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Currently directs a translational research laboratory which focuses on human and mechanistic studies to understand the interactions between various viral pathogens. Using a variety of cell culture systems, molecular virology techniques,
and patient-derived samples, I investigate the pathogenic and evolutionary mechanisms by which viruses interact with the host and cause disease. At present, laboratory studies involve hepatitis B virus (HBV), hepatitis C virus
(HCV), hepatitis E virus (HEV), pegiviruses (HPgV; GBV-C), and HIV and include international collaborations in South Africa, Botswana, India, Nigeria, and Ghana.
HIV/AIDS pathogenesis; ontogeny of the immune system; immune dysfunction in aging; human immunology.
Metatranscriptomics and preclinical drug development for treatment of the AIDS-related opportunistic pathogen Pneumocystis carinii.
Using a combination of human studies and developmentally appropriate preclinical models in non-human primates and mice, our lab investigates the cellular components and molecular targets by which intestinal commensal bacteria direct
development of innate defenses of the lungs in newborns.
The overall goals of the Guan laboratory is to understand the fundamental principles of cell signaling in the regulation of basic cellular functions in normal cell and developmental processes and to determine how the disruption of
normal signaling pathways lead to diseases such as cancer.
Dr. Hagan’s research is focused on using computational and systems biology approaches to understand immune development, aging, and response to vaccination and infection.
The Kottyan lab works to identify the molecular mechanisms mediating the genetic etiology of Systemic lupus erythematous and Eosinophilic Esophagitis.
Dr. Mersha’s research interests lie in combining quantitative, ancestry and statistical genomics to unravel genetic and non-genetic contributions to asthma and asthma-related allergic disorders in human populations.
Molecular regulation of spermatogonial stem cell differentiation into sperm, using single cell sequencing technologies, molecular biology, functional genomics, bioinformatics, biochemistry, and mouse genetics.
My lab investigates biological mechanisms behind the development of Acute Myeloid Leukemia (AML) and how co-mutations synergize to drive disease using single cell multi-omics and preclinical mouse models of AML.
Systems biology to immunoengineer, building mathematical models of the immune system from high-dimensional genomics measurements, to re-engineer immune responses in the context of autoimmune and other diseases.
The primary focus of my research is to examine the effects of coagulation proteins, proteases, and receptors in the pathogenesis cardiovascular disease (CVD), specifically atherosclerosis and abdominal aortic aneurysms (AAAs).
Dr. Pestian's lab focuses on developing advanced technology for the care of neuropsychiatric illness. The lab also focuses on earlier identification of individuals at risk of suicide, depression, and bipolar and anxiety disorders using
verbal and non-verbal language.
Pediatric infectious disease; HIV assembly, HIV biology/pathogenesis, HIV vaccines; vaccines and therapeutics for children (clinical trials).
Dr. Timchenko is working with molecular mechanisms of Liver Cancer and Non-Alcoholic Fatty Liver Disease. His work focuses on the epigenetic changes that cause these liver diseases.
Research on rare lung diseases including pulmonary alveolar proteinosis, cystic fibrosis, alpha-1 antitrypsin deficiency and lymphangioleiomyomatosis. Mechanisms of alveolar macrophage function. Experimental approaches include molecular
techniques using gene knockout, transgenic and conditional gene expression mouse models and non-human primates, in vitro and in vivo viral gene transfer, and bone marrow transplantation.
The Weirauch lab uses computational and experimental tools to understand the mechanisms of gene transcriptional regulation and how these mechanisms go awry in disease states.
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