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Konstantinos Drosatos, MSc, PhD, FAHA


Pharmacology & Systems Physiology | College of Medicine

  • PhD: University of Crete & Boston University (Molecular Biology & Biomedicine)
  • MSc: University of Crete (Molecular Biology & Biomedicine)
  • BSc: Aristotle University of Thessaloniki (Biology)
Contact Information
Research Interests

His graduate training focused on the transcriptional regulation mechanisms of ApoE and the role of ApoE in lipoprotein clearance. In these studies, he demonstrated the importance of the stress activated JNK signaling pathway in the regulation of apoE transcription and created a modified ApoE protein molecule that treats hyperlipidemia. In addition, he discovered that miR370 targe...

Peer Reviewed Publications 2022. , ,

Hoffman, Matthew; Palioura, Dimitra; Kyriazis, Ioannis D; Cimini, Maria; Badolia, Rachit; Rajan, Sudarsan; Gao, Erhe; Nikolaidis, Nikolas; Schulze, P Christian; Goldberg, Ira J; Kishore, Raj; Yang, Vincent W; Bannister, Thomas D; Bialkowska, Agnieszka B; Selzman, Craig H; Drakos, Stavros G; Drosatos, Konstantinos 2021. Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy. Circulation, 143 11, 1139-1156

Kyriazis, Ioannis D; Hoffman, Matthew; Gaignebet, Lea; Lucchese, Anna Maria; Markopoulou, Eftychia; Palioura, Dimitra; Wang, Chao; Bannister, Thomas D; Christofidou-Solomidou, Melpo; Oka, Shin-Ichi; Sadoshima, Junichi; Koch, Walter J; Goldberg, Ira J; Yang, Vincent W; Bialkowska, Agnieszka B; Kararigas, Georgios; Drosatos, Konstantinos 2021. KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy. Circulation research, 128 3, 335-357

Palioura, Dimitra; Lazou, Antigone; Drosatos, Konstantinos 2021. Krüppel-like factor (KLF)5: An emerging foe of cardiovascular health. Journal of molecular and cellular cardiology, 163 , 56-66

Sithara, Thomas; Drosatos, Konstantinos 2021. Metabolic Complications in Cardiac Aging. Frontiers in physiology, 12 , 669497

Hoffman, Matthew; Kyriazis, Ioannis D; Dimitriou, Alexandra; Mishra, Santosh K; Koch, Walter J; Drosatos, Konstantinos 2020. B-type natriuretic peptide is upregulated by c-Jun N-terminal kinase and contributes to septic hypotension. JCI insight, 5 8,

Joseph, Leroy C; Reyes, Michael V; Lakkadi, Kundanika R; Gowen, Blake H; Hasko, Gyorgy; Drosatos, Konstantinos; Morrow, John P 2020. PKC? causes sepsis-induced cardiomyopathy by inducing mitochondrial dysfunction. American journal of physiology. Heart and circulatory physiology, 318 4, H778-H786

Kalliora, Charikleia; Drosatos, Konstantinos 2020. The Glitazars Paradox: Cardiotoxicity of the Metabolically Beneficial Dual PPAR? and PPAR? Activation. Journal of cardiovascular pharmacology, 76 5, 514-526

Lieu, Melissa; Traynham, Christopher J; de Lucia, Claudio; Pfleger, Jessica; Piedepalumbo, Michela; Roy, Rajika; Petovic, Jennifer; Landesberg, Gavin; Forrester, Steven J; Hoffman, Matthew; Grisanti, Laurel A; Yuan, Ancai; Gao, Erhe; Drosatos, Konstantinos; Eguchi, Satoru; Scalia, Rosario; Tilley, Douglas G; Koch, Walter J 2020. Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging. American journal of physiology. Heart and circulatory physiology, 318 5, H1162-H1175

Pfleger, Jessica; Coleman, Ryan C; Ibetti, Jessica; Roy, Rajika; Kyriazis, Ioannis D; Gao, Erhe; Drosatos, Konstantinos; Koch, Walter J 2020. Genomic Binding Patterns of Forkhead Box Protein O1 Reveal Its Unique Role in Cardiac Hypertrophy. Circulation, 142 9, 882-898

Cao, Tongtong; Liccardo, Daniela; LaCanna, Ryan; Zhang, Xiaoying; Lu, Rong; Finck, Brian N; Leigh, Tani; Chen, Xiongwen; Drosatos, Konstantinos; Tian, Ying 2019. Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice. Frontiers in cell and developmental biology, 7 , 42

