MEDS 3020 | 3 credit hours

Fall Semester | Syllabus (PDF)

MWF 3:35pm - 4:30 PM Online via Webex

Michael Lieberman, PhD | michael.lieberman@uc.edu | 513-558-5645
Iain Cartwright, PhD | iain.cartwright@uc.edu | 513-558-5532 
Paul Rosevear, PhD | paul.rosevear@uc.edu | 513-558-3370

A one‐semester course designed to introduce students to the basic tenets of biochemistry. The topics that will be discussed have been chosen to comply with the guidelines for the biochemistry component of the medical college admission test (MCAT), which will be incorporated into the 2015 offering of the MCAT. 

The course will be taught in three components: the first is protein structure and function, enzyme mechanisms, and enzyme kinetics. 

The second component is nucleic acid biochemistry, including DNA replication and repair, synthesis of RNA (transcription), synthesis of proteins (translation), regulation of gene expression, and molecular techniques. 

The third component includes biochemical thermodynamics and an introduction to metabolism, which includes glycolysis, gluconeogenesis, TCA cycle, oxidative phosphorylation, glycogen metabolism, and fatty-acid metabolism. 

The course will emphasize the relationship of biochemistry to disease, and will discuss, in particular, sickle-cell anemia, prion diseases, collagen disorders, thalassemias, cancer in relation to mutations in DNA repair, toxins that affect RNA and protein synthesis, diabetes (both type 1 and type 2), glycogen storage diseases, mitochondrial disorders, and abnormalities in fatty-acid oxidation.

Textbook

Michael Lieberman, Allan D. Marks, Colleen Smith (2006)Marks’ Essentials of Medical Biochemistry: A Clinical Approach, 1st Edition, Lippincott Williams & Wilkins, 
ISBN (Paperback): 978-0781793407
ISBN (E-Book): 978-1451114959