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Photo of  Dennis W. McGraw, MD

Dennis W. McGraw, MD

Adjunct Associate Professor

Director, Veterans Hospital Pulmonary

Internal Medicine | College of Medicine

  • Fellowship: University of Arkansas for Medical Sciences (Pulmonary and Critical Care Medicine )
  • Residency: University of Arkansas for Medical Sciences (Internal Medicine )
  • Internship : University of Arkansas for Medical Sciences (Internal Medicine )
  • Medical Degree: University of Mississippi Medical Center
  • Bachelor's Degree : Millsaps College (Biology, Cum Laude)
Board Certifications & Licenses

American Board of Internal Medicine (Certification Date: 1989-09-13)
American Board of Internal Medicine (Pulmonary Disease) (Certification Date: 1992-11-04) - (Recertification Date: 2024-05-26)


Critical Care Medicine
Internal Medicine

Contact Information
Research Interests

G-Protein Receptor Signaling (Asthma, G-Protein Coupled Receptors, Adrenergic Receptors, Airway Smooth Muscle).

Clinical Interests

Critical Care Medicine

Pulmonary Disease

Peer Reviewed Publications

Liu, Huan; Osterburg, Andrew R; Flury, Jennifer; Swank, Zulma; McGraw, Dennis W; Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Kumar, Ashish; Tazi, Abdellatif; Inoue, Yoshikazu; Hirose, Masaki; McCormack, Francis X; Borchers, Michael T 2020. MAPK mutations and cigarette smoke promote the pathogenesis of pulmonary Langerhans cell histiocytosis. JCI insight, 5 4,

Saito, Atsushi; Nikolaidis, Nikolaos M; Amlal, Hassane; Uehara, Yasuaki; Gardner, Jason C; LaSance, Kathleen; Pitstick, Lori B; Bridges, James P; Wikenheiser-Brokamp, Kathryn A; McGraw, Dennis W; Woods, Jason C; Sabbagh, Yves; Schiavi, Susan C; Altini?ik, Göksel; Jakopovi?, Marko; Inoue, Yoshikazu; McCormack, Francis X 2015. Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment. Science translational medicine, 7 313, 313ra181

Gupta, Nishant; Kralovic, Stephen M; McGraw, Dennis 2014. Lemierre syndrome: not so forgotten! American journal of critical care : an official publication, American Association of Critical-Care Nurses, 23 2, 176-9

Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A 2012. Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3. The Journal of investigative dermatology, 132 9, 2255-62

Reszka, Krzysztof J; Sallans, Larry; Macha, Stephen; Brown, Kari; McGraw, Dennis W; Kovacic, Melinda Butsch; Britigan, Bradley E 2011. Airway peroxidases catalyze nitration of the {beta}2-agonist salbutamol and decrease its pharmacological activity. The Journal of pharmacology and experimental therapeutics, 336 2, 440-9

Sun, Xuming; Yang, Li V; Tiegs, Brian C; Arend, Lois J; McGraw, Dennis W; Penn, Raymond B; Petrovic, Snezana 2010. Deletion of the pH sensor GPR4 decreases renal acid excretion. Journal of the American Society of Nephrology : JASN, 21 10, 1745-55

Borchers, Michael T; Wesselkamper, Scott C; Curull, Victor; Ramirez-Sarmiento, Alba; Sánchez-Font, Albert; Garcia-Aymerich, Judith; Coronell, Carlos; Lloreta, Josep; Agusti, Alvar G; Gea, Joaquim; Howington, John A; Reed, Michael F; Starnes, Sandra L; Harris, Nathaniel L; Vitucci, Mark; Eppert, Bryan L; Motz, Gregory T; Fogel, Kevin; McGraw, Dennis W; Tichelaar, Jay W; Orozco-Levi, Mauricio 2009. Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease. The Journal of clinical investigation, 119 3, 636-49

Reszka, Krzysztof J; McGraw, Dennis W; Britigan, Bradley E 2009. Peroxidative metabolism of beta2-agonists salbutamol and fenoterol and their analogues. Chemical research in toxicology, 22 6, 1137-50

McGraw, Dennis W; Elwing, Jean M; Fogel, Kevin M; Wang, Wayne C H; Glinka, Clare B; Mihlbachler, Kathryn A; Rothenberg, Marc E; Liggett, Stephen B 2007. Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation. The Journal of clinical investigation, 117 5, 1391-8

McGraw, Dennis W; Fogel, Kevin M; Kong, Sue; Litonjua, Augusto A; Kranias, Evangelia G; Aronow, Bruce J; Liggett, Stephen B 2006. Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility. Physiological genomics, 27 2, 171-7

McGraw, Dennis W; Mihlbachler, Kathryn A; Schwarb, Mary Rose; Rahman, Fahema F; Small, Kersten M; Almoosa, Khalid F; Liggett, Stephen B 2006. Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. The Journal of clinical investigation, 116 5, 1400-9

McGraw, Dennis W; Liggett, Stephen B 2005. Molecular mechanisms of beta2-adrenergic receptor function and regulation. Proceedings of the American Thoracic Society, 2 4, 292-6; discussion 31