Hoffman, Matthew; Kyriazis, Ioannis D; Lucchese, Anna M; de Lucia, Claudio; Piedepalumbo, Michela; Bauer, Michael; Schulze, P Christian; Bonios, Michael J; Koch, Walter J; Drosatos, Konstantinos 2019. Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice. Journal of the American Heart Association, 8 10, e012260

Kalliora, Charikleia; Kyriazis, Ioannis D; Oka, Shin-Ichi; Lieu, Melissa J; Yue, Yujia; Area-Gomez, Estela; Pol, Christine J; Tian, Ying; Mizushima, Wataru; Chin, Adave; Scerbo, Diego; Schulze, P Christian; Civelek, Mete; Sadoshima, Junichi; Madesh, Muniswamy; Goldberg, Ira J; Drosatos, Konstantinos 2019. Dual peroxisome-proliferator-activated-receptor-?/? activation inhibits SIRT1-PGC1? axis and causes cardiac dysfunction. JCI insight, 5 ,

Kokkinaki, Dimitra; Hoffman, Matthew; Kalliora, Charikleia; Kyriazis, Ioannis D; Maning, Jennifer; Lucchese, Anna Maria; Shanmughapriya, Santhanam; Tomar, Dhanendra; Park, Joon Young; Wang, Hong; Yang, Xiao-Feng; Madesh, Muniswamy; Lymperopoulos, Anastasios; Koch, Walter J; Christofidou-Solomidou, Melpo; Drosatos, Konstantinos 2019. Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Journal of molecular and cellular cardiology, 127 , 232-245

Pol, Christine J; Pollak, Nina M; Jurczak, Michael J; Zacharia, Effimia; Karagiannides, Iordanes; Kyriazis, Ioannis D; Ntziachristos, Panagiotis; Scerbo, Diego A; Brown, Brett R; Aifantis, Iannis; Shulman, Gerald I; Goldberg, Ira J; Drosatos, Konstantinos 2019. Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21. Biochimica et biophysica acta. Molecular basis of disease, 1865 9, 2125-2137

Woodall, Benjamin P; Gresham, Kenneth S; Woodall, Meryl A; Valenti, Mesele-Christina; Cannavo, Alessandro; Pfleger, Jessica; Chuprun, J Kurt; Drosatos, Konstantinos; Koch, Walter J 2019. Alteration of myocardial GRK2 produces a global metabolic phenotype. JCI insight, 5 ,

Cheng, Zhongjian; Shen, Xinggui; Jiang, Xiaohua; Shan, Huimin; Cimini, Maria; Fang, Pu; Ji, Yong; Park, Joon Young; Drosatos, Konstantinos; Yang, Xiaofeng; Kevil, Christopher G; Kishore, Raj; Wang, Hong 2018. Hyperhomocysteinemia potentiates diabetes-impaired EDHF-induced vascular relaxation: Role of insufficient hydrogen sulfide. Redox biology, 16 , 215-225

Kalea, Anastasia Z; Drosatos, Konstantinos; Buxton, Jessica L 2018. Nutriepigenetics and cardiovascular disease. Current opinion in clinical nutrition and metabolic care, 21 4, 252-259

Pollak, Nina M; Hoffman, Matthew; Goldberg, Ira J; Drosatos, Konstantinos 2018. Krüppel-like factors: Crippling and un-crippling metabolic pathways. JACC. Basic to translational science, 3 1, 132-156

Sato, Priscila Y; Chuprun, J Kurt; Grisanti, Laurel A; Woodall, Meryl C; Brown, Brett R; Roy, Rajika; Traynham, Christopher J; Ibetti, Jessica; Lucchese, Anna M; Yuan, Ancai; Drosatos, Konstantinos; Tilley, Doug G; Gao, Erhe; Koch, Walter J 2018. Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation. Science signaling, 11 560,

Son, Ni-Huiping; Basu, Debapriya; Samovski, Dmitri; Pietka, Terri A; Peche, Vivek S; Willecke, Florian; Fang, Xiang; Yu, Shui-Qing; Scerbo, Diego; Chang, Hye Rim; Sun, Fei; Bagdasarov, Svetlana; Drosatos, Konstantinos; Yeh, Steve T; Mullick, Adam E; Shoghi, Kooresh I; Gumaste, Namrata; Kim, KyeongJin; Huggins, Lesley-Ann; Lhakhang, Tenzin; Abumrad, Nada A; Goldberg, Ira J 2018. Endothelial cell CD36 optimizes tissue fatty acid uptake. The Journal of clinical investigation, 128 10, 4329-4342

