Eric S. Wohleb, PhD

Allgire, Emily; McAlees, Jaclyn W; Ahlbrand, Rebecca A; Mancz, Elizabeth; Vollmer, Lauren L; Winter, Andrew; McMurray, Katherine M J; Maile, Laura; Sanders, Bryan; Ryan, William G; Pool, Allan-Hermann; Ifergan, Igal; Wohleb, Eric S; Davidson, Steve; McCullumsmith, Robert E; Lewkowich, Ian P; Sah, Renu 2025. A novel interoceptive subfornical organ to infralimbic cortex circuit relays airway inflammation effects on fear extinction. bioRxiv, ,

Bollinger, Justin L; Johnsamuel, Shobha; Vollmer, Lauren L; Kuhn, Alexander M; Wohleb, Eric S 2025. Stress-induced dysfunction of neurovascular astrocytes in the prefrontal cortex contributes to sex-dependent deficits in cognition and behavior. Molecular psychiatry, 30 9, 4128-4141

Smith, Brittany L; Brooks-Patton, Brandon; Bollinger, Justin L; Guzman, Tess A; Brendle, Alexander H; Woodburn, Samuel C; Makela, Anna G; Wohleb, Eric S; Reyes, Teresa M 2025. Prefrontal cortical microglial transcriptome relates to mouse offspring executive function deficits after perinatal opioid exposure in a sex-dependent manner. Brain, behavior, and immunity, 127 , 112-125

Walter, Ellen; Angst, Gabrielle; Bollinger, Justin; Truong, Linh; Ware, Elena; Wohleb, Eric S; Fan, Yanbo; Wang, Chenran 2025. Atg5 in microglia regulates sex-specific effects on postnatal neurogenesis in Alzheimer's disease. npj aging, 11 1, 18

Bollinger, Justin L; Horchar, Matthew J; Wohleb, Eric S 2024. Repeated Activation of Pyramidal Neurons in the Prefrontal Cortex Alters Microglial Phenotype in Male Mice. The Journal of pharmacology and experimental therapeutics, 388 2, 715-723

Davis, Alyshia B; Lloyd, Kelsey R; Bollinger, Justin L; Wohleb, Eric S; Reyes, Teresa M 2024. Adolescent high fat diet alters the transcriptional response of microglia in the prefrontal cortex in response to stressors in both male and female mice. Stress (Amsterdam, Netherlands), 27 1, 2365864

Kuhn, Alexander M; Bosis, Kelly E; Wohleb, Eric S 2024. Looking Back to Move Forward: Research in Stress, Behavior, and Immune Function. Neuroimmunomodulation, 31 1, 211-229

Bollinger, Justin L; Dadosky, David T; Flurer, James K; Rainer, Ivanka L; Woodburn, Samuel C; Wohleb, Eric S 2023. Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 48 9, 1347-1357

Smail, Marissa A; Smith, Brittany L; Shukla, Rammohan; Alganem, Khaled; Eby, Hunter M; Bollinger, Justin L; Parikh, Ria K; Chambers, James B; Reigle, James K; Moloney, Rachel D; Nawreen, Nawshaba; Wohleb, Eric S; Pantazopoulos, Harry; McCullumsmith, Robert E; Herman, James P 2023. Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix. Molecular psychiatry, ,

Woodburn, Samuel C; Asrat, Helina S; Flurer, James K; Schwierling, Hana C; Bollinger, Justin L; Vollmer, Lauren L; Wohleb, Eric S 2023. Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress. Brain, behavior, and immunity, 109 , 127-138

Morano, Rachel; Yates, Emily; Barnes, Rachel; Wohleb, Eric S; Perez-Tilve, Diego 2022. Influence of Nutritional Status and Leptin Action on Agrp and Pomc Co-Expression in Hypothalamic Melanocortin System Neurons. Neuroendocrinology, 112 3, 287-297

Koo, Ja Wook; Wohleb, Eric S 2021. How Stress Shapes Neuroimmune Function: Implications for the Neurobiology of Psychiatric Disorders. Biological psychiatry, 90 2, 74-84

Woodburn, Samuel C; Bollinger, Justin L; Wohleb, Eric S 2021. The semantics of microglia activation: neuroinflammation, homeostasis, and stress. Journal of neuroinflammation, 18 1, 258

Woodburn, Samuel C; Bollinger, Justin L; Wohleb, Eric S 2021. Synaptic and behavioral effects of chronic stress are linked to dynamic and sex-specific changes in microglia function and astrocyte dystrophy. Neurobiology of stress, 14 , 100312

