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Our laboratory focuses on understanding the mechanisms involved in the neuroendocrine control of energy balance. We investigate how afferent endocrine signals, such as GLP-1, ghrelin and leptin, interact with neural circuits, specifically the melanocortin system, to regulate metabolism, and how those interactions are influenced by nutrient and environmental status. We also work on identifying the specific efferent mechanisms whereby those neural circuits in the brain control metabolism in peripheral tissues. Our technical approach is focused in the in vivo and ex vivo analysis of glucose and lipid metabolism, energy intake and energy expenditure in rodent models. In addition, we collaborate with the pharmaceutical industry to develop new therapies to treat obesity and diabetes.
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