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Photo of  Trisha M. Wise-Draper, MD,PhD

Trisha M. Wise-Draper, MD,PhD


Internal Medicine | College of Medicine

  • Residency: University of Cincinnati Medical Center (Internal Medicine)
  • Fellowship: University of Cincinnati (Hematology/Oncology )
  • Medical Degree: University of Cincinnati
  • Residency: University of Cincinnati (Internal Medicine )
  • Doctoral Degree: University of Cincinnati (Cancer Biology)
  • Bachelor's Degree: Miami University (Zoology)
Board Certifications & Licenses

American Board of Internal Medicine (Certification Date: 2013-08-06)
American Board of Internal Medicine (Medical Oncology) (Certification Date: 2015-10-27)


Internal Medicine
Medical Oncology

Contact Information
Research Interests

The laboratory focuses on translational mechanisms of therapeutic resistance and biomarkers in cancer. Our main model of disease is head and neck cancer (HNC) which is the 6th most common cancer worldwide.  Many treatments for HNC are toxic and result in significant morbidity. In addition, the outcomes in locally advanced HNC, especially those with high risk features and those that develop recurrence, are poor.  Therefore, using patient tissue/blood samples as well as established HNC cell lines ...

Clinical Interests

Hematology and Oncology

Lung Cancer

Thyroid Cancer

Adenoid Cancer

Alveolar Ridge Cancer

Bucal Cavity Cancer

Ear Cancer

Laryngeal Cancer

Mouth Cancer

Nasopharyngeal Cancer

Neck Cancer

Oral Cancer

Oropharyngeal Cancer

Parotid Gland Cancer

Pharynx Cancer

Salivary Gland Cancer

Soft Palate Cancer

Throat Cancer


Tongue Cancer

Tonsil Cancer

Peer Reviewed Publications

Agresta, Laura; Lehn, Maria; Lampe, Kristin; Cantrell, Rachel; Hennies, Cassandra; Szabo, Sara; Wise-Draper, Trisha; Conforti, Laura; Hoebe, Kasper; Janssen, Edith M 2020. CD244 represents a new therapeutic target in head and neck squamous cell carcinoma. Journal for immunotherapy of cancer, 8 1,

Chimote, Ameet A; Gawali, Vaibhavkumar S; Newton, Hannah S; Wise-Draper, Trisha M; Conforti, Laura 2020. A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer. Frontiers in pharmacology, 11 , 143

Gulati, Shuchi; Desai, Janki; Palackdharry, Sarah M; Morris, John C; Zhu, Zheng; Jandarov, Roman; Riaz, Muhammad K; Takiar, Vinita; Mierzwa, Michelle; Gutkind, J Silvio; Molinolo, Alfredo; Desai, Pankaj B; Sadraei, Nooshin Hashemi; Wise-Draper, Trisha M 2020. Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer. Cancer, 126 2, 354-362

Tsurutani, Junji; Iwata, Hiroji; Krop, Ian; Jänne, Pasi A; Doi, Toshihiko; Takahashi, Shunji; Park, Haeseong; Redfern, Charles; Tamura, Kenji; Wise-Draper, Trisha M; Saito, Kaku; Sugihara, Masahiro; Singh, Jasmeet; Jikoh, Takahiro; Gallant, Gilles; Li, Bob T 2020. Targeting HER2 with Trastuzumab Deruxtecan: A Dose-Expansion, Phase I Study in Multiple Advanced Solid Tumors. Cancer discovery, ,

Haque, Sulsal; Karivedu, Vidhya; Riaz, Muhammed K; Choi, David; Roof, Logan; Hassan, Sarah Z; Zhu, Zheng; Jandarov, Roman; Takiar, Vinita; Tang, Alice; Wise-Draper, Trisha 2019. High-risk pathological features at the time of salvage surgery predict poor survival after definitive therapy in patients with head and neck squamous cell carcinoma. Oral oncology, 88 , 9-15

