Today is Friday, Nov. 22, 2019

Department of

Cancer Biology - Guan Laboratory

Publications

2019

Gao, Chenxi; Chen, Guangming; Zhang, Dennis Han; Zhang, Judy; Kuan, Shih-Fan; Hu, Wenhuo; Esni, Farzad; Gao, Xuan; Guan, Jun-Lin; Chu, Edward; Hu, Jing 2019. PYK2 is involved in premalignant acinar cell reprogramming and pancreatic ductal adenocarcinoma maintenance by phosphorylating ?-cateninY654. Cellular and molecular gastroenterology and hepatology, ,

Ho, Wan Yun; Tai, Yee Kit; Chang, Jer-Cherng; Liang, Jason; Tyan, Sheue-Houy; Chen, Song; Guan, Jun-Lin; Zhou, Huilin; Shen, Han-Ming; Koo, Edward; Ling, Shuo-Chien 2019. The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy. Autophagy, , 1-16

Huang, Huilin; Weng, Hengyou; Zhou, Keren; Wu, Tong; Zhao, Boxuan Simen; Sun, Mingli; Chen, Zhenhua; Deng, Xiaolan; Xiao, Gang; Auer, Franziska; Klemm, Lars; Wu, Huizhe; Zuo, Zhixiang; Qin, Xi; Dong, Yunzhu; Zhou, Yile; Qin, Hanjun; Tao, Shu; Du, Juan; Liu, Jun; Lu, Zhike; Yin, Hang; Mesquita, Ana; Yuan, Celvie L; Hu, Yueh-Chiang; Sun, Wenju; Su, Rui; Dong, Lei; Shen, Chao; Li, Chenying; Qing, Ying; Jiang, Xi; Wu, Xiwei; Sun, Miao; Guan, Jun-Lin; Qu, Lianghu; Wei, Minjie; Müschen, Markus; Huang, Gang; He, Chuan; Yang, Jianhua; Chen, Jianjun 2019. Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally. Nature, 567 7748, 414-419

Jeong, Kyuho; Kim, Jung-Hyun; Murphy, James M; Park, Hyeonsoo; Kim, Su-Jeong; Rodriguez, Yelitza; Kong, Hyunkyung; Choi, Chungsik; Guan, Jun-Lin; Taylor, Joan M; Lincoln, Thomas M; Gerthoffer, William T; Kim, Jun-Sub; Ahn, Eun-Young Erin; Schlaepfer, David D; Lim, Ssang-Taek Steve 2019. Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-mediated Cyclin D1 Transcription. Circulation research, ,

Thomas, Neil; Choi, Han Kyoung; Wei, Xiaoxi; Wang, Li; Mishina, Yuji; Guan, Jun-Lin; Liu, Fei 2019. Autophagy Regulates Craniofacial Bone Acquisition. Calcified tissue international, ,

Zachari, Maria; Gudmundsson, Sigurdur R; Li, Ziyue; Manifava, Maria; Shah, Ronak; Smith, Matthew; Stronge, James; Karanasios, Eleftherios; Piunti, Caterina; Kishi-Itakura, Chieko; Vihinen, Helena; Jokitalo, Eija; Guan, Jun-Lin; Buss, Folma; Smith, Andrew M; Walker, Simon A; Eskelinen, Eeva-Liisa; Ktistakis, Nicholas T 2019. Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform. Developmental cell, ,

2018

Chen, Qixin; Jin, Chengzhi; Shao, Xintian; Guan, Ruilin; Tian, Zhiqi; Wang, Chenran; Liu, Fei; Ling, Peixue; Guan, Jun-Lin; Ji, Liangnian; Wang, Fengshan; Chao, Hui; Diao, Jiajie 2018. Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore. Small (Weinheim an der Bergstrasse, Germany), 14 41, e1802166

Choi, Han Kyoung; Yuan, Hebao; Fang, Fang; Wei, Xiaoxi; Liu, Lu; Li, Qing; Guan, Jun-Lin; Liu, Fei 2018. Tsc1 regulates the balance between osteoblast and adipocyte differentiation through autophagy/Notch1/β-catenin cascade. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, ,

Huang, Huilin; Weng, Hengyou; Sun, Wenju; Qin, Xi; Shi, Hailing; Wu, Huizhe; Zhao, Boxuan Simen; Mesquita, Ana; Liu, Chang; Yuan, Celvie L; Hu, Yueh-Chiang; Hüttelmaier, Stefan; Skibbe, Jennifer R; Su, Rui; Deng, Xiaolan; Dong, Lei; Sun, Miao; Li, Chenying; Nachtergaele, Sigrid; Wang, Yungui; Hu, Chao; Ferchen, Kyle; Greis, Kenneth D; Jiang, Xi; Wei, Minjie; Qu, Lianghu; Guan, Jun-Lin; He, Chuan; Yang, Jianhua; Chen, Jianjun 2018. Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nature cell biology, 20 3, 285-295

