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Metabolic Biology Laboratory
Chasing signaling mechanisms that alter cardiac and systemic metabolic pathways in health and disease

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Our research investigates transcriptional regulation mechanisms that link cardiac stress with altered myocardial fatty acid and glucose metabolism. Our long-term goal pertains to the application of interventions that can improve cardiac function by modulating fatty acid oxidation and energy production.

We are interested in the role of Kruppel-like factors (KLFs) and particularly, KLF5 and its role in the regulation of cardiac fatty acid oxidation during diabetes, myocardial ischemia, ischemia/reperfusion and aging. We also investigate the role of cardiomyocyte KLF5 in regulating systemic metabolism via an undiscovered cross-talk mechanism between the heart and the adipose tissue.

Furthermore, we study the role of the cellular energetic machinery in the alleviation of cardiomyopathy in sepsis.

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Department of
Pharmacology and Systems Physiology

College of Medicine
231 Albert Sabin Way
Cincinnati, OH 45267-0575

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