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Photo of  Sing Sing Way, M.D., Ph.D.

Sing Sing Way, M.D., Ph.D.

Contact Information
  • CCHMC S Building
  • 240 Albert Sabin Way
  • Cincinnati, Ohio 45229
  • Office 513-636-7603
  • Email singsing.way@cchmc.org

Peer Reviewed Publications

Chaturvedi, Vandana; Ertelt, James M; Jiang, Tony T; Kinder, Jeremy M; Xin, Lijun; Owens, Kathryn J; Jones, Helen N; Way, Sing Sing 2015. CXCR3 blockade protects against Listeria monocytogenes infection-induced fetal wastage. The Journal of clinical investigation, 125 4, 1713-25

Kinder, Jeremy M; Jiang, Tony T; Ertelt, James M; Xin, Lijun; Strong, Beverly S; Shaaban, Aimen F; Way, Sing Sing 2015. Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells. Cell, 162 3, 505-15

Nanton, Minelva R; Lee, Seung-Joo; Atif, Shaikh M; Nuccio, Sean-Paul; Taylor, Justin J; Bäumler, Andreas J; Way, Sing Sing; McSorley, Stephen J 2015. Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development. European journal of immunology, 45 2, 428-41

PrabhuDas, Mercy; Bonney, Elizabeth; Caron, Kathleen; Dey, Sudhansu; Erlebacher, Adrian; Fazleabas, Asgerally; Fisher, Susan; Golos, Thaddeus; Matzuk, Martin; McCune, Joseph M; Mor, Gil; Schulz, Laura; Soares, Michael; Spencer, Thomas; Strominger, Jack; Way, Sing Sing; Yoshinaga, Koji 2015. Immune mechanisms at the maternal-fetal interface: perspectives and challenges. Nature immunology, 16 4, 328-34

Xin, Lijun; Jiang, Tony T; Kinder, Jeremy M; Ertelt, James M; Way, Sing Sing 2015. Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna(Dhe) mice. Aging cell, ,

Clark, Dayna R; Chaturvedi, Vandana; Kinder, Jeremy M; Jiang, Tony T; Xin, Lijun; Ertelt, James M; Way, Sing Sing 2014. Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8(+) T cells during pregnancy. Cellular & molecular immunology, 11 6, 595-605

Drummond, Rebecca A; Wallace, Carol; Reid, Delyth M; Way, Sing Sing; Kaplan, Daniel H; Brown, Gordon D 2014. Cutting edge: Failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis. Journal of immunology (Baltimore, Md. : 1950), 193 11, 5381-5

Jiang, Tony T; Chaturvedi, Vandana; Ertelt, James M; Kinder, Jeremy M; Clark, Dayna R; Valent, Amy M; Xin, Lijun; Way, Sing Sing 2014. Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications. Journal of immunology (Baltimore, Md. : 1950), 192 11, 4949-56

Xin, Lijun; Ertelt, James M; Rowe, Jared H; Jiang, Tony T; Kinder, Jeremy M; Chaturvedi, Vandana; Elahi, Shokrollah; Way, Sing Sing 2014. Cutting edge: committed Th1 CD4+ T cell differentiation blocks pregnancy-induced Foxp3 expression with antigen-specific fetal loss. Journal of immunology (Baltimore, Md. : 1950), 192 7, 2970-4

Xin, Lijun; Jiang, Tony T; Chaturvedi, Vandana; Kinder, Jeremy M; Ertelt, James M; Rowe, Jared H; Steinbrecher, Kris A; Way, Sing Sing 2014. Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2. Proceedings of the National Academy of Sciences of the United States of America, 111 29, 10672-7

Burnaevskiy, Nikolay; Fox, Thomas G; Plymire, Daniel A; Ertelt, James M; Weigele, Bethany A; Selyunin, Andrey S; Way, Sing Sing; Patrie, Steven M; Alto, Neal M 2013. Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ. Nature, 496 7443, 106-9

