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University of Cincinnati Department of Radiology Research and Development Project 08/01/2020-Present
Role: PI’s: Rifat Wahab, DO, Ann Brown, MD
University of Cincinnati Office of Innovation, Cincytech (Brown) 09/2020-Present Specific aim to create a minimum viable product (MVP) to demonstrate the feasibility of a machine learning algorithm to detect and quantify an early sign of heart disease on mammograms.
Role: PI: Ann Brown, MD
NIH/National Cancer Institute, Coordinated by ECOG-ACRIN Cancer Research Group
TMIST is first randomized, controlled trial that seeks to identify women in which digital breast tomosynthesis (DBT) may outperform 2D digital mammography in reducing advanced breast cancer development. The study will also create the world’s largest curated dataset of breast cancer screening clinical data, images and bio-specimens to help researcher’s tailor future screening to a woman’s individual risk.
Role: Participating Site PI: Lawrence Sobel, MD
University of Cincinnati Department of Radiology Research and Development Project 09/01/2017-Present
Role: PI: Susan Braley, MD
University of Cincinnati Department of Radiology Pilot Research Grant 03/01/2019-Present
Prospective study following longitudinal ultrasound screening of the patellar tendon in a population of male and female college athletes from 2 sports commonly associated with patellar tendinopathy, basketball and volleyball. Currently little is known regarding the natural history associated with patellar tendinopathy and even less is known regarding the state of the tendon prior to the development of symptoms. Point of care screening for at-risk athletes, and subsequently following them for 2 years will significantly enhance the understanding of the genesis of symptomatic patellar tendinopathy. Role: PI: Susan Braley, MD
NIH/NINDS R01NS103824 (Khatri*, Kissela*, Vagal) 09/01/2018-08/31/2023
Aim of this project is to characterize the entire imaging spectrum of brain health in stroke and TIA patients in collaboration with Department of Neurology’s* large population based study.
Role: Contact PI: Achala Vagal, MD, MS (Central Readers: Cornelius, Gaskill-Shipley, Tomsick, Vagal, Wang, Wang)
RF1 NIH/NINDS NS117643 (Khatri, Kissela, Vagal) 08/15/2020-05/31/2024
Project will create prediction model of post stroke dementia incorporating imaging parameters in biracial ischemic stroke/hemorrhagic stroke/TIA population using state of the art modeling approaches.
Role: Contact Co-PI: Achala Vagal, MD, MS
The primary goal of the two stage, phase 3, multicenter trial is to determine if the rivaroxaban or ticagrelor or both are superior to the clopidogrel arm for lowering the 1-year rate of the primary endpoint (ischemic stroke, ICH or vascular death). NIH funded multisite study with ~115 sites in the USA, enrollment goal of~1700 subjects.
Role: Imaging Management Center
University of Cincinnati Gardner Neuroscience Institute (UCGNI) – James J. & Joan A. Gardner Family Foundation (Alberto Espay, MD – Department of Neurology)
Theory is that neurodegenerative diseases such as Parkinson’s & Alzheimer’s are not one disease but many when considered from genetic and molecular perspectives. Study aimed at defining patient groups based on molecular features rather than symptoms to allow for early diagnosis and development of disease-specific neuroprotective treatment for each molecular form.
Role: Imaging Core Lab
Department of Radiology Pilot
06/21/2017-Present
The purpose of this study is to determine if there is significant decline in Radiology resident’s cognitive function while working night shifts.
Role: PI: Carl Flink, MD
Cerevovus/Johnson & Johnson (Demchuk, Khatri, Nagel, Nogueira) 07/01/2018-06/01/2022
Primary objective to test efficacy and safety of immediate mechanical thrombectomy versus initial medical treatment in patients presenting with cerebral ischemia in the setting of proximal large vessel occlusions (LVO) and low baseline NIHSS score.
ClinicalTrials.gov Identifier: NCT04167527
Role: Imaging Management Center; Co-Central Reader: Achala Vagal, MD, MS
The aim of this observational study is to determine the impact of childhood CV risk factors on structural & functional indicators of brain health and cognitive performance in midlife.NIH funded multisite study with Enrollment goal of ~ 2500 subjects.
Site PI: Dr. Achala Vagal; MD, MS
Department of Radiology Pilot Grant
Project aim to assess detection sensitivity of a new MRI scanning protocol increasing isotropic spatial resolution from 1mm to 0.7mm for detection of small brain tumors.
Role: PI: Mary Gaskill-Shipley, MD
NIH/NINDS U01NS100699 (Adeoye, Barreto, Broderick, Derdeyn, Grotta) 06/01/2018-04/30/23
Primary objective to determine if acute ischemic stroke patients treated with IV rt-PA followed by argatroban or eptifibatide results in improved 90-day outcomes as compared with patients treated with IV rt-PA alone within 3 hours of symptom onset.
