June Goto, PhD

Peer Reviewed Publications

Brown, Farrah N; Iwasawa, Eri; Shula, Crystal; Fugate, Elizabeth M; Lindquist, Diana M; Mangano, Francesco T; Goto, June 2023. Early postnatal microglial ablation in the Ccdc39 mouse model reveals adverse effects on brain development and in neonatal hydrocephalus. Fluids and barriers of the CNS, 20 1, 42

Bedolla, Alicia; Taranov, Aleksandr; Luo, Fucheng; Wang, Jiapeng; Turcato, Flavia; Fugate, Elizabeth M; Greig, Nigel H; Lindquist, Diana M; Crone, Steven A; Goto, June; Luo, Yu 2022. Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation. Journal of neuroinflammation, 19 1, 3

Duy, Phan Q; Weise, Stefan C; Marini, Claudia; Li, Xiao-Jun; Liang, Dan; Dahl, Peter J; Ma, Shaojie; Spajic, Ana; Dong, Weilai; Juusola, Jane; Kiziltug, Emre; Kundishora, Adam J; Koundal, Sunil; Pedram, Maysam Z; Torres-Fernández, Lucia A; Händler, Kristian; De Domenico, Elena; Becker, Matthias; Ulas, Thomas; Juranek, Stefan A; Cuevas, Elisa; Hao, Le Thi; Jux, Bettina; Sousa, André M M; Liu, Fuchen; Kim, Suel-Kee; Li, Mingfeng; Yang, Yiying; Takeo, Yutaka; Duque, Alvaro; Nelson-Williams, Carol; Ha, Yonghyun; Selvaganesan, Kartiga; Robert, Stephanie M; Singh, Amrita K; Allington, Garrett; Furey, Charuta G; Timberlake, Andrew T; Reeves, Benjamin C; Smith, Hannah; Dunbar, Ashley; DeSpenza, Tyrone; Goto, June; Marlier, Arnaud; Moreno-De-Luca, Andres; Yu, Xin; Butler, William E; Carter, Bob S; Lake, Evelyn M R; Constable, R Todd; Rakic, Pasko; Lin, Haifan; Deniz, Engin; Benveniste, Helene; Malvankar, Nikhil S; Estrada-Veras, Juvianee I; Walsh, Christopher A; Alper, Seth L; Schultze, Joachim L; Paeschke, Katrin; Doetzlhofer, Angelika; Wulczyn, F Gregory; Jin, Sheng Chih; Lifton, Richard P; Sestan, Nenad; Kolanus, Waldemar; Kahle, Kristopher T 2022. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nature neuroscience, 25 4, 458-473

Iwasawa, Eri; Brown, Farrah N; Shula, Crystal; Kahn, Fatima; Lee, Sang Hoon; Berta, Temugin; Ladle, David R; Campbell, Kenneth; Mangano, Francesco T; Goto, June 2022. The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience, 42 9, 1820-1844

Neupane, Sanjiv; Goto, June; Berardinelli, Steven J; Ito, Atsuko; Haltiwanger, Robert S; Holdener, Bernadette C 2021. Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ. Glycobiology, 31 8, 988-1004

Goulding, Danielle S; Vogel, R Caleb; Pandya, Chirayu D; Shula, Crystal; Gensel, John C; Mangano, Francesco T; Goto, June; Miller, Brandon A 2020. Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice. Journal of neurosurgery. Pediatrics, , 1-8

Jin, Sheng Chih; Dong, Weilai; Kundishora, Adam J; Panchagnula, Shreyas; Moreno-De-Luca, Andres; Furey, Charuta G; Allocco, August A; Walker, Rebecca L; Nelson-Williams, Carol; Smith, Hannah; Dunbar, Ashley; Conine, Sierra; Lu, Qiongshi; Zeng, Xue; Sierant, Michael C; Knight, James R; Sullivan, William; Duy, Phan Q; DeSpenza, Tyrone; Reeves, Benjamin C; Karimy, Jason K; Marlier, Arnaud; Castaldi, Christopher; Tikhonova, Irina R; Li, Boyang; Peña, Helena Perez; Broach, James R; Kabachelor, Edith M; Ssenyonga, Peter; Hehnly, Christine; Ge, Li; Keren, Boris; Timberlake, Andrew T; Goto, June; Mangano, Francesco T; Johnston, James M; Butler, William E; Warf, Benjamin C; Smith, Edward R; Schiff, Steven J; Limbrick, David D; Heuer, Gregory; Jackson, Eric M; Iskandar, Bermans J; Mane, Shrikant; Haider, Shozeb; Guclu, Bulent; Bayri, Yasar; Sahin, Yener; Duncan, Charles C; Apuzzo, Michael L J; DiLuna, Michael L; Hoffman, Ellen J; Sestan, Nenad; Ment, Laura R; Alper, Seth L; Bilguvar, Kaya; Geschwind, Daniel H; Günel, Murat; Lifton, Richard P; Kahle, Kristopher T 2020. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature medicine, 26 11, 1754-1765

Emmert, A Scott; Iwasawa, Eri; Shula, Crystal; Schultz, Preston; Lindquist, Diana; Dunn, R Scott; Fugate, Elizabeth M; Hu, Yueh-Chiang; Mangano, Francesco T; Goto, June 2019. Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: genetic interaction with L1cam. Disease models & mechanisms, 12 11,