Elahi, Shokrollah; Ertelt, James M; Kinder, Jeremy M; Jiang, Tony T; Zhang, Xuzhe; Xin, Lijun; Chaturvedi, Vandana; Strong, Beverly S; Qualls, Joseph E; Steinbrecher, Kris A; Kalfa, Theodosia A; Shaaban, Aimen F; Way, Sing Sing 2013. Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection. Nature, 504 7478, 158-62

Ertelt, James M; Buyukbasaran, Esra Z; Jiang, Tony T; Rowe, Jared H; Xin, Lijun; Way, Sing Sing 2013. B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells. Journal of leukocyte biology, 94 2, 367-76

Rowe, Jared H; Ertelt, James M; Xin, Lijun; Way, Sing Sing 2013. Regulatory T cells and the immune pathogenesis of prenatal infection. Reproduction (Cambridge, England), 146 6, R191-203

Shafiani, Shahin; Dinh, Crystal; Ertelt, James M; Moguche, Albanus O; Siddiqui, Imran; Smigiel, Kate S; Sharma, Pawan; Campbell, Daniel J; Way, Sing Sing; Urdahl, Kevin B 2013. Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity, 38 6, 1261-70

Tubo, Noah J; Pagán, Antonio J; Taylor, Justin J; Nelson, Ryan W; Linehan, Jonathan L; Ertelt, James M; Huseby, Eric S; Way, Sing Sing; Jenkins, Marc K 2013. Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell, 153 4, 785-96

Kanistanon, Duangjit; Powell, Daniel A; Hajjar, Adeline M; Pelletier, Mark R; Cohen, Ilana E; Way, Sing Sing; Skerrett, Shawn J; Wang, Xiaoyuan; Raetz, Christian R H; Ernst, Robert K 2012. Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses. Infection and immunity, 80 3, 943-51

Nanton, Minelva R; Way, Sing Sing; Shlomchik, Mark J; McSorley, Stephen J 2012. Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion. Journal of immunology (Baltimore, Md. : 1950), 189 12, 5503-7

Rowe, Jared H; Ertelt, James M; Way, Sing Sing 2012. Innate IFN-? is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection. Journal of immunology (Baltimore, Md. : 1950), 189 2, 876-84

Rowe, Jared H; Ertelt, James M; Way, Sing Sing 2012. Foxp3(+) regulatory T cells, immune stimulation and host defence against infection. Immunology, 136 1, 1-10

Rowe, Jared H; Ertelt, James M; Xin, Lijun; Way, Sing Sing 2012. Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature, 490 7418, 102-6

Rowe, Jared H; Ertelt, James M; Xin, Lijun; Way, Sing Sing 2012. Listeria monocytogenes cytoplasmic entry induces fetal wastage by disrupting maternal Foxp3+ regulatory T cell-sustained fetal tolerance. PLoS pathogens, 8 8, e1002873

Ertelt, James M; Johanns, Tanner M; Mysz, Margaret A; Nanton, Minelva R; Rowe, Jared H; Aguilera, Marijo N; Way, Sing Sing 2011. Selective culling of high avidity antigen-specific CD4+ T cells after virulent Salmonella infection. Immunology, 134 4, 487-97

Ertelt, James M; Rowe, Jared H; Mysz, Margaret A; Singh, Charanjeet; Roychowdhury, Monika; Aguilera, Marijo N; Way, Sing Sing 2011. Foxp3+ regulatory T cells impede the priming of protective CD8+ T cells. Journal of immunology (Baltimore, Md. : 1950), 187 5, 2569-77

Han, Jin-Young; Hanson, David C; Way, Sing Sing 2011. Herpes zoster and meningitis due to reactivation of varicella vaccine virus in an immunocompetent child. The Pediatric infectious disease journal, 30 3, 266-8

Johanns, Tanner M; Law, Calvin Y; Kalekar, Lokeshchandra A; O'Donnell, Hope; Ertelt, James M; Rowe, Jared H; Way, Sing Sing 2011. Early eradication of persistent Salmonella infection primes antibody-mediated protective immunity to recurrent infection. Microbes and infection / Institut Pasteur, 13 4, 322-30

