Skip to main content
Photo of Temugin Berta, PhD

Temugin Berta, PhD

Associate Professor

Anesthesiology | College of Medicine

  • Post-Doctoral Fellowship: Duke University
  • Post-Doctoral Fellowship: Harvard University
  • Doctoral Degree: University of Lausanne
Contact Information

Peer Reviewed Publications

Luo, Xin; Chen, Ouyang; Wang, Zilong; Bang, Sangsu; Ji, Jasmine; Lee, Sang Hoon; Huh, Yul; Furutani, Kenta; He, Qianru; Tao, Xueshu; Ko, Mei-Chuan; Bortsov, Andrey; Donnelly, Christopher R; Chen, Yong; Nackley, Andrea; Berta, Temugin; Ji, Ru-Rong 2021. IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice. Neuron, 109 17, 2691-2706.e5

Zhang, Li; Xie, Wenrui; Zhang, Jingdong; Shanahan, Hailey; Tonello, Raquel; Lee, Sang Hoon; Strong, Judith A; Berta, Temugin; Zhang, Jun-Ming 2021. Key role of CCR2-expressing macrophages in a mouse model of low back pain and radiculopathy. Brain, behavior, and immunity, 91 , 556-567

Gattlen, Christophe; Deftu, Alexandru-Florian; Tonello, Raquel; Ling, Yuejuan; Berta, Temugin; Ristoiu, Violeta; Suter, Marc René 2020. The inhibition of Kir2.1 potassium channels depolarizes spinal microglial cells, reduces their proliferation, and attenuates neuropathic pain. Glia, ,

Lee, Sang Hoon; Tonello, Raquel; Choi, Youngin; Jung, Sung Jun; Berta, Temugin 2020. Sensory Neuron-Expressed TRPC4 Is a Target for the Relief of Psoriasiform Itch and Skin Inflammation in Mice. The Journal of investigative dermatology, 140 11, 2221-2229.e6

Lee, Sang Hoon; Tonello, Raquel; Im, Sang-Taek; Jeon, Hawon; Park, Jeongsu; Ford, Zachary; Davidson, Steve; Kim, Yong Ho; Park, Chul-Kyu; Berta, Temugin 2020. Resolvin D3 controls mouse and human TRPV1-positive neurons and preclinical progression of psoriasis. Theranostics, 10 26, 12111-12126

Tonello, Raquel; Xie, Wenrui; Lee, Sang Hoon; Wang, Min; Liu, Xiaojuan; Strong, Judith A; Zhang, Jun-Ming; Berta, Temugin 2020. Local Sympathectomy Promotes Antiinflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice. Anesthesiology, ,

Tonello, Raquel; Xie, Wenrui; Lee, Sang Hoon; Wang, Min; Liu, Xiaojuan; Strong, Judith A; Zhang, Jun-Ming; Berta, Temugin 2020. Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice. Anesthesiology, 132 6, 1540-1553

Liu, Xiaojuan; Tonello, Raquel; Ling, Yuejuan; Gao, Yong-Jing; Berta, Temugin 2019. Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-? and stromal-derived cell factor 1. Journal of neuroinflammation, 16 1, 209

Serafin, Elizabeth K; Chamessian, Alexander; Li, Jie; Zhang, Xiang; McGann, Amanda; Brewer, Chelsie L; Berta, Temugin; Baccei, Mark 2019. Transcriptional profile of spinal dynorphin-lineage interneurons in the developing mouse. Pain, 160 10, 2380-2397

Tonello, Raquel; Lee, Sang Hoon; Berta, Temugin 2019. Monoclonal Antibody Targeting the Matrix Metalloproteinase 9 Prevents and Reverses Paclitaxel-Induced Peripheral Neuropathy in Mice. The journal of pain : official journal of the American Pain Society, 20 5, 515-527

Chamessian, Alexander; Young, Michael; Qadri, Yawar; Berta, Temugin; Ji, Ru-Rong; Van de Ven, Thomas 2018. Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn. Scientific reports, 8 1, 6809

Chang, Wonseok; Berta, Temugin; Kim, Yong Ho; Lee, Sanghoon; Lee, Seok-Yong; Ji, Ru-Rong 2018. Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel. Neuroscience bulletin, 34 1, 4-12

Chen, Gang; Luo, Xin; Qadri, M Yawar; Berta, Temugin; Ji, Ru-Rong 2018. Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes. Neuroscience bulletin, 34 1, 98-108

Ibrahim, Shaimaa I A; Xie, Wenrui; Strong, Judith A; Tonello, Raquel; Berta, Temugin; Zhang, Jun-Ming 2018. Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain. Frontiers in cellular neuroscience, 12 , 453

Lee, Sang Hoon; Cho, Pyung Sun; Tonello, Raquel; Lee, Han Kyu; Jang, Jun Ho; Park, Gi Yeon; Hwang, Sun Wook; Park, Chul-Kyu; Jung, Sung Jun; Berta, Temugin 2018. Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice. The Journal of allergy and clinical immunology, ,

