Today is

Department of

Psychiatry and Behavioral Neuroscience

Photo of  Richard Komoroski, PhD

Richard Komoroski, PhD

Research Professor of Psychiatry & Behavioral Neuroscience and Biomedical Engineering and Associate Director in the Center for Imaging Research

Contact Information
  • UC Department of Psychiatry and Behavioral Neuroscience
  • PO Box 670583
  • Cincinnati, Ohio 45267-0583
  • Office 513-558-2391
  • Email richard.komoroski@uc.edu

Peer Reviewed Publications

Komoroski, Richard A; Lindquist, Diana M; Pearce, John M 2013. Lithium compartmentation in brain by (7) Li MRS: effect of total lithium concentration. NMR in biomedicine, 26 9, 1152-7

Pearce, John M; Mahoney, Mary C; Lee, Jing-Huei; Chu, Wen-Jang; Cecil, Kim M; Strakowski, Stephen M; Komoroski, Richard A 2013. 1H NMR analysis of choline metabolites in fine-needle-aspirate biopsies of breast cancer. Magma (New York, N.Y.), 26 3, 337-43

Herman, James P; Lindquist, Diana; Komoroski, Richard A 2012. Linking cerebral metabolic function to stress vulnerability (Commentary on Knapman et al.). The European journal of neuroscience, 35 3, 411

Lee, Jing-Huei; Adler, Caleb; Norris, Matthew; Chu, Wen-Jang; Fugate, Elizabeth M; Strakowski, Stephen M; Komoroski, Richard A 2012. 4-T 7Li 3D MR spectroscopy imaging in the brains of bipolar disorder subjects. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 68 2, 363-8

Komoroski, Richard A; Holder, John C; Pappas, Alex A; Finkbeiner, Alex E 2011. 31P NMR of phospholipid metabolites in prostate cancer and benign prostatic hyperplasia. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 65 4, 911-3

Pearce, John M; Komoroski, Richard A; Mrak, Robert E 2009. Phospholipid composition of postmortem schizophrenic brain by 31P NMR spectroscopy. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 61 1, 28-34

Komoroski, Richard A; Pearce, John M 2008. Estimating intracellular lithium in brain in vivo by localized 7Li magnetic resonance spectroscopy. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 60 1, 21-6

Komoroski, Richard A; Pearce, John M; Mrak, Robert E 2008. 31P NMR spectroscopy of phospholipid metabolites in postmortem schizophrenic brain. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 59 3, 469-74

Freeman, Thomas; Kimbrell, Tim; Booe, Leroy; Myers, Michael; Cardwell, David; Lindquist, Diana M; Hart, John; Komoroski, Richard A 2006. Evidence of resilience: neuroimaging in former prisoners of war. Psychiatry research, 146 1, 59-64

Kimbrell, Tim; Leulf, Claire; Cardwell, David; Komoroski, Richard A; Freeman, Thomas W 2005. Relationship of in vivo medial temporal lobe magnetic resonance spectroscopy to documented combat exposure in veterans with chronic posttraumatic stress disorder. Psychiatry research, 140 1, 91-4

Komoroski, Richard A 2005. Biomedical applications of 7Li NMR. NMR in biomedicine, 18 2, 67-73

Komoroski, Richard A; Kotrla, Kathryn J; Lemen, Lisa; Lindquist, Diana; Diaz, P; Foundas, Anne 2004. Brain metabolite concentration ratios in vivo: multisite reproducibility by single-voxel 1H MR spectroscopy. Magnetic resonance imaging, 22 5, 721-5

Komoroski, Richard A; Pearce, John M 2004. Localized 7Li MR spectroscopy and spin relaxation in rat brain in vivo. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 52 1, 164-8

Pearce, John M; Lyon, Melvin; Komoroski, Richard A 2004. Localized 7Li MR spectroscopy: in vivo brain and serum concentrations in the rat. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 52 5, 1087-92