Rowe, Jared H; Ertelt, James M; Aguilera, Marijo N; Farrar, Michael A; Way, Sing Sing 2011. Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens. Cell host & microbe, 10 1, 54-64

Rudd, Brian D; Venturi, Vanessa; Li, Gang; Samadder, Partha; Ertelt, James M; Way, Sing Sing; Davenport, Miles P; Nikolich-Žugich, Janko 2011. Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions. Proceedings of the National Academy of Sciences of the United States of America, 108 33, 13694-9

Curtis, Meredith M; Rowell, Emily; Shafiani, Shahin; Negash, Amina; Urdahl, Kevin B; Wilson, Christopher B; Way, Sing Sing 2010. Fidelity of pathogen-specific CD4+ T cells to the Th1 lineage is controlled by exogenous cytokines, interferon-gamma expression, and pathogen lifestyle. Cell host & microbe, 8 2, 163-73

Ertelt, James M; Johanns, Tanner M; Rowe, Jared H; Way, Sing Sing 2010. Interleukin (IL)-21-independent pathogen-specific CD8+ T-cell expansion, and IL-21-dependent suppression of CD4+ T-cell IL-17 production. Immunology, 131 2, 183-91

Johanns, Tanner M; Ertelt, James M; Lai, Joseph C; Rowe, Jared H; Avant, Ross A; Way, Sing Sing 2010. Naturally occurring altered peptide ligands control Salmonella-specific CD4+ T cell proliferation, IFN-gamma production, and protective potency. Journal of immunology (Baltimore, Md. : 1950), 184 2, 869-76

Johanns, Tanner M; Ertelt, James M; Rowe, Jared H; Way, Sing Sing 2010. Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection. PLoS pathogens, 6 8, e1001043

Rudd, Brian D; Venturi, Vanessa; Smithey, Megan J; Way, Sing Sing; Davenport, Miles P; Nikolich-Zugich, Janko 2010. Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection. Journal of immunology (Baltimore, Md. : 1950), 184 6, 2958-65

Winstead, Colleen J; Reilly, Cavan S; Moon, James J; Jenkins, Marc K; Hamilton, Sara E; Jameson, Stephen C; Way, Sing Sing; Khoruts, Alexander 2010. CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia. Journal of immunology (Baltimore, Md. : 1950), 184 9, 4749-60

Curtis, Meredith M; Way, Sing Sing 2009. Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology, 126 2, 177-85

Curtis, Meredith M; Way, Sing Sing; Wilson, Christopher B 2009. IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons. Journal of immunology (Baltimore, Md. : 1950), 183 1, 381-7

Ertelt, James M; Rowe, Jared H; Johanns, Tanner M; Lai, Joseph C; McLachlan, James B; Way, Sing Sing 2009. Selective priming and expansion of antigen-specific Foxp3- CD4+ T cells during Listeria monocytogenes infection. Journal of immunology (Baltimore, Md. : 1950), 182 5, 3032-8

Rowe, Jared H; Johanns, Tanner M; Ertelt, James M; Lai, Joseph C; Way, Sing Sing 2009. Cytotoxic T-lymphocyte antigen 4 blockade augments the T-cell response primed by attenuated Listeria monocytogenes resulting in more rapid clearance of virulent bacterial challenge. Immunology, 128 1 Suppl, e471-8

Asplin, Iain R; Carl, David J; Way, Sing Sing; Jones, Amanda L 2008. Role of Toll-like receptor 2 in innate resistance to Group B Streptococcus. Microbial pathogenesis, 44 1, 43-51

Muller, William J; Orgun, Nural N; Dong, Lichun; Koelle, David M; Huang, Meei-Li; Way, Sing Sing 2008. Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2. Archives of virology, 153 6, 1165-9

Orgun, Nural N; Mathis, Meredith A; Wilson, Christopher B; Way, Sing Sing 2008. Deviation from a strong Th1-dominated to a modest Th17-dominated CD4 T cell response in the absence of IL-12p40 and type I IFNs sustains protective CD8 T cells. Journal of immunology (Baltimore, Md. : 1950), 180 6, 4109-15