Priebe, Alaini; Hunke, Megan; Tonello, Raquel; Sonawane, Yogesh; Berta, Temugin; Natarajan, Amarnath; Bhuvanesh, Nattamai; Pattabiraman, Mahesh; Chandra, Surabhi 2018. Ferulic acid dimer as a non-opioid therapeutic for acute pain. Journal of pain research, 11 , 1075-1085

Song, Zongbin; Xie, Wenrui; Strong, Judith A; Berta, Temugin; Ulrich-Lai, Yvonne M; Guo, Qulian; Zhang, Jun-Ming 2018. High-fat diet exacerbates postoperative pain and inflammation in a sex-dependent manner. Pain, 159 9, 1731-1741

Berta, Temugin; Lee, Jee Eun; Park, Chul-Kyu 2017. Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain. Mediators of inflammation, 2017 , 9383184

Berta, Temugin; Perrin, Florence E; Pertin, Marie; Tonello, Raquel; Liu, Yen-Chin; Chamessian, Alexander; Kato, Ann C; Ji, Ru-Rong; Decosterd, Isabelle 2017. Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain. Scientific reports, 7 1, 9367

Berta, Temugin; Qadri, Yawar; Tan, Ping-Heng; Ji, Ru-Rong 2017. Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain. Expert opinion on therapeutic targets, 21 7, 695-703

Chamessian, Alexander G; Qadri, Yawar J; Cummins, Matthew; Hendrickson, Michele; Berta, Temugin; Buchheit, Thomas; Van de Ven, Thomas 2017. 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. Somatosensory & motor research, 34 2, 72-79

Berta, T; Qadri, Y J; Chen, G; Ji, R R 2016. Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence. Journal of dental research, 95 10, 1124-31

Chen, Gang; Xie, Rou-Gang; Gao, Yong-Jing; Xu, Zhen-Zhong; Zhao, Lin-Xia; Bang, Sangsu; Berta, Temugin; Park, Chul-Kyu; Lay, Mark; Chen, Wei; Ji, Ru-Rong 2016. ?-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain. Nature communications, 7 , 12531

Han, Qingjian; Kim, Yong Ho; Wang, Xiaoming; Liu, Di; Zhang, Zhi-Jun; Bey, Alexandra L; Lay, Mark; Chang, Wonseok; Berta, Temugin; Zhang, Yan; Jiang, Yong-Hui; Ji, Ru-Rong 2016. SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. Neuron, 92 6, 1279-1293

Jiang, Bao-Chun; Cao, De-Li; Zhang, Xin; Zhang, Zhi-Jun; He, Li-Na; Li, Chun-Hua; Zhang, Wen-Wen; Wu, Xiao-Bo; Berta, Temugin; Ji, Ru-Rong; Gao, Yong-Jing 2016. CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. The Journal of clinical investigation, 126 2, 745-61

Liu, Chien-Cheng; Gao, Yong-Jing; Luo, Hao; Berta, Temugin; Xu, Zhen-Zhong; Ji, Ru-Rong; Tan, Ping-Heng 2016. Interferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions. Scientific reports, 6 , 34356

Liu, Tong; Han, Qingjian; Chen, Gang; Huang, Ya; Zhao, Lin-Xia; Berta, Temugin; Gao, Yong-Jing; Ji, Ru-Rong 2016. Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice. Pain, 157 4, 806-17

Martini, Alessandra Cadete; Berta, Temugin; Forner, Stefânia; Chen, Gang; Bento, Allisson Freire; Ji, Ru-Rong; Rae, Giles Alexander 2016. Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection. Journal of neuroinflammation, 13 1, 75

Taves, Sarah; Berta, Temugin; Liu, Da-Lu; Gan, Sophie; Chen, Gang; Kim, Yong Ho; Van de Ven, Thomas; Laufer, Stefan; Ji, Ru-Rong 2016. Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord. Brain, behavior, and immunity, 55 , 70-81

McKelvey, Rebecca; Berta, Temugin; Old, Elizabeth; Ji, Ru-Rong; Fitzgerald, Maria 2015. Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 35 2, 457-66

Soens, Mieke; Wang, Jeffrey C-F; Berta, Temugin; Strichartz, Gary 2015. Systemic Progesterone Administration in Early Life Alters the Hyperalgesic Responses to Surgery in the Adult: A Study on Female Rats. Anesthesia and analgesia, 121 2, 545-55

Xu, Zhen-Zhong; Kim, Yong Ho; Bang, Sangsu; Zhang, Yi; Berta, Temugin; Wang, Fan; Oh, Seog Bae; Ji, Ru-Rong 2015. Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. Nature medicine, 21 11, 1326-31

Berta, Temugin; Park, Chul-Kyu; Xu, Zhen-Zhong; Xie, Ruo-Gang; Liu, Tong; Lü, Ning; Liu, Yen-Chin; Ji, Ru-Rong 2014. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-? secretion. The Journal of clinical investigation, 124 3, 1173-86

