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Mark B. Schapiro, MD

Professor of Clinical-Affiliate

Pediatrics | College of Medicine

Education/Credentials
  • Fellowship: National Institute on Aging
  • Residency: Boston City Hospital (Pediatric Neurology)
  • Medical Degree: University of Tennessee
Contact Information

Peer Reviewed Publications

Jacola, L M; Byars, A W; Hickey, F; Vannest, J; Holland, S K; Schapiro, M B 2014. Functional magnetic resonance imaging of story listening in adolescents and young adults with Down syndrome: evidence for atypical neurodevelopment. Journal of intellectual disability research : JIDR, 58 10, 892-902

Szaflarski, Jerzy P; Rajagopal, Akila; Altaye, Mekibib; Byars, Anna W; Jacola, Lisa; Schmithorst, Vincent J; Schapiro, Mark B; Plante, Elena; Holland, Scott K 2012. Left-handedness and language lateralization in children. Brain research, 1433 , 85-97

Tenney, Jeffrey R; Schapiro, Mark B 2012. Child Neurology: Hemiconvulsion-hemiplegia-epilepsy syndrome. Neurology, 79 1, e1-4

Jacola, Lisa M; Byars, Anna W; Chalfonte-Evans, Melinda; Schmithorst, Vincent J; Hickey, Fran; Patterson, Bonnie; Hotze, Stephanie; Vannest, Jennifer; Chiu, Chung-Yiu; Holland, Scott K; Schapiro, Mark B 2011. Functional magnetic resonance imaging of cognitive processing in young adults with Down syndrome. American journal on intellectual and developmental disabilities, 116 5, 344-59

Tenney, Jeffrey R; Hopkin, Robert J; Schapiro, Mark B 2011. Deletion of 14-3-3{varepsilon} and CRK: a clinical syndrome with macrocephaly, developmental delay, and generalized epilepsy. Journal of child neurology, 26 2, 223-7

Tenney, Jeffrey R; Schapiro, Mark B 2010. Child neurology: alternating hemiplegia of childhood. Neurology, 74 14, e57-9

Ricciardi, Emiliano; Pietrini, Pietro; Schapiro, Mark B; Rapoport, Stanley I; Furey, Maura L 2009. Cholinergic modulation of visual working memory during aging: a parametric PET study. Brain research bulletin, 79 5, 322-32

Furey, Maura L; Ricciardi, Emiliano; Schapiro, Mark B; Rapoport, Stanley I; Pietrini, Pietro 2008. Cholinergic enhancement eliminates modulation of neural activity by task difficulty in the prefrontal cortex during working memory. Journal of cognitive neuroscience, 20 7, 1342-53

Tillema, Jan-Mendelt; Byars, Anna W; Jacola, Lisa M; Schapiro, Mark B; Schmithorst, Vince J; Szaflarski, Jerzy P; Holland, Scott K 2008. Reprint of "Cortical reorganization of language functioning following perinatal left MCA stroke" [Brain and Language 105 (2008) 99-111]. Brain and language, 106 3, 184-94

Tillema, Jan-Mendelt; Byars, Anna W; Jacola, Lisa M; Schapiro, Mark B; Schmithorst, Vince J; Szaflarski, Jerzy P; Holland, Scott K 2008. Cortical reorganization of language functioning following perinatal left MCA stroke. Brain and language, 105 2, 99-111

Miles, Michael V; Patterson, Bonnie J; Chalfonte-Evans, Melinda L; Horn, Paul S; Hickey, Francis J; Schapiro, Mark B; Steele, Paul E; Tang, Peter H; Hotze, Stephanie L 2007. Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21. Pediatric neurology, 37 6, 398-403

Jacola, L M; Schapiro, M B; Schmithorst, V J; Byars, A W; Strawsburg, R H; Szaflarski, J P; Plante, E; Holland, S K 2006. Functional magnetic resonance imaging reveals atypical language organization in children following perinatal left middle cerebral artery stroke. Neuropediatrics, 37 1, 46-52

Miles, Michael V; Patterson, Bonnie J; Schapiro, Mark B; Hickey, Francis J; Chalfonte-Evans, Melinda; Horn, Paul S; Hotze, Stephanie L 2006. Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trial. Pediatric neurology, 35 1, 30-7

Dinopoulos, A; Cecil, K M; Schapiro, M B; Papadimitriou, A; Hadjigeorgiou, G M; Wong, B; deGrauw, T; Egelhoff, J C 2005. Brain MRI and proton MRS findings in infants and children with respiratory chain defects. Neuropediatrics, 36 5, 290-301

Freo, Ulderico; Ricciardi, Emiliano; Pietrini, Pietro; Schapiro, Mark B; Rapoport, Stanley I; Furey, Maura L 2005. Pharmacological modulation of prefrontal cortical activity during a working memory task in young and older humans: a PET study with physostigmine. The American journal of psychiatry, 162 11, 2061-70

Ibáñez, Vicente; Pietrini, Pietro; Furey, Maura L; Alexander, Gene E; Millet, Philippe; Bokde, Arun L W; Teichberg, Diane; Schapiro, Mark B; Horwitz, Barry; Rapoport, Stanley I 2004. Resting state brain glucose metabolism is not reduced in normotensive healthy men during aging, after correction for brain atrophy. Brain research bulletin, 63 2, 147-54

Rapoport, Stanley I; Schapiro, Mark B; May, Conrad 2004. Reduced brain delivery of homovanillic acid to cerebrospinal fluid during human aging. Archives of neurology, 61 11, 1721-4

