Education/CredentialsPostdoctoral fellowhip: University of California, San Diego (Pharmacology)Doctoral Degree: UT Southwestern Medical Center (Microbiology and Immunology)Master's Degree: National Institute of Vaccine and Serum (Virology and Immunology)Bachelor's Degree: Wuhan University (Virology) Contact Information Kettering Lab Complex 410 Office 513-558-0371 Email xiay@ucmail.uc.edu Research InterestsThe research focuses on establishing an understanding of the role of signal transduction pathways in cell responses to physiological and environmental agents. The ongoing work employs genetic, biochemical and molecular biological techniques to address fundamental questions regarding the function and regulatory mechanisms of signaling kinases in the areas of environmental toxicology, developmental biology, tissue regeneration, and cancer prevention and treatment. Peer Reviewed Publications Chen, Liang; Mongan, Maureen; Meng, Qinghang; Wang, Qin; Kao, Winston; Xia, Ying 2016. Corneal Wound Healing Requires IKB kinase ? Signaling in Keratocytes. PloS one, 11 3, e0151869Chen, Liang; Peng, Zhimin; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Sartor, Maureen; Chen, Jing; Niu, Liang; Medvedovic, Mario; Kao, Winston; Xia, Ying 2016. Loss of I?B kinase ? promotes myofibroblast transformation and senescence through activation of the ROS-TGF? autocrine loop. Protein & cell, 7 5, 338-50Ko, Chia-I; Fan, Yunxia; de Gannes, Matthew; Wang, Qin; Xia, Ying; Puga, Alvaro 2016. Repression of the Aryl Hydrocarbon Receptor Is Required to Maintain Mitotic Progression and Prevent Loss of Pluripotency of Embryonic Stem Cells. Stem cells (Dayton, Ohio), 34 12, 2825-2839Carreira, Vinicius S; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro 2015. Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult. PloS one, 10 11, e0142440Carreira, Vinicius S; Fan, Yunxia; Wang, Qing; Zhang, Xiang; Kurita, Hisaka; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro 2015. Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes. Toxicological sciences : an official journal of the Society of Toxicology, 147 2, 425-35Mongan, Maureen; Meng, Qinghang; Wang, Jingjing; Kao, Winston W-Y; Puga, Alvaro; Xia, Ying 2015. Gene-Environment Interactions Target Mitogen-activated Protein 3 Kinase 1 (MAP3K1) Signaling in Eyelid Morphogenesis. The Journal of biological chemistry, 290 32, 19770-9Sánchez-Martín, Francisco Javier; Fan, Yunxia; Carreira, Vinicius; Ovesen, Jerald L; Vonhandorf, Andrew; Xia, Ying; Puga, Alvaro 2015. Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice. Toxicological sciences : an official journal of the Society of Toxicology, 146 1, 52-64Yousaf, Rizwan; Meng, Qinghang; Hufnagel, Robert B; Xia, Ying; Puligilla, Chandrakala; Ahmed, Zubair M; Riazuddin, Saima 2015. MAP3K1 function is essential for cyto-architecture of mouse organ of Corti and survival of auditory hair cells. Disease models & mechanisms, , Ko, Chia-I; Wang, Qin; Fan, Yunxia; Xia, Ying; Puga, Alvaro 2014. Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in murine embryonic stem cells. Stem cell research, 12 1, 296-308Kurita, Hisaka; Schnekenburger, Michael; Ovesen, Jerald L; Xia, Ying; Puga, Alvaro 2014. The Ah Receptor Recruits IKK? to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. Toxicological sciences : an official journal of the Society of Toxicology, 139 1, 121-32Meng, Qinghang; Jin, Chang; Chen, Yinglei; Chen, Jing; Medvedovic, Mario; Xia, Ying 2014. Expression of signaling components in embryonic eyelid epithelium. PloS one, 9 2, e87038Meng, Qinghang; Mongan, Maureen; Carreira, Vinicius; Kurita, Hisaka; Liu, Chia-Yang; Kao, Winston; Xia, Ying 2014. Eyelid closure in embryogenesis is required for ocular adnexa development. Investigative ophthalmology & visual science, , Meng, Qinghang; Mongan, Maureen; Wang, Jingjing; Tang, Xiaofang; Zhang, Jinling; Kao, Winston; Xia, Ying 2014. Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1. Developmental biology, 395 1, 29-37Ovesen, Jerald L; Fan, Yunxia; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro 2014. Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional response to benzo[a]pyrene. Toxicology, 316 , 14-24Ovesen, Jerald L; Fan, Yunxia; Zhang, Xiang; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro 2014. Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure. PloS one, 9 5, e97849Jin, Chang; Chen, Jing; Meng, Qinghang; Carreira, Vinicius; Tam, Neville N C; Geh, Esmond; Karyala, Saikumar; Ho, Shuk-Mei; Zhou, Xiangtian; Medvedovic, Mario; Xia, Ying 2013. Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Developmental biology, 374 1, 96-107Sánchez-Martín, Francisco Javier; Fan, Yunxia; Lindquist, Diana M; Xia, Ying; Puga, Alvaro 2013. Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in neurons differentiated from mouse embryonic stem cells. PloS one, 8 11, e80558Wang, Jingcai; Chen, Liang; Ko, Chia-I; Zhang, Lin; Puga, Alvaro; Xia, Ying 2012. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation. The Journal of biological chemistry, 287 4, 2787-97Wang, Jingcai; Xia, Ying 2012. Assessing developmental roles of MKK4 and MKK7 in vitro. Communicative & integrative biology, 5 4, 319-24Chen, Liang; Meng, Qinghang; Kao, Winston; Xia, Ying 2011. I?B kinase ? regulates epithelium migration during corneal wound healing. PloS one, 6 1, e16132Deng, Maoxian; Ding, Wei; Min, Xuewen; Xia, Ying 2011. MLCK-independent phosphorylation of MLC20 and its regulation by MAP kinase pathway in human bladder smooth muscle cells. Cytoskeleton (Hoboken, N.J.), 68 3, 139-49Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying 2011. Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure. Proceedings of the National Academy of Sciences of the United States of America, 108 42, 17349-54Meng, Qinghang; Xia, Ying 2011. c-Jun, at the crossroad of the signaling network. Protein & cell, 2 11, 889-98Mongan, Maureen; Wang, Jingcai; Liu, Hongshan; Fan, Yunxia; Jin, Chang; Kao, Winston Y-W; Xia, Ying 2011. Loss of MAP3K1 enhances proliferation and apoptosis during retinal development. Development (Cambridge, England), 138 18, 4001-12Warr, Nick; Bogani, Debora; Siggers, Pam; Brixey, Rachel; Tateossian, Hilda; Dopplapudi, Asha; Wells, Sara; Cheeseman, Michael; Xia, Ying; Ostrer, Harry; Greenfield, Andy 2011. Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1. PloS one, 6 5, e19572Fan, Yunxia; Boivin, Gregory P; Knudsen, Erik S; Nebert, Daniel W; Xia, Ying; Puga, Alvaro 2010. The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer research, 70 1, 212-20Meng, Qinghang; Peng, Zhimin; Chen, Liang; Si, Jutong; Dong, Zhongyun; Xia, Ying 2010. Nuclear Factor-?B modulates cellular glutathione and prevents oxidative stress in cancer cells. Cancer letters, 299 1, 45-53Peng, Zhimin; Geh, Esmond; Chen, Liang; Meng, Qinghang; Fan, Yunxia; Sartor, Maureen; Shertzer, Howard G; Liu, Zheng-Gang; Puga, Alvaro; Xia, Ying 2010. Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione. Molecular pharmacology, 77 5, 784-92Zhu, Yu-Jia; Xia, Ying; Ren, Guan-Jun; Wang, Meng-Zhao; Zeng, Xuan; Zhang, Li 2010. Efficacy and clinical/molecular predictors of erlotinib monotherapy for Chinese advanced non-small cell lung cancer. Chinese medical journal, 123 22, 3200-5Chen, Liang; Ovesen, Jerald L; Puga, Alvaro; Xia, Ying 2009. Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation. Environmental health perspectives, 117 7, 1124-30Kao, Winston W-Y; Xia, Ying; Liu, Chia-Yang; Saika, Shizuya 2008. Signaling pathways in morphogenesis of cornea and eyelid. The ocular surface, 6 1, 9-23Malthankar-Phatak, Gauri H; Patel, Anant B; Xia, Ying; Hong, Soonsun; Chowdhury, Golam M I; Behar, Kevin L; Orina, Isaac A; Lai, James C K 2008. Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons. Brain research, 1229 , 147-54Marlowe, Jennifer L; Fan, Yunxia; Chang, Xiaoqing; Peng, Li; Knudsen, Erik S; Xia, Ying; Puga, Alvaro 2008. The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Molecular biology of the cell, 19 8, 3263-71Mongan, Maureen; Tan, Zongqing; Chen, Liang; Peng, Zhimin; Dietsch, Maggie; Su, Bing; Leikauf, George; Xia, Ying 2008. Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury. Toxicological sciences : an official journal of the Society of Toxicology, 104 2, 405-11Takatori, Atsushi; Geh, Esmond; Chen, Liang; Zhang, Lin; Meller, Jarek; Xia, Ying 2008. Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2. Development (Cambridge, England), 135 1, 23-32Peng, Zhimin; Peng, Li; Fan, Yunxia; Zandi, Ebrahim; Shertzer, Howard G; Xia, Ying 2007. A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity. The Journal of biological chemistry, 282 29, 21487-96Deng, Maoxian; Chen, Wei-Li; Takatori, Atsushi; Peng, Zhimin; Zhang, Lin; Mongan, Maureen; Parthasarathy, Ranjani; Sartor, Maureen; Miller, Marian; Yang, Jianhua; Su, Bing; Kao, Winston W-Y; Xia, Ying 2006. A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing. Molecular biology of the cell, 17 8, 3446-55Kao, Winston W-Y; Funderburgh, James L; Xia, Ying; Liu, Chia-Yang; Conrad, Gary W 2006. Focus on molecules: lumican. Experimental eye research, 82 1, 3-4Kann, Simone; Estes, Cameron; Reichard, John F; Huang, Ming-Ya; Sartor, Maureen A; Schwemberger, Sandy; Chen, Ying; Dalton, Timothy P; Shertzer, Howard G; Xia, Ying; Puga, Alvaro 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicological sciences : an official journal of the Society of Toxicology, 87 2, 365-84Kann, Simone; Huang, Ming-Ya; Estes, Cameron; Reichard, John F; Sartor, Maureen A; Xia, Ying; Puga, Alvaro 2005. Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes. Molecular pharmacology, 68 2, 336-46Puga, Alvaro; Tomlinson, Craig R; Xia, Ying 2005. Ah receptor signals cross-talk with multiple developmental pathways. Biochemical pharmacology, 69 2, 199-207Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying 2005. MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Molecular and cellular biology, 25 1, 60-5Gao, Min; Labuda, Tord; Xia, Ying; Gallagher, Ewen; Fang, Deyu; Liu, Yun-Cai; Karin, Michael 2004. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science (New York, N.Y.), 306 5694, 271-5Tan, Zongqing; Huang, Mingya; Puga, Alvaro; Xia, Ying 2004. A critical role for MAP kinases in the control of Ah receptor complex activity. Toxicological sciences : an official journal of the Society of Toxicology, 82 1, 80-7Xia, Ying; Kao, Winston W-Y 2004. The signaling pathways in tissue morphogenesis: a lesson from mice with eye-open at birth phenotype. Biochemical pharmacology, 68 6, 997-1001Xia, Ying; Karin, Michael 2004. The control of cell motility and epithelial morphogenesis by Jun kinases. Trends in cell biology, 14 2, 94-101Zhang, Lu; Lou, Danwen; Jiao, Hongyuan; Zhang, Dongsheng; Wang, Xinkang; Xia, Ying; Zhang, Jianhua; Xu, Ming 2004. Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 13, 3344-54Khoo, Shih; Griffen, Steven C; Xia, Ying; Baer, Richard J; German, Michael S; Cobb, Melanie H 2003. Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. The Journal of biological chemistry, 278 35, 32969-77Liang, Qiangrong; Bueno, Orlando F; Wilkins, Benjamin J; Kuan, Chia-Yi; Xia, Ying; Molkentin, Jeffery D 2003. c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. The EMBO journal, 22 19, 5079-89Zhang, Lin; Deng, Maoxian; Kao, Candace W C; Kao, Winston W Y; Xia, Ying 2003. MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis. Molecular vision, 9 , 584-93Zhang, Lin; Wang, Wei; Hayashi, Yasuhito; Jester, James V; Birk, David E; Gao, Min; Liu, Chia-Yang; Kao, Winston W-Y; Karin, Michael; Xia, Ying 2003. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. The EMBO journal, 22 17, 4443-54Puga, Alvaro; Xia, Ying; Elferink, Cornelis 2002. Role of the aryl hydrocarbon receptor in cell cycle regulation. Chemico-biological interactions, 141 1-2, 117-30Roy, Sanjit K; Hu, Junbo; Meng, Qingjun; Xia, Ying; Shapiro, Paul S; Reddy, Sekhar P M; Platanias, Leonidas C; Lindner, Daniel J; Johnson, Peter F; Pritchard, Catrin; Pagés, Gilles; Pouyssegur, Jacques; Kalvakolanu, Dhananjaya V 2002. MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proceedings of the National Academy of Sciences of the United States of America, 99 12, 7945-50Tan, Zongqing; Chang, Xiaoqing; Puga, Alvaro; Xia, Ying 2002. Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochemical pharmacology, 64 5-6, 771-80Wang, Qin; Chen, Jing; Ko, Chia-I; Fan, Yunxia; Carreira, Vinicius; Chen, Yinglei; Xia, Ying; Medvedovic, Mario; Puga, Alvaro . Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis. Environmental health perspectives, 121 11-12, 1334-43
Research InterestsThe research focuses on establishing an understanding of the role of signal transduction pathways in cell responses to physiological and environmental agents. The ongoing work employs genetic, biochemical and molecular biological techniques to address fundamental questions regarding the function and regulatory mechanisms of signaling kinases in the areas of environmental toxicology, developmental biology, tissue regeneration, and cancer prevention and treatment.