Emmert, A Scott; Vuong, Shawn M; Shula, Crystal; Lindquist, Diana; Yuan, Weihong; Hu, Yueh-Chiang; Mangano, Francesco T; Goto, June 2019. Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam. Journal of neurosurgery, 132 3, 945-958

Abdelhamed, Zakia; Vuong, Shawn M; Hill, Lauren; Shula, Crystal; Timms, Andrew; Beier, David; Campbell, Kenneth; Mangano, Francesco T; Stottmann, Rolf W; Goto, June 2018. A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice. Development (Cambridge, England), 145 1,

Hu, Zhongdong; Wang, Ying; Huang, Fuqiang; Chen, Rongrong; Li, Chunjia; Wang, Fang; Goto, June; Kwiatkowski, David J; Wdzieczak-Bakala, Joanna; Tu, Pengfei; Liu, Jianmiao; Zha, Xiaojun; Zhang, Hongbing 2015. Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis. The Journal of biological chemistry, 290 42, 25756-65

Prabhakar, Shilpa; Zhang, Xuan; Goto, June; Han, Sangyeul; Lai, Charles; Bronson, Roderick; Sena-Esteves, Miguel; Ramesh, Vijaya; Stemmer-Rachamimov, Anat; Kwiatkowski, David J; Breakefield, Xandra O 2015. Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model. Neurobiology of disease, 82 , 22-31

Di Nardo, Alessia; Wertz, Mary H; Kwiatkowski, Erica; Tsai, Peter T; Leech, Jarrett D; Greene-Colozzi, Emily; Goto, June; Dilsiz, Pelin; Talos, Delia M; Clish, Clary B; Kwiatkowski, David J; Sahin, Mustafa 2014. Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1. Human molecular genetics, 23 14, 3865-74

Prabhakar, Shilpa; Goto, June; Zhang, Xuan; Zuang, Xuan; Sena-Esteves, Miguel; Bronson, Roderick; Brockmann, Jillian; Gianni, Davide; Wojtkiewicz, Gregory R; Chen, John W; Stemmer-Rachamimov, Anat; Kwiatkowski, David J; Breakefield, Xandra O 2013. Stochastic model of Tsc1 lesions in mouse brain. PloS one, 8 5, e64224

Tsai, Peter T; Greene-Colozzi, Emily; Goto, June; Anderl, Stefanie; Kwiatkowski, David J; Sahin, Mustafa 2013. Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice. Behavior genetics, 43 1, 51-9

Anderl, Stefanie; Freeland, Megan; Kwiatkowski, David J; Goto, June 2011. Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex. Human molecular genetics, 20 23, 4597-604

Goto, June; Talos, Delia M; Klein, Peter; Qin, Wei; Chekaluk, Yvonne I; Anderl, Stefanie; Malinowska, Izabela A; Di Nardo, Alessia; Bronson, Roderick T; Chan, Jennifer A; Vinters, Harry V; Kernie, Steven G; Jensen, Frances E; Sahin, Mustafa; Kwiatkowski, David J 2011. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proceedings of the National Academy of Sciences of the United States of America, 108 45, E1070-9

Malhowski, Amy J; Hira, Haider; Bashiruddin, Sarah; Warburton, Rod; Goto, June; Robert, Blanton; Kwiatkowski, David J; Finlay, Geraldine A 2011. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin. Human molecular genetics, 20 7, 1290-305

Sun, Qian; Chen, Xinxin; Ma, Jianhui; Peng, Haiyong; Wang, Fang; Zha, Xiaojun; Wang, Yanan; Jing, Yanling; Yang, Hongwang; Chen, Rongrong; Chang, Long; Zhang, Yu; Goto, June; Onda, Hiroaki; Chen, Tong; Wang, Ming-Rong; Lu, Youyong; You, Han; Kwiatkowski, David; Zhang, Hongbing 2011. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proceedings of the National Academy of Sciences of the United States of America, 108 10, 4129-34

Liang, M-C; Ma, J; Chen, L; Kozlowski, P; Qin, W; Li, D; Goto, J; Shimamura, T; Hayes, D N; Meyerson, M; Kwiatkowski, D J; Wong, K-K 2010. TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity. Oncogene, 29 11, 1588-97

Pollizzi, Kristen; Malinowska-Kolodziej, Izabela; Doughty, Cheryl; Betz, Charles; Ma, Jian; Goto, June; Kwiatkowski, David J 2009. A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles. Human molecular genetics, 18 13, 2378-87

Goto, June; Tezuka, Tohru; Nakazawa, Takanobu; Sagara, Hiroshi; Yamamoto, Tadashi 2008. Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development. Molecular and cellular neurosciences, 38 2, 203-12

Nakazawa, Takanobu; Komai, Shoji; Watabe, Ayako M; Kiyama, Yuji; Fukaya, Masahiro; Arima-Yoshida, Fumiko; Horai, Reiko; Sudo, Katsuko; Ebine, Kazumi; Delawary, Mina; Goto, June; Umemori, Hisashi; Tezuka, Tohru; Iwakura, Yoichiro; Watanabe, Masahiko; Yamamoto, Tadashi; Manabe, Toshiya 2006. NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. The EMBO journal, 25 12, 2867-77

Goto, June; Tezuka, Tohru; Nakazawa, Takanobu; Tsukamoto, Nobuo; Nakamura, Takahisa; Ajima, Rieko; Yokoyama, Kazumasa; Ohta, Tsutomu; Ohki, Misao; Yamamoto, Tadashi 2004. Altered gene expression in the adult brain of fyn-deficient mice. Cellular and molecular neurobiology, 24 1, 149-59