Schapiro, Mark B; Schmithorst, Vince J; Wilke, Marko; Byars, Anna Weber; Strawsburg, Richard H; Holland, Scott K 2004. BOLD fMRI signal increases with age in selected brain regions in children. Neuroreport, 15 17, 2575-8

Tang, Yang; Schapiro, Mark B; Franz, David N; Patterson, Bonnie J; Hickey, Francis J; Schorry, Elizabeth K; Hopkin, Robert J; Wylie, Matthew; Narayan, Tina; Glauser, Tracy A; Gilbert, Donald L; Hershey, Andrew D; Sharp, Frank R 2004. Blood expression profiles for tuberous sclerosis complex 2, neurofibromatosis type 1, and Down's syndrome. Annals of neurology, 56 6, 808-14

Teipel, Stefan J; Alexander, Gene E; Schapiro, Marc B; Möller, Hans-Jürgen; Rapoport, Stanley I; Hampel, Harald 2004. Age-related cortical grey matter reductions in non-demented Down's syndrome adults determined by MRI with voxel-based morphometry. Brain : a journal of neurology, 127 Pt 4, 811-24

Teipel, Stefan J; Schapiro, Mark B; Alexander, Gene E; Krasuski, Jack S; Horwitz, Barry; Hoehne, Christian; Möller, Hans-Jürgen; Rapoport, Stanley I; Hampel, Harald 2003. Relation of corpus callosum and hippocampal size to age in nondemented adults with Down's syndrome. The American journal of psychiatry, 160 10, 1870-8

Buerger, Katharina; Zinkowski, Raymond; Teipel, Stefan J; Tapiola, Tero; Arai, Hiroyuki; Blennow, Kaj; Andreasen, Niels; Hofmann-Kiefer, Klaus; DeBernardis, John; Kerkman, Daniel; McCulloch, Cheryl; Kohnken, Russell; Padberg, Frank; Pirttilä, Tuula; Schapiro, Marc B; Rapoport, Stanley I; Möller, Hans-Jürgen; Davies, Peter; Hampel, Harald 2002. Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231. Archives of neurology, 59 8, 1267-72

deGrauw, T J; Salomons, G S; Cecil, K M; Chuck, G; Newmeyer, A; Schapiro, M B; Jakobs, C 2002. Congenital creatine transporter deficiency. Neuropediatrics, 33 5, 232-8

Hampel, Harald; Teipel, Stefan J; Bayer, Wolfram; Alexander, Gene E; Schwarz, Robert; Schapiro, Mark B; Rapoport, Stanley I; Möller, Hans-Jürgen 2002. Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease. Journal of the neurological sciences, 194 1, 15-9

Krasuski, Jack S; Alexander, Gene E; Horwitz, Barry; Rapoport, Stanley I; Schapiro, Mark B 2002. Relation of medial temporal lobe volumes to age and memory function in nondemented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's disease. The American journal of psychiatry, 159 1, 74-81

Teipel, Stefan J; Bayer, Wolfram; Alexander, Gene E; Zebuhr, York; Teichberg, Diane; Kulic, Luka; Schapiro, Marc B; Möller, Hans-Jürgen; Rapoport, Stanley I; Hampel, Harald 2002. Progression of corpus callosum atrophy in Alzheimer disease. Archives of neurology, 59 2, 243-8

Bokde, A L; Pietrini, P; Ibáñez, V; Furey, M L; Alexander, G E; Graff-Radford, N R; Rapoport, S I; Schapiro, M B; Horwitz, B 2001. The effect of brain atrophy on cerebral hypometabolism in the visual variant of Alzheimer disease. Archives of neurology, 58 3, 480-6

Huang, W; Alexander, G E; Chang, L; Shetty, H U; Krasuski, J S; Rapoport, S I; Schapiro, M B 2001. Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study. Neurology, 57 4, 626-32

Silverman, D H; Small, G W; Chang, C Y; Lu, C S; Kung De Aburto, M A; Chen, W; Czernin, J; Rapoport, S I; Pietrini, P; Alexander, G E; Schapiro, M B; Jagust, W J; Hoffman, J M; Welsh-Bohmer, K A; Alavi, A; Clark, C M; Salmon, E; de Leon, M J; Mielke, R; Cummings, J L; Kowell, A P; Gambhir, S S; Hoh, C K; Phelps, M E 2001. Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome. JAMA : the journal of the American Medical Association, 286 17, 2120-7

Furey, M L; Pietrini, P; Alexander, G E; Mentis, M J; Szczepanik, J; Shetty, U; Greig, N H; Holloway, H W; Schapiro, M B; Freo, U 2000. Time course of pharmacodynamic and pharmacokinetic effects of physostigmine assessed by functional brain imaging in humans. Pharmacology, biochemistry, and behavior, 66 3, 475-81

Furey, M L; Pietrini, P; Alexander, G E; Schapiro, M B; Horwitz, B 2000. Cholinergic enhancement improves performance on working memory by modulating the functional activity in distinct brain regions: a positron emission tomography regional cerebral blood flow study in healthy humans. Brain research bulletin, 51 3, 213-8

Hampel, H; Teipel, S J; Alexander, G E; Horwitz, B; Pietrini, P; Hippius, H; Möller, H J; Schapiro, M B; Rapoport, S I 2000. Corpus callosum measurement as an in vivo indicator for neocortical neuronal integrity, but not white matter pathology, in Alzheimer's disease. Annals of the New York Academy of Sciences, 903 , 470-6