Orgun, Nural N; Way, Sing Sing 2008. A critical role for phospholipase C in protective immunity conferred by listeriolysin O-deficient Listeria monocytogenes. Microbial pathogenesis, 44 2, 159-63

Rowe, Jared H; Johanns, Tanner M; Ertelt, James M; Way, Sing Sing 2008. PDL-1 blockade impedes T cell expansion and protective immunity primed by attenuated Listeria monocytogenes. Journal of immunology (Baltimore, Md. : 1950), 180 11, 7553-7

Kollmann, Tobias R; Reikie, Brian; Blimkie, Darren; Way, Sing Sing; Hajjar, Adeline M; Arispe, Kiea; Shaulov, Angela; Wilson, Christopher B 2007. Induction of protective immunity to Listeria monocytogenes in neonates. Journal of immunology (Baltimore, Md. : 1950), 178 6, 3695-701

Orr, Mark T; Orgun, Nural N; Wilson, Christopher B; Way, Sing Sing 2007. Cutting edge: recombinant Listeria monocytogenes expressing a single immune-dominant peptide confers protective immunity to herpes simplex virus-1 infection. Journal of immunology (Baltimore, Md. : 1950), 178 8, 4731-5

Way, Sing Sing; Havenar-Daughton, Colin; Kolumam, Ganesh A; Orgun, Nural N; Murali-Krishna, Kaja 2007. IL-12 and type-I IFN synergize for IFN-gamma production by CD4 T cells, whereas neither are required for IFN-gamma production by CD8 T cells after Listeria monocytogenes infection. Journal of immunology (Baltimore, Md. : 1950), 178 7, 4498-505

Way, Sing Sing; Wilson, Christopher B 2005. The Mycobacterium tuberculosis ESAT-6 homologue in Listeria monocytogenes is dispensable for growth in vitro and in vivo. Infection and immunity, 73 9, 6151-3

Darveau, Richard P; Pham, Thu-Thao T; Lemley, Kayde; Reife, Robert A; Bainbridge, Brian W; Coats, Stephen R; Howald, William N; Way, Sing Sing; Hajjar, Adeline M 2004. Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4. Infection and immunity, 72 9, 5041-51

Kollmann, Tobias R; Way, Sing Sing; Harowicz, Heidi L; Hajjar, Adeline M; Wilson, Christopher B 2004. Deficient MHC class I cross-presentation of soluble antigen by murine neonatal dendritic cells. Blood, 103 11, 4240-2

Way, Sing Sing; Thompson, Lucas J; Lopes, Jared E; Hajjar, Adeline M; Kollmann, Tobias R; Freitag, Nancy E; Wilson, Christopher B 2004. Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity. Cellular microbiology, 6 3, 235-42

Way, Sing Sing; Wilson, Christopher B 2004. Cutting edge: immunity and IFN-gamma production during Listeria monocytogenes infection in the absence of T-bet. Journal of immunology (Baltimore, Md. : 1950), 173 10, 5918-22

Shetron-Rama, Lynne M; Mueller, Kimberly; Bravo, Juan M; Bouwer, H G Archie; Way, Sing Sing; Freitag, Nancy E 2003. Isolation of Listeria monocytogenes mutants with high-level in vitro expression of host cytosol-induced gene products. Molecular microbiology, 48 6, 1537-51

Way, Sing Sing; Kollmann, Tobias R; Hajjar, Adeline M; Wilson, Christopher B 2003. Cutting edge: protective cell-mediated immunity to Listeria monocytogenes in the absence of myeloid differentiation factor 88. Journal of immunology (Baltimore, Md. : 1950), 171 2, 533-7

Kinder, Jeremy M; Jiang, Tony T; Clark, Dayna R; Chaturvedi, Vandana; Xin, Lijun; Ertelt, James M; Way, Sing Sing . Pregnancy-induced maternal regulatory T cells, bona fide memory or maintenance by antigenic reminder from fetal cell microchimerism? Chimerism, 5 1, 16-9