Liu, Bingjie; Du, Ruikai; Zhou, Lei; Xu, Jiahui; Chen, Song; Chen, Ji; Yang, Xiaoli; Liu, Dong-Xu; Shao, Zhi-Ming; Zhang, Lixing; Yu, Zuoren; Xie, Ni; Guan, Jun-Lin; Liu, Suling 2018. miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/?-Catenin Axis. Theranostics, 8 21, 5801-5813

Nwadike, Chinwendu; Williamson, Leon E; Gallagher, Laura E; Guan, Jun-Lin; Chan, Edmond Y W 2018. AMPK inhibits ULK1-dependent autophagosome formation and lysosomal acidification via distinct mechanisms. Molecular and cellular biology, ,

Ogawa, Michinaga; Matsuda, Ryuta; Takada, Naoki; Tomokiyo, Mikado; Yamamoto, Shouji; Shizukusihi, Sayaka; Yamaji, Toshiyuki; Yoshikawa, Yuko; Yoshida, Mitsutaka; Tanida, Isei; Koike, Masato; Murai, Miyo; Morita, Hidetoshi; Takeyama, Haruko; Ryo, Akihide; Guan, Jun-Lin; Yamamoto, Masahiro; Inoue, Jun-Ichiro; Yanagawa, Toru; Fukuda, Mitsunori; Kawabe, Hiroshi; Ohnishi, Makoto 2018. Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1 mediated K63-linked ubiquitination. Cellular microbiology, , e12846

Sun, Shaogang; Wu, Hsin-Jung; Guan, Jun-Lin 2018. Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice. Scientific reports, 8 1, 2550

Thiagarajan, Praveena S; Sinyuk, Maksim; Turaga, Soumya M; Mulkearns-Hubert, Erin E; Hale, James S; Rao, Vinay; Demelash, Abeba; Saygin, Caner; China, Arnab; Alban, Tyler J; Hitomi, Masahiro; Torre-Healy, Luke A; Alvarado, Alvaro G; Jarrar, Awad; Wiechert, Andrew; Adorno-Cruz, Valery; Fox, Paul L; Calhoun, Benjamin C; Guan, Jun-Lin; Liu, Huiping; Reizes, Ofer; Lathia, Justin D 2018. Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase. Nature communications, 9 1, 578

Yeo, Syn Kok; Paul, Ritama; Haas, Michael; Wang, Chenran; Guan, Jun-Lin 2018. Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer. Autophagy, ,

2017

Chen, Xiaoyi; Clark, Jason; Wunderlich, Mark; Fan, Cuiqing; Davis, Ashley; Chen, Song; Guan, Jun-Lin; Mulloy, James C; Kumar, Ashish; Zheng, Yi 2017. Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy, 13 5, 955-966

He, Yun; Sun, Xiumei; Wang, Li; Mishina, Yuji; Guan, Jun-Lin; Liu, Fei 2017. Male germline recombination of a conditional allele by the widely used Dermo1-cre (Twist2-cre) transgene. Genesis (New York, N.Y. : 2000), ,

Martin, E E; Huang, W; Anwar, T; Arellano-Garcia, C; Burman, B; Guan, J-L; Gonzalez, M E; Kleer, C G 2017. MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas. Oncogene, 36 16, 2275-2285

Ruiz-Torres, Sasha J; Benight, Nancy M; Karns, Rebekah A; Lower, Elyse E; Guan, Jun-Lin; Waltz, Susan E 2017. HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling. Oncotarget, 8 35, 58918-58933

Wacker, Rahel; Eickel, Nina; Schmuckli-Maurer, Jacqueline; Annoura, Takeshi; Niklaus, Livia; Khan, Shahid M; Guan, Jun-Lin; Heussler, Volker T 2017. LC3-association with the parasitophorous vacuole membrane of Plasmodium berghei liver stages follows a noncanonical autophagy pathway. Cellular microbiology, ,

Wang, Bo; Iyengar, Rekha; Li-Harms, Xiujie; Joo, Joung Hyuck; Wright, Christopher; Lavado, Alfonso; Horner, Linda; Yang, Mao; Guan, Jun-Lin; Frase, Sharon; Green, Douglas R; Cao, Xinwei; Kundu, Mondira 2017. The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy, , 1-16

Wang, Chenran; Yeo, Syn; Haas, Michael A; Guan, Jun-Lin 2017. Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia. The Journal of cell biology, 216 8, 2581-2596

Xia, Houjun; Wang, Wei; Crespo, Joel; Kryczek, Ilona; Li, Wei; Wei, Shuang; Bian, Zhaoqun; Maj, Tomasz; He, Mingxiao; Liu, Rebecca J; He, Youwen; Rattan, Ramandeep; Munkarah, Adnan; Guan, Jun-Lin; Zou, Weiping 2017. Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. Science immunology, 2 17,

Yeo, Syn Kok; Guan, Jun-Lin 2017. Breast Cancer: Multiple Subtypes within a Tumor? Trends in cancer, 3 11, 753-760