Brown, Shelley; Freeman, Thomas; Kimbrell, Tim; Cardwell, David; Komoroski, Richard 2003. In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of former prisoners of war with and without posttraumatic stress disorder. The Journal of neuropsychiatry and clinical neurosciences, 15 3, 367-70

Komoroski, R A; Pearce, J M; Griffin, W S; Mrak, R E; Omori, M; Karson, C N 2001. Phospholipid abnormalities in postmortem schizophrenic brains detected by 31P nuclear magnetic resonance spectroscopy: a preliminary study. Psychiatry research, 106 3, 171-80

Komoroski, E M; Komoroski, R A; Valentine, J L; Pearce, J M; Kearns, G L 2000. The use of nuclear magnetic resonance spectroscopy in the detection of drug intoxication. Journal of analytical toxicology, 24 3, 180-7

Komoroski, R A 2000. Applications of (7)Li NMR in biomedicine. Magnetic resonance imaging, 18 2, 103-16

Lindquist, D M; Dachtler, M; Hawk, R M; Karson, C N; Albert, K; Komoroski, R A 2000. Contribution of trifluoperazine metabolites to the in vivo (19)F NMR spectrum of rat brain. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 43 5, 756-9

Lindquist, D M; Hawk, R M; Karson, C N; Komoroski, R A 2000. Effects of antipsychotic drugs on metabolite ratios in rat brain in vivo. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 43 3, 355-8

Pearce, J M; Komoroski, R A 2000. Analysis of phospholipid molecular species in brain by (31)P NMR spectroscopy. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 44 2, 215-23

Komoroski, R A; Heimberg, C; Cardwell, D; Karson, C N 1999. Effects of gender and region on proton MRS of normal human brain. Magnetic resonance imaging, 17 3, 427-33

Freeman, T W; Cardwell, D; Karson, C N; Komoroski, R A 1998. In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of subjects with combat-related posttraumatic stress disorder. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 40 1, 66-71

Heimberg, C; Komoroski, R A; Lawson, W B; Cardwell, D; Karson, C N 1998. Regional proton magnetic resonance spectroscopy in schizophrenia and exploration of drug effect. Psychiatry research, 83 2, 105-15

Komoroski, R A; Pearce, J M; Newton, J E 1998. Lithium visibility in rat brain and muscle in vivo by 7Li NMR imaging. Journal of magnetic resonance (San Diego, Calif. : 1997), 133 1, 98-103

Komoroski, R A; Pearce, J M; Newton, J E 1997. The distribution of lithium in rat brain and muscle in vivo by 7Li NMR imaging. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 38 2, 275-8

Mohanakrishnan, P; Fowler, A H; Vonsattel, J P; Jolles, P R; Husain, M M; Liem, P; Myers, L; Komoroski, R A 1997. Regional metabolic alterations in Alzheimer's disease: an in vitro 1H NMR study of the hippocampus and cerebellum. The journals of gerontology. Series A, Biological sciences and medical sciences, 52 2, B111-7

Omori, M; Pearce, J; Komoroski, R A; Griffin, W S; Mrak, R E; Husain, M M; Karson, C N 1997. In vitro 1H-magnetic resonance spectroscopy of postmortem brains with schizophrenia. Biological psychiatry, 42 5, 359-66

Mohanakrishnan, P; Fowler, A H; Vonsattel, J P; Husain, M M; Jolles, P R; Liem, P; Komoroski, R A 1995. An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale, 102 3, 503-10

Komoroski, R A 1994. In vivo NMR of drugs. Analytical chemistry, 66 20, 1024A-1033A

Komoroski, R A; Newton, J E; Cardwell, D; Sprigg, J; Pearce, J; Karson, C N 1994. In vivo 19F spin relaxation and localized spectroscopy of fluoxetine in human brain. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 31 2, 204-11

Mrak, R E; Fowler, A; Komoroski, R A 1994. n-Amyl alcohol partitioning in synaptic plasma membranes. Chemistry and physics of lipids, 70 2, 147-53