Huang, W; Galdzicki, Z; van Gelderen, P; Balbo, A; Chikhale, E G; Schapiro, M B; Rapoport, S I 2000. Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment. Neuroreport, 11 3, 445-8

Murphy, E J; Schapiro, M B; Rapoport, S I; Shetty, H U 2000. Phospholipid composition and levels are altered in Down syndrome brain. Brain research, 867 1-2, 9-18

Alexander, G E; Mentis, M J; Van Horn, J D; Grady, C L; Berman, K F; Furey, M L; Pietrini, P; Rapoport, S I; Schapiro, M B; Moeller, J R 1999. Individual differences in PET activation of object perception and attention systems predict face matching accuracy. Neuroreport, 10 9, 1965-71

Huang, W; Alexander, G E; Daly, E M; Shetty, H U; Krasuski, J S; Rapoport, S I; Schapiro, M B 1999. High brain myo-inositol levels in the predementia phase of Alzheimer's disease in adults with Down's syndrome: a 1H MRS study. The American journal of psychiatry, 156 12, 1879-86

Murphy, D G; Mentis, M J; Pietrini, P; Grady, C L; Moore, C J; Horwitz, B; Hinton, V; Dobkin, C S; Schapiro, M B; Rapoport, S I 1999. Premutation female carriers of fragile X syndrome: a pilot study on brain anatomy and metabolism. Journal of the American Academy of Child and Adolescent Psychiatry, 38 10, 1294-301

Pietrini, P; Furey, M L; Alexander, G E; Mentis, M J; Dani, A; Guazzelli, M; Rapoport, S I; Schapiro, M B 1999. Association between brain functional failure and dementia severity in Alzheimer's disease: resting versus stimulation PET study. The American journal of psychiatry, 156 3, 470-3

Schapiro, M B; Berman, K F; Alexander, G E; Weinberger, D R; Rapoport, S I 1999. Regional cerebral blood flow in Down syndrome adults during the Wisconsin Card Sorting Test: exploring cognitive activation in the context of poor performance. Biological psychiatry, 45 9, 1190-6

Teipel, S J; Hampel, H; Pietrini, P; Alexander, G E; Horwitz, B; Daley, E; Möller, H J; Schapiro, M B; Rapoport, S I 1999. Region-specific corpus callosum atrophy correlates with the regional pattern of cortical glucose metabolism in Alzheimer disease. Archives of neurology, 56 4, 467-73

Beason-Held, L L; Purpura, K P; Krasuski, J S; Maisog, J M; Daly, E M; Mangot, D J; Desmond, R E; Optican, L M; Schapiro, M B; VanMeter, J W 1998. Cortical regions involved in visual texture perception: a fMRI study. Brain research. Cognitive brain research, 7 2, 111-8

Hampel, H; Teipel, S J; Alexander, G E; Horwitz, B; Teichberg, D; Schapiro, M B; Rapoport, S I 1998. Corpus callosum atrophy is a possible indicator of region- and cell type-specific neuronal degeneration in Alzheimer disease: a magnetic resonance imaging analysis. Archives of neurology, 55 2, 193-8

Ibáñez, V; Pietrini, P; Alexander, G E; Furey, M L; Teichberg, D; Rajapakse, J C; Rapoport, S I; Schapiro, M B; Horwitz, B 1998. Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease. Neurology, 50 6, 1585-93

Krasuski, J S; Alexander, G E; Horwitz, B; Daly, E M; Murphy, D G; Rapoport, S I; Schapiro, M B 1998. Volumes of medial temporal lobe structures in patients with Alzheimer's disease and mild cognitive impairment (and in healthy controls). Biological psychiatry, 43 1, 60-8

Mentis, M J; Alexander, G E; Krasuski, J; Pietrini, P; Furey, M L; Schapiro, M B; Rapoport, S I 1998. Increasing required neural response to expose abnormal brain function in mild versus moderate or severe Alzheimer's disease: PET study using parametric visual stimulation. The American journal of psychiatry, 155 6, 785-94

Parshad, R; Price, F M; Schapiro, M B; Sanford, K K 1998. Effect of DNA repair inhibitors on the in vitro test for Alzheimer's disease. Journal of the American Geriatrics Society, 46 10, 1331-3

Teipel, S J; Hampel, H; Alexander, G E; Schapiro, M B; Horwitz, B; Teichberg, D; Daley, E; Hippius, H; Möller, H J; Rapoport, S I 1998. Dissociation between corpus callosum atrophy and white matter pathology in Alzheimer's disease. Neurology, 51 5, 1381-5

Wu, Z; Kinslow, C; Pettigrew, K D; Rapoport, S I; Schapiro, M B 1998. Role of familial factors in late-onset Alzheimer disease as a function of age. Alzheimer disease and associated disorders, 12 3, 190-7

Alexander, G E; Furey, M L; Grady, C L; Pietrini, P; Brady, D R; Mentis, M J; Schapiro, M B 1997. Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis. The American journal of psychiatry, 154 2, 165-72

Alexander, G E; Saunders, A M; Szczepanik, J; Strassburger, T L; Pietrini, P; Dani, A; Furey, M L; Mentis, M J; Roses, A D; Rapoport, S I; Schapiro, M B 1997. Relation of age and apolipoprotein E to cognitive function in Down syndrome adults. Neuroreport, 8 8, 1835-40