2016

Chen, Song; Wang, Chenran; Yeo, Syn; Liang, Chun-Chi; Okamoto, Takako; Sun, Shaogang; Wen, Jian; Guan, Jun-Lin 2016. Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model. Genes & development, 30 7, 856-69

Park, Sunmin; Buck, Michael D; Desai, Chandni; Zhang, Xin; Loginicheva, Ekaterina; Martinez, Jennifer; Freeman, Michael L; Saitoh, Tatsuya; Akira, Shizuo; Guan, Jun-Lin; He, You-Wen; Blackman, Marcia A; Handley, Scott A; Levine, Beth; Green, Douglas R; Reese, Tiffany A; Artyomov, Maxim N; Virgin, Herbert W 2016. Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation. Cell host & microbe, 19 1, 91-101

Santeford, Andrea; Wiley, Luke A; Park, Sunmin; Bamba, Sonya; Nakamura, Rei; Gdoura, Abdelaziz; Ferguson, Thomas A; Rao, P Kumar; Guan, Jun-Lin; Saitoh, Tatsuya; Akira, Shizuo; Xavier, Ramnik; Virgin, Herbert W; Apte, Rajendra S 2016. Impaired autophagy in macrophages promotes inflammatory eye disease. Autophagy, 12 10, 1876-1885

Sun, Chunhui; Yuan, Hebao; Wang, Li; Wei, Xiaoxi; Williams, Linford; Krebsbach, Paul H; Guan, Jun-Lin; Liu, Fei 2016. FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation By Enhancing Wnt Signaling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, ,

Sun, Shaogang; Guan, Jun-Lin 2016. Modeling lymphangiosarcoma in mice. Cell cycle (Georgetown, Tex.), , 0

Wagener, Brant M; Hu, Meng; Zheng, Anni; Zhao, Xueke; Che, Pulin; Brandon, Angela; Anjum, Naseem; Snapper, Scott; Creighton, Judy; Guan, Jun-Lin; Han, Qimei; Cai, Guo-Qiang; Han, Xiaosi; Pittet, Jean-Francois; Ding, Qiang 2016. Neuronal Wiskott-Aldrich syndrome protein regulates TGF-β1-mediated lung vascular permeability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30 7, 2557-69

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin 2016. Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. The Journal of cell biology, 212 5, 545-60

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin 2016. Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. The Journal of cell biology, 212 7, 879

Yeo, Syn Kok; Guan, Jun-Lin 2016. Hierarchical heterogeneity in mammary tumors and its regulation by autophagy. Autophagy, 12 10, 1960-1961

Yeo, Syn Kok; Wen, Jian; Chen, Song; Guan, Jun-Lin 2016. Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad Signaling. Cancer research, 76 11, 3397-410

2015

Fang, Fang; Sun, Shaogang; Wang, Li; Guan, Jun-Lin; Giovannini, Marco; Zhu, Yuan; Liu, Fei 2015. Neural Crest-Specific TSC1 Deletion in Mice Leads to Sclerotic Craniofacial Bone Lesion. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30 7, 1195-205

Martinez, Jennifer; Malireddi, R K Subbarao; Lu, Qun; Cunha, Larissa Dias; Pelletier, Stephane; Gingras, Sebastien; Orchard, Robert; Guan, Jun-Lin; Tan, Haiyan; Peng, Junmin; Kanneganti, Thirumala-Devi; Virgin, Herbert W; Green, Douglas R 2015. Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nature cell biology, 17 7, 893-906

Sun, Shaogang; Chen, Song; Liu, Fei; Wu, Haige; McHugh, Jonathan; Bergin, Ingrid L; Gupta, Anita; Adams, Denise; Guan, Jun-Lin 2015. Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling. Cancer cell, 28 6, 758-72

Tai, Yu-Ling; Chu, Pei-Yu; Lai, I-Rue; Wang, Ming-Yang; Tseng, Hui-Yuan; Guan, Jun-Lin; Liou, Jun-Yang; Shen, Tang-Long 2015. An EGFR/Src-dependent beta-4 integrin/FAK complex contributes to malignancy of breast cancer. Scientific reports, 5 , 16408

Wei, Huijun; Guan, Jun-Lin 2015. Blocking tumor growth by targeting autophagy and SQSTM1 in vivo. Autophagy, 11 5, 854-5

Wen, Jian; Yeo, Syn; Wang, Chenran; Chen, Song; Sun, Shaogang; Haas, Michael A; Tu, Wei; Jin, Feng; Guan, Jun-Lin 2015. Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis. Breast cancer research and treatment, 149 3, 619-29

Yao, Jingyu; Jia, Lin; Khan, Naheed; Lin, Chengmao; Mitter, Sayak K; Boulton, Michael E; Dunaief, Joshua L; Klionsky, Daniel J; Guan, Jun-Lin; Thompson, Debra A; Zacks, David N 2015. Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium. Autophagy, 11 6, 939-53