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Our research investigates transcriptional regulation mechanisms that link cardiac stress with altered myocardial fatty acid and glucose metabolism. Our long-term goal pertains to the application of interventions that can improve cardiac function by modulating
fatty acid oxidation and energy production.
We are interested in the role of Kruppel-like factors (KLFs) and particularly, KLF5 and its role in the regulation of cardiac fatty acid oxidation during diabetes, myocardial ischemia, ischemia/reperfusion and aging. We also investigate the role of cardiomyocyte
KLF5 in regulating systemic metabolism via an undiscovered cross-talk mechanism between the heart and the adipose tissue.
Furthermore, we study the role of the cellular energetic machinery in the alleviation of cardiomyopathy in sepsis.
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