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Photo of  Renu Sah, PhD

Renu Sah, PhD


Professor, Dept. of Pharmacology & Systems Biology University of Cincinnati, Cincinnati, OH

Pharmacology & Systems Physiology | College of Medicine

  • Doctoral Degree: Lucknow University (Biochemistry)
  • Post-Doctoral Training: University of Wisconsin and Duke University (Neuropharmacology)
Contact Information
Research Interests

The focus of my research program is to understand mechanisms underlying fear and anxiety behaviors and how they manifest into disorders such as Panic Disorder (PD) and Posttraumatic Stress disorder (PTSD). The long term goal is to delineate novel brain circuits and therapeutic targets. My lab is particularly interested in how the brain processes fear generated by "external" versus "internal"  threats to survival. For example, a life-threatening experience in combat or crime (exter...

Peer Reviewed Publications

Reeder, Evan L; O'Connell, Christopher J; Collins, Sean M; Traubert, Owen D; Norman, Sophia V; Cáceres, Román A; Sah, Renu; Smith, David W; Robson, Matthew J 2023. Increased Carbon Dioxide Respiration Prevents the Effects of Acceleration/Deceleration Elicited Mild Traumatic Brain Injury. Neuroscience, 509 , 20-35

McMurray, Katherine M J; Sah, Renu 2022. Neuroimmune mechanisms in fear and panic pathophysiology. Frontiers in psychiatry, 13 , 1015349

McMurray, Katherine M J; Winter, Andrew; Ahlbrand, Rebecca; Wilson, Allison; Shukla, Sachi; Sah, Renu 2022. Subfornical organ interleukin 1 receptor: A novel regulator of spontaneous and conditioned fear associated behaviors in mice. Brain, behavior, and immunity, 101 , 304-317

Wang, Jiapeng; Ware, Kierra; Bedolla, Alicia; Allgire, Emily; Turcato, Flavia Correa; Weed, Maxwell; Sah, Renu; Luo, Yu 2022. Disruption of Sonic Hedgehog Signaling Accelerates Age-Related Neurogenesis Decline and Abolishes Stroke-Induced Neurogenesis and Leads to Increased Anxiety Behavior in Stroke Mice. Translational stroke research, 13 5, 830-844

Winter, Andrew; McMurray, Katherine M J; Ahlbrand, Rebecca; Allgire, Emily; Shukla, Sachi; Jones, James; Sah, Renu 2022. The subfornical organ regulates acidosis-evoked fear by engaging microglial acid-sensor TDAG8 and forebrain neurocircuits in male mice. Journal of neuroscience research, 100 9, 1732-1746

Allgire, Emily; McAlees, Jaclyn W; Lewkowich, Ian P; Sah, Renu 2021. Asthma and posttraumatic stress disorder (PTSD): Emerging links, potential models and mechanisms. Brain, behavior, and immunity, ,

McMurray, Katherine M J; Gray, Alijah; Horn, Paul; Sah, Renu 2020. High Behavioral Sensitivity to Carbon Dioxide Associates with Enhanced Fear Memory and Altered Forebrain Neuronal Activation. Neuroscience, 429 , 92-105

McMurray, Katherine M J; Strawn, Jeffrey R; Sah, Renu 2019. Fluoxetine Modulates Spontaneous and Conditioned Behaviors to Carbon Dioxide (CO2) Inhalation and Alters Forebrain-Midbrain Neuronal Activation. Neuroscience, 396 , 108-118

McMurray, Katherine M J; Vollmer, Lauren Larke; Ahlbrand, Rebecca; Thomas, Joshua; Winter, Andrew; Lewkowich, Ian P; Sah, Renu 2019. Immunomodulatory T cell death associated gene-8 (TDAG8) receptor in depression-associated behaviors. Physiology & behavior, 209 , 112598

Wilson, Marlene A; Liberzon, Israel; Lindsey, Merry L; Lokshina, Yana; Risbrough, Victoria B; Sah, Renu; Wood, Susan K; Williamson, John B; Spinale, Francis G 2019. Common pathways and communication between the brain and heart: connecting post-traumatic stress disorder and heart failure. Stress (Amsterdam, Netherlands), 22 5, 530-547

Winter, Andrew; Ahlbrand, Rebecca; Sah, Renu 2019. Recruitment of central angiotensin II type 1 receptor associated neurocircuits in carbon dioxide associated fear. Progress in neuro-psychopharmacology & biological psychiatry, 92 , 378-386