Berardi, A; Haxby, J V; De Carli, C; Schapiro, M B 1997. Face and word memory differences are related to patterns of right and left lateral ventricle size in healthy aging. The journals of gerontology. Series B, Psychological sciences and social sciences, 52 1, P54-61

Furey, M L; Pietrini, P; Haxby, J V; Alexander, G E; Lee, H C; VanMeter, J; Grady, C L; Shetty, U; Rapoport, S I; Schapiro, M B; Freo, U 1997. Cholinergic stimulation alters performance and task-specific regional cerebral blood flow during working memory. Proceedings of the National Academy of Sciences of the United States of America, 94 12, 6512-6

Mentis, M J; Alexander, G E; Grady, C L; Horwitz, B; Krasuski, J; Pietrini, P; Strassburger, T; Hampel, H; Schapiro, M B; Rapoport, S I 1997. Frequency variation of a pattern-flash visual stimulus during PET differentially activates brain from striate through frontal cortex. NeuroImage, 5 2, 116-28

Murphy, D G; Mentis, M J; Pietrini, P; Grady, C; Daly, E; Haxby, J V; De La Granja, M; Allen, G; Largay, K; White, B J; Powell, C M; Horwitz, B; Rapoport, S I; Schapiro, M B 1997. A PET study of Turner's syndrome: effects of sex steroids and the X chromosome on brain. Biological psychiatry, 41 3, 285-98

Pietrini, P; Dani, A; Furey, M L; Alexander, G E; Freo, U; Grady, C L; Mentis, M J; Mangot, D; Simon, E W; Horwitz, B; Haxby, J V; Schapiro, M B 1997. Low glucose metabolism during brain stimulation in older Down's syndrome subjects at risk for Alzheimer's disease prior to dementia. The American journal of psychiatry, 154 8, 1063-9

Strassburger, T L; Lee, H C; Daly, E M; Szczepanik, J; Krasuski, J S; Mentis, M J; Salerno, J A; DeCarli, C; Schapiro, M B; Alexander, G E 1997. Interactive effects of age and hypertension on volumes of brain structures. Stroke; a journal of cerebral circulation, 28 7, 1410-7

Asthana, S; Greig, N H; Holloway, H W; Raffaele, K C; Berardi, A; Schapiro, M B; Rapoport, S I; Soncrant, T T 1996. Clinical pharmacokinetics of arecoline in subjects with Alzheimer's disease. Clinical pharmacology and therapeutics, 60 3, 276-82

Dani, A; Pietrini, P; Furey, M L; McIntosh, A R; Grady, C L; Horwitz, B; Freo, U; Alexander, G E; Schapiro, M B 1996. Brain cognition and metabolism in Down syndrome adults in association with development of dementia. Neuroreport, 7 18, 2933-6

Mentis, M J; Horwitz, B; Grady, C L; Alexander, G E; VanMeter, J W; Maisog, J M; Pietrini, P; Schapiro, M B; Rapoport, S I 1996. Visual cortical dysfunction in Alzheimer's disease evaluated with a temporally graded "stress test" during PET. The American journal of psychiatry, 153 1, 32-40

Murphy, D G; DeCarli, C; McIntosh, A R; Daly, E; Mentis, M J; Pietrini, P; Szczepanik, J; Schapiro, M B; Grady, C L; Horwitz, B; Rapoport, S I 1996. Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging. Archives of general psychiatry, 53 7, 585-94

Parshad, R P; Sanford, K K; Price, F M; Melnick, L K; Nee, L E; Schapiro, M B; Tarone, R E; Robbins, J H 1996. Fluorescent light-induced chromatid breaks distinguish Alzheimer disease cells from normal cells in tissue culture. Proceedings of the National Academy of Sciences of the United States of America, 93 10, 5146-50

Pietrini, P; Furey, M L; Graff-Radford, N; Freo, U; Alexander, G E; Grady, C L; Dani, A; Mentis, M J; Schapiro, M B 1996. Preferential metabolic involvement of visual cortical areas in a subtype of Alzheimer's disease: clinical implications. The American journal of psychiatry, 153 10, 1261-8

Raffaele, K C; Asthana, S; Berardi, A; Haxby, J V; Morris, P P; Schapiro, M B; Soncrant, T T 1996. Differential response to the cholinergic agonist arecoline among different cognitive modalities in Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 15 2, 163-70

Shetty, H U; Holloway, H W; Schapiro, M B 1996. Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease. Clinical chemistry, 42 2, 298-302

Asthana, S; Greig, N H; Hegedus, L; Holloway, H H; Raffaele, K C; Schapiro, M B; Soncrant, T T 1995. Clinical pharmacokinetics of physostigmine in patients with Alzheimer's disease. Clinical pharmacology and therapeutics, 58 3, 299-309

Asthana, S; Raffaele, K C; Berardi, A; Greig, N H; Haxby, J V; Schapiro, M B; Soncrant, T T 1995. Treatment of Alzheimer disease by continuous intravenous infusion of physostigmine. Alzheimer disease and associated disorders, 9 4, 223-32

Asthana, S; Raffaele, K C; Greig, N H; Berardi, A; Morris, P P; Schapiro, M B; Rapoport, S I; Blackman, M R; Soncrant, T T 1995. Neuroendocrine responses to intravenous infusion of arecoline in patients with Alzheimer's disease. Psychoneuroendocrinology, 20 6, 623-36

