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Photo of KyoungHyun Kim, PhD

KyoungHyun Kim, PhD

Contact Information
  • UC Institute Member Seal

Peer Reviewed Publications

Khanal, Tilak; Choi, Kwangmin; Leung, Yuet-Kin; Wang, Jiang; Kim, Dasom; Janakiram, Vinothini; Cho, Sung-Gook; Puga, Alvaro; Ho, Shuk-Mei; Kim, Kyounghyun 2017. Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Scientific reports, 7 1, 10662

Gandhy, Shruti U; Imanirad, Parisa; Jin, Un-Ho; Nair, Vijayalekshmi; Hedrick, Eric; Cheng, Yating; Corton, J Christopher; Kim, KyoungHyun; Safe, Stephen 2015. Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC. Oncotarget, 6 28, 26359-72

Khanal, Tilak; Kim, Dasom; Johnson, Abby; Choubey, Divaker; Kim, Kyounghyun 2015. Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter. Toxicology letters, 237 3, 228-36

Jutooru, Indira; Guthrie, Aaron S; Chadalapaka, Gayathri; Pathi, Satya; Kim, KyoungHyun; Burghardt, Robert; Jin, Un-Ho; Safe, Stephen 2014. Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Molecular and cellular biology, 34 13, 2382-95

Ko, Seong-Gyu; Yin, Chang Shik; Du, Bing; Kim, KyoungHyun 2014. Herbal medicines for inflammatory diseases. Mediators of inflammation, 2014 , 982635

Yang, Won Seok; Chadalapaka, Gayathri; Cho, Sung-Gook; Lee, Syng-Ook; Jin, Un-Ho; Jutooru, Indira; Choi, Kwangmin; Leung, Yuet-Kin; Ho, Shuk-Mei; Safe, Stephen; Kim, Kyounghyun 2014. The Transcriptional Repressor ZBTB4 Regulates EZH2 Through a MicroRNA-ZBTB4-Specificity Protein Signaling Axis. Neoplasia (New York, N.Y.), 16 12, 1059-69

Zhang, Zichao; Kim, KyoungHyun; Li, Xiao; Moreno, Myriam; Sharp, Thad; Goodheart, Michael J; Safe, Stephen; Dupuy, Adam J; Amendt, Brad A 2014. MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression. Molecular cancer therapeutics, 13 7, 1942-51

Chadalapaka, Gayathri; Jutooru, Indira; Sreevalsan, Sandeep; Pathi, Satya; Kim, Kyounghyun; Chen, Candy; Crose, Lisa; Linardic, Corinne; Safe, Stephen 2013. Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors. International journal of cancer. Journal international du cancer, 132 4, 795-806

Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S, Safe S. 2013. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene, 32 13, 1616

Gandhy, Shruti U; Kim, Kyounghyun; Larsen, Lesley; Rosengren, Rhonda J; Safe, Stephen 2012. Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs. BMC cancer, 12 , 564

Kim, Kyounghyun; Chadalapaka, Gayathri; Pathi, Satya S; Jin, Un-Ho; Lee, Ju-Seog; Park, Yun-Yong; Cho, Sung-Gook; Chintharlapalli, Sudhakar; Safe, Stephen 2012. Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters. Molecular cancer therapeutics, 11 9, 1852-62

Liu, Xinyi; Jutooru, Indira; Lei, Ping; Kim, KyoungHyun; Lee, Syng-Ook; Brents, Lisa K; Prather, Paul L; Safe, Stephen 2012. Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. Molecular cancer therapeutics, 11 7, 1421-31

Park, Yun-Yong; Jung, Sung Yun; Jennings, Nicholas B; Rodriguez-Aguayo, Cristian; Peng, Guang; Lee, Se-Ran; Kim, Sang Bae; Kim, Kyounghyun; Leem, Sun-Hee; Lin, Shiaw-Yih; Lopez-Berestein, Gabriel; Sood, Anil K; Lee, Ju-Seog 2012. FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair. Carcinogenesis, 33 10, 1843-53

Park, Yun-Yong; Kim, Kyounghyun; Kim, Sang-Bae; Hennessy, Bryan T; Kim, Soo Mi; Park, Eun Sung; Lim, Jae Yun; Li, Jane; Lu, Yiling; Gonzalez-Angulo, Ana Maria; Jeong, Woojin; Mills, Gordon B; Safe, Stephen; Lee, Ju-Seog 2012. Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. EMBO molecular medicine, 4 1, 52-67

