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Photo of William Zacharias, MD

William Zacharias, MD

Assistant Professor-Affiliate

Pediatrics | College of Medicine

Education/Credentials
  • : University Hospital of Pennsylvania (Postdoctoral Fellow)
  • : University Hospital of Pennsylvania (Fellowship in Pulmonary and Critical Care Medicine)
  • : University Hospital of Pennsylvania (Residency in Internal Medicine)
  • : University Hospital of Pennsylvaniz (Internship in Internal Medicine)
  • M.D.: Univeristy of Michigan (School of Medicine, Ph.D., Dept. of Cell and Developmental Biology)
  • B.A.: Northwestern University (Biological Sciences; Departmental Honors for Research in Biology)
Board Certifications & Licenses

American Board of Internal Medicine (Critical Care Medicine) (Certification Date: 20171018)
American Board of Internal Medicine (Certification Date: 20150803)
American Board of Internal Medicine (Pulmonary Disease) (Certification Date: 20161005)

Specialties

Critical Care Medicine
Internal Medicine

Contact Information

Clinical Interests

Critical Care Medicine

Lung Disease

Pulmonary Disease

Chronic Cough

Dyspnea

Histoplasmosis

Legionnaires' Disease (Legionellosis)

Pleurisy

Pneumonia

Respiration Disorders

Respiratory Insufficiency

Respiratory Syncytial Virus (RSV)

Respiratory Tract Disease

Respiratory Tract Infections

Severe Acute Respiratory Syndrome (SARS)

Shortness of Breath

Sin Nombre Virus Infection (Hantavirus pulmonary syndrome)

Thoracic Disease

Tuberculosis

Whooping Cough (Pertussis)

Peer Reviewed Publications

Basil, Maria C; Katzen, Jeremy; Engler, Anna E; Guo, Minzhe; Herriges, Michael J; Kathiriya, Jaymin J; Windmueller, Rebecca; Ysasi, Alexandra B; Zacharias, William J; Chapman, Hal A; Kotton, Darrell N; Rock, Jason R; Snoeck, Hans-Willem; Vunjak-Novakovic, Gordana; Whitsett, Jeffrey A; Morrisey, Edward E 2020. The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Cell stem cell, 26 4, 482-502

Jackson, Courtney M; Mukherjee, Shibabrata; Wilburn, Adrienne N; Cates, Chris; Lewkowich, Ian P; Deshmukh, Hitesh; Zacharias, William J; Chougnet, Claire A 2020. Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms. Frontiers in immunology, 11 , 1285

Oherle, Katherine; Acker, Elizabeth; Bonfield, Madeline; Wang, Timothy; Gray, Jerilyn; Lang, Ian; Bridges, James; Lewkowich, Ian; Xu, Yan; Ahlfeld, Shawn; Zacharias, William; Alenghat, Theresa; Deshmukh, Hitesh 2020. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity, 52 4, 716-718

Oherle, Katherine; Acker, Elizabeth; Bonfield, Madeline; Wang, Timothy; Gray, Jerilyn; Lang, Ian; Bridges, James; Lewkowich, Ian; Xu, Yan; Ahlfeld, Shawn; Zacharias, William; Alenghat, Theresa; Deshmukh, Hitesh 2020. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity, 52 2, 275-294.e9

Paris, Andrew J; Hayer, Katharina E; Oved, Joseph H; Avgousti, Daphne C; Toulmin, Sushila A; Zepp, Jarod A; Zacharias, William J; Katzen, Jeremy B; Basil, Maria C; Kremp, Madison M; Slamowitz, April R; Jayachandran, Sowmya; Sivakumar, Aravind; Dai, Ning; Wang, Ping; Frank, David B; Eisenlohr, Laurence C; Cantu, Edward; Beers, Michael F; Weitzman, Matthew D; Morrisey, Edward E; Worthen, G Scott 2020. STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury. Nature cell biology, 22 10, 1197-1210

Rajaram, Sanjeeth; Canaday, Laura M; Ochayon, David E; Rangel, Kelly M; Ali, Ayad; Gyurova, Ivayla E; Krishnamurthy, Durga; Fletcher, Jonathan S; Reighard, Seth D; Cox, Andrew; Weirauch, Matthew T; Kottyan, Leah C; Deshmukh, Hitesh; Zacharias, William J; Borchers, Michael T; Waggoner, Stephen N 2020. The Promise and Peril of Natural Killer Cell Therapies in Pulmonary Infection. Immunity, 52 6, 887-889

Swarr, Daniel; Putcha, Nirupama; Zacharias, William 2020. "PIK"ing Out New Epigenetic Markers in Lung Disease. American journal of respiratory and critical care medicine, 201 9, 1029-1030

Xiao, Deyi; Li, Xiaohong; Rouchka, Eric C; Waigel, Sabine; Zacharias, Wolfgang; McMasters, Kelly M; Hao, Hongying 2020. Comparative gene expression analysis in melanocytes driven by tumor cell-derived exosomes. Experimental cell research, 386 1, 111690

Alapati, Deepthi; Zacharias, William J; Hartman, Heather A; Rossidis, Avery C; Stratigis, John D; Ahn, Nicholas J; Coons, Barbara; Zhou, Su; Li, Hiaying; Singh, Kshitiz; Katzen, Jeremy; Tomer, Yaniv; Chadwick, Alexandra C; Musunuru, Kiran; Beers, Michael F; Morrisey, Edward E; Peranteau, William H 2019. In utero gene editing for monogenic lung disease. Science translational medicine, 11 488,