Azari, N P; Pettigrew, K D; Pietrini, P; Murphy, D G; Horwitz, B; Schapiro, M B 1995. Sex differences in patterns of hemispheric cerebral metabolism: a multiple regression/discriminant analysis of positron emission tomographic data. The International journal of neuroscience, 81 1-2, 1-20

DeCarli, C; Murphy, D G; McIntosh, A R; Teichberg, D; Schapiro, M B; Horwitz, B 1995. Discriminant analysis of MRI measures as a method to determine the presence of dementia of the Alzheimer type. Psychiatry research, 57 2, 119-30

Giedd, J N; Rapoport, J L; Kruesi, M J; Parker, C; Schapiro, M B; Allen, A J; Leonard, H L; Kaysen, D; Dickstein, D P; Marsh, W L 1995. Sydenham's chorea: magnetic resonance imaging of the basal ganglia. Neurology, 45 12, 2199-202

Grady, C L; McIntosh, A R; Horwitz, B; Maisog, J M; Ungerleider, L G; Mentis, M J; Pietrini, P; Schapiro, M B; Haxby, J V 1995. Age-related reductions in human recognition memory due to impaired encoding. Science (New York, N.Y.), 269 5221, 218-21

Horwitz, B; McIntosh, A R; Haxby, J V; Furey, M; Salerno, J A; Schapiro, M B; Rapoport, S I; Grady, C L 1995. Network analysis of PET-mapped visual pathways in Alzheimer type dementia. Neuroreport, 6 17, 2287-92

Salerno, J A; Grady, C; Mentis, M; Gonzalez-Aviles, A; Wagner, E; Schapiro, M B; Rapoport, S I 1995. Brain metabolic function in older men with chronic essential hypertension. The journals of gerontology. Series A, Biological sciences and medical sciences, 50 3, M147-54

Schapiro, M B; Murphy, D G; Hagerman, R J; Azari, N P; Alexander, G E; Miezejeski, C M; Hinton, V J; Horwitz, B; Haxby, J V; Kumar, A 1995. Adult fragile X syndrome: neuropsychology, brain anatomy, and metabolism. American journal of medical genetics, 60 6, 480-93

Shetty, H U; Schapiro, M B; Holloway, H W; Rapoport, S I 1995. Polyol profiles in Down syndrome. myo-Inositol, specifically, is elevated in the cerebrospinal fluid. The Journal of clinical investigation, 95 2, 542-6

Azari, N P; Horwitz, B; Pettigrew, K D; Grady, C L; Haxby, J V; Giacometti, K R; Schapiro, M B 1994. Abnormal pattern of cerebral glucose metabolic rates involving language areas in young adults with Down syndrome. Brain and language, 46 1, 1-20

DeCarli, C; Murphy, D G; Gillette, J A; Haxby, J V; Teichberg, D; Schapiro, M B; Horwitz, B 1994. Lack of age-related differences in temporal lobe volume of very healthy adults. AJNR. American journal of neuroradiology, 15 4, 689-96

Godec, M S; Asher, D M; Kozachuk, W E; Masters, C L; Rubi, J U; Payne, J A; Rubi-Villa, D J; Wagner, E E; Rapoport, S I; Schapiro, M B 1994. Blood buffy coat from Alzheimer's disease patients and their relatives does not transmit spongiform encephalopathy to hamsters. Neurology, 44 6, 1111-5

Mentis, M J; Salerno, J; Horwitz, B; Grady, C; Schapiro, M B; Murphy, D G; Rapoport, S I 1994. Reduction of functional neuronal connectivity in long-term treated hypertension. Stroke; a journal of cerebral circulation, 25 3, 601-7

Murphy, D G; Allen, G; Haxby, J V; Largay, K A; Daly, E; White, B J; Powell, C M; Schapiro, M B 1994. The effects of sex steroids, and the X chromosome, on female brain function: a study of the neuropsychology of adult Turner syndrome. Neuropsychologia, 32 11, 1309-23

Azari, N P; Pettigrew, K D; Schapiro, M B; Haxby, J V; Grady, C L; Pietrini, P; Salerno, J A; Heston, L L; Rapoport, S I; Horwitz, B 1993. Early detection of Alzheimer's disease: a statistical approach using positron emission tomographic data. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 13 3, 438-47

Azari, N P; Pietrini, P; Horwitz, B; Pettigrew, K D; Leonard, H L; Rapoport, J L; Schapiro, M B; Swedo, S E 1993. Individual differences in cerebral metabolic patterns during pharmacotherapy in obsessive-compulsive disorder: a multiple regression/discriminant analysis of positron emission tomographic data. Biological psychiatry, 34 11, 798-809

Kittur, S D; Adler, W H; Martin, G R; Schapiro, M B; Rapoport, S I; Gunzler, V 1993. Laminin concentrations in serum and cerebrospinal fluid in aging and Alzheimer's disease. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 11 1, 95-9

Murphy, D G; DeCarli, C D; Daly, E; Gillette, J A; McIntosh, A R; Haxby, J V; Teichberg, D; Schapiro, M B; Rapoport, S I; Horwitz, B 1993. Volumetric magnetic resonance imaging in men with dementia of the Alzheimer type: correlations with disease severity. Biological psychiatry, 34 9, 612-21

Sanford, K K; Parshad, R; Price, F M; Tarone, R E; Schapiro, M B 1993. X-ray-induced chromatid damage in cells from Down syndrome and Alzheimer disease patients in relation to DNA repair and cancer proneness. Cancer genetics and cytogenetics, 70 1, 25-30