Kofuji, Satoshi; Hirayama, Akiyoshi; Eberhardt, Alexander Otto; Kawaguchi, Risa; Sugiura, Yuki; Sampetrean, Oltea; Ikeda, Yoshiki; Warren, Mikako; Sakamoto, Naoya; Kitahara, Shuji; Yoshino, Hirofumi; Yamashita, Daisuke; Sumita, Kazutaka; Wolfe, Kara; Lange, Lisa; Ikeda, Satsuki; Shimada, Hiroko; Minami, Noriaki; Malhotra, Akshiv; Morioka, Shin; Ban, Yuki; Asano, Maya; Flanary, Victoria L; Ramkissoon, Annmarie; Chow, Lionel M L; Kiyokawa, Juri; Mashimo, Tomoyuki; Lucey, Greg; Mareninov, Sergey; Ozawa, Tatsuya; Onishi, Nobuyuki; Okumura, Koichi; Terakawa, Jumpei; Daikoku, Takiko; Wise-Draper, Trisha; Majd, Nazanin; Kofuji, Kaori; Sasaki, Mika; Mori, Masaru; Kanemura, Yonehiro; Smith, Eric P; Anastasiou, Dimitrios; Wakimoto, Hiroaki; Holland, Eric C; Yong, William H; Horbinski, Craig; Nakano, Ichiro; DeBerardinis, Ralph J; Bachoo, Robert M; Mischel, Paul S; Yasui, Wataru; Suematsu, Makoto; Saya, Hideyuki; Soga, Tomoyoshi; Grummt, Ingrid; Bierhoff, Holger; Sasaki, Atsuo T 2019. IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma. Nature cell biology, 21 8, 1003-1014

Ribrag, Vincent; Avigan, David E; Green, Damian J; Wise-Draper, Trisha; Posada, Juan G; Vij, Ravi; Zhu, Ying; Farooqui, Mohammed Z H; Marinello, Patricia; Siegel, David S 2019. Phase 1b trial of pembrolizumab monotherapy for relapsed/refractory multiple myeloma: KEYNOTE-013. British journal of haematology, 186 3, e41-e44

Chimote, Ameet A; Balajthy, Andras; Arnold, Michael J; Newton, Hannah S; Hajdu, Peter; Qualtieri, Julianne; Wise-Draper, Trisha; Conforti, Laura 2018. A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. Science signaling, 11 527,

Haque, Sulsal-Ul; Niu, Liang; Kuhnell, Damaris; Hendershot, Jacob; Biesiada, Jacek; Niu, Wen; Hagan, Matthew C; Kelsey, Karl T; Casper, Keith A; Wise-Draper, Trisha M; Medvedovic, Mario; Langevin, Scott M 2018. Differential expression and prognostic value of long non-coding RNA in HPV-negative head and neck squamous cell carcinoma. Head & neck, 40 7, 1555-1564

Wise-Draper, Trisha; Sendilnathan, Arun; Palackdharry, Sarah; Pease, Nicholas; Qualtieri, Julianne; Butler, Randall; Sadraei, Nooshin Hashemi; Morris, John C; Patil, Yash; Wilson, Keith; Mark, Jonathan; Casper, Keith; Takiar, Vinita; Lane, Adam; Privette Vinnedge, Lisa 2018. Decreased plasma DEK Oncogene Levels Correlate with p16-Negative Disease and Advanced Tumor Stage in a Case-Control Study of Patients with Head and Neck Squamous Cell Carcinoma. Translational oncology, 11 1, 168-174

Chimote, Ameet A; Hajdu, Peter; Sfyris, Alexandros M; Gleich, Brittany N; Wise-Draper, Trisha; Casper, Keith A; Conforti, Laura 2017. Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer. Cancer research, 77 1, 53-61

Langevin, Scott; Kuhnell, Damaris; Parry, Tess; Biesiada, Jacek; Huang, Shouxiong; Wise-Draper, Trisha; Casper, Keith; Zhang, Xiang; Medvedovic, Mario; Kasper, Susan 2017. Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro reveals common secretion profiles and potential utility as salivary biomarkers. Oncotarget, 8 47, 82459-82474

Wise-Draper, Trisha M; Moorthy, Ganesh; Salkeni, Mohamad A; Karim, Nagla Abdel; Thomas, Hala Elnakat; Mercer, Carol A; Beg, M Shalaan; O'Gara, Sue; Olowokure, Olugbenga; Fathallah, Hassana; Kozma, Sara C; Thomas, George; Rixe, Olivier; Desai, Pankaj; Morris, John C 2017. A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies. Targeted oncology, 12 3, 323-332

