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Photo of  Jeffery Molkentin, Ph.D.

Jeffery Molkentin, Ph.D.

Research Interests

Molecular biology of heart and skeletal muscle disease

Education/Credentials
  • B.S.: Marquette University
  • PhD: Medical College of Wisconsin
Contact Information
  • Cincinnati Children's Hospital Medical Center
  • 240 Albert Sabin Way, MLC7020
  • Molecular Cardiovascular Biology
  • Cincinnati, Ohio 45229
  • Office 513-636-3557
  • Fax 513-636-5958
  • Email jeff.molkentin@cchmc.org
  • UC Institute Member Seal

Peer Reviewed Publications

Antonucci, Salvatore; Di Sante, Moises; Sileikyte, Justina; Deveraux, Jordan; Bauer, Tyler; Bround, Michael J; Menabò, Roberta; Paillard, Melanie; Alanova, Petra; Carraro, Michela; Ovize, Michel; Molkentin, Jeffery D; Cohen, Michael; Forte, Michael A; Bernardi, Paolo; Di Lisa, Fabio; Murphy, Elizabeth 2020. A novel class of cardioprotective small-molecule PTP inhibitors. Pharmacological research, 151 , 104548

Pereira, Ana Helena M; Cardoso, Alisson C; Consonni, Silvio R; Oliveira, Renata R; Saito, Angela; Vaggione, Maria Luisa B; Matos-Souza, Jose R; Carazzolle, Marcelo F; Gonçalves, Anderson; Fernandes, Juliano L; Ribeiro, Gustavo C A; Lopes, Mauricio M; Molkentin, Jeffery D; Franchini, Kleber G 2020. MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure. EBioMedicine, 51 , 102571

Vagnozzi, Ronald J; Maillet, Marjorie; Sargent, Michelle A; Khalil, Hadi; Johansen, Anne Katrine Z; Schwanekamp, Jennifer A; York, Allen J; Huang, Vincent; Nahrendorf, Matthias; Sadayappan, Sakthivel; Molkentin, Jeffery D 2020. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature, 577 7790, 405-409

Altamimi, Tariq R; Karwi, Qutuba G; Uddin, Golam Mezbah; Fukushima, Arata; Kwong, Jennifer Q; Molkentin, Jeffery D; Lopaschuk, Gary D 2019. Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve. Journal of molecular and cellular cardiology, 127 , 223-231

Boyer, Justin G; Prasad, Vikram; Song, Taejeong; Lee, Donghoon; Fu, Xing; Grimes, Kelly M; Sargent, Michelle A; Sadayappan, Sakthivel; Molkentin, Jeffery D 2019. ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. JCI insight, 5 ,

Brody, Matthew J; Vanhoutte, Davy; Bakshi, Chinmay V; Liu, Ruije; Correll, Robert N; Sargent, Michelle A; Molkentin, Jeffery D 2019. Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. The Journal of biological chemistry, 294 22, 8918-8929

Correll, Robert N; Grimes, Kelly M; Prasad, Vikram; Lynch, Jeffrey M; Khalil, Hadi; Molkentin, Jeffery D 2019. Overlapping and differential functions of ATF6? versus ATF6? in the mouse heart. Scientific reports, 9 1, 2059

Johansen, Anne Katrine Z; Molkentin, Jeffery D 2019. Hippo signaling does it again: arbitrating cardiac fibroblast identity and activation. Genes & development, 33 21-22, 1457-1459

Karch, Jason; Bround, Michael J; Khalil, Hadi; Sargent, Michelle A; Latchman, Nadina; Terada, Naohiro; Peixoto, Pablo M; Molkentin, Jeffery D 2019. Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD. Science advances, 5 8, eaaw4597

Khalil, Hadi; Kanisicak, Onur; Vagnozzi, Ronald J.; Johansen, Anne Katrine; Maliken, Bryan D.; Prasad, Vikram; Boyer, Justin G.; Brody, Matthew J.; Schips, Tobias; Kilian, Katja K.; Correll, Robert N.; Kawasaki, Kunito; Nagata, Kazuhiro; Molkentin, Jeffery D. 2019. Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart JCI insight, 4 15, e128722

Murphy, Elizabeth; Bernardi, Paolo; Cohen, Michael; Di Lisa, Fabio; Forte, Michael; Molkentin, Jeffery D; Ovize, Michel 2019. Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease. Circulation research, 124 9, 1294-1296

Schips, Tobias G; Vanhoutte, Davy; Vo, Alexander; Correll, Robert N; Brody, Matthew J; Khalil, Hadi; Karch, Jason; Tjondrokoesoemo, Andoria; Sargent, Michelle A; Maillet, Marjorie; Ross, Robert S; Molkentin, Jeffery D 2019. Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. Nature communications, 10 1, 76

Vagnozzi, Ronald J; Johansen, Anne Katrine Z; Molkentin