Schapiro, M B; Pietrini, P; Grady, C L; Ball, M J; DeCarli, C; Kumar, A; Kaye, J A; Haxby, J V 1993. Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry, 56 8, 859-64

Swedo, S E; Leonard, H L; Schapiro, M B; Casey, B J; Mannheim, G B; Lenane, M C; Rettew, D C 1993. Sydenham's chorea: physical and psychological symptoms of St Vitus dance. Pediatrics, 91 4, 706-13

Azari, N P; Rapoport, S I; Grady, C L; DeCarli, C; Haxby, J V; Schapiro, M B; Horwitz, B 1992. Gender differences in correlations of cerebral glucose metabolic rates in young normal adults. Brain research, 574 1-2, 198-208

Azari, N P; Rapoport, S I; Salerno, J A; Grady, C L; Gonzalez-Aviles, A; Schapiro, M B; Horwitz, B 1992. Interregional correlations of resting cerebral glucose metabolism in old and young women. Brain research, 589 2, 279-90

DeCarli, C; Haxby, J V; Gillette, J A; Teichberg, D; Rapoport, S I; Schapiro, M B 1992. Longitudinal changes in lateral ventricular volume in patients with dementia of the Alzheimer type. Neurology, 42 10, 2029-36

Grady, C L; Haxby, J V; Horwitz, B; Schapiro, M B; Rapoport, S I; Ungerleider, L G; Mishkin, M; Carson, R E; Herscovitch, P 1992. Dissociation of object and spatial vision in human extrastriate cortex: age-related changes in activation of regional cerebral blood flow measured with [(15) o]water and positron emission tomography. Journal of cognitive neuroscience, 4 1, 23-34

Haxby, J V; Raffaele, K; Gillette, J; Schapiro, M B; Rapoport, S I 1992. Individual trajectories of cognitive decline in patients with dementia of the Alzheimer type. Journal of clinical and experimental neuropsychology, 14 4, 575-92

Haxby, J V; Schapiro, M B 1992. Longitudinal study of neuropsychological function in older adults with Down syndrome. Progress in clinical and biological research, 379 , 35-50

Horwitz, B; Grady, C L; Haxby, J V; Schapiro, M B; Rapoport, S I; Ungerleider, L G; Mishkin, M 1992. Functional Associations among Human Posterior Extrastriate Brain Regions during Object and Spatial Vision. Journal of cognitive neuroscience, 4 4, 311-22

Murphy, D G; DeCarli, C; Schapiro, M B; Rapoport, S I; Horwitz, B 1992. Age-related differences in volumes of subcortical nuclei, brain matter, and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging. Archives of neurology, 49 8, 839-45

Salerno, J A; Murphy, D G; Horwitz, B; DeCarli, C; Haxby, J V; Rapoport, S I; Schapiro, M B 1992. Brain atrophy in hypertension. A volumetric magnetic resonance imaging study. Hypertension, 20 3, 340-8

Schapiro, M B; Azari, N P; Grady, C L; Haxby, J V; Horwitz, B 1992. Down syndrome: differentiating mental retardation and dementia with brain imaging techniques. Progress in clinical and biological research, 379 , 103-22

Swedo, S E; Pietrini, P; Leonard, H L; Schapiro, M B; Rettew, D C; Goldberger, E L; Rapoport, S I; Rapoport, J L; Grady, C L 1992. Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Revisualization during pharmacotherapy. Archives of general psychiatry, 49 9, 690-4

Godec, M S; Asher, D M; Masters, C L; Kozachuk, W E; Friedland, R P; Gibbs, C J; Gajdusek, D C; Rapoport, S I; Schapiro, M B 1991. Evidence against the transmissibility of Alzheimer's disease. Neurology, 41 8, 1320

Haxby, J V; Grady, C L; Horwitz, B; Ungerleider, L G; Mishkin, M; Carson, R E; Herscovitch, P; Schapiro, M B; Rapoport, S I 1991. Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proceedings of the National Academy of Sciences of the United States of America, 88 5, 1621-5

Horwitz, B; Swedo, S E; Grady, C L; Pietrini, P; Schapiro, M B; Rapoport, J L; Rapoport, S I 1991. Cerebral metabolic pattern in obsessive-compulsive disorder: altered intercorrelations between regional rates of glucose utilization. Psychiatry research, 40 4, 221-37

Kumar, A; Schapiro, M B; Grady, C L; Matocha, M F; Haxby, J V; Moore, A M; Luxenberg, J S; St George-Hyslop, P H; Robinette, C D; Ball, M J 1991. Anatomic, metabolic, neuropsychological, and molecular genetic studies of three pairs of identical twins discordant for dementia of the Alzheimer's type. Archives of neurology, 48 2, 160-8

Kumar, A; Schapiro, M B; Grady, C; Haxby, J V; Wagner, E; Salerno, J A; Friedland, R P; Rapoport, S I 1991. High-resolution PET studies in Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 4 1, 35-46

Raffaele, K C; Berardi, A; Morris, P P; Asthana, S; Haxby, J V; Schapiro, M B; Rapoport, S I; Soncrant, T T 1991. Effects of acute infusion of the muscarinic cholinergic agonist arecoline on verbal memory and visuo-spatial function in dementia of the Alzheimer type. Progress in neuro-psychopharmacology & biological psychiatry, 15 5, 643-8