ClinicalTrials.gov Identifier: NCT03735979
Role: Collaborating Imaging Core Lab; Co-Central Readers: Achala Vagal, MD, MS, Max Wintermark, MD (Stanford University)
University of Cincinnati Gardner Neuroscience Institute (UCGNI) Grant 10/01/2020-Present
Role: PI: Lilly Wang, MBBS, MPH
NIH/NINDS R01NS100417 (Woo) Info pending 10/01/2020-08/31/2022
Re-enrollment of ROSE cohort at 12-24 months (18 +/1 6 months) with follow-up 3T DTI, RNA blood sample and cognitive assessments at 6 and 12 month enrollment.
Role: Imaging Core Lab; Co-investigator/Central Reader: Achala Vagal, MD, MS
NIH/NINDS R01NS100417 (Woo) 09/01/2017-08/31/2022
Specific aim of study to improve motor and cognitive recovery prediction after supratentorial intracerebral hemorrhage (ICH) by adding proportion of tract injury as measured by diffusion tensor imaging (DTI) independent of the ICH volume, location, age, gender and intraventricular hemorrhage (IVH). ClinicalTrials.gov Identifier: NCT04007757
NIH/NINDS U01NS110772 (Broderick, Grotta, Naidech, Elm) 03/01/2020-12/31/2024
Primary objective to test the hypothesis that treatment with rFIIa within two hours of symptom onset in appropriately selected patients with spontaneous intracerebral hemorrhage (ICH) improves outcome as measured by the ordinal distribution of the modified Rankin Scale (mRS) at 180 days as compared to placebo.
ClinicalTrials.gov Identifier: NCT03496883
Role: Imaging Management Center; Central Reader: Achala Vagal, MD, MS
NIH/NINDS U24NS100688 (Adeoye) 07/15/2017-05/31/2022
The goal of SIREN is to conduct high-quality, multi-site clinical trials to improve outcomes for patients with neurologic, cardiac, respiratory, hematologic and trauma emergency events.
Role: Co-investigator, UC SIREN Team: Achala Vagal, MD, MS
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Department of Radiology Pilot Grant (Verma) 06/2016-06/2018
Retrospective study to determine the diagnostic accuracy of MR textural analysis to differentiate benign transition zone prostatic hypertrophy from high-grade transition zone prostatic tumors by assessing transition zone heterogeneity.
Role: PI: Sadhna Verma, MD
Department of Radiology Pilot Grant (Kapur) 06/2016-06/2018
Retrospective study to determine the diagnostic accuracy of CT texture analysis of part-solid lung nodules to differentiate pre-invasive lesions from minimally invasive and invasive adenocarcinoma.
Role: PI: Sangita Kapur, MD
University of Cincinnati Neuroscience Foundation (Guarneschelli) 06/01/2010-06/30/2012
The study assessed differences in treatment volume for radiation planning in gliomas as calculated using 1.5T versus 3T magnets and analyzed recurrence patterns in relation to the target volumes.
Role: Co-Investigator: Achala Vagal, MD, MS
NIH/NINDS RO1NS030678 (Kissela, Kleindorfer – Dept. of Neurology) 07/1993-04/01/2020
Major goals of project to examine incidence rates, causes, and treatment of ischemic and hemorrhagic stroke and to compare the incidence rate and survival of stroke and stroke sub-types in blacks and whites by gender and age group.
ClinicalTrials.gov Identifier: NCT00642213
Role: Co-Investigators: Thomas Tomsick, MD, Achala Vagal, MD, MS
NIH/NINDS N01NS32324 1983-1985
Dose-escalation study performed in 27 subjects to determine the highest safe and potentially optimal dose of naloxone for treatment of acute cerebral ischemia.
Role: Central CT Imaging Reader, Co-Investigator: Thomas Tomsick, MD
Nuvelo Corporation (Clark, Lu) 2/01/2006-02/01/2007
Role: Co-Investigator: Thomas Tomsick, MD
The Neuroscience Institute Research Fund 2001-2002
Role: Principal Investigator: Thomas Tomsick, MD
NIH/NINDS R01NS22611 1987-1994
Study to determine whether the addition of carotid endarterectomy to aggressive medical management can reduce the incidence of cerebral infarction in patients with asymptomatic carotid artery stenosis.