Stamatelopoulos, Kimon; Pol, Christine J; Ayers, Colby; Georgiopoulos, Georgios; Gatsiou, Aikaterini; Brilakis, Emmanouil S; Khera, Amit; Drosatos, Konstantinos; de Lemos, James A; Stellos, Konstantinos 2018. Amyloid-Beta (1-40) Peptide and Subclinical Cardiovascular Disease. Journal of the American College of Cardiology, 72 9, 1060-1061

Zeng, Huihong; Nanayakkara, Gayani K; Shao, Ying; Fu, Hangfei; Sun, Yu; Cueto, Ramon; Yang, William Y; Yang, Qian; Sheng, Haitao; Wu, Na; Wang, Luqiao; Yang, Wuping; Chen, Hongping; Shao, Lijian; Sun, Jianxin; Qin, Xuebin; Park, Joon Y; Drosatos, Konstantinos; Choi, Eric T; Zhu, Qingxian; Wang, Hong; Yang, Xiaofeng 2018. DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. Frontiers in physiology, 9 , 516

Zhang, Xiaokan; Ji, Ruiping; Liao, Xianghai; Castillero, Estibaliz; Kennel, Peter J; Brunjes, Danielle L; Franz, Marcus; Möbius-Winkler, Sven; Drosatos, Konstantinos; George, Isaac; Chen, Emily I; Colombo, Paolo C; Schulze, P Christian 2018. MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation. Circulation, 137 19, 2052-2067

Ji, Ruiping; Akashi, Hirokazu; Drosatos, Konstantinos; Liao, Xianghai; Jiang, Hongfeng; Kennel, Peter J; Brunjes, Danielle L; Castillero, Estibaliz; Zhang, Xiaokan; Deng, Lily Y; Homma, Shunichi; George, Isaac J; Takayama, Hiroo; Naka, Yoshifumi; Goldberg, Ira J; Schulze, P Christian 2017. Increased de novo ceramide synthesis and accumulation in failing myocardium. JCI insight, 2 14,

Ji, Ruiping; Akashi, Hirokazu; Drosatos, Konstantinos; Liao, Xianghai; Jiang, Hongfeng; Kennel, Peter J; Brunjes, Danielle L; Castillero, Estibaliz; Zhang, Xiaokan; Deng, Lily Y; Homma, Shunichi; George, Isaac J; Takayama, Hiroo; Naka, Yoshifumi; Goldberg, Ira J; Schulze, P Christian 2017. Increased de novo ceramide synthesis and accumulation in failing myocardium. JCI insight, 2 9,

Joseph, Leroy C; Kokkinaki, Dimitra; Valenti, Mesele-Christina; Kim, Grace J; Barca, Emanuele; Tomar, Dhanendra; Hoffman, Nicholas E; Subramanyam, Prakash; Colecraft, Henry M; Hirano, Michio; Ratner, Adam J; Madesh, Muniswamy; Drosatos, Konstantinos; Morrow, John P 2017. Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function. JCI insight, 2 17,

Drosatos, Konstantinos 2016. Fatty old hearts: role of cardiac lipotoxicity in age-related cardiomyopathy. Pathobiology of aging & age related diseases, 6 , 32221

Drosatos, Konstantinos; Pollak, Nina M; Pol, Christine J; Ntziachristos, Panagiotis; Willecke, Florian; Valenti, Mesele-Christina; Trent, Chad M; Hu, Yunying; Guo, Shaodong; Aifantis, Iannis; Goldberg, Ira J 2016. Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function. Circulation research, 118 2, 241-53

Schulze, P Christian; Drosatos, Konstantinos; Goldberg, Ira J 2016. Lipid Use and Misuse by the Heart. Circulation research, 118 11, 1736-51

Drosatos, Konstantinos; Lymperopoulos, Anastasios; Kennel, Peter Johannes; Pollak, Nina; Schulze, P Christian; Goldberg, Ira J 2015. Pathophysiology of sepsis-related cardiac dysfunction: driven by inflammation, energy mismanagement, or both? Current heart failure reports, 12 2, 130-40