Peer Reviewed Publications Chen, Liang; Mongan, Maureen; Meng, Qinghang; Wang, Qin; Kao, Winston; Xia, Ying 2016. Corneal Wound Healing Requires IKB kinase ? Signaling in Keratocytes. PloS one, 11 3, e0151869Chen, Liang; Peng, Zhimin; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Sartor, Maureen; Chen, Jing; Niu, Liang; Medvedovic, Mario; Kao, Winston; Xia, Ying 2016. Loss of I?B kinase ? promotes myofibroblast transformation and senescence through activation of the ROS-TGF? autocrine loop. Protein & cell, 7 5, 338-50Ko, Chia-I; Fan, Yunxia; de Gannes, Matthew; Wang, Qin; Xia, Ying; Puga, Alvaro 2016. Repression of the Aryl Hydrocarbon Receptor Is Required to Maintain Mitotic Progression and Prevent Loss of Pluripotency of Embryonic Stem Cells. Stem cells (Dayton, Ohio), 34 12, 2825-2839Carreira, Vinicius S; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro 2015. Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult. PloS one, 10 11, e0142440Carreira, Vinicius S; Fan, Yunxia; Wang, Qing; Zhang, Xiang; Kurita, Hisaka; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro 2015. Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes. Toxicological sciences : an official journal of the Society of Toxicology, 147 2, 425-35Mongan, Maureen; Meng, Qinghang; Wang, Jingjing; Kao, Winston W-Y; Puga, Alvaro; Xia, Ying 2015. Gene-Environment Interactions Target Mitogen-activated Protein 3 Kinase 1 (MAP3K1) Signaling in Eyelid Morphogenesis. The Journal of biological chemistry, 290 32, 19770-9Sánchez-Martín, Francisco Javier; Fan, Yunxia; Carreira, Vinicius; Ovesen, Jerald L; Vonhandorf, Andrew; Xia, Ying; Puga, Alvaro 2015. Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice. Toxicological sciences : an official journal of the Society of Toxicology, 146 1, 52-64Yousaf, Rizwan; Meng, Qinghang; Hufnagel, Robert B; Xia, Ying; Puligilla, Chandrakala; Ahmed, Zubair M; Riazuddin, Saima 2015. MAP3K1 function is essential for cyto-architecture of mouse organ of Corti and survival of auditory hair cells. Disease models & mechanisms, , Ko, Chia-I; Wang, Qin; Fan, Yunxia; Xia, Ying; Puga, Alvaro 2014. Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in murine embryonic stem cells. Stem cell research, 12 1, 296-308Kurita, Hisaka; Schnekenburger, Michael; Ovesen, Jerald L; Xia, Ying; Puga, Alvaro 2014. The Ah Receptor Recruits IKK? to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. Toxicological sciences : an official journal of the Society of Toxicology, 139 1, 121-32Meng, Qinghang; Jin, Chang; Chen, Yinglei; Chen, Jing; Medvedovic, Mario; Xia, Ying 2014. Expression of signaling components in embryonic eyelid epithelium. PloS one, 9 2, e87038Meng, Qinghang; Mongan, Maureen; Carreira, Vinicius; Kurita, Hisaka; Liu, Chia-Yang; Kao, Winston; Xia, Ying 2014. Eyelid closure in embryogenesis is required for ocular adnexa development. Investigative ophthalmology & visual science, , Meng, Qinghang; Mongan, Maureen; Wang, Jingjing; Tang, Xiaofang; Zhang, Jinling; Kao, Winston; Xia, Ying 2014. Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1. Developmental biology, 395 1, 29-37Ovesen, Jerald L; Fan, Yunxia; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro 2014. Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional response to benzo[a]pyrene. Toxicology, 316 , 14-24Ovesen, Jerald L; Fan, Yunxia; Zhang, Xiang; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro 2014. Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure. PloS one, 9 5, e97849Jin, Chang; Chen, Jing; Meng, Qinghang; Carreira, Vinicius; Tam, Neville N C; Geh, Esmond; Karyala, Saikumar; Ho, Shuk-Mei; Zhou, Xiangtian; Medvedovic, Mario; Xia, Ying 2013. Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Developmental biology, 374 1, 96-107Sánchez-Martín, Francisco Javier; Fan, Yunxia; Lindquist, Diana M; Xia, Ying; Puga, Alvaro 2013. Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in neurons differentiated from mouse embryonic stem cells. PloS one, 8 11, e80558Wang, Jingcai; Chen, Liang; Ko, Chia-I; Zhang, Lin; Puga, Alvaro; Xia, Ying 2012. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation. The Journal of biological chemistry, 287 4, 2787-97Wang, Jingcai; Xia, Ying 2012. Assessing developmental roles of MKK4 and MKK7 in vitro. Communicative & integrative biology, 5 4, 319-24Chen, Liang; Meng, Qinghang; Kao, Winston; Xia, Ying 2011. I?B kinase ? regulates epithelium migration during corneal wound healing. PloS one, 6 1, e16132Deng, Maoxian; Ding, Wei; Min, Xuewen; Xia, Ying 2011. MLCK-independent phosphorylation of MLC20 and its regulation by MAP kinase pathway in human bladder smooth muscle cells. Cytoskeleton (Hoboken, N.J.), 68 3, 139-49Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying 2011. Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure. Proceedings of the National Academy of Sciences of the United States of America, 108 42, 17349-54Meng, Qinghang; Xia, Ying 2011. c-Jun, at the crossroad of the signaling network. Protein & cell, 2 11, 889-98Mongan, Maureen; Wang, Jingcai; Liu, Hongshan; Fan, Yunxia; Jin, Chang; Kao, Winston Y-W; Xia, Ying 2011. Loss of MAP3K1 enhances proliferation and apoptosis during retinal development. Development (Cambridge, England), 138 18, 4001-12Warr, Nick; Bogani, Debora; Siggers, Pam; Brixey, Rachel; Tateossian, Hilda; Dopplapudi, Asha; Wells, Sara; Cheeseman, Michael; Xia, Ying; Ostrer, Harry; Greenfield, Andy 2011. Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1. PloS one, 6 5, e19572Fan, Yunxia; Boivin, Gregory P; Knudsen, Erik S; Nebert, Daniel W; Xia, Ying; Puga, Alvaro 2010. The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer research, 70 1, 212-20Meng, Qinghang; Peng, Zhimin; Chen, Liang; Si, Jutong; Dong, Zhongyun; Xia, Ying 2010. Nuclear Factor-?B modulates cellular glutathione and prevents oxidative stress in cancer cells. Cancer letters, 299 1, 45-53Peng, Zhimin; Geh, Esmond; Chen, Liang; Meng, Qinghang; Fan, Yunxia; Sartor, Maureen; Shertzer, Howard G; Liu, Zheng-Gang; Puga, Alvaro; Xia, Ying 2010. Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione. Molecular pharmacology, 77 5, 784-92Zhu, Yu-Jia; Xia, Ying; Ren, Guan-Jun; Wang, Meng-Zhao; Zeng, Xuan; Zhang, Li 2010. Efficacy and clinical/molecular predictors of erlotinib monotherapy for Chinese advanced non-small cell lung cancer. Chinese medical journal, 123 22, 3200-5Chen, Liang; Ovesen, Jerald L; Puga, Alvaro; Xia, Ying 2009. Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation. Environmental health perspectives, 117 7, 1124-30Kao, Winston W-Y; Xia, Ying; Liu, Chia-Yang; Saika, Shizuya 2008. Signaling pathways in morphogenesis of cornea and eyelid. The ocular surface, 6 1, 9-23Malthankar-Phatak, Gauri H; Patel, Anant B; Xia, Ying; Hong, Soonsun; Chowdhury, Golam M I; Behar, Kevin L; Orina, Isaac A; Lai, James C K 2008. Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons. Brain research, 1229 , 147-54Marlowe, Jennifer L; Fan, Yunxia; Chang, Xiaoqing; Peng, Li; Knudsen, Erik S; Xia, Ying; Puga, Alvaro 2008. The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Molecular biology of the cell, 19 8, 3263-71Mongan, Maureen; Tan, Zongqing; Chen, Liang; Peng, Zhimin; Dietsch, Maggie; Su, Bing; Leikauf, George; Xia, Ying 2008. Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury. Toxicological sciences : an official journal of the Society of Toxicology, 104 2, 405-11Takatori, Atsushi; Geh, Esmond; Chen, Liang; Zhang, Lin; Meller, Jarek; Xia, Ying 2008. Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2. Development (Cambridge, England), 135 1, 23-32Peng, Zhimin; Peng, Li; Fan, Yunxia; Zandi, Ebrahim; Shertzer, Howard G; Xia, Ying 2007. A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity. The Journal of biological chemistry, 282 29, 21487-96Deng, Maoxian; Chen, Wei-Li; Takatori, Atsushi; Peng, Zhimin; Zhang, Lin; Mongan, Maureen; Parthasarathy, Ranjani; Sartor, Maureen; Miller, Marian; Yang, Jianhua; Su, Bing; Kao, Winston W-Y; Xia, Ying 2006. A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing. Molecular biology of the cell, 17 8, 3446-55Kao, Winston W-Y; Funderburgh, James L; Xia, Ying; Liu, Chia-Yang; Conrad, Gary W 2006. Focus on molecules: lumican. Experimental eye research, 82 1, 3-4Kann, Simone; Estes, Cameron; Reichard, John F; Huang, Ming-Ya; Sartor, Maureen A; Schwemberger, Sandy; Chen, Ying; Dalton, Timothy P; Shertzer, Howard G; Xia, Ying; Puga, Alvaro 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicological sciences : an official journal of the Society of Toxicology, 87 2, 365-84Kann, Simone; Huang, Ming-Ya; Estes, Cameron; Reichard, John F; Sartor, Maureen A; Xia, Ying; Puga, Alvaro 2005. Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes. Molecular pharmacology, 68 2, 336-46Puga, Alvaro; Tomlinson, Craig R; Xia, Ying 2005. Ah receptor signals cross-talk with multiple developmental pathways. Biochemical pharmacology, 69 2, 199-207Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying 2005. MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Molecular and cellular biology, 25 1, 60-5Gao, Min; Labuda, Tord; Xia, Ying; Gallagher, Ewen; Fang, Deyu; Liu, Yun-Cai; Karin, Michael 2004. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science (New York, N.Y.), 306 5694, 271-5Tan, Zongqing; Huang, Mingya; Puga, Alvaro; Xia, Ying 2004. A critical role for MAP kinases in the control of Ah receptor complex activity. Toxicological sciences : an official journal of the Society of Toxicology, 82 1, 80-7Xia, Ying; Kao, Winston W-Y 2004. The signaling pathways in tissue morphogenesis: a lesson from mice with eye-open at birth phenotype. Biochemical pharmacology, 68 6, 997-1001Xia, Ying; Karin, Michael 2004. The control of cell motility and epithelial morphogenesis by Jun kinases. Trends in cell biology, 14 2, 94-101Zhang, Lu; Lou, Danwen; Jiao, Hongyuan; Zhang, Dongsheng; Wang, Xinkang; Xia, Ying; Zhang, Jianhua; Xu, Ming 2004. Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 13, 3344-54Khoo, Shih; Griffen, Steven C; Xia, Ying; Baer, Richard J; German, Michael S; Cobb, Melanie H 2003. Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. The Journal of biological chemistry, 278 35, 32969-77Liang, Qiangrong; Bueno, Orlando F; Wilkins, Benjamin J; Kuan, Chia-Yi; Xia, Ying; Molkentin, Jeffery D 2003. c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. The EMBO journal, 22 19, 5079-89Zhang, Lin; Deng, Maoxian; Kao, Candace W C; Kao, Winston W Y; Xia, Ying 2003. MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis. Molecular vision, 9 , 584-93Zhang, Lin; Wang, Wei; Hayashi, Yasuhito; Jester, James V; Birk, David E; Gao, Min; Liu, Chia-Yang; Kao, Winston W-Y; Karin, Michael; Xia, Ying 2003. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. The EMBO journal, 22 17, 4443-54Puga, Alvaro; Xia, Ying; Elferink, Cornelis 2002. Role of the aryl hydrocarbon receptor in cell cycle regulation. Chemico-biological interactions, 141 1-2, 117-30Roy, Sanjit K; Hu, Junbo; Meng, Qingjun; Xia, Ying; Shapiro, Paul S; Reddy, Sekhar P M; Platanias, Leonidas C; Lindner, Daniel J; Johnson, Peter F; Pritchard, Catrin; Pagés, Gilles; Pouyssegur, Jacques; Kalvakolanu, Dhananjaya V 2002. MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proceedings of the National Academy of Sciences of the United States of America, 99 12, 7945-50Tan, Zongqing; Chang, Xiaoqing; Puga, Alvaro; Xia, Ying 2002. Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochemical pharmacology, 64 5-6, 771-80Wang, Qin; Chen, Jing; Ko, Chia-I; Fan, Yunxia; Carreira, Vinicius; Chen, Yinglei; Xia, Ying; Medvedovic, Mario; Puga, Alvaro . Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis. Environmental health perspectives, 121 11-12, 1334-43
Chen, Liang; Mongan, Maureen; Meng, Qinghang; Wang, Qin; Kao, Winston; Xia, Ying 2016. Corneal Wound Healing Requires IKB kinase ? Signaling in Keratocytes. PloS one, 11 3, e0151869Chen, Liang; Peng, Zhimin; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Sartor, Maureen; Chen, Jing; Niu, Liang; Medvedovic, Mario; Kao, Winston; Xia, Ying 2016. Loss of I?B kinase ? promotes myofibroblast transformation and senescence through activation of the ROS-TGF? autocrine loop. Protein & cell, 7 5, 338-50Ko, Chia-I; Fan, Yunxia; de Gannes, Matthew; Wang, Qin; Xia, Ying; Puga, Alvaro 2016. Repression of the Aryl Hydrocarbon Receptor Is Required to Maintain Mitotic Progression and Prevent Loss of Pluripotency of Embryonic Stem Cells. Stem cells (Dayton, Ohio), 34 12, 2825-2839Carreira, Vinicius S; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro 2015. Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult. PloS one, 10 11, e0142440Carreira, Vinicius S; Fan, Yunxia; Wang, Qing; Zhang, Xiang; Kurita, Hisaka; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro 2015. Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes. Toxicological sciences : an official journal of the Society of Toxicology, 147 2, 425-35Mongan, Maureen; Meng, Qinghang; Wang, Jingjing; Kao, Winston W-Y; Puga, Alvaro; Xia, Ying 2015. Gene-Environment Interactions Target Mitogen-activated Protein 3 Kinase 1 (MAP3K1) Signaling in Eyelid Morphogenesis. The Journal of biological chemistry, 290 32, 19770-9Sánchez-Martín, Francisco Javier; Fan, Yunxia; Carreira, Vinicius; Ovesen, Jerald L; Vonhandorf, Andrew; Xia, Ying; Puga, Alvaro 2015. Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice. Toxicological sciences : an official journal of the Society of Toxicology, 146 1, 52-64Yousaf, Rizwan; Meng, Qinghang; Hufnagel, Robert B; Xia, Ying; Puligilla, Chandrakala; Ahmed, Zubair M; Riazuddin, Saima 2015. MAP3K1 function is essential for cyto-architecture of mouse organ of Corti and survival of auditory hair cells. Disease models & mechanisms, , Ko, Chia-I; Wang, Qin; Fan, Yunxia; Xia, Ying; Puga, Alvaro 2014. Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in murine embryonic stem cells. Stem cell research, 12 1, 296-308Kurita, Hisaka; Schnekenburger, Michael; Ovesen, Jerald L; Xia, Ying; Puga, Alvaro 2014. The Ah Receptor Recruits IKK? to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. Toxicological sciences : an official journal of the Society of Toxicology, 139 1, 121-32Meng, Qinghang; Jin, Chang; Chen, Yinglei; Chen, Jing; Medvedovic, Mario; Xia, Ying 2014. Expression of signaling components in embryonic eyelid epithelium. PloS one, 9 2, e87038Meng, Qinghang; Mongan, Maureen; Carreira, Vinicius; Kurita, Hisaka; Liu, Chia-Yang; Kao, Winston; Xia, Ying 2014. Eyelid closure in embryogenesis is required for ocular adnexa development. Investigative ophthalmology & visual science, , Meng, Qinghang; Mongan, Maureen; Wang, Jingjing; Tang, Xiaofang; Zhang, Jinling; Kao, Winston; Xia, Ying 2014. Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1. Developmental biology, 395 1, 29-37Ovesen, Jerald L; Fan, Yunxia; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro 2014. Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional response to benzo[a]pyrene. Toxicology, 316 , 14-24Ovesen, Jerald L; Fan, Yunxia; Zhang, Xiang; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro 2014. Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure. PloS one, 9 5, e97849Jin, Chang; Chen, Jing; Meng, Qinghang; Carreira, Vinicius; Tam, Neville N C; Geh, Esmond; Karyala, Saikumar; Ho, Shuk-Mei; Zhou, Xiangtian; Medvedovic, Mario; Xia, Ying 2013. Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Developmental biology, 374 1, 96-107Sánchez-Martín, Francisco Javier; Fan, Yunxia; Lindquist, Diana M; Xia, Ying; Puga, Alvaro 2013. Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in neurons differentiated from mouse embryonic stem cells. PloS one, 8 11, e80558Wang, Jingcai; Chen, Liang; Ko, Chia-I; Zhang, Lin; Puga, Alvaro; Xia, Ying 2012. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation. The Journal of biological chemistry, 287 4, 2787-97Wang, Jingcai; Xia, Ying 2012. Assessing developmental roles of MKK4 and MKK7 in vitro. Communicative & integrative biology, 5 4, 319-24Chen, Liang; Meng, Qinghang; Kao, Winston; Xia, Ying 2011. I?B kinase ? regulates epithelium migration during corneal wound healing. PloS one, 6 1, e16132Deng, Maoxian; Ding, Wei; Min, Xuewen; Xia, Ying 2011. MLCK-independent phosphorylation of MLC20 and its regulation by MAP kinase pathway in human bladder smooth muscle cells. Cytoskeleton (Hoboken, N.J.), 68 3, 139-49Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying 2011. Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure. Proceedings of the National Academy of Sciences of the United States of America, 108 42, 17349-54Meng, Qinghang; Xia, Ying 2011. c-Jun, at the crossroad of the signaling network. Protein & cell, 2 11, 889-98Mongan, Maureen; Wang, Jingcai; Liu, Hongshan; Fan, Yunxia; Jin, Chang; Kao, Winston Y-W; Xia, Ying 2011. Loss of MAP3K1 enhances proliferation and apoptosis during retinal development. Development (Cambridge, England), 138 18, 4001-12Warr, Nick; Bogani, Debora; Siggers, Pam; Brixey, Rachel; Tateossian, Hilda; Dopplapudi, Asha; Wells, Sara; Cheeseman, Michael; Xia, Ying; Ostrer, Harry; Greenfield, Andy 2011. Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1. PloS one, 6 5, e19572Fan, Yunxia; Boivin, Gregory P; Knudsen, Erik S; Nebert, Daniel W; Xia, Ying; Puga, Alvaro 2010. The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer research, 70 1, 212-20Meng, Qinghang; Peng, Zhimin; Chen, Liang; Si, Jutong; Dong, Zhongyun; Xia, Ying 2010. Nuclear Factor-?B modulates cellular glutathione and prevents oxidative stress in cancer cells. Cancer letters, 299 1, 45-53Peng, Zhimin; Geh, Esmond; Chen, Liang; Meng, Qinghang; Fan, Yunxia; Sartor, Maureen; Shertzer, Howard G; Liu, Zheng-Gang; Puga, Alvaro; Xia, Ying 2010. Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione. Molecular pharmacology, 77 5, 784-92Zhu, Yu-Jia; Xia, Ying; Ren, Guan-Jun; Wang, Meng-Zhao; Zeng, Xuan; Zhang, Li 2010. Efficacy and clinical/molecular predictors of erlotinib monotherapy for Chinese advanced non-small cell lung cancer. Chinese medical journal, 123 22, 3200-5Chen, Liang; Ovesen, Jerald L; Puga, Alvaro; Xia, Ying 2009. Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation. Environmental health perspectives, 117 7, 1124-30Kao, Winston W-Y; Xia, Ying; Liu, Chia-Yang; Saika, Shizuya 2008. Signaling pathways in morphogenesis of cornea and eyelid. The ocular surface, 6 1, 9-23Malthankar-Phatak, Gauri H; Patel, Anant B; Xia, Ying; Hong, Soonsun; Chowdhury, Golam M I; Behar, Kevin L; Orina, Isaac A; Lai, James C K 2008. Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons. Brain research, 1229 , 147-54Marlowe, Jennifer L; Fan, Yunxia; Chang, Xiaoqing; Peng, Li; Knudsen, Erik S; Xia, Ying; Puga, Alvaro 2008. The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Molecular biology of the cell, 19 8, 3263-71Mongan, Maureen; Tan, Zongqing; Chen, Liang; Peng, Zhimin; Dietsch, Maggie; Su, Bing; Leikauf, George; Xia, Ying 2008. Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury. Toxicological sciences : an official journal of the Society of Toxicology, 104 2, 405-11Takatori, Atsushi; Geh, Esmond; Chen, Liang; Zhang, Lin; Meller, Jarek; Xia, Ying 2008. Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2. Development (Cambridge, England), 135 1, 23-32Peng, Zhimin; Peng, Li; Fan, Yunxia; Zandi, Ebrahim; Shertzer, Howard G; Xia, Ying 2007. A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity. The Journal of biological chemistry, 282 29, 21487-96Deng, Maoxian; Chen, Wei-Li; Takatori, Atsushi; Peng, Zhimin; Zhang, Lin; Mongan, Maureen; Parthasarathy, Ranjani; Sartor, Maureen; Miller, Marian; Yang, Jianhua; Su, Bing; Kao, Winston W-Y; Xia, Ying 2006. A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing. Molecular biology of the cell, 17 8, 3446-55Kao, Winston W-Y; Funderburgh, James L; Xia, Ying; Liu, Chia-Yang; Conrad, Gary W 2006. Focus on molecules: lumican. Experimental eye research, 82 1, 3-4Kann, Simone; Estes, Cameron; Reichard, John F; Huang, Ming-Ya; Sartor, Maureen A; Schwemberger, Sandy; Chen, Ying; Dalton, Timothy P; Shertzer, Howard G; Xia, Ying; Puga, Alvaro 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicological sciences : an official journal of the Society of Toxicology, 87 2, 365-84Kann, Simone; Huang, Ming-Ya; Estes, Cameron; Reichard, John F; Sartor, Maureen A; Xia, Ying; Puga, Alvaro 2005. Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes. Molecular pharmacology, 68 2, 336-46Puga, Alvaro; Tomlinson, Craig R; Xia, Ying 2005. Ah receptor signals cross-talk with multiple developmental pathways. Biochemical pharmacology, 69 2, 199-207Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying 2005. MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Molecular and cellular biology, 25 1, 60-5Gao, Min; Labuda, Tord; Xia, Ying; Gallagher, Ewen; Fang, Deyu; Liu, Yun-Cai; Karin, Michael 2004. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science (New York, N.Y.), 306 5694, 271-5Tan, Zongqing; Huang, Mingya; Puga, Alvaro; Xia, Ying 2004. A critical role for MAP kinases in the control of Ah receptor complex activity. Toxicological sciences : an official journal of the Society of Toxicology, 82 1, 80-7Xia, Ying; Kao, Winston W-Y 2004. The signaling pathways in tissue morphogenesis: a lesson from mice with eye-open at birth phenotype. Biochemical pharmacology, 68 6, 997-1001Xia, Ying; Karin, Michael 2004. The control of cell motility and epithelial morphogenesis by Jun kinases. Trends in cell biology, 14 2, 94-101Zhang, Lu; Lou, Danwen; Jiao, Hongyuan; Zhang, Dongsheng; Wang, Xinkang; Xia, Ying; Zhang, Jianhua; Xu, Ming 2004. Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 13, 3344-54Khoo, Shih; Griffen, Steven C; Xia, Ying; Baer, Richard J; German, Michael S; Cobb, Melanie H 2003. Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. The Journal of biological chemistry, 278 35, 32969-77Liang, Qiangrong; Bueno, Orlando F; Wilkins, Benjamin J; Kuan, Chia-Yi; Xia, Ying; Molkentin, Jeffery D 2003. c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. The EMBO journal, 22 19, 5079-89Zhang, Lin; Deng, Maoxian; Kao, Candace W C; Kao, Winston W Y; Xia, Ying 2003. MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis. Molecular vision, 9 , 584-93Zhang, Lin; Wang, Wei; Hayashi, Yasuhito; Jester, James V; Birk, David E; Gao, Min; Liu, Chia-Yang; Kao, Winston W-Y; Karin, Michael; Xia, Ying 2003. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. The EMBO journal, 22 17, 4443-54Puga, Alvaro; Xia, Ying; Elferink, Cornelis 2002. Role of the aryl hydrocarbon receptor in cell cycle regulation. Chemico-biological interactions, 141 1-2, 117-30Roy, Sanjit K; Hu, Junbo; Meng, Qingjun; Xia, Ying; Shapiro, Paul S; Reddy, Sekhar P M; Platanias, Leonidas C; Lindner, Daniel J; Johnson, Peter F; Pritchard, Catrin; Pagés, Gilles; Pouyssegur, Jacques; Kalvakolanu, Dhananjaya V 2002. MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma. Proceedings of the National Academy of Sciences of the United States of America, 99 12, 7945-50Tan, Zongqing; Chang, Xiaoqing; Puga, Alvaro; Xia, Ying 2002. Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochemical pharmacology, 64 5-6, 771-80Wang, Qin; Chen, Jing; Ko, Chia-I; Fan, Yunxia; Carreira, Vinicius; Chen, Yinglei; Xia, Ying; Medvedovic, Mario; Puga, Alvaro . Disruption of aryl hydrocarbon receptor homeostatic levels during embryonic stem cell differentiation alters expression of homeobox transcription factors that control cardiomyogenesis. Environmental health perspectives, 121 11-12, 1334-43