Brown, S G; Hawk, R M; Komoroski, R A 1993. Competition of Li(I) and Mg(II) for ATP binding: a 31P NMR study. Journal of inorganic biochemistry, 49 1, 1-8

Campbell, G D; Ramaprasad, S; Olsen, K M; Tryka, A F; Komoroski, R A; Blaszczak, L C; Parr, T R 1993. Comparison of the in vivo and in vitro nuclear magnetic resonance detection of trifluoromethyl penicillin V in rats. Journal of pharmaceutical sciences, 82 1, 48-51

Karson, C N; Newton, J E; Livingston, R; Jolly, J B; Cooper, T B; Sprigg, J; Komoroski, R A 1993. Human brain fluoxetine concentrations. The Journal of neuropsychiatry and clinical neurosciences, 5 3, 322-9

Komoroski, R A; Newton, J E; Sprigg, J R; Cardwell, D; Mohanakrishnan, P; Karson, C N 1993. In vivo 7Li nuclear magnetic resonance study of lithium pharmacokinetics and chemical shift imaging in psychiatric patients. Psychiatry research, 50 2, 67-76

Patel, N; Chiang, P; Krasnow, A Z; Carrera, G F; Komoroski, R A; Isitman, A T; Collier, B D 1993. Skeletal metastasis of malignant glucagonoma mimicking avascular necrosis of the hip scintigraphic and MRI correlation. Clinical nuclear medicine, 18 1, 70-2

Pearce, J M; Komoroski, R A 1993. Resolution of phospholipid molecular species by 31P NMR. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 29 6, 724-31

Pearce, J M; Krone, J T; Pappas, A A; Komoroski, R A 1993. Analysis of saturated phosphatidylcholine in amniotic fluid by 31P NMR. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 30 4, 476-84

Fowler, A H; Pappas, A A; Holder, J C; Finkbeiner, A E; Dalrymple, G V; Mullins, M S; Sprigg, J R; Komoroski, R A 1992. Differentiation of human prostate cancer from benign hypertrophy by in vitro 1H NMR. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 25 1, 140-7

Gullapalli, R P; Hawk, R M; Komoroski, R A 1992. Effect of lithium on the double-quantum behavior of 23Na in normal human erythrocytes. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 27 1, 1-12

Karson, C N; Newton, J E; Mohanakrishnan, P; Sprigg, J; Komoroski, R A 1992. Fluoxetine and trifluoperazine in human brain: a 19F-nuclear magnetic resonance spectroscopy study. Psychiatry research, 45 2, 95-104

Pappas, A A; Komoroski, R A; Thompson, J R; Hough, A J 1992. Nuclear magnetic resonance spectroscopy in pathology: II. Current and future clinical applications. Human pathology, 23 1, 4-12

Ramaprasad, S; Newton, J E; Cardwell, D; Fowler, A H; Komoroski, R A 1992. In vivo 7Li NMR imaging and localized spectroscopy of rat brain. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 25 2, 308-18

Gullapalli, R P; Hawk, R M; Komoroski, R A 1991. A 7Li NMR study of visibility, spin relaxation, and transport in normal human erythrocytes. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 20 2, 240-52

Komoroski, R A; Newton, J E; Karson, C; Cardwell, D; Sprigg, J 1991. Detection of psychoactive drugs in vivo in humans using 19F NMR spectroscopy. Biological psychiatry, 29 7, 711-4

Komoroski, R A; Pappas, A; Hough, A 1991. Nuclear magnetic resonance in pathology: I. Principles and general aspects. Human pathology, 22 11, 1077-84

Pearce, J M; Shifman, M A; Pappas, A A; Komoroski, R A 1991. Analysis of phospholipids in human amniotic fluid by 31P NMR. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 21 1, 107-16

Komoroski, R A; Newton, J E; Walker, E; Cardwell, D; Jagannathan, N R; Ramaprasad, S; Sprigg, J 1990. In vivo NMR spectroscopy of lithium-7 in humans. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 15 3, 347-56

