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Photo of  Tammy M. Holm, MD,PhD

Tammy M. Holm, MD,PhD

Assistant Professor of Clinical

Surgery | College of Medicine

  • Fellowship: Massachusetts General Hospital (Endocrine Surgery)
  • Residency: Brigham and Women's Hospital (General Surgery)
  • Doctoral Degree: Johns Hopkins University (Medicine, Human Genetics)
  • Medical Degree: Johns Hopkins University School of Medicine (Medicine, Human Genetics)
  • Undergraduate Degree: Boston University
Board Certifications & Licenses

American Board of Surgery (Certification Date: 2015-01-26)

Contact Information
Research Interests

Diseases of the thyroid, parathyroid, and adrenal glands

Clinical Interests


Surgical Oncology

Thoracic Surgery

Thyroid Cancer

Acute Lymphocytic Leukemia

Adrenal Cancer

Adrenal Cortex Cancers

Adrenal Gland Cancers

Adrenal Rest Tumor

Adrenal Tumors

Adrenocortical Carcinoma

Anaplastic Thyroid Cancer

Endocrine Cancers

Follicular Thyroid Cancer

Hurthle Cell Thyroid Cancer

Papillary Thyroid Cancer

Parathyroid Cancer

Peer Reviewed Publications

Delman, Aaron M; Turner, Kevin M; Ammann, Allison M; Sisak, Stephanie; Farooqui, Zishaan; Holm, Tammy M 2023. The national rate of malignancy among Bethesda III, IV, and V thyroid nodules is higher than expected: A NSQIP analysis. Surgery, 173 3, 645-652

Ammann, Allison M; Delman, Aaron M; Bethi, Mridula; Turner, Kevin M; Sedaghat, Ahmad R; Holm, Tammy M 2022. Gender Disparities in Academic Productivity and Promotion Among Endocrine Surgery Faculty. The Journal of surgical research, 277 , 335-341

Delman, Aaron M; Turner, Kevin M; Ahmad, Mirza; Silski, Latifa A S; Hanseman, Dennis; Tang, Alice; Steward, David; Shah, Shimul A; Holm, Tammy M 2022. Surgery Is Underutilized in the Management of Tertiary Hyperparathyroidism. The Journal of surgical research, 277 , 261-268

Delman, Aaron M; Turner, Kevin M; Ammann, Allison M; Tang, Alice; Steward, David; Holm, Tammy M 2022. Avoiding delays in time to renal transplantation: Pretransplant thyroid malignancy does not affect patient or graft survival after renal transplantation. Surgery, 171 1, 220-226

Delman, Aaron M; Turner, Kevin M; Griffith, Azante; Schepers, Emily; Ammann, Allison M; Holm, Tammy M 2022. Minimally Invasive Surgery for Resectable Adrenocortical Carcinoma: A Nationwide Analysis. The Journal of surgical research, 279 , 200-207

Holm, Tammy M 2022. Endocrine surgery: A pain in the neck? American journal of surgery, 224 1 Pt B, 313-314

Holm, Tammy M; Bian, Z Christine; Manupati, Kanakaraju; Guan, Jun-Lin 2022. Inhibition of autophagy mitigates cell migration and invasion in thyroid cancer. Surgery, 171 1, 235-244

Holm, Tammy M; Yeo, Syn; Turner, Kevin M; Guan, Jun-Lin 2022. Targeting Autophagy in Thyroid Cancer: EMT, Apoptosis, and Cancer Stem Cells. Frontiers in cell and developmental biology, 10 , 821855

Lynch, Caroline A; Bethi, Mridula; Tang, Alice; Lee, Paul; Steward, David; Holm, Tammy M 2022. Thyroid nodules >4 cm with atypia of undetermined significance cytology independently associate with malignant pathology. Surgery, 171 3, 725-730

Manupati, Kanakaraju; Paul, Ritama; Hao, Mingang; Haas, Michael; Bian, Zhaoqun Christine; Holm, Tammy M; Guan, Jun-Lin; Yeo, Syn Kok 2022. Biglycan Promotes Cancer Stem Cell Properties, NFκB Signaling and Metastatic Potential in Breast Cancer Cells. Cancers, 14 2,