Frank, David B; Penkala, Ian J; Zepp, Jarod A; Sivakumar, Aravind; Linares-Saldana, Ricardo; Zacharias, William J; Stolz, Katharine G; Pankin, Josh; Lu, MinQi; Wang, Qiaohong; Babu, Apoorva; Li, Li; Zhou, Su; Morley, Michael P; Jain, Rajan; Morrisey, Edward E 2019. Early lineage specification defines alveolar epithelial ontogeny in the murine lung. Proceedings of the National Academy of Sciences of the United States of America, 116 10, 4362-4371

Tighe, Robert M; Redente, Elizabeth F; Yu, Yen-Rei; Herold, Susanne; Sperling, Anne I; Curtis, Jeffrey L; Duggan, Ryan; Swaminathan, Suchitra; Nakano, Hideki; Zacharias, William J; Janssen, William J; Freeman, Christine M; Brinkman, Ryan R; Singer, Benjamin D; Jakubzick, Claudia V; Misharin, Alexander V 2019. Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report. American journal of respiratory cell and molecular biology, 61 2, 150-161

Dolinay, Tamás; Aonbangkhen, Chanat; Zacharias, William; Cantu, Edward; Pogoriler, Jennifer; Stablow, Alec; Lawrence, Gladys G; Suzuki, Yoshikazu; Chenoweth, David M; Morrisey, Edward; Christie, Jason D; Beers, Michael F; Margulies, Susan S 2018. Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury. Respiratory research, 19 1, 157

Rossidis, Avery C; Stratigis, John D; Chadwick, Alexandra C; Hartman, Heather A; Ahn, Nicholas J; Li, Haiying; Singh, Kshitiz; Coons, Barbara E; Li, Li; Lv, Wenjian; Zoltick, Philip W; Alapati, Deepthi; Zacharias, William; Jain, Rajan; Morrisey, Edward E; Musunuru, Kiran; Peranteau, William H 2018. In utero CRISPR-mediated therapeutic editing of metabolic genes. Nature medicine, 24 10, 1513-1518

Zacharias, William J; Frank, David B; Zepp, Jarod A; Morley, Michael P; Alkhaleel, Farrah A; Kong, Jun; Zhou, Su; Cantu, Edward; Morrisey, Edward E 2018. Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature, 555 7695, 251-255

Jacob, Anjali; Morley, Michael; Hawkins, Finn; McCauley, Katherine B; Jean, J C; Heins, Hillary; Na, Cheng-Lun; Weaver, Timothy E; Vedaie, Marall; Hurley, Killian; Hinds, Anne; Russo, Scott J; Kook, Seunghyi; Zacharias, William; Ochs, Matthias; Traber, Katrina; Quinton, Lee J; Crane, Ana; Davis, Brian R; White, Frances V; Wambach, Jennifer; Whitsett, Jeffrey A; Cole, F Sessions; Morrisey, Edward E; Guttentag, Susan H; Beers, Michael F; Kotton, Darrell N 2017. Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Cell stem cell, 21 4, 472-488.e10

Zepp, Jarod A; Zacharias, William J; Frank, David B; Cavanaugh, Christina A; Zhou, Su; Morley, Michael P; Morrisey, Edward E 2017. Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung. Cell, 170 6, 1134-1148.e10

Paris, Andrew J; Liu, Yuhong; Mei, Junjie; Dai, Ning; Guo, Lei; Spruce, Lynn A; Hudock, Kristin M; Brenner, Jacob S; Zacharias, William J; Mei, Hankun D; Slamowitz, April R; Bhamidipati, Kartik; Beers, Michael F; Seeholzer, Steven H; Morrisey, Edward E; Worthen, G Scott 2016. Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury. American journal of physiology. Lung cellular and molecular physiology, 311 6, L1062-L1075

Zacharias, William J; Madison, Blair B; Kretovich, Katherine E; Walton, Katherine D; Richards, Neil; Udager, Aaron M; Li, Xing; Gumucio, Deborah L 2011. Hedgehog signaling controls homeostasis of adult intestinal smooth muscle. Developmental biology, 355 1, 152-62

Zacharias, William J; Li, Xing; Madison, Blair B; Kretovich, Katherine; Kao, John Y; Merchant, Juanita L; Gumucio, Deborah L 2010. Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria. Gastroenterology, 138 7, 2368-77, 2377.e1-4

Kolterud, Asa; Grosse, Ann S; Zacharias, William J; Walton, Katherine D; Kretovich, Katherine E; Madison, Blair B; Waghray, Meghna; Ferris, Jennifer E; Hu, Chunbo; Merchant, Juanita L; Dlugosz, Andrzej A; Kottmann, Andreas H; Gumucio, Deborah L 2009. Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology, 137 2, 618-28

Lees, Charlie W; Zacharias, William J; Tremelling, Mark; Noble, Colin L; Nimmo, Elaine R; Tenesa, Albert; Cornelius, Jennine; Torkvist, Leif; Kao, John; Farrington, Susan; Drummond, Hazel E; Ho, Gwo-Tzer; Arnott, Ian D R; Appelman, Henry D; Diehl, Lauri; Campbell, Harry; Dunlop, Malcolm G; Parkes, Miles; Howie, Sarah E M; Gumucio, Deborah L; Satsangi, Jack 2008. Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. PLoS medicine, 5 12, e239

Krause, Ange; Zacharias, William; Camarata, Troy; Linkhart, Barbara; Law, Evelyn; Lischke, Antje; Miljan, Erik; Simon, Hans-Georg 2004. Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. Developmental biology, 273 1, 106-20