Schubert, Inga; Ahlbrand, Rebecca; Winter, Andrew; Vollmer, Lauren; Lewkowich, Ian; Sah, Renu 2018. Enhanced fear and altered neuronal activation in forebrain limbic regions of CX3CR1-deficient mice. Brain, behavior, and immunity, 68 , 34-43

Strawn, Jeffrey R; Vollmer, Lauren L; McMurray, Katherine M J; Mills, Jeffrey A; Mossman, Sarah A; Varney, Sara T; Schroeder, Heidi K; Sah, Renu 2018. Acid-sensing T cell death associated gene-8 receptor expression in panic disorder. Brain, behavior, and immunity, 67 , 36-41

Winter, Andrew; Ahlbrand, Rebecca; Naik, Devanshi; Sah, Renu 2017. Differential behavioral sensitivity to carbon dioxide (CO2) inhalation in rats. Neuroscience, 346 , 423-433

Schmeltzer, Sarah N; Herman, James P; Sah, Renu 2016. Neuropeptide Y (NPY) and posttraumatic stress disorder (PTSD): A translational update. Experimental neurology, 284 Pt B, 196-210

Smith, Brittany L; Schmeltzer, Sarah N; Packard, Benjamin A; Sah, Renu; Herman, James P 2016. Divergent effects of repeated restraint versus chronic variable stress on prefrontal cortical immune status after LPS injection. Brain, behavior, and immunity, 57 , 263-270

Sun, Xuming; Tommasi, Ellen; Molina, Doris; Sah, Renu; Brosnihan, K Bridget; Diz, Debra; Petrovic, Snezana 2016. Deletion of proton-sensing receptor GPR4 associates with lower blood pressure and lower binding of angiotensin II receptor in SFO. American journal of physiology. Renal physiology, 311 6, F1260-F1266

Vollmer, Lauren L; Schmeltzer, Sarah; Schurdak, Jennifer; Ahlbrand, Rebecca; Rush, Jennifer; Dolgas, Charles M; Baccei, Mark L; Sah, Renu 2016. Neuropeptide Y Impairs Retrieval of Extinguished Fear and Modulates Excitability of Neurons in the Infralimbic Prefrontal Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 4, 1306-15

Vollmer, Lauren Larke; Ghosal, Sriparna; McGuire, Jennifer L; Ahlbrand, Rebecca L; Li, Ke-Yong; Santin, Joseph M; Ratliff-Rang, Christine A; Patrone, Luis G A; Rush, Jennifer; Lewkowich, Ian P; Herman, James P; Putnam, Robert W; Sah, Renu 2016. Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear. Biological psychiatry, 80 7, 541-51

Sah, Renu; Ulrich-Lai, Yvonne M 2015. Introduction to the 2014 Neurobiology of Stress Special Issue. Physiology & behavior, 150 , 1

Schmeltzer, Sarah N; Vollmer, Lauren L; Rush, Jennifer E; Weinert, Mychal; Dolgas, Charles M; Sah, Renu 2015. History of chronic stress modifies acute stress-evoked fear memory and acoustic startle in male rats. Stress (Amsterdam, Netherlands), 18 2, 244-53

Vollmer, Lauren Larke; Schmeltzer, Sarah N; Ahlbrand, Rebecca; Sah, Renu 2015. A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior. Physiology & behavior, 150 , 78-82

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Park, Edwards A; Sallee, Floyd R; Parker, Steven L 2014. Dimers of G-protein coupled receptors as versatile storage and response units. International journal of molecular sciences, 15 3, 4856-77

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Park, Edwards A; Parker, Steven L 2014. On the expansion of ribosomal proteins and RNAs in eukaryotes. Amino acids, 46 7, 1589-604

Sah, Renu; Ekhator, Nosakhare N; Jefferson-Wilson, Lena; Horn, Paul S; Geracioti, Thomas D 2014. Cerebrospinal fluid neuropeptide Y in combat veterans with and without posttraumatic stress disorder. Psychoneuroendocrinology, 40 , 277-83

Müller, Timo D; Müller, Anne; Yi, Chun-Xia; Habegger, Kirk M; Meyer, Carola W; Gaylinn, Bruce D; Finan, Brian; Heppner, Kristy; Trivedi, Chitrang; Bielohuby, Maximilian; Abplanalp, William; Meyer, Franziska; Piechowski, Carolin L; Pratzka, Juliane; Stemmer, Kerstin; Holland, Jenna; Hembree, Jazzmin; Bhardwaj, Nakul; Raver, Christine; Ottaway, Nickki; Krishna, Radha; Sah, Renu; Sallee, Floyd R; Woods, Stephen C; Perez-Tilve, Diego; Bidlingmaier, Martin; Thorner, Michael O; Krude, Heiko; Smiley, David; DiMarchi, Richard; Hofmann, Susanna; Pfluger, Paul T; Kleinau, Gunnar; Biebermann, Heike; Tschöp, Matthias H 2013. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nature communications, 4 , 1968