Bollinger, Justin L; Horchar, Matthew J; Wohleb, Eric S 2020. Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, ,

Gerhard, Danielle M; Pothula, Santosh; Liu, Rong-Jian; Wu, Min; Li, Xiao-Yuan; Girgenti, Matthew J; Taylor, Seth R; Duman, Catharine H; Delpire, Eric; Picciotto, Marina; Wohleb, Eric S; Duman, Ronald S 2020. GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions. The Journal of clinical investigation, 130 3, 1336-1349

Bollinger, J L; Wohleb, E S 2019. The formative role of microglia in stress-induced synaptic deficits and associated behavioral consequences. Neuroscience letters, 711 , 134369

Deyama, Satoshi; Bang, Eunyoung; Wohleb, Eric S; Li, Xiao-Yuan; Kato, Taro; Gerhard, Danielle M; Dutheil, Sophie; Dwyer, Jason M; Taylor, Seth R; Picciotto, Marina R; Duman, Ronald S 2019. Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine. The American journal of psychiatry, 176 5, 388-400

Girgenti, Matthew J; Wohleb, Eric S; Mehta, Sameet; Ghosal, Sriparna; Fogaca, Manoela V; Duman, Ronald S 2019. Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes. Translational psychiatry, 9 1, 292

Horchar, Matthew J; Wohleb, Eric S 2019. Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress Brain, Behavior, and Immunity, ,

Franklin, Tina C; Wohleb, Eric S; Zhang, Yi; Fogaça, Manoela; Hare, Brendan; Duman, Ronald S 2018. Persistent Increase in Microglial RAGE Contributes to Chronic Stress-Induced Priming of Depressive-like Behavior. Biological psychiatry, 83 1, 50-60

Wohleb, Eric S; Terwilliger, Rosemarie; Duman, Catharine H; Duman, Ronald S 2018. Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior Biological Psychiatry, 83 1, 38-49

Bath, Kevin G; Russo, Scott J; Pleil, Kristen E; Wohleb, Eric S; Duman, Ronald S; Radley, Jason J 2017. Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development. Neurobiology of stress, 7 , 137-151

Bolyard, Chelsea; Meisen, W Hans; Banasavadi-Siddegowda, Yeshavanth; Hardcastle, Jayson; Yoo, Ji Young; Wohleb, Eric S; Wojton, Jeffrey; Yu, Jun-Ge; Dubin, Samuel; Khosla, Maninder; Xu, Bo; Smith, Jonathan; Alvarez-Breckenridge, Christopher; Pow-Anpongkul, Pete; Pichiorri, Flavia; Zhang, Jianying; Old, Matthew; Zhu, Dan; Van Meir, Erwin G; Godbout, Jonathan P; Caligiuri, Michael A; Yu, Jianhua; Kaur, Balveen 2017. BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research, 23 7, 1809-1819

Wohleb, Eric S; Delpech, Jean-Christophe 2017. Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences. Progress in neuro-psychopharmacology & biological psychiatry, 79 Pt A, 40-48

Wohleb, Eric S; Gerhard, Danielle; Thomas, Alex; Duman, Ronald S 2017. Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine. Current neuropharmacology, 15 1, 11-20

Das, Amitava; Ghatak, Subhadip; Sinha, Mithun; Chaffee, Scott; Ahmed, Noha S; Parinandi, Narasimham L; Wohleb, Eric S; Sheridan, John F; Sen, Chandan K; Roy, Sashwati 2016. Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes. Journal of immunology (Baltimore, Md. : 1950), 196 12, 5089-100

Dutheil, Sophie; Ota, Kristie T; Wohleb, Eric S; Rasmussen, Kurt; Duman, Ronald S 2016. High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41 7, 1874-87

Gerhard, Danielle M; Wohleb, Eric S; Duman, Ronald S 2016. Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity. Drug discovery today, 21 3, 454-64

Hansen, Christopher N; Norden, Diana M; Faw, Timothy D; Deibert, Rochelle; Wohleb, Eric S; Sheridan, John F; Godbout, Jonathan P; Basso, D Michele 2016. Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury. Experimental neurology, 282 , 86-98

McKim, Daniel B; Niraula, Anzela; Tarr, Andrew J; Wohleb, Eric S; Sheridan, John F; Godbout, Jonathan P 2016. Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 9, 2590-604

McKim, Daniel B; Patterson, Jenna M; Wohleb, Eric S; Jarrett, Brant L; Reader, Brenda F; Godbout, Jonathan P; Sheridan, John F 2016. Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat. Biological psychiatry, 79 10, 803-813

