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Photo of  Xiaoting Zhang, PHD

Xiaoting Zhang, PHD


John and Gladys Strauss Endowed Chair

Cancer Biology | College of Medicine

  • Fellowship: Rockefeller University (Biochemistry, Molecular Biology and Genetics)
  • Doctoral Degree: The University of Iowa (Molecular Biology )
  • Master's Degree: Fudan University (Genetics )
  • Bachelor's Degree: Zhejiang University (Biochemistry & Microbiology )
Contact Information
Research Interests

Mechanisms of transcriptional and epigenetic regulation of gene expression in breast cancer and development of RNA-based nanotherapeutics.

Peer Reviewed Publications

Andreani, Cristina; Bartolacci, Caterina; Persico, Giuseppe; Casciaro, Francesca; Amatori, Stefano; Fanelli, Mirco; Giorgio, Marco; Galié, Mirco; Tomassoni, Daniele; Wang, Junbiao; Zhang, Xiaoting; Bick, Gregory; Coppari, Roberto; Marchini, Cristina; Amici, Augusto 2023. SIRT6 promotes metastasis and relapse in HER2-positive breast cancer. Scientific reports, 13 1, 22000

Yi, Fei; Cai, Chunmiao; Ruan, Banzhan; Hao, Mingang; Yeo, Syn Kok; Haas, Michael; Yang, Fuchun; Zhang, Xiaoting; Guan, Jun-Lin 2023. Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region. Autophagy, 19 6, 1662-1677

Bick, Gregory; Zhang, Jasmine; Lower, Elyse E; Zhang, Xiaoting 2022. Transcriptional coactivator MED1 in the interface of anti-estrogen and anti-HER2 therapeutic resistance. Cancer drug resistance (Alhambra, Calif.), 5 2, 498-510

Cai, Chunmiao; Bi, Dexi; Bick, Gregory; Wei, Qing; Liu, Hu; Lu, Ling; Zhang, Xiaoting; Qin, Huanlong 2021. Hepatocyte nuclear factor HNF1A is a potential regulator in shaping the super-enhancer landscape in colorectal cancer liver metastasis. FEBS letters, ,

Hao, Mingang; Yeo, Syn Kok; Turner, Kevin; Harold, Alexis; Yang, Yongguang; Zhang, Xiaoting; Guan, Jun-Lin 2021. Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles. Developmental cell, 56 3, 341-355.e5

Yang Y, Leonard M, Luo Q, Yeo S, Bick G, Hao M, Cai C, Charif M, Wang J, Guan J, Lower EE and Zhang X. 2021. Functional cooperation between Co-amplfied Genes Promotes Aggressive Phenotypes of HER2+ breast cancer Cell Reports , ,

Yang, Yongguang; Leonard, Marissa; Luo, Zhenhua; Yeo, Syn; Bick, Gregory; Hao, Mingang; Cai, Chunmiao; Charif, Mahmoud; Wang, Jiang; Guan, Jun-Lin; Lower, Elyse E; Zhang, Xiaoting 2021. Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer. Cell reports, 34 10, 108822

Gregory Bick, Dan Zhao and Xiaoting Zhang 2019. Estrogen Receptor-Mediated Gene Transcription and Cistrome. Estrogen Receptor and Breast Cancer, Springer Nature , 379-403

Leonard M, Tan J, Yang Y, Mahmoud C, Lower EE, and Zhang X 2019. Emerging Approaches to Overcome Breast Cancer Endocrine Resistance. Estrogen Receptor and Breast Cancer, Springer Nature , 379-403

Leonard, Marissa; Zhang, Xiaoting 2019. Estrogen receptor coactivator Mediator Subunit 1 (MED1) as a tissue-specific therapeutic target in breast cancer. Journal of Zhejiang University. Science. B, 20 5, 381-390

Xiaoting Zhang 2019. Book: Estrogen Receptor and Breast Cancer --- Celebrating 60th anniversary of the discovery of ER Springer Nature, ,

Yang, Yongguang; Leonard, Marissa; Zhang, Yijuan; Zhao, Dan; Mahmoud, Charif; Khan, Shugufta; Wang, Jiang; Lower, Elyse E; Zhang, Xiaoting 2018. HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1. Cancer research, 78 2, 422-435

Zhang Y, Leonard M, Shu Y, Yang Y, Shu D, Guo P, and Zhang X. 2018. Overcoming Tamoxifen Resistance of Human Breast Cancer by Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles ACS Nano , 11 1, 335-346

Leonard M and Zhang X 2016. First Therapeutic Aptamer: VEGF-Targeting Macugen Aptamers: Tools for Targeted Nanotherapy and Molecular Imaging, Pan Stanford Publishing , Page 319-335.