Parker, Michael S; Sah, Renu; Parker, Steven L 2012. Surface masking shapes the traffic of the neuropeptide Y Y2 receptor. Peptides, 37 1, 40-8

Estes, Anne-Marie; McAllen, Kathleen; Parker, Michael S; Sah, Renu; Sweatman, Trevor; Park, Edwards A; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Walker, Mary W; Parker, Steven L 2011. Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers. Amino acids, 40 2, 371-80

McGuire, Jennifer L; Larke, Lauren E; Sallee, Floyd R; Herman, James P; Sah, Renu 2011. Differential Regulation of Neuropeptide Y in the Amygdala and Prefrontal Cortex during Recovery from Chronic Variable Stress. Frontiers in behavioral neuroscience, 5 , 54

McGuire, Jennifer; Herman, James P; Horn, Paul S; Sallee, Floyd R; Sah, Renu 2010. Enhanced fear recall and emotional arousal in rats recovering from chronic variable stress. Physiology & behavior, 101 4, 474-82

McGuire, Jennifer; Herman, James P; Ghosal, Sriparna; Eaton, Katherine; Sallee, Floyd R; Sah, Renu 2009. Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brain. Biochemical and biophysical research communications, 386 3, 420-5

Sah, Renu; Ekhator, Nosakhare N; Strawn, Jeffrey R; Sallee, Floyd R; Baker, Dewleen G; Horn, Paul S; Geracioti, Thomas D 2009. Low cerebrospinal fluid neuropeptide Y concentrations in posttraumatic stress disorder. Biological psychiatry, 66 7, 705-7

Parker, Steven L; Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd R 2008. Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi alpha subunit function in CHO cells. European journal of pharmacology, 579 1-3, 13-25

Parker, Steven L; Parker, Michael S; Wong, Ying Y; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd 2008. Importance of a N-terminal aspartate in the internalization of the neuropeptide Y Y2 receptor. European journal of pharmacology, 594 1-3, 26-31

Eaton, Katherine; Sallee, Floyd R; Sah, Renu 2007. Relevance of neuropeptide Y (NPY) in psychiatry. Current topics in medicinal chemistry, 7 17, 1645-59

Sah, Renu; Parker, Steven L; Sheriff, Sulaiman; Eaton, Katherine; Balasubramaniam, Ambikaipakan; Sallee, Floyd R 2007. Interaction of NPY compounds with the rat glucocorticoid-induced receptor (GIR) reveals similarity to the NPY-Y2 receptor. Peptides, 28 2, 302-9

Brunskill, Eric W; Ehrman, Lisa A; Williams, Michael T; Klanke, Justin; Hammer, Daniel; Schaefer, Tori L; Sah, Renu; Dorn, Gerald W; Potter, S Steven; Vorhees, Charles V 2005. Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. The European journal of neuroscience, 22 6, 1265-76

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Parker, Steven L 2005. Lithium inhibits internalization and endosomal processing of both neuropeptide Y (NPY) Y1 and transferrin receptors. Neuroscience letters, 374 1, 43-6

Parker, Steven L; Parker, Michael S; Sah, Renu; Sallee, Floyd 2005. Angiogenesis and rhodopsin-like receptors: a role for N-terminal acidic residues? Biochemical and biophysical research communications, 335 4, 983-92

Sah, Renu; Balasubramaniam, Ambikaipakan; Parker, Michael S; Sallee, Floyd; Parker, Steven L 2005. Neuropeptide Y as a partial agonist of the Y1 receptor. European journal of pharmacology, 525 1-3, 60-8

Williams, Michael T; Schaefer, Tori L; Ehrman, Lisa A; Able, Jessica A; Gudelsky, Gary A; Sah, Renu; Vorhees, Charles V 2005. 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity. Brain research, 1039 1-2, 97-107

Galeffi, Francesca; Sah, Renu; Pond, Brooks B; George, Amanda; Schwartz-Bloom, Rochelle D 2004. Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 18, 4478-88

Sah, Renu; Galeffi, Francesca; Ahrens, Rebecca; Jordan, Gwendolyn; Schwartz-Bloom, Rochelle D 2002. Modulation of the GABA(A)-gated chloride channel by reactive oxygen species. Journal of neurochemistry, 80 3, 383-91