Tang, Alice L; Kloos, Richard T; Aunins, Benjamin; Holm, Tammy M; Roth, Mara Y; Yeh, Michael W; Randolph, Gregory W; Tabangin, Meredith E; Altaye, Mekibib; Steward, David L 2021. Pathologic Features Associated With Molecular Subtypes of Well-Differentiated Thyroid Cancer. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 27 3, 206-211

Turner, Kevin M; Yeo, Syn Kok; Holm, Tammy M; Shaughnessy, Elizabeth; Guan, Jun-Lin 2021. Heterogeneity within molecular subtypes of breast cancer. American journal of physiology. Cell physiology, 321 2, C343-C354

Holm, Tammy M; Stathatos, Nikolaos; Sadow, Peter M; Juliano, Amy F; Cunnane, Mary Beth; Carter, Margaret S; Kamani, Yash V; Randolph, Gregory W 2019. A Gossypiboma From Kazakhstan. Ear, nose, & throat journal, , 145561319840512

Lubitz, Carrie C; Zhan, Tiannan; Gunda, Viswanath; Amin, Salma; Gigliotti, Benjamin J; Fingeret, Abbey L; Holm, Tammy M; Wachtel, Heather; Sadow, Peter M; Wirth, Lori J; Sullivan, Ryan J; Panka, David J; Parangi, Sareh 2018. Circulating BRAFV600E Levels Correlate with Treatment in Patients with Thyroid Carcinoma. Thyroid : official journal of the American Thyroid Association, 28 3, 328-339

Lubitz, Carrie C; Parangi, Sareh; Holm, Tammy M; Bernasconi, M Jordana; Schalck, Aislyn P; Suh, Hyunsuk; Economopoulos, Konstantinos P; Gunda, Viswanath; Donovan, Samuel E; Sadow, Peter M; Wirth, Lori J; Sullivan, Ryan J; Panka, David J 2016. Detection of Circulating BRAF(V600E) in Patients with Papillary Thyroid Carcinoma. The Journal of molecular diagnostics : JMD, 18 1, 100-8

Wong, Daniel J; Holm, Tammy M; Dyer, George S M; Gates, Jonathan D 2015. Late onset venous thoracic outlet syndrome following clavicle non-union fracture: A case report. Vascular, 23 2, 183-7

Habashi, Jennifer P; Doyle, Jefferson J; Holm, Tammy M; Aziz, Hamza; Schoenhoff, Florian; Bedja, Djahida; Chen, YiChun; Modiri, Alexandra N; Judge, Daniel P; Dietz, Harry C 2011. Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism. Science (New York, N.Y.), 332 6027, 361-5

Holm, Tammy M; Habashi, Jennifer P; Doyle, Jefferson J; Bedja, Djahida; Chen, YiChun; van Erp, Christel; Lindsay, Mark E; Kim, David; Schoenhoff, Florian; Cohn, Ronald D; Loeys, Bart L; Thomas, Craig J; Patnaik, Samarjit; Marugan, Juan J; Judge, Daniel P; Dietz, Harry C 2011. Noncanonical TGF? signaling contributes to aortic aneurysm progression in Marfan syndrome mice. Science (New York, N.Y.), 332 6027, 358-61

Cohn, Ronald D; van Erp, Christel; Habashi, Jennifer P; Soleimani, Arshia A; Klein, Erin C; Lisi, Matthew T; Gamradt, Matthew; ap Rhys, Colette M; Holm, Tammy M; Loeys, Bart L; Ramirez, Francesco; Judge, Daniel P; Ward, Christopher W; Dietz, Harry C 2007. Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states. Nature medicine, 13 2, 204-10

Habashi, Jennifer P; Judge, Daniel P; Holm, Tammy M; Cohn, Ronald D; Loeys, Bart L; Cooper, Timothy K; Myers, Loretha; Klein, Erin C; Liu, Guosheng; Calvi, Carla; Podowski, Megan; Neptune, Enid R; Halushka, Marc K; Bedja, Djahida; Gabrielson, Kathleen; Rifkin, Daniel B; Carta, Luca; Ramirez, Francesco; Huso, David L; Dietz, Harry C 2006. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science (New York, N.Y.), 312 5770, 117-21

Holm T.M.;Pai S.I. 12-18-2012. The Superior Laryngeal Nerve Thyroid Surgery: Preventing and Managing Complications, , 129-135

