- Fellowship: Boston Children's (Harvard) (Pediatric Infectious Diseases )
- Residency: Boston Children's (Harvard) (Pediatrics)
- Medical Degree: Baylor College of Medicine (Medicine)
- Bachelor's Degree: Denison University (English)
Research Interests: pathogenesis of infections caused by Candida albicans; fungal pathogenesis; biofilm formation; role of candidal vaginal colonization in pre-term birth
Clinical Interests: pediatric infectious diseases
Peer Reviewed Publications
Burns, Audrea M; Moore, Daniel J; Forster, Catherine S; Powell, Weston; Thammasitboon, Satid; Hostetter, Margaret K; Weiss, Pnina; Boyer, Debra; Ward, Mark A; Blankenburg, Rebecca; Heyman, Melvin B; Rassbach, Caroline E; McPhillips, Heather; French, Anthony; Nguyen, Suong; Byrne, Bobbi J; Parsons, Donald Williams; Gonzalez, Fernando; Nowalk, Andrew J; Ho, Jacqueline; Kumar, Shelley; Orange, Jordan S; Ackerman, Kate G 2021. Physician-Scientist Training and Programming in Pediatric Residency Programs: A National Survey. The Journal of pediatrics, ,
Gordon, Catherine M; Hostetter, Margaret K; DeBaun, Michael R 2021. Academic pipeline initiatives in pediatrics. Pediatric research, ,
Barrett, Katherine J; Cooley, T Michelle; Schwartz, Alan L; Hostetter, Margaret K; Clapp, D Wade; Permar, Sallie R 2020. Addressing Gaps in Pediatric Scientist Development: The Department Chair View of 2 AMSPDC-Sponsored Programs. The Journal of pediatrics, 222 , 7-12.e4
Hostetter, Margaret K 2020. Ensuring Equity in Compensation and Career Advancement for Female Physicians. Mayo Clinic proceedings, 95 1, 3-5
Dermody, Terence S; Hirsch, Raphael; Hostetter, Margaret K; Orange, Jordan S; St Geme, Joseph W 2019. Expanding the Pipeline for Pediatric Physician-Scientists. The Journal of pediatrics, 207 , 3-7.e1
Wikenheiser-Brokamp, Kathryn A; Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; DeWitt, Thomas G; Loch, Jill; Strauss, Arnold W; Muglia, Louis J; Hostetter, Margaret K 2017. Evaluation of Fellows' CrossTalk Effectiveness in Promoting Transdisciplinary Networking and Research. The Journal of pediatrics, 181 , 5-6.e3
Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; Muglia, Louis J; Wikenheiser-Brokamp, Kathryn A; Loch, Jill; Hostetter, Margaret K; Strauss, Arnold W; DeWitt, Thomas G 2015. Enhancing Pediatric Fellows' Research Training: Development of an Office of Pediatric Clinical Fellowships. The Journal of pediatrics, 167 3, 506-7.e1
Patel, Zubin H; Kottyan, Leah C; Lazaro, Sara; Williams, Marc S; Ledbetter, David H; Tromp, Hbgerard; Rupert, Andrew; Kohram, Mojtaba; Wagner, Michael; Husami, Ammar; Qian, Yaping; Valencia, C Alexander; Zhang, Kejian; Hostetter, Margaret K; Harley, John B; Kaufman, Kenneth M 2014. The struggle to find reliable results in exome sequencing data: filtering out Mendelian errors. Frontiers in genetics, 5 , 16
Green, Julianne V; Orsborn, Kris I; Zhang, Minlu; Tan, Queenie K G; Greis, Kenneth D; Porollo, Alexey; Andes, David R; Long Lu, Jason; Hostetter, Margaret K 2013. Heparin-binding motifs and biofilm formation by Candida albicans. The Journal of infectious diseases, 208 10, 1695-704
Hostetter, Margaret K 2012. Success for the physician-scientist in a resource-limited environment. The Journal of pediatrics, 161 1, 1-2.e1
Hostetter, Margaret Kendrick 2012. What we don't see. The New England journal of medicine, 366 14, 1328-34
Liu, Geoffrey; Vellucci, Vincent F; Kyc, Stephanie; Hostetter, Margaret K 2009. Simvastatin inhibits Candida albicans biofilm in vitro. Pediatric research, 66 6, 600-4
Devore-Carter, Denise; Kar, Sujata; Vellucci, Vincent; Bhattacherjee, Vasker; Domanski, Paul; Hostetter, Margaret K 2008. Superantigen-like effects of a Candida albicans polypeptide. The Journal of infectious diseases, 197 7, 981-9