Rapoport, S I; Horwitz, B; Grady, C L; Haxby, J V; DeCarli, C; Schapiro, M B 1991. Abnormal brain glucose metabolism in Alzheimer's disease, as measured by position emission tomography. Advances in experimental medicine and biology, 291 , 231-48

Rapoport, S I; Pettigrew, K D; Schapiro, M B 1991. Discordance and concordance of dementia of the Alzheimer type (DAT) in monozygotic twins indicate heritable and sporadic forms of Alzheimer's disease. Neurology, 41 10, 1549-53

Swedo, S E; Rapoport, J L; Leonard, H L; Schapiro, M B; Rapoport, S I; Grady, C L 1991. Regional cerebral glucose metabolism of women with trichotillomania. Archives of general psychiatry, 48 9, 828-33

Devinsky, O; Sato, S; Conwit, R A; Schapiro, M B 1990. Relation of EEG alpha background to cognitive function, brain atrophy, and cerebral metabolism in Down's syndrome. Age-specific changes. Archives of neurology, 47 1, 58-62

Grady, C L; Haxby, J V; Schapiro, M B; Gonzalez-Aviles, A; Kumar, A; Ball, M J; Heston, L; Rapoport, S I 1990. Subgroups in dementia of the Alzheimer type identified using positron emission tomography. The Journal of neuropsychiatry and clinical neurosciences, 2 4, 373-84

Horwitz, B; Schapiro, M B; Grady, C L; Rapoport, S I 1990. Cerebral metabolic pattern in young adult Down's syndrome subjects: altered intercorrelations between regional rates of glucose utilization. Journal of mental deficiency research, 34 ( Pt 3) , 237-52

Kozachuk, W E; DeCarli, C; Schapiro, M B; Wagner, E E; Rapoport, S I; Horwitz, B 1990. White matter hyperintensities in dementia of Alzheimer's type and in healthy subjects without cerebrovascular risk factors. A magnetic resonance imaging study. Archives of neurology, 47 12, 1306-10

Kumar, A; Schapiro, M B; Haxby, J V; Grady, C L; Friedland, R P 1990. Cerebral metabolic and cognitive studies in dementia with frontal lobe behavioral features. Journal of psychiatric research, 24 2, 97-109

May, C; Kaye, J A; Atack, J R; Schapiro, M B; Friedland, R P; Rapoport, S I 1990. Cerebrospinal fluid production is reduced in healthy aging. Neurology, 40 3 Pt 1, 500-3

Miura, S A; Schapiro, M B; Grady, C L; Kumar, A; Salerno, J A; Kozachuk, W E; Wagner, E; Rapoport, S I; Horwitz, B 1990. Effect of gender on glucose utilization rates in healthy humans: a positron emission tomography study. Journal of neuroscience research, 27 4, 500-4

Schapiro, M B; Atack, J R; Hanin, I; May, C; Haxby, J V; Rapoport, S I 1990. Lumbar cerebrospinal fluid choline in healthy aging and in Down's syndrome. Archives of neurology, 47 9, 977-80

Schapiro, M B; Grady, C L; Kumar, A; Herscovitch, P; Haxby, J V; Moore, A M; White, B; Friedland, R P; Rapoport, S I 1990. Regional cerebral glucose metabolism is normal in young adults with Down syndrome. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 10 2, 199-206

Green, J E; Rosenbaum, K N; Rapoport, S I; Schapiro, M B; White, B J 1989. Variant nucleolus organizing regions and the risk of Down syndrome. Clinical genetics, 35 4, 243-50

Schapiro, M B; Luxenberg, J S; Kaye, J A; Haxby, J V; Friedland, R P; Rapoport, S I 1989. Serial quantitative CT analysis of brain morphometrics in adult Down's syndrome at different ages. Neurology, 39 10, 1349-53

Schapiro, M B; Rapoport, S I 1989. Basal metabolic rate in healthy Down's syndrome adults. Journal of mental deficiency research, 33 ( Pt 3) , 211-9

Swedo, S E; Schapiro, M B; Grady, C L; Cheslow, D L; Leonard, H L; Kumar, A; Friedland, R; Rapoport, S I; Rapoport, J L 1989. Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Archives of general psychiatry, 46 6, 518-23

Friedland, R P; Koss, E; Haxby, J V; Grady, C L; Luxenberg, J; Schapiro, M B; Kaye, J 1988. NIH conference. Alzheimer disease: clinical and biological heterogeneity. Annals of internal medicine, 109 4, 298-311

Schapiro, M B; Ball, M J; Grady, C L; Haxby, J V; Kaye, J A; Rapoport, S I 1988. Dementia in Down's syndrome: cerebral glucose utilization, neuropsychological assessment, and neuropathology. Neurology, 38 6, 938-42

Kay, A D; Schapiro, M B; Riker, A K; Haxby, J V; Rapoport, S I; Cutler, N R 1987. Cerebrospinal fluid monoaminergic metabolites are elevated in adults with Down's syndrome. Annals of neurology, 21 4, 408-11

Schapiro, M B; Creasey, H; Schwartz, M; Haxby, J V; White, B; Moore, A; Rapoport, S I 1987. Quantitative CT analysis of brain morphometry in adult Down's syndrome at different ages. Neurology, 37 8, 1424-7

Schapiro, M B; Haxby, J V; Grady, C L; Duara, R; Schlageter, N L; White, B; Moore, A; Sundaram, M; Larson, S M; Rapoport, S I 1987. Decline in cerebral glucose utilisation and cognitive function with aging in Down's syndrome. Journal of neurology, neurosurgery, and psychiatry, 50 6, 766-74