Zhang, Shu; Kim, KyoungHyun; Jin, Un Ho; Pfent, Catherine; Cao, Huojun; Amendt, Brad; Liu, Xinyi; Wilson-Robles, Heather; Safe, Stephen 2012. Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells. Molecular cancer therapeutics, 11 1, 108-18

Claerhout, Sofie; Lim, Jae Yun; Choi, Woonyoung; Park, Yun-Yong; Kim, Kyounghyun; Kim, Sang-Bae; Lee, Ju-Seog; Mills, Gordon B; Cho, Jae Yong 2011. Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer. PloS one, 6 9, e24662

Kim, Kyounghyun; Burghardt, Robert; Barhoumi, Rola; Lee, Syng-Ook; Liu, Xinyi; Safe, Stephen 2011. MDM2 regulates estrogen receptor ? and estrogen responsiveness in breast cancer cells. Journal of molecular endocrinology, 46 2, 67-79

Yoon, Kyungsil; Lee, Syng-Ook; Cho, Sung-Dae; Kim, Kyounghyun; Khan, Shaheen; Safe, Stephen 2011. Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors. Carcinogenesis, 32 6, 836-42

Lee, Syng-Ook; Abdelrahim, Maen; Yoon, Kyungsil; Chintharlapalli, Sudhakar; Papineni, Sabitha; Kim, Kyounghyun; Wang, Huamin; Safe, Stephen 2010. Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. Cancer research, 70 17, 6824-36

Li, Xiangrong; Mertens-Talcott, Susanne U; Zhang, Shu; Kim, Kyounghyun; Ball, Judith; Safe, Stephen 2010. MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells. Endocrinology, 151 6, 2462-73

Safe, Stephen; Kim, Kyounghyun; Kim, Kyoungkim 2008. Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. Journal of molecular endocrinology, 41 5, 263-75

Wu, Fei; Xu, Rui; Kim, Kyounghyun; Martin, James; Safe, Stephen 2008. In vivo profiling of estrogen receptor/specificity protein-dependent transactivation. Endocrinology, 149 11, 5696-705

Naugler, Willscott E; Sakurai, Toshiharu; Kim, Sunhwa; Maeda, Shin; Kim, Kyounghyun; Elsharkawy, Ahmed M; Karin, Michael 2007. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science (New York, N.Y.), 317 5834, 121-4

Abdelrahim, Maen; Ariazi, Eric; Kim, Kyounghyun; Khan, Shaheen; Barhoumi, Rola; Burghardt, Robert; Liu, Shengxi; Hill, Denise; Finnell, Richard; Wlodarczyk, Bogdan; Jordan, V Craig; Safe, Stephen 2006. 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer research, 66 4, 2459-67

Khan, Shaheen; Barhoumi, Rola; Burghardt, Robert; Liu, Shengxi; Kim, Kyounghyun; Safe, Stephen 2006. Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells. Molecular endocrinology (Baltimore, Md.), 20 9, 2199-214

Kim, Kyounghyun; Barhoumi, Rola; Burghardt, Robert; Safe, Stephen 2005. Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer. Molecular endocrinology (Baltimore, Md.), 19 4, 843-54

Lee, Jeongeun Eun; Kim, Kyounghyun; Sacchettini, James C; Smith, Clare V; Safe, Stephen 2005. DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. The Journal of biological chemistry, 280 10, 8819-30

Safe S, Kim K. 2004. Nuclear receptor-mediated transactivation through interaction with Sp proteins. Prog Nucleic Acid Res Mol Biol, 77 , 1

Safe, Stephen; Kim, Kyounghyun 2004. Nuclear receptor-mediated transactivation through interaction with Sp proteins. Progress in nucleic acid research and molecular biology, 77 , 1-36

Kim, Kyounghyun; Thu, Nguyen; Saville, Brad; Safe, Stephen 2003. Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells. Molecular endocrinology (Baltimore, Md.), 17 5, 804-17

Porter W, Wang F, Duan R, Qin C, Castro-Rivera E, Kim K, Safe S. 2001. Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. J Mol Endocrinol., 26 1, 31

Yang GY, Liao J, Kim K, Yurkow EJ, Yang CS 1998. Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis, 19 4, 611