Frank, Charlotte F; Hostetter, Margaret K 2007. Cleavage of E-cadherin: a mechanism for disruption of the intestinal epithelial barrier by Candida albicans. Translational research : the journal of laboratory and clinical medicine, 149 4, 211-22
Vellucci, Vincent F; Gygax, Scott E; Hostetter, Margaret K 2007. Involvement of Candida albicans pyruvate dehydrogenase complex protein X (Pdx1) in filamentation. Fungal genetics and biology : FG & B, 44 10, 979-90
Hostetter, Margaret K 2004. A piece of my mind. Stitches. JAMA : the journal of the American Medical Association, 291 3, 282
Hostetter, Margaret K 2002. Career development for physician-scientists: the model of the Pediatric Scientist Development Program. The Journal of pediatrics, 140 2, 143-4
McDonough, Justin A; Bhattacherjee, Vasker; Sadlon, Tania; Hostetter, Margaret K 2002. Involvement of Candida albicans NADH dehydrogenase complex I in filamentation. Fungal genetics and biology : FG & B, 36 2, 117-27
Zhang, Y; Masi, A W; Barniak, V; Mountzouros, K; Hostetter, M K; Green, B A 2001. Recombinant PhpA protein, a unique histidine motif-containing protein from Streptococcus pneumoniae, protects mice against intranasal pneumococcal challenge. Infection and immunity, 69 6, 3827-36
Cheng, Q; Finkel, D; Hostetter, M K 2000. Novel purification scheme and functions for a C3-binding protein from Streptococcus pneumoniae. Biochemistry, 39 18, 5450-7
Hostetter, M K 2000. RGD-mediated adhesion in fungal pathogens of humans, plants and insects. Current opinion in microbiology, 3 4, 344-8
Madsen, M; Lebenthal, Y; Cheng, Q; Smith, B L; Hostetter, M K 2000. A pneumococcal protein that elicits interleukin-8 from pulmonary epithelial cells. The Journal of infectious diseases, 181 4, 1330-6
San-Blas, G; Travassos, L R; Fries, B C; Goldman, D L; Casadevall, A; Carmona, A K; Barros, T F; Puccia, R; Hostetter, M K; Shanks, S G; Copping, V M; Knox, Y; Gow, N A 2000. Fungal morphogenesis and virulence. Medical mycology, 38 Suppl 1 , 79-86
Smith, B L; Hostetter, M K 2000. C3 as substrate for adhesion of Streptococcus pneumoniae. The Journal of infectious diseases, 182 2, 497-508
Bendel, C M; Kinneberg, K M; Jechorek, R P; Gale, C A; Erlandsen, S L; Hostetter, M K; Wells, C L 1999. Systemic infection following intravenous inoculation of mice with Candida albicans int1 mutant strains. Molecular genetics and metabolism, 67 4, 343-51
Hostetter, M K 1999. Integrin-like proteins in Candida spp. and other microorganisms. Fungal genetics and biology : FG & B, 28 3, 135-45
Hostetter, M K 1999. Opsonic and nonopsonic interactions of C3 with Streptococcus pneumoniae. Microbial drug resistance (Larchmont, N.Y.), 5 2, 85-9
Hostetter, M K 1999. Epidemiology of travel-related morbidity and mortality in children. Pediatrics in review / American Academy of Pediatrics, 20 7, 228-33
Hostetter, M K 1999. Infectious diseases in internationally adopted children: findings in children from China, Russia, and eastern Europe. Advances in pediatric infectious diseases, 14 , 147-61
Kinneberg, K M; Bendel, C M; Jechorek, R P; Cebelinski, E A; Gale, C A; Berman, J G; Erlandsen, S L; Hostetter, M K; Wells, C L 1999. Effect of INT1 gene on Candida albicans murine intestinal colonization. The Journal of surgical research, 87 2, 245-51
Gale, C A; Bendel, C M; McClellan, M; Hauser, M; Becker, J M; Berman, J; Hostetter, M K 1998. Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1. Science (New York, N.Y.), 279 5355, 1355-8
Hostetter, M K 1998. Linkage of adhesion, morphogenesis, and virulence in Candida albicans. The Journal of laboratory and clinical medicine, 132 4, 258-63