Role: Imaging Core Lab, Co-Investigator: Thomas Tomsick, MD
NIH/NINDS P50NS044283 (Pancioli) 08/01/2010-04/30/2012
Primary goal to determine safety of the combination of medium dose of IV recombinant tissue plasminogen activator (rt-PA) plus IV eptifibatide compared to standard dose rt-PA started within 3 hours of symptom onset in patients with acute ischemic stroke.
ClinicalTrials.gov Identifier: NCT00894803
Role: Imaging Core Lab, Co-Central Readers: Thomas Tomsick, MD, Achala Vagal, MD, MS
NIH/NINDS P50NS044283 (Pancioli) 05/01/2013-11/30/2014
Primary goal to determine if individuals with acute ischemic stroke treated with a full dose of IV recombinant tissue plasminogen activator (rt-PA) plus IV eptifibatide started within 3 hours of symptom onset are more likely to have a better outcome than individuals treated with standard IV rt-PA alone.
ClinicalTrials.gov Identifier: NCT01977456
GE Medical Systems 1997-2000
NIH/NINDS U01NS092076 (Albers) 04/2016-08/23/2017
Primary goal of study to evaluate the hypothesis that FDA cleared Thrombectomy devices plus medical management leads to superior clinical outcomes in acute ischemic stroke patients at 90 days when compared to medical management alone in appropriately selected subjects with the Target mismatch profile and an MCA (M1 segment) or IC occlusion who can be randomized and have endovascular treatment initiated between 6-16 hours after last seen well.
ClinicalTrials.gov Identifier: NCT02586415
Role: Local Site Principal Investigator: Achala Vagal, MD, MS
Air Force Research Laboratory (Goodman) 08/02/2018-10/25/2019
Primary objective to understand the impact of aeromedical evacuation techniques in TBI.
The Neuroscience Institute Research Grant 01/01/2006-01/01/2007
Genentech, Inc. 1994-1995
Randomized controlled study to test feasibility and provide preliminary data regarding the relative benefits and risks of combined intravenous and intra-arterial rt-PA for patients with acute ischemic stroke.
Role: CT & Angiography Imaging Core Lab, Co-Investigator, Interventional Committee Director: Thomas Tomsick, MD
NIH/NINDS N01NS32324, NIH/NINDS 8606 1986-1988
Role: Local CT Imaging Reader, Co-Investigator: Thomas Tomsick, MD
Glaxo Wellcome, Inc,.
Role: CT Imaging Core Lab & Adjudication Panel: Thomas Tomsick, MD
NIH/NINDS R01NS36695 (Broderick) 1997-2007
Major goals of project to examine the roles of genetic and environmental factors which increase risk for hemorrhagic stroke.
American College of Radiology Foundation Award (Mahoney, Vagal) 06/01/2019-06/01/2020
Primary objective to use human centered design thinking methodology to improve patient experience in Radiology.
Role: PI: Achala Vagal, MD, MS
NIH/NINDS R01NS039160 (Broderick, Tomsick) 01/01/2004-05/2006
Primary goal of study to provide preliminary data about the benefits and risks of combined intravenous (IV) and intra-arterial (IA) rt-PA and low-intensity ultrasound energy in ischemic stroke patients with baseline NIHSS >/= 10 in whom IV treatment can be started within 3 hours of stroke onset..
ClinicalTrials.gov Identifier: NCT00243906
Role: Imaging Core Lab, Principal Interventional Investigator, Central CT & Angio Reader: Thomas Tomsick, MD
NIH/NINDS PAR03051 (Broderick, Tomsick) 07/01/2004-06/30/2005
Goals of project to plan for submission of and possible execution of major multi-center phase III randomized trial of combined intravenous and intra-arterial approach to recanalization using rt-PA in patients with acute ischemic stroke.
Role: Co-Principal Investigator: Thomas Tomsick, MD
NIH/NINDS U01NS052220 (Broderick, Tomsick) 07/01/2005-06/30/2010
Primary goal of study to examine whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalization is superior to standard IV rt-PA alone when initiated within 3 hours of acute ischemic stroke onset.
ClinicalTrials.gov Identifier: NCT00359424
Role: Imaging Management Center, Angiography Core Lab, Principal Interventional Investigator, Co-Angiography Reader: Thomas Tomsick, MD
NIH/NINDS R01NS039160 (Broderick, Tomsick) 09/30/2000-06/30/2003
Multi-center, open-labeled, single arm pilot study to investigate the feasibility and safety of a combined intravenous and intra-arterial approach to recanalization using rt-PA in patients with ischemic stroke.
Role: Imaging Core Lab, Co-Principal Investigator, Central CT & Angio Reader: Thomas Tomsick, MD
UC Neuroscience Institute-Neurobiology Research Center Pilot Grant (Coleman) 01/2016-12/2017
Goal of this study to refine a clinical and imaging-based model for predicting language recovery in acute stroke patients.
