancer Biology assistant professor, has been awarded an NIH R01 grant from the National Cancer Institute and an NIH R35 Maximizing Investigators' Research Award (MIRA) for Early Stage Investigators from the National Institute of General Medical Sciences (NIGMS). The five year R01 grant entitled "Investigating Mechanisms of Deregulated Nucleotide Metabolism in Cancer" will focus on defining the mechanisms that underlie deregulation of nucleotide metabolism in lymphomas and myelomas that overexpress the MYC oncogene. His five year R35 grant entitled "Defining the biological roles of PRPS isozymes in normal and diseased settings" will focus on defining the mechanisms responsible for regulating nucleotide metabolism in normal and disease settings.