Chasar, D W; Fackler, J P; Mazany, A M; Komoroski, R A; Kroenke, W J 1986. 2,4,6-Tris(2,6-di-tert-butyl-4-substituted-phenoxy)-1,3,5,2,4,6-trioxatriphosphorinanes. Synthesis, characterization, x-ray structure, and solid-state phosphorus-31 NMR of a novel family of phosphorus(III)-oxygen heterocycles. Journal of the American Chemical Society, 108 19, 5956-62

Lader, H J; Komoroski, R A; Mandelkern, L 1977. A nuclear magnetic resonance study of the helix-coil transition of poly(L-glutamic acid). Biopolymers, 16 4, 895-905

Deslauriers, R; Komoroski, R A; Levy, G C; Paiva, A C; Smith, I C 1976. Conformational heterogeneity in linear peptides in solution: a carbon-1 3 NMR study of (Pro3, Pro5)-angiotensin-II. FEBS letters, 62 1, 50-6

Deslauriers, R; Komoroski, R A; Levy, G C; Seely, J H; Smith, I C 1976. A carbon-13 nuclear magnetic resonance study of hyperactive and hypoactive derivatives of luteinizing hormone-releasing hormone: des-Gly-NH210-[DLeu6]LH-RH ethylamide and des-Gly-NH210-[L-Leu6]LH-RH ethylamide. Biochemistry, 15 21, 4672-5

Komoroski, R A; Peat, I R; Levy, G C 1975. High field carbon-13 NMR spectroscopy. Conformational mobility in gramicidin S and frequency dependence of 13-C spin-lattice relaxation times. Biochemical and biophysical research communications, 65 1, 272-9

Komoroski, R A; Allerhand, A 1974. Observation of resonances from some minor bases in the natural-abundance carbon-13 nuclear magnetic resonance spectrum of unfractionated yeast transfer ribonucleic acid. Evidence for fast internal motion of the dihydrouracil rings. Biochemistry, 13 2, 369-72

Allerhand, A; Komoroski, R A 1973. Study of internal rotations in gramicidin S by means of carbon-13 spin-lattice relaxation measurements. Journal of the American Chemical Society, 95 25, 8228-31

Fung, C H; Mildvan, A S; Allerhand, A; Komoroski, R; Scrutton, M C 1973. Interaction of pyruvate with pyruvate carboxylase and pyruvate kinase as studied by paramagnetic effects on 13 C relaxation rates. Biochemistry, 12 4, 620-9

Komoroski, R A; Allerhand, A 1972. Natural-abundance carbon-13 Fourier-transform nuclear magnetic resonance spectra and spin lattice relaxation times of unfractionated yeast transfer-FNA. Proceedings of the National Academy of Sciences of the United States of America, 69 7, 1804-8

Komoroski, R A . Measurement of psychoactive drugs in the human brain in vivo by MR spectroscopy. AJNR. American journal of neuroradiology, 14 5, 1038-42

Wu, C C; Komoroski, R A; Mandelkern, L . The observation of cis residues in poly(L-proline) in aqueous solution. Macromolecules, 8 5, 635-7

Abstract Publications

B. Southers, S. Strakowski, M. DelBello, W-J. Chu, J-H. Lee, R. Komoroski, M.J. Kim, W. Weber, C. Adler 05-2008. Treatment response of quetiapine in bipolar mania using 1H-MRS , ,

R.A. Komoroski, J.M. Pearce, R.E. Mrak 05-2008. Phospholipid Composition of Postmortem Schizophrenic Brain by 31P NMR , , 1630

J.M. Pearce, R.E.Mrak, R.A. Komoroski 05-2007. 31P NMR of Phospholipid Metabolites in Postmortem Schizophrenic Brain , ,

R.A. Komoroski, J.M. Pearce, R.E.Mrak 05-2007. 31P NMR of Phospholipid Metabolites in Postmortem Schizophrenic Brain , , 2744