Schapiro, M B; Kay, A D; May, C; Ryker, A K; Haxby, J V; Kaufman, S; Milstien, S; Rapoport, S I 1987. Cerebrospinal fluid monoamines in Down's syndrome adults at different ages. Journal of mental deficiency research, 31 ( Pt 3) , 259-69

Schapiro, M; Auslander, M O; Schapiro, M B 1987. The electronic video endoscope: clinical experience with 1200 diagnostic and therapeutic cases in the community hospital. Gastrointestinal endoscopy, 33 2, 63-8

Cutler, N R; Heston, L L; Davies, P; Haxby, J V; Schapiro, M B 1985. NIH Conference. Alzheimer's disease and Down's syndrome: new insights. Annals of internal medicine, 103 4, 566-78

Cutler, N R; Duara, R; Creasey, H; Grady, C L; Haxby, J V; Schapiro, M B; Rapoport, S I 1984. NIH Conference. Brain imaging: aging and dementia. Annals of internal medicine, 101 3, 355-69

Helikson, M A; Schapiro, M B; Garfinkel, D J; Shermeta, D W 1982. Congenital segmental dilatation of the colon. Journal of pediatric surgery, 17 2, 201-2

Schapiro, H; Jackson, N J; Rosato, F E; McDougal, H D; Chaudhuri, T K; Gayle, R G; Carwell, G; Schapiro, M B 1978. Chemoneurolysis of the canine gastric submucosa. Effects on Heidenhain pouch secretion. The American surgeon, 44 12, 785-8

Asthana, S; Raffaele, K C; Greig, N H; Schapiro, M B; Blackman, M R; Soncrant, T T . Neuroendocrine responses to intravenous infusion of physostigmine in patients with Alzheimer disease. Alzheimer disease and associated disorders, 13 2, 102-8

Atack, J R; Rapoport, S I; Schapiro, M B . Cerebrospinal fluid production is normal in Down syndrome. Neurobiology of aging, 19 4, 307-9

Atack, John R; Schapiro, Mark B . Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF. Neurobiology of aging, 23 3, 389-96

Azari, N P; Pettigrew, K D; Pietrini, P; Horwitz, B; Schapiro, M B . Detection of an Alzheimer disease pattern of cerebral metabolism in Down syndrome. Dementia (Basel, Switzerland), 5 2, 69-78

Beason-Held, L L; Purpura, K P; Van Meter, J W; Azari, N P; Mangot, D J; Optican, L M; Mentis, M J; Alexander, G E; Grady, C L; Horwitz, B; Rapoport, S I; Schapiro, M B . PET reveals occipitotemporal pathway activation during elementary form perception in humans. Visual neuroscience, 15 3, 503-10

Grady, C L; Haxby, J V; Horwitz, B; Gillette, J; Salerno, J A; Gonzalez-Aviles, A; Carson, R E; Herscovitch, P; Schapiro, M B; Rapoport, S I . Activation of cerebral blood flow during a visuoperceptual task in patients with Alzheimer-type dementia. Neurobiology of aging, 14 1, 35-44

Levine, B K; Beason-Held, L L; Purpura, K P; Aronchick, D M; Optican, L M; Alexander, G E; Horwitz, B; Rapoport, S I; Schapiro, M B . Age-related differences in visual perception: a PET study. Neurobiology of aging, 21 4, 577-84

Pietrini, P; Azari, N P; Grady, C L; Salerno, J A; Gonzales-Aviles, A; Heston, L L; Pettigrew, K D; Horwitz, B; Haxby, J V; Schapiro, M B . Pattern of cerebral metabolic interactions in a subject with isolated amnesia at risk for Alzheimer's disease: a longitudinal evaluation. Dementia (Basel, Switzerland), 4 2, 94-101

Rosman, N P; Schapiro, M B; Haddow, J E . Muscle weakness caused by an iodine-deficient diet: investigation of a nutritional myopathy. Journal of neuropathology and experimental neurology, 37 2, 192-211

Rosman, N P; Schapiro, M B; Wolf, P A . Sclerotic atrophy of the cerebellum: a clinicopathological survey. Journal of neuropathology and experimental neurology, 37 2, 174-91

Schapiro, M B . MR quantification of brain structures. AJNR. American journal of neuroradiology, 14 2, 507-9

Schapiro, M B; Haxby, J V; Grady, C L . Nature of mental retardation and dementia in Down syndrome: study with PET, CT, and neuropsychology. Neurobiology of aging, 13 6, 723-34

Schapiro, M B; Rapoport, S I . Familial Alzheimer's disease: genetic analysis related to disease heterogeneity, Down syndrome and human brain evolution. Neurobiology of aging, 10 5, 435-6; discussion 44

Schapiro, M B; Rosman, N P; Kemper, T L . Effects of chronic exposure to alcohol on the developing brain. Neurobehavioral toxicology and teratology, 6 5, 351-6

Teipel, S J; Bayer, W; Alexander, G E; Bokde, A L W; Zebuhr, Y; Teichberg, D; Müller-Spahn, F; Schapiro, M B; Möller, H-J; Rapoport, S I; Hampel, H . Regional pattern of hippocampus and corpus callosum atrophy in Alzheimer's disease in relation to dementia severity: evidence for early neocortical degeneration. Neurobiology of aging, 24 1, 85-94