NIH/NINDS UCLA SPOTRIAS Grant P50NS44378 (Kidwell) 05/2004-5/2010
Multi-center, randomized, controlled, blinded outcome evaluator, phase IIb trial to investigate whether diffusion-perfusion MR imaging can identify patients who will benefit substantially from mechanical embolectomy with the Concentric MERCI™ Retriever device for the treatment of acute ischemic stroke up to 8 hours from symptom onset.
Role: Local Site Principal Investigator: Thomas Tomsick, MD
Boston Scientific Neuroradiology Education & Research Foundation Grant 11/2007-07/01/2010
The primary purpose of the study is to demonstrate that intracranial aneurysm recurrence after coil embolization involves combination of aneurysm growth and coil compaction.
Role: Principal Investigator: Todd Abruzzo, MD
University of Cincinnati Neuroscience Foundation Grant (Hartings) 06/01/2010-06/30/2011
The goal of the study is to assess the role of cortical spreading depolarizations (CSD) using subdural electrode strips in delayed deterioration after aneurysmal subarachnoid hemorrhage.
Knoll Pharmaceuticals 1989-1991
NIH/NINDS 2U01NS058982 (Adeoye, Pancioli) 09/30/2012-05/31/2018
University of Cincinnati is participating clinical site hub in a network with goal to improve outcomes of patients with acute neurologic problems through innovative research focused on the emergent phase of patient care.
Role: Co-Investigator UC NETT Team: Achala Vagla, MD, MS
Center for Clinical and Translational Science and Training (CCTST) KL2 Research Award (Vagal) 07/01/2015-06/30/2016
The goal of the study is to understand the natural fate and prognostic value of the penumbra in untreated patients. KL2 provides mentored career development experience in clinical and translational research.
American Roentgen Ray Society Scholarship (Vagal) 07/01/2012-06/30/2014
The goal of the study is to understand the natural fate and prognostic value of the ischemic penumbra. The ARRS Scholarship is intended to support study in a field selected by the scholar that will enable the scholar to attain his/her professional career goal.
Center for Clinical and Translational Science and Training (CCTST) CT2 Research Award (Vagal)
07/01/2014-06/30/2015
The goal of the study is to understand the natural fate and prognostic value of the penumbra in untreated patients. As the institutional equivalent of the CTSA funded KL2 program, the CT2 provides mentored career development experience in clinical and translational research.
NIH/NINDS R01NS02374 1990-1992
Genentech, Inc. (Khatri) 01/01/2014-04/30/2018
Phase IIIb, multicenter trial to evaluate the efficacy and safety of alteplase in patients with mild stroke (NIHSS </= 5 and not clearly disabling).
Adrian Medical 1995
Lilly Research Laboratories 1997-2000
Certus International, Inc. 1999-2000
Neuroradiology Education and Research Fund of the American Society of Neuroradiology via the Boston Scientific Fellowship in Cerebrovascular Disease Research Award 2008
Role: Principal Investigator: Humberto Morales, MD, Mentor: Thomas Tomsick, MD
Department of Defense W81XWH-08-2-0016 (Hartings) 10/01/2008-04/30/2014
The goal of the study is to determine whether cortical spreading depolarization’s occurring spontaneously after traumatic brain injury are associated with poor outcomes.
Role: Imaging Core Lab, Central Reader: Achala Vagal, MD, MS
University of Cincinnati Interdisciplinary Research Council (Bonomo) 07/01/2009-06/30/2011
The goal is to establish the novel use of CTA and CTP to detect vasospasm in patients with severe TBI and to explore the correlation between CSF markers seen in SAH induced vasospasm.
The Neuroscience Institute Research Fund 1999-2000
NIH/NINDS R01NS26933 1991-1994
Tri-Point Industries 1990-1993
Role: Principal Site Investigator: Thomas Tomsick, MD
Interventional Therapeutics Corporation 1987-1993
Target Therapeutics 1992-1996
Cordis Endovascular Systems 1994
Cordis Endovascular Systems 1997 – 2000
GE Healthcare 04/01/2018-04/31/2019
Major goal of this project to apply design thinking to understand the entire patient journey through radiology and create persona involving all stakeholders including patients, families, clinicians and radiology staff.
Role: Co-PI’s: Mary Mahoney, MD, Achala Vagal, MD, MS
3188 Bellevue AvenueCincinnati, Ohio 45219
Phone: 513-584-4396Fax: 513-584-0431Email: radiology@uc.edu
To verify completion of Residency or Fellowship click here: Verify Completion