Old, Matthew O; Wise-Draper, Trisha; Wright, Chadwick L; Kaur, Balveen; Teknos, Theodoros 2016. The current status of oncolytic viral therapy for head and neck cancer. World journal of otorhinolaryngology - head and neck surgery, 2 2, 84-89

Riaz, Muhammad Kashif; Bal, Susan; Wise-Draper, Trisha 2016. The impending financial healthcare burden and ethical dilemma of systemic therapy in metastatic cancer. Journal of surgical oncology, ,

Adams, A K; Hallenbeck, G E; Casper, K A; Patil, Y J; Wilson, K M; Kimple, R J; Lambert, P F; Witte, D P; Xiao, W; Gillison, M L; Wikenheiser-Brokamp, K A; Wise-Draper, T M; Wells, S I 2015. DEK promotes HPV-positive and -negative head and neck cancer cell proliferation. Oncogene, 34 7, 868-77

Malhotra, Akshiv; Sendilnathan, Arun; Old, Matthew O; Wise-Draper, Trisha M 2015. Oncolytic virotherapy for head and neck cancer: current research and future developments. Oncolytic virotherapy, 4 , 83-93

Pease, Nicholas A; Wise-Draper, Trisha; Privette Vinnedge, Lisa 2015. Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer. Journal of oncology, 2015 , 106517

Adams, Allie K; Wise-Draper, Trisha M; Wells, Susanne I 2014. Human papillomavirus induced transformation in cervical and head and neck cancers. Cancers, 6 3, 1793-820

Ghose, Abhimanyu; Yellu, Mahender; Wise-Draper, Trisha; Sharma, Divya; Qualtieri, Julianne; Latif, Tahir; Medlin, Stephen 2014. Lymphoma presenting as secondary HLH: a review with a tale of two cases. Clinical lymphoma, myeloma & leukemia, 14 6, e187-93

Bahassi, El Mustapha; Li, Ya-Qin; Wise-Draper, Trisha M; Deng, Li; Wang, Jiang; Darnell, Colleen N; Wilson, Keith M; Wells, Susanne I; Stambrook, Peter J; Rixe, Olivier 2013. A patient-derived somatic mutation in the epidermal growth factor receptor ligand-binding domain confers increased sensitivity to cetuximab in head and neck cancer. European journal of cancer (Oxford, England : 1990), 49 10, 2345-55

Wise-Draper, Trisha M; Draper, David J; Gutkind, J Silvio; Molinolo, Alfredo A; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. Future directions and treatment strategies for head and neck squamous cell carcinomas. Translational research : the journal of laboratory and clinical medicine, 160 3, 167-77

Kavanaugh, Gina M; Wise-Draper, Trisha M; Morreale, Richard J; Morrison, Monique A; Gole, Boris; Schwemberger, Sandy; Tichy, Elisia D; Lu, Lu; Babcock, George F; Wells, James M; Drissi, Rachid; Bissler, John J; Stambrook, Peter J; Andreassen, Paul R; Wiesmüller, Lisa; Wells, Susanne I 2011. The human DEK oncogene regulates DNA damage response signaling and repair. Nucleic acids research, 39 17, 7465-76

Wise-Draper, Trisha M; Mintz-Cole, Rachael A; Morris, Teresa A; Simpson, David S; Wikenheiser-Brokamp, Kathryn A; Currier, Mark A; Cripe, Timothy P; Grosveld, Gerard C; Wells, Susanne I 2009. Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo. Cancer research, 69 5, 1792-9

Wise-Draper, Trisha M; Morreale, Richard J; Morris, Teresa A; Mintz-Cole, Rachael A; Hoskins, Elizabeth E; Balsitis, Scott J; Husseinzadeh, Nader; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Lambert, Paul F; Wells, Susanne I 2009. DEK proto-oncogene expression interferes with the normal epithelial differentiation program. The American journal of pathology, 174 1, 71-81