Hostetter, M K 1998. Infectious diseases in internationally adopted children: the past five years. The Pediatric infectious disease journal, 17 6, 517-8
Albers, L H; Johnson, D E; Hostetter, M K; Iverson, S; Miller, L C 1997. Health of children adopted from the former Soviet Union and Eastern Europe. Comparison with preadoptive medical records. JAMA : the journal of the American Medical Association, 278 11, 922-4
DeMuri, G P; Hostetter, M K 1996. Evidence for a beta 1 integrin fibronectin receptor in Candida tropicalis. The Journal of infectious diseases, 174 1, 127-32
Hostetter, M K 1996. Steadfast in the 'steady state'. Archives of pediatrics & adolescent medicine, 150 9, 897-8
Hostetter, M K 1996. An integrin-like protein in Candida albicans: implications for pathogenesis. Trends in microbiology, 4 6, 242-6
Hostetter, M K 1996. Adhesion and morphogenesis in Candida albicans. Pediatric research, 39 4 Pt 1, 569-73
Hostetter, M K 1996. New insights into candidal infections. Advances in pediatrics, 43 , 209-30
Hostetter, M K; Johnson, D 1996. Medical examination of the internationally adopted child: screening for infectious diseases and developmental delay. Postgraduate medicine, 99 4, 70-2, 75-7, 81-2
Hostetter, Margaret K; Johnson, Dana 1996. Medical examination of the internationally adopted child. Postgraduate medicine, 99 4, 70-82
Salazar, J C; Bloom, K E; Hostetter, M K; Leonardi, C L 1996. Drug-resistant tuberculosis verrucosa cutis in a Southeast Asian teenager. The Pediatric infectious disease journal, 15 9, 834-6
Bendel, C M; St Sauver, J; Carlson, S; Hostetter, M K 1995. Epithelial adhesion in yeast species: correlation with surface expression of the integrin analog. The Journal of infectious diseases, 171 6, 1660-3
DeMuri, G P; Hostetter, M K 1995. Resistance to antifungal agents. Pediatric clinics of North America, 42 3, 665-85
Faix, R G; Finkel, D J; Andersen, R D; Hostetter, M K 1995. Genotypic analysis of a cluster of systemic Candida albicans infections in a neonatal intensive care unit. The Pediatric infectious disease journal, 14 12, 1063-8
Hostetter, M K; Tao, N J; Gale, C; Herman, D J; McClellan, M; Sharp, R L; Kendrick, K E 1995. Antigenic and functional conservation of an integrin I-domain in Saccharomyces cerevisiae. Biochemical and molecular medicine, 55 2, 122-30
Michael, E J; McClellan, M; Huebner, H; Hostetter, M K 1995. Expression of CD21 and synthesis of its ligands by HeLa cells after growth in serum-free medium. The Journal of laboratory and clinical medicine, 125 1, 102-12
Angel, C S; Ruzek, M; Hostetter, M K 1994. Degradation of C3 by Streptococcus pneumoniae. The Journal of infectious diseases, 170 3, 600-8
Hostetter, M K 1994. Society for Pediatric Research presidential address 1994: yeast as metaphor. Pediatric research, 36 6, 692-8
Hostetter, M K 1994. Adhesins and ligands involved in the interaction of Candida spp. with epithelial and endothelial surfaces. Clinical microbiology reviews, 7 1, 29-42
Bendel, C M; Hostetter, M K 1993. Distinct mechanisms of epithelial adhesion for Candida albicans and Candida tropicalis. Identification of the participating ligands and development of inhibitory peptides. The Journal of clinical investigation, 92 4, 1840-9
Hostetter, M K 1993. The third component of complement: new functions for an old friend. The Journal of laboratory and clinical medicine, 122 5, 491-6
Clark, E C; Nath, K A; Hostetter, T H; Hostetter, M K 1992. Hyperosmolality impairs ammonia-mediated inflammation: implications for the renal medulla. The American journal of physiology, 263 1 Pt 2, R148-55