Cameron D.; Chen J.; Chen Y.; Coucke P.; Davis E.; De Backer J.; De Paepe A.; Dietz H.; Hellemans J.; Holm T.; Judge D.; Katsanis N.; Kress W.; Leitch C.; Loeys B.; Meyers J.; Myers L.; Neptune E.; Podowski M.; Rifkin D.; Sharifi N.; Spevak P.; Webb C.; Xu F. 12-09-2005. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused b Nature Genetics, 37 3, 275-281

Campbell M.J.;McCoy K.L.;Shen W.T.;Carty S.E.;Lubitz C.C.;Moalem J.;Nehs M.;Holm T.;Greenblatt D.Y.;Press D.;Feng X.;Siperstein A.E.;Mitmaker E.;Benay C.;Tabah R.;Oltmann S.C.;Chen H.;Sippel R.S.;Brekke A.;Vriens M.R.;Lodewijk L.;Stephen A.E.;Nagar S.;Angelos P.;Ghanem M.;Prescott J.D.;Zeiger M.A.;Aragon Han P.;Sturgeon C.;Elaraj D.M.;Nixon I.J.;Patel S.G.;Bayles S.W.;Heneghan R.;Ochieng P.;Guerrero M.A.;Ruan D.T. 12-01-2013. A multi-institutional international study of risk factors for hematoma after thyroidectomy Surgery (United States), 154 6, 1283-1291

Alba Greco M.; Braverman A.C.; Byers P.H.; Callewaert B.L.; Cameron D.E.; Coucke P.J.; De Backer J.F.; De Paepe A.M.; Dietz H.C.; Faravelli F.; Holm T.; Loeys B.L.; Manouvrier S.; Milewicz D.M.; Oswald G.L.; Pannu H.; Pyeritz R.E.; Roberts A.E.; Schwarze U.; Symoens S.; Thomas G.H. 08-24-2006. Aneurysm syndromes caused by mutations in the TGF-? receptor New England Journal of Medicine, 355 8, 788-798

Carlson O.; De Backer J.; Dietz H.; Fu Q.; Griswold B.; Habashi J.; Holm T.; Huso D.; Loch D.; Loeys B.; Matt P.; McDonnell N.; Schoenhoff F.; Van Erp C.; Van Eyk J. 08-11-2009. Circulating transforming growth factor-? in marfan syndrome Circulation, 120 6, 526-532

Adès L.C.; Baspinar O.; Callewaert B.L.; Coucke P.J.; Dasouki M.; De Paepe A.M.; Dietz H.C.; Earing M.G.; Holm T.; Hoyer J.; Loeys B.L.; Pickart A.; Rauch A.; Renard M.; Sakai L.Y.; Trapane P.; Veith R. 08-01-2010. Altered TGF? signaling and cardiovascular manifestations in patients with autosomal recessive cutis European Journal of Human Genetics, 18 8, 895-901

Black J.; Dietz H.; Doyle J.; Habashi J.; Holm T.; Huso D.; Liu G.; Matt P.; Schoenhoff F.; Van Eyk J. 04-01-2010. Murine model of surgically induced acute aortic dissection type A Journal of Thoracic and Cardiovascular Surgery, 139 4, 1041-1047

Ap Rhys C.; Cohn R.; Dietz H.; Gamradt M.; Habashi J.; Holm T.; Judge D.; Klein E.; Lisi M.; Loeys B.; Ramirez F.; Soleimani A.; Van Erp C.; Ward C. 04-01-2007. Erratum: Angiotensin II type 1 receptor blockade attenuates TGF-?-induced failure of muscle regenera Nature Medicine, 13 4, 511

Marti J.L.;Holm T.;Randolph G. 02-01-2016. Universal Use of Intraoperative Nerve Monitoring by Recently Fellowship-Trained Thyroid Surgeons is World Journal of Surgery, 40 2, 337-343

Varmeh S.;Borre P.V.;Gunda V.;Brauner E.;Holm T.;Wang Y.;Sadreyev R.I.;Parangi S. 01-01-2016. Genome-wide analysis of differentially expressed miRNA in PLX4720-resistant and parental human thyro Surgery (United States), 159 1, 152-162