Hoskins, E E; Gunawardena, R W; Habash, K B; Wise-Draper, T M; Jansen, M; Knudsen, E S; Wells, S I 2008. Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway. Oncogene, 27 35, 4798-808

Wise-Draper, Trisha M; Wells, Susanne I 2008. Papillomavirus E6 and E7 proteins and their cellular targets. Frontiers in bioscience : a journal and virtual library, 13 , 1003-17

Wise-Draper, Trisha M; Allen, Hillary V; Jones, Elizabeth E; Habash, Kristen B; Matsuo, Hiroshi; Wells, Susanne I 2006. Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions. Molecular and cellular biology, 26 20, 7506-19

Wise-Draper, Trisha M; Allen, Hillary V; Thobe, Megan N; Jones, Elizabeth E; Habash, Kristen B; Münger, Karl; Wells, Susanne I 2005. The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7. Journal of virology, 79 22, 14309-17

Brana I.; Cohen E.E.W.; Cook C.E.; Harrington K.J.; Hong D.S.; Keilholz U.; McCoon P.; Mehta M.; Mesia R.; Mitchell P.D.; Mugundu G.M.; Perez Segura P.; Scott M.L.; Wise-Draper T. 10-01-2018. A phase Ib/II study (SCORES) of durvalumab (D) plus danvatirsen (DAN; AZD9150) or AZD5069 (CX2i) in Annals of oncology : official journal of the European Society for Medical Oncology, 29 , viii372

Adams A.;Wise-Draper T.;Wells S. 09-15-2014. Human papillomavirus induced transformation in cervical and head and neck cancers Cancers, 6 3, 1793-1820

Wells S.;Aronow B.;Wise T.;Williams S.;Couget J.;Howley P. 06-10-2003. Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer Proceedings of the National Academy of Sciences of the United States of America, 100 12, 7093-7098

Wise-Draper T.;Wells S. 03-01-2005. Efficient transfection of siRNA against HPV oncogenes BioSpektrum, 11 1, 107-108

Chimote A.A.;Gawali V.S.;Newton H.S.;Wise-Draper T.M.;Conforti L. 02-28-2020. A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabi Frontiers in Pharmacology, 11 ,

Wise-Draper T.;Sendilnathan A.;Palackdharry S.;Pease N.;Qualtieri J.;Butler R.;Sadraei N.;Morris J.;Patil Y.;Wilson K.;Mark J.;Casper K.;Takiar V.;Lane A.;Privette Vinnedge L. 01-01-2018. Decreased plasma DEK Oncogene Levels Correlate with p16-Negative Disease and Advanced Tumor Stage in Translational Oncology, 11 1, 168-174

Langevin S.;Kuhnell D.;Parry T.;Biesiada J.;Huang S.;Wise-Draper T.;Casper K.;Zhang X.;Medvedovic M.;Kasper S. 01-01-2017. Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro re Oncotarget, 8 47, 82459-82474

Pease N.;Wise-Draper T.;Privette Vinnedge L. 01-01-2015. Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer Journal of Oncology, 2015 ,

Wise-Draper T.M.;Draper D.J.;Gutkind J.S.;Molinolo A.A.;Wikenheiser-Brokamp K.A.;Wells S.I. 01-01-2012. Future directions and treatment strategies for head and neck squamous cell carcinomas Translational Research, 160 3, 167-177

Abstract Publications

Adams, A.K., Hallenbeck, G.E., Casper, K.A., Patil, Y.J., Wilson, K.M., Kimple, R.J., Lambert, P.F., Witte, D.P., Xiao, W., Gillison, M.L., Wise-Draper T.M., and Wikenheiser-Brokamp, K.A. 2015. DEK promotes HPV-positive and-negative head and neck cancer cell proliferation Oncogene, 34(7) , 868

Pease, N.A., Wise-Draper, T. and Privette Vinnedge, L. 2015. Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer Journal of oncology, ,

Wise-Draper, T.M., Mintz-Cole, R.A., Morris, T.A., Simpson, D.S., Wikenheiser-Brokamp, K.A., Currier, M.A., Cripe, T.P., Grosveld, G.C. and Wells, S.I. 2009. Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo Cancer research, 69(5) , 1792