Henwick, S; Hetherington, S V; Hostetter, M K 1992. Specificity of three anti-complement factor 3 monoclonal antibodies. Journal of immunological methods, 153 1-2, 173-84
Nath, K A; Salahudeen, A K; Clark, E C; Hostetter, M K; Hostetter, T H 1992. Role of cellular metabolites in progressive renal injury. Kidney international. Supplement, 38 , S109-13
Zach, T L; Hill, L D; Herrman, V A; Leuschen, M P; Hostetter, M K 1992. Effect of glucocorticoids on C3 gene expression by the A549 human pulmonary epithelial cell line. Journal of immunology (Baltimore, Md. : 1950), 148 12, 3964-9
Clark, E C; Nath, K A; Hostetter, M K; Hostetter, T H 1991. Role of ammonia in progressive interstitial nephritis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 17 5 Suppl 1, 15-9
Gustafson, K S; Vercellotti, G M; Bendel, C M; Hostetter, M K 1991. Molecular mimicry in Candida albicans. Role of an integrin analogue in adhesion of the yeast to human endothelium. The Journal of clinical investigation, 87 6, 1896-902
Hostetter, M K; Iverson, S; Thomas, W; McKenzie, D; Dole, K; Johnson, D E 1991. Medical evaluation of internationally adopted children. The New England journal of medicine, 325 7, 479-85
Nath, K A; Hostetter, M K; Hostetter, T H 1991. Increased ammoniagenesis as a determinant of progressive renal injury. American journal of kidney diseases : the official journal of the National Kidney Foundation, 17 6, 654-7
Nath, K A; Hostetter, M K; Hostetter, T H 1991. The role of ammonia in progressive renal injury. Contributions to nephrology, 92 , 78-82
Clark, E C; Nath, K A; Hostetter, M K; Hostetter, T H 1990. Role of ammonia in tubulointerstitial injury. Mineral and electrolyte metabolism, 16 5, 315-21
Clark, R B; Pakiz, C B; Hostetter, M K 1990. Synergistic activity of aminoglycoside-beta-lactam combinations against Pseudomonas aeruginosa with an unusual aminoglycoside antibiogram. Medical microbiology and immunology, 179 2, 77-86
Hostetter, M K 1990. Handicaps to host defense. Effects of hyperglycemia on C3 and Candida albicans. Diabetes, 39 3, 271-5
Hostetter, M K; Lorenz, J S; Preus, L; Kendrick, K E 1990. The iC3b receptor on Candida albicans: subcellular localization and modulation of receptor expression by glucose. The Journal of infectious diseases, 161 4, 761-8
Lugenbill, C; Clark, R B; Fagnant, R J; Hostetter, M K; Hill, W C 1990. Comparison of the cervicovaginal gram stain and rapid latex agglutination slide test for identification of group B streptococci. Journal of perinatology : official journal of the California Perinatal Association, 10 4, 403-5
Moy, J N; Nelson, R D; Richards, K L; Hostetter, M K 1990. Identification of an IgA inhibitor of neutrophil chemotaxis and its membrane target for the metabolic burst. Immunology, 69 2, 257-63
Hostetter, M K; Iverson, S; Dole, K; Johnson, D 1989. Unsuspected infectious diseases and other medical diagnoses in the evaluation of internationally adopted children. Pediatrics, 83 4, 559-64
Hostetter, M K; Johnson, G M 1989. The erythrocyte as instigator of inflammation. Generation of amidated C3 by erythrocyte adenosine deaminase. The Journal of clinical investigation, 84 2, 665-71
Nath, K A; Hostetter, M K; Hostetter, T H 1989. Ammonia-complement interaction in the pathogenesis of progressive renal injury. Kidney international. Supplement, 27 , S52-4
Zach, T L; Hostetter, M K 1989. Biochemical abnormalities of the third component of complement in neonates. Pediatric research, 26 2, 116-20
Clark, R B; Sanders, C C; Pakiz, C B; Hostetter, M K 1988. Aminoglycoside resistance among Pseudomonas aeruginosa isolates with an unusual disk diffusion antibiogram. Antimicrobial agents and chemotherapy, 32 5, 689-92