Leonard M, Zhang Y and Zhang X. 2015. Small non-coding RNAs and aptamers in diagnostics and therapeutics Methods in Molecular Biology, 1296 , 225-33

Leonard, Marissa; Zhang, Yijuan; Zhang, Xiaoting 2015. Small non-coding RNAs and aptamers in diagnostics and therapeutics. Methods in molecular biology (Clifton, N.J.), 1296 , 225-33

Czyzyk-Krzeska, M F; Zhang, X 2014. MiR-155 at the heart of oncogenic pathways Oncogene, 33 6, 677-8

Germer, Katherine; Leonard, Marissa; Zhang, Xiaoting 2013. RNA aptamers and their therapeutic and diagnostic applications. International Journal of Biochemistry and Molecular Biology, 4 1, 27-40

Zhang L; Cui J; Leonard M; Nephew K; Li Y and Zhang X 2013. Silencing MED1 Sensitizes Breast Cancer Cells to pure Anti-estrogen Fulvestrant Therapy in vitro and in vivo PLoS ONE , 8(7): e70641 ,

Zhang, Lijiang; Cui, Jiajun; Leonard, Marissa; Nephew, Kenneth; Li, Yongquan; Zhang, Xiaoting 2013. Silencing MED1 sensitizes breast cancer cells to pure anti-estrogen fulvestrant in vitro and in vivo. PloS one, 8 7, e70641

Cui J, Germer K, Wu T, Wang J, Luo J, Wang SC, Wang Q, and Zhang X 2012. Cross-talk Between HER2 and MED1 Regulates Tamoxifen Resistance of Human Breast Cancer Cells Cancer Research, 72 21, 5625-34

Cui, Jiajun; Germer, Katherine; Wu, Tianying; Wang, Jiang; Luo, Jia; Wang, Shao-chun; Wang, Qianben; Zhang, Xiaoting 2012. Cross-talk between HER2 and MED1 regulates tamoxifen resistance of human breast cancer cells. Cancer research, 72 21, 5625-34

Chen Z, Zhang C, Wu D, Rorick A, Zhang X, and Wang Q 2011. Specific phosphorylation of coactivator Mediator 1coding for UBE2C locus looping leads to androgen receptor negative prostate cancer growth EMBO J., 30(12):2405-19 ,

Pfaff D, Waters J, Kahn I, Zhang X and Numan M. 2011. Estrogen receptor-initiated mechanisms causal to mammalian reproductive behaviors. Endocrinology, 152 4, 1209-17

Zhang D, Jiang P, Xu Q, and Zhang X 2011. ARGLU1 interacts with MED1 and is required for estrogen receptor-mediated transcription and breast cancer cell growth. Journal of Biological Chemistry, 286(20):17746-54 ,

Zhang, Dingxiao; Jiang, Pingping; Xu, Qinqin; Zhang, Xiaoting 2011. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. The Journal of biological chemistry, 286 20, 17746-54

Chen, W.; Zhang, X.; Birsoy, K.; Roeder, R. G. 2010. A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism Proc Natl Acad Sci U S A, 107 22 , 10196-201

Jiang, P.; Hu, Q.; Ito, M.; Meyer, S.; Waltz, S.; Khan, S.; Roeder, R. G.; Zhang, X. 2010. Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation Proc Natl Acad Sci U S A, 107 15 , 6765-70

Jiang, Pingping; Hu, Qiuping; Ito, Mitsuhiro; Meyer, Sara; Waltz, Susan; Khan, Sohaib; Roeder, Robert G; Zhang, Xiaoting 2010. Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 107 15, 6765-70

Zhang, X; Leung, Y-K; Ho, S-M 2007. AP-2 regulates the transcription of estrogen receptor (ER)-beta by acting through a methylation hotspot of the 0N promoter in prostate cancer cells. Oncogene, 26 52, 7346-54

Stumpf M, Waskow C, Krötschel M, Essen D, Rodriguez P, Zhang X, Guyot B, Roeder RG and Borggrefe T. 2006. The Mediator Complex Functions as a Coactivator for GATA1 in Erythropoiesis via Subunit Med1/TRAP220 Proc. Natl. Acad. Sci., 103:18504-9 ,

Zhang, X.; Kolaczkowska, A.; Devaux, F.; Panwar, S. L.; Hallstrom, T. C.; Jacq, C.; Moye-Rowley, W. S. 2005. Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination J Biol Chem, 280 4 , 2759-70

Zhang, X.; Krutchinsky, A.; Fukuda, A.; Chen, W.; Yamamura, S.; Chait, B. T.; Roeder, R. G. 2005. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription Mol Cell, 19 1 , 89-100

Le Crom, S.; Devaux, F.; Marc, P.; Zhang, X.; Moye-Rowley, W. S.; Jacq, C. 2002. New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system Mol Cell Biol, 22 8 , 2642-9

Zhang, X.; Cui, Z.; Miyakawa, T.; Moye-Rowley, W. S. 2001. Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae J Biol Chem, 276 12 , 8812-9

Zhang, X.; Moye-Rowley, W. S. 2001. Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase J Biol Chem, 276 51 , 47844-52

Zhang, X.; De Micheli, M.; Coleman, S. T.; Sanglard, D.; Moye-Rowley, W. S. 2000. Analysis of the oxidative stress regulation of the Candida albicans transcription factor, Cap1p Mol Microbiol, 36 3 , 618-29

Zhang, X., Ma, B., Shu, N., Chen, SZ, and Zhao, SY. 1997. Cloning the Gene Coding for Human Glial Cell Line-derived Neurotrophic Factor and its Expression in Escherichia Coli Chinese Journal of Biotechnology, 13(4): 426-9 ,

Zhang, X., Chen, SZ, and Zhao, SY. 1996. The Gene Structure of Ciliary Neurotrophic Factor and its Receptor Foreign Med. Sci. (Molecular Biology), 18(5):225-9 ,