Pol, Christine J; Lieu, Melissa; Drosatos, Konstantinos 2015. PPARs: Protectors or Opponents of Myocardial Function? PPAR research, 2015 , 835985

Sato, Priscila Y; Chuprun, J Kurt; Ibetti, Jessica; Cannavo, Alessandro; Drosatos, Konstantinos; Elrod, John W; Koch, Walter J 2015. GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels. Journal of molecular and cellular cardiology, 89 Pt B, 360-4

Willecke, Florian; Scerbo, Diego; Nagareddy, Prabhakara; Obunike, Joseph C; Barrett, Tessa J; Abdillahi, Mariane L; Trent, Chad M; Huggins, Lesley A; Fisher, Edward A; Drosatos, Konstantinos; Goldberg, Ira J 2015. Lipolysis, and not hepatic lipogenesis, is the primary modulator of triglyceride levels in streptozotocin-induced diabetic mice. Arteriosclerosis, thrombosis, and vascular biology, 35 1, 102-10

Bosma, Madeleen; Dapito, Dianne H; Drosatos-Tampakaki, Zoi; Huiping-Son, Ni; Huang, Li-Shin; Kersten, Sander; Drosatos, Konstantinos; Goldberg, Ira J 2014. Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity. Biochimica et biophysica acta, 1841 12, 1648-55

Drosatos, Konstantinos; Schulze, P Christian 2014. Savings precede spending: fatty acid utilization relies on triglyceride formation for cardiac energetics. Circulation, 130 20, 1775-7

Drosatos-Tampakaki, Zoi; Drosatos, Konstantinos; Siegelin, Yasemin; Gong, Shan; Khan, Salmiyeh; Van Dyke, Thomas; Goldberg, Ira J; Schulze, P Christian; Schulze-Späte, Ulrike 2014. Palmitic acid and DGAT1 deficiency enhance osteoclastogenesis, while oleic acid-induced triglyceride formation prevents it. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 29 5, 1183-95

Drosatos, Konstantinos; Khan, Raffay S; Trent, Chad M; Jiang, Hongfeng; Son, Ni-Huiping; Blaner, William S; Homma, Shunichi; Schulze, P Christian; Goldberg, Ira J 2013. Peroxisome proliferator-activated receptor-? activation prevents sepsis-related cardiac dysfunction and mortality in mice. Circulation. Heart failure, 6 3, 550-62

Drosatos, Konstantinos; Schulze, P Christian 2013. Cardiac lipotoxicity: molecular pathways and therapeutic implications. Current heart failure reports, 10 2, 109-21

Garcia-Arcos, Itsaso; Hiyama, Yaeko; Drosatos, Konstantinos; Bharadwaj, Kalyani G; Hu, Yunying; Son, Ni Huiping; O'Byrne, Sheila M; Chang, Chuchun L; Deckelbaum, Richard J; Takahashi, Manabu; Westerterp, Marit; Obunike, Joseph C; Jiang, Hongfeng; Yagyu, Hiroaki; Blaner, William S; Goldberg, Ira J 2013. Adipose-specific lipoprotein lipase deficiency more profoundly affects brown than white fat biology. The Journal of biological chemistry, 288 20, 14046-14058

Georgiadou, Dimitra; Chroni, Angeliki; Drosatos, Konstantinos; Kypreos, Kyriakos E; Zannis, Vassilis I; Stratikos, Efstratios 2013. Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles. Atherosclerosis, 226 2, 385-91

Khan, Raffay S; Chokshi, Aalap; Drosatos, Konstantinos; Jiang, Hongfeng; Yu, Shuiqing; Harris, Collette R; Schulze, P Christian; Homma, Shunichi; Blaner, William S; Shulman, Gerald I; Huang, Li-Shin; Goldberg, Ira J 2013. Fish oil selectively improves heart function in a mouse model of lipid-induced cardiomyopathy. Journal of cardiovascular pharmacology, 61 4, 345-54

Wan, Elaine; Yeap, Xin Yi; Dehn, Shirley; Terry, Rachael; Novak, Margaret; Zhang, Shuang; Iwata, Shinichi; Han, Xiaoqiang; Homma, Shunichi; Drosatos, Konstantinos; Lomasney, Jon; Engman, David M; Miller, Stephen D; Vaughan, Douglas E; Morrow, John P; Kishore, Raj; Thorp, Edward B 2013. Enhanced efferocytosis of apoptotic cardiomyocytes through myeloid-epithelial-reproductive tyrosine kinase links acute inflammation resolution to cardiac repair after infarction. Circulation research, 113 8, 1004-12