Wohleb, Eric S 2016. Neuron-Microglia Interactions in Mental Health Disorders: "For Better, and For Worse" Frontiers in Immunology, 7 , 544

Wohleb, Eric S; Franklin, Tina; Iwata, Masaaki; Duman, Ronald S 2016. Integrating neuroimmune systems in the neurobiology of depression Nature Reviews Neuroscience, 17 8, 497-511

Wohleb, Eric S; Wu, Min; Gerhard, Danielle M; Taylor, Seth R; Picciotto, Marina R; Alreja, Meenakshi; Duman, Ronald S 2016. GABA interneurons mediate the rapid antidepressant-like effects of scopolamine The Journal of Clinical Investigation, 126 7, 2482-94

Delpech, Jean-Christophe; Madore, Charlotte; Nadjar, Agnes; Joffre, Corinne; Wohleb, Eric S; Layé, Sophie 2015. Microglia in neuronal plasticity: Influence of stress. Neuropharmacology, 96 Pt A, 19-28

Fuchikami, Manabu; Thomas, Alexandra; Liu, Rongjian; Wohleb, Eric S; Land, Benjamin B; DiLeone, Ralph J; Aghajanian, George K; Duman, Ronald S 2015. Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. Proceedings of the National Academy of Sciences of the United States of America, 112 26, 8106-11

Meisen, W Hans; Wohleb, Eric S; Jaime-Ramirez, Alena Cristina; Bolyard, Chelsea; Yoo, Ji Young; Russell, Luke; Hardcastle, Jayson; Dubin, Samuel; Muili, Kamaldeen; Yu, Jianhua; Caligiuri, Michael; Godbout, Jonathan; Kaur, Balveen 2015. The Impact of Macrophage- and Microglia-Secreted TNFα on Oncolytic HSV-1 Therapy in the Glioblastoma Tumor Microenvironment. Clinical cancer research : an official journal of the American Association for Cancer Research, 21 14, 3274-85

Navarria, Andrea; Wohleb, Eric S; Voleti, Bhavya; Ota, Kristie T; Dutheil, Sophie; Lepack, Ashley E; Dwyer, Jason M; Fuchikami, Manabu; Becker, Astrid; Drago, Filippo; Duman, Ronald S 2015. Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors. Neurobiology of disease, 82 , 254-261

Reader, B F; Jarrett, B L; McKim, D B; Wohleb, E S; Godbout, J P; Sheridan, J F 2015. Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety. Neuroscience, 289 , 429-42

Sawicki, C M; McKim, D B; Wohleb, E S; Jarrett, B L; Reader, B F; Norden, D M; Godbout, J P; Sheridan, J F 2015. Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain. Neuroscience, 302 , 151-64

Wohleb, Eric S; McKim, Daniel B; Shea, Daniel T; Powell, Nicole D; Tarr, Andrew J; Sheridan, John F; Godbout, Jonathan P 2014. Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain. Biological psychiatry, 75 12, 970-81

Wohleb, Eric S; McKim, Daniel B; Sheridan, John F; Godbout, Jonathan P 2014. Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior. Frontiers in neuroscience, 8 , 447

Wohleb, Eric S; Patterson, Jenna M; Sharma, Vikram; Quan, Ning; Godbout, Jonathan P; Sheridan, John F 2014. Knockdown of interleukin-1 receptor type-1 on endothelial cells attenuated stress-induced neuroinflammation and prevented anxiety-like behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 34 7, 2583-91

Voorhees, Jeffrey L; Tarr, Andrew J; Wohleb, Eric S; Godbout, Jonathan P; Mo, Xiaokui; Sheridan, John F; Eubank, Timothy D; Marsh, Clay B 2013. Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10. PloS one, 8 3, e58488

Wohleb, Eric S; Godbout, Jonathan P 2013. Basic aspects of the immunology of neuroinflammation. Modern trends in pharmacopsychiatry, 28 , 1-19

Wohleb, Eric S; Powell, Nicole D; Godbout, Jonathan P; Sheridan, John F 2013. Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience, 33 34, 13820-33

Wohleb, Eric S; Fenn, Ashley M; Pacenta, Ann M; Powell, Nicole D; Sheridan, John F; Godbout, Jonathan P 2012. Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice. Psychoneuroendocrinology, 37 9, 1491-505

Wohleb, Eric S; Hanke, Mark L; Corona, Angela W; Powell, Nicole D; Stiner, La'Tonia M; Bailey, Michael T; Nelson, Randy J; Godbout, Jonathan P; Sheridan, John F 2011. β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31 17, 6277-88