Chen, Gang; Park, Chul-Kyu; Xie, Rou-Gang; Berta, Temugin; Nedergaard, Maiken; Ji, Ru-Rong 2014. Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. Brain : a journal of neurology, 137 Pt 8, 2193-209

Liu, Xing-Jun; Zhang, Yanli; Liu, Tong; Xu, Zhen-Zhong; Park, Chul-Kyu; Berta, Temugin; Jiang, Dianhua; Ji, Ru-Rong 2014. Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter. Cell research, 24 11, 1374-7

Park, Chul-Kyu; Xu, Zhen-Zhong; Berta, Temugin; Han, Qingjian; Chen, Gang; Liu, Xing-Jun; Ji, Ru-Rong 2014. Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. Neuron, 82 1, 47-54

Berta, T; Liu, Y-C; Xu, Z-Z; Ji, R-R 2013. Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1? and ERK signaling in the spinal cord of mice. Neuroscience, 247 , 376-85

Ji, Ru-Rong; Berta, Temugin; Nedergaard, Maiken 2013. Glia and pain: is chronic pain a gliopathy? Pain, 154 Suppl 1 , S10-28

Taves, Sarah; Berta, Temugin; Chen, Gang; Ji, Ru-Rong 2013. Microglia and spinal cord synaptic plasticity in persistent pain. Neural plasticity, 2013 , 753656

Xu, Zhen-Zhong; Berta, Temugin; Ji, Ru-Rong 2013. Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 8 1, 37-41

Xu, Zhen-Zhong; Liu, Xing-Jun; Berta, Temugin; Park, Chul-Kyu; Lü, Ning; Serhan, Charles N; Ji, Ru-Rong 2013. Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. Annals of neurology, 74 3, 490-5

Berta, Temugin; Liu, Tong; Liu, Yen-Chin; Xu, Zhen-Zhong; Ji, Ru-Rong 2012. Acute morphine activates satellite glial cells and up-regulates IL-1? in dorsal root ganglia in mice via matrix metalloprotease-9. Molecular pain, 8 , 18

Liu, Tong; Berta, Temugin; Xu, Zhen-Zhong; Park, Chul-Kyu; Zhang, Ling; Lü, Ning; Liu, Qin; Liu, Yang; Gao, Yong-Jing; Liu, Yen-Chin; Ma, Qiufu; Dong, Xinzhong; Ji, Ru-Rong 2012. TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. The Journal of clinical investigation, 122 6, 2195-207

Liu, Yen-Chin; Berta, Temugin; Liu, Tong; Tan, Ping-Heng; Ji, Ru-Rong 2012. Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice. Molecular pain, 8 , 19

Tan, P H; Gao, Y J; Berta, T; Xu, Z Z; Ji, R R 2012. Short small-interfering RNAs produce interferon-?-mediated analgesia. British journal of anaesthesia, 108 4, 662-9

Zhang, Ling; Berta, Temugin; Xu, Zhen-Zhong; Liu, Tong; Park, Jong Yeon; Ji, Ru-Rong 2011. TNF-? contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2. Pain, 152 2, 419-27

Liu, Tong; Xu, Zhen-Zhong; Park, Chul-Kyu; Berta, Temugin; Ji, Ru-Rong 2010. Toll-like receptor 7 mediates pruritus. Nature neuroscience, 13 12, 1460-2

Xu, Zhen-Zhong; Zhang, Ling; Liu, Tong; Park, Jong Yeon; Berta, Temugin; Yang, Rong; Serhan, Charles N; Ji, Ru-Rong 2010. Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. Nature medicine, 16 5, 592-7, 1p following

Suter, Marc R; Berta, Temugin; Gao, Yong-Jing; Decosterd, Isabelle; Ji, Ru-Rong 2009. Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury. Molecular pain, 5 , 53

Berta, Temugin; Poirot, Olivier; Pertin, Marie; Ji, Ru-Rong; Kellenberger, Stephan; Decosterd, Isabelle 2008. Transcriptional and functional profiles of voltage-gated Na(+) channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain. Molecular and cellular neurosciences, 37 2, 196-208

Poirot, Olivier; Berta, Temugin; Decosterd, Isabelle; Kellenberger, Stephan 2006. Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury. The Journal of physiology, 576 Pt 1, 215-34

Pertin, Marie; Ji, Ru-Rong; Berta, Temugin; Powell, Andrew J; Karchewski, Laurie; Tate, Simon N; Isom, Lori L; Woolf, Clifford J; Gilliard, Nicolas; Spahn, Donat R; Decosterd, Isabelle 2005. Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 25 47, 10970-80

Girard, P; Porte, L; Berta, T; Jordan, M; Wurm, F M 2001. Calcium phosphate transfection optimization for serum-free suspension culture. Cytotechnology, 35 3, 175-80