Gilmore, B J; Retsinas, E M; Lorenz, J S; Hostetter, M K 1988. An iC3b receptor on Candida albicans: structure, function, and correlates for pathogenicity. The Journal of infectious diseases, 157 1, 38-46
Goldhagen, J; Alford, B A; Prewitt, L H; Thompson, L; Hostetter, M K 1988. Suppurative thrombophlebitis of the internal jugular vein: report of three cases and review of the pediatric literature. The Pediatric infectious disease journal, 7 6, 410-4
Gordon, D L; Rice, J; Finlay-Jones, J J; McDonald, P J; Hostetter, M K 1988. Analysis of C3 deposition and degradation on bacterial surfaces after opsonization. The Journal of infectious diseases, 157 4, 697-704
Hostetter, T H; Nath, K A; Hostetter, M K 1988. Infection-related chronic interstitial nephropathy. Seminars in nephrology, 8 1, 11-6
Gordon, D L; Johnson, G M; Hostetter, M K 1987. Characteristics of iC3b binding to human polymorphonuclear leucocytes. Immunology, 60 4, 553-8
Tolins, J P; Hostetter, M K; Hostetter, T H 1987. Hypokalemic nephropathy in the rat. Role of ammonia in chronic tubular injury. The Journal of clinical investigation, 79 5, 1447-58
Gordon, D L; Hostetter, M K 1986. Complement and host defence against microorganisms. Pathology, 18 4, 365-75
Gordon, D L; Johnson, G M; Hostetter, M K 1986. Ligand-receptor interactions in the phagocytosis of virulent Streptococcus pneumoniae by polymorphonuclear leukocytes. The Journal of infectious diseases, 154 4, 619-26
Hostetter, M K 1986. Serotypic variations among virulent pneumococci in deposition and degradation of covalently bound C3b: implications for phagocytosis and antibody production. The Journal of infectious diseases, 153 4, 682-93
Gordon, D L; Krueger, R A; Quie, P G; Hostetter, M K 1985. Amidation of C3 at the thiolester site: stimulation of chemiluminescence and phagocytosis by a new inflammatory mediator. Journal of immunology (Baltimore, Md. : 1950), 134 5, 3339-45
Nath, K A; Hostetter, M K; Hostetter, T H 1985. Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3. The Journal of clinical investigation, 76 2, 667-75
Hostetter, M K; Krueger, R A; Schmeling, D J 1984. The biochemistry of opsonization: central role of the reactive thiolester of the third component of complement. The Journal of infectious diseases, 150 5, 653-61
Hostetter, M K; Levy, H L; Winter, H S; Knight, G J; Haddow, J E 1983. Evidence for liver disease preceding amino acid abnormalities in hereditary tyrosinemia. The New England journal of medicine, 308 21, 1265-7
Hostetter, M K; Thomas, M L; Rosen, F S; Tack, B F 1982. Binding of C3b proceeds by a transesterification reaction at the thiolester site. Nature, 298 5869, 72-5
Hostetter, M K; Schwartz, A L; Siber, G R; Schiffman, G 1981. Pneumococcal vaccine failure. American journal of diseases of children (1960), 135 12, 1149-50
Mann, J; O'Brien, R; Hostetter, M K; Alper, C A; Rosen, F S; Babior, B M 1981. The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway. Journal of immunology (Baltimore, Md. : 1950), 126 6, 2370-2
Giebink, G S; Carlson, B A; Hetherington, S V; Hostetter, M K; Le, C T; Juhn, S K . Bacterial and polymorphonuclear leukocyte contribution to middle ear inflammation in chronic otitis media with effusion. The Annals of otology, rhinology, and laryngology, 94 4 Pt 1, 398-402
Hostetter, M K; Gordon, D L . Biochemistry of C3 and related thiolester proteins in infection and inflammation. Reviews of infectious diseases, 9 1, 97-109
Johnson, D E; Miller, L C; Iverson, S; Thomas, W; Franchino, B; Dole, K; Kiernan, M T; Georgieff, M K; Hostetter, M K . The health of children adopted from Romania. JAMA : the journal of the American Medical Association, 268 24, 3446-51