Pathak, Anand; del Monte, Federica; Zhao, Wen; Schultz, Jo-El; Lorenz, John N; Bodi, Ilona; Weiser, Doug; Hahn, Harvey; Carr, Andrew N; Syed, Faisal; Mavila, Nirmala; Jha, Leena; Qian, Jiang; Marreez, Yehia; Chen, Guoli; McGraw, Dennis W; Heist, E Kevin; Guerrero, J Luis; DePaoli-Roach, Anna A; Hajjar, Roger J; Kranias, Evangelia G 2005. Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. Circulation research, 96 7, 756-66

McGraw, Dennis W; Almoosa, Khalid F; Paul, Richard J; Kobilka, Brian K; Liggett, Stephen B 2003. Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox. The Journal of clinical investigation, 112 4, 619-26

Small, Kersten M; McGraw, Dennis W; Liggett, Stephen B 2003. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annual review of pharmacology and toxicology, 43 , 381-411

McGraw, Dennis W 2002. Transgenic techniques to delineate cell-specific effects of beta2-adrenergic receptors in the lung. The Journal of allergy and clinical immunology, 110 6 Suppl, S236-41

Sartori, C; Fang, X; McGraw, D W; Koch, P; Snider, M E; Folkesson, H G; Matthay, M A 2002. Selected contribution: long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice. Journal of applied physiology (Bethesda, Md. : 1985), 93 5, 1875-80

Krane, C M; Fortner, C N; Hand, A R; McGraw, D W; Lorenz, J N; Wert, S E; Towne, J E; Paul, R J; Whitsett, J A; Menon, A G 2001. Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation. Proceedings of the National Academy of Sciences of the United States of America, 98 24, 14114-9

McGraw, D W; Fukuda, N; James, P F; Forbes, S L; Woo, A L; Lingrel, J B; Witte, D P; Matthay, M A; Liggett, S B 2001. Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance. American journal of physiology. Lung cellular and molecular physiology, 281 4, L895-903

Cao, W; McGraw, D W; Lee, T T; Dicker-Brown, A; Hiller, F C; Cornett, L E; Jones, S M 2000. Expression of functional beta 2-adrenergic receptors in a rat airway epithelial cell line (SPOC1) and cell density-dependent induction by glucocorticoids. Experimental lung research, 26 6, 421-35

Drysdale, C M; McGraw, D W; Stack, C B; Stephens, J C; Judson, R S; Nandabalan, K; Arnold, K; Ruano, G; Liggett, S B 2000. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proceedings of the National Academy of Sciences of the United States of America, 97 19, 10483-8

McGraw, D W; Forbes, S L; Mak, J C; Witte, D P; Carrigan, P E; Leikauf, G D; Liggett, S B 2000. Transgenic overexpression of beta(2)-adrenergic receptors in airway epithelial cells decreases bronchoconstriction. American journal of physiology. Lung cellular and molecular physiology, 279 2, L379-89

McGraw, D W; Forbes, S L; Kramer, L A; Witte, D P; Fortner, C N; Paul, R J; Liggett, S B 1999. Transgenic overexpression of beta(2)-adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity. The Journal of biological chemistry, 274 45, 32241-7

McGraw, D W; Liggett, S B 1999. Coding block and 5 leader cistron polymorphisms of the beta2-adrenergic receptor. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 29 Suppl 4 , 43-5

Baeyens, D A; McGraw, D W; Jacobi, S E; Cornett, L E 1998. Transcription of the beta2-adrenergic receptor gene in rat liver is regulated during early postnatal development by an upstream repressor element. Journal of cellular physiology, 175 3, 333-40

Cornett, L E; Hiller, F C; Jacobi, S E; Cao, W; McGraw, D W 1998. Identification of a glucocorticoid response element in the rat beta2-adrenergic receptor gene. Molecular pharmacology, 54 6, 1016-23

McGraw, D W; Donnelly, E T; Eason, M G; Green, S A; Liggett, S B 1998. Role of beta ARK in long-term agonist-promoted desensitisation of the beta 2-adrenergic receptor. Cellular signalling, 10 3, 197-204

McGraw, D W; Forbes, S L; Kramer, L A; Liggett, S B 1998. Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression. The Journal of clinical investigation, 102 11, 1927-32

McGraw, D W; Liggett, S B 1997. Heterogeneity in beta-adrenergic receptor kinase expression in the lung accounts for cell-specific desensitization of the beta2-adrenergic receptor. The Journal of biological chemistry, 272 11, 7338-44

McGraw, D W; Jacobi, S E; Hiller, F C; Cornett, L E 1996. Structural and functional analysis of the 5'-flanking region of the rat beta 2-adrenergic receptor gene. Biochimica et biophysica acta, 1305 3, 135-8

McGraw, D W; Chai, S E; Hiller, F C; Cornett, L E . Regulation of the beta 2-adrenergic receptor and its mRNA in the rat lung by dexamethasone. Experimental lung research, 21 4, 535-46