Chokshi, Aalap; Drosatos, Konstantinos; Cheema, Faisal H; Ji, Ruiping; Khawaja, Tuba; Yu, Shuiqing; Kato, Tomoko; Khan, Raffay; Takayama, Hiroo; Knöll, Ralph; Milting, Hendrik; Chung, Christine S; Jorde, Ulrich; Naka, Yoshifumi; Mancini, Donna M; Goldberg, Ira J; Schulze, P Christian 2012. Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure. Circulation, 125 23, 2844-53

Drosatos, Konstantinos; Bharadwaj, Kalyani G; Lymperopoulos, Anastasios; Ikeda, Shota; Khan, Raffay; Hu, Yunying; Agarwal, Rajiv; Yu, Shuiqing; Jiang, Hongfeng; Steinberg, Susan F; Blaner, William S; Koch, Walter J; Goldberg, Ira J 2011. Cardiomyocyte lipids impair ?-adrenergic receptor function via PKC activation. American journal of physiology. Endocrinology and metabolism, 300 3, E489-99

Drosatos, Konstantinos; Drosatos-Tampakaki, Zoi; Khan, Raffay; Homma, Shunichi; Schulze, P Christian; Zannis, Vassilis I; Goldberg, Ira J 2011. Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction. The Journal of biological chemistry, 286 42, 36331-9

Vedantham, Srinivasan; Noh, HyeLim; Ananthakrishnan, Radha; Son, Ni; Hallam, Kellie; Hu, Yunying; Yu, Shuiquing; Shen, Xiaoping; Rosario, Rosa; Lu, Yan; Ravindranath, Thyyar; Drosatos, Konstantinos; Huggins, Lesley Ann; Schmidt, Ann Marie; Goldberg, Ira J; Ramasamy, Ravichandran 2011. Human aldose reductase expression accelerates atherosclerosis in diabetic apolipoprotein E-/- mice. Arteriosclerosis, thrombosis, and vascular biology, 31 8, 1805-13

Vezeridis, Alexander M; Drosatos, Konstantinos; Zannis, Vassilis I 2011. Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4. Journal of lipid research, 52 1, 45-56

Iliopoulos, Dimitrios; Drosatos, Konstantinos; Hiyama, Yaeko; Goldberg, Ira J; Zannis, Vassilis I 2010. MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism. Journal of lipid research, 51 6, 1513-23

Khan, Raffay S; Drosatos, Konstaninos; Goldberg, Ira J 2010. Creating and curing fatty hearts. Current opinion in clinical nutrition and metabolic care, 13 2, 145-9

Sanoudou, D; Duka, A; Drosatos, K; Hayes, K C; Zannis, V I 2010. Role of Esrrg in the fibrate-mediated regulation of lipid metabolism genes in human ApoA-I transgenic mice. The pharmacogenomics journal, 10 3, 165-79

Park, Tae-Sik; Hu, Yunying; Noh, Hye-Lim; Drosatos, Konstantinos; Okajima, Kazue; Buchanan, Jonathan; Tuinei, Joseph; Homma, Shunichi; Jiang, Xian-Cheng; Abel, E Dale; Goldberg, Ira J 2008. Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. Journal of lipid research, 49 10, 2101-12

Zannis, Vassilis I; Koukos, Georgios; Drosatos, Konstantinos; Vezeridis, Alexander; Zanni, Eleni E; Kypreos, Kyriakos E; Chroni, Angeliki 2008. Discrete roles of apoA-I and apoE in the biogenesis of HDL species: lessons learned from gene transfer studies in different mouse models. Annals of medicine, 40 Suppl 1 , 14-28

Drosatos, Konstantinos; Kypreos, Kyriakos E; Zannis, Vassilis I 2007. Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein. Biochemistry, 46 33, 9645-53

Drosatos, Konstantinos; Sanoudou, Despina; Kypreos, Kyriakos E; Kardassis, Dimitris; Zannis, Vassilis I 2007. A dominant negative form of the transcription factor c-Jun affects genes that have opposing effects on lipid homeostasis in mice. The Journal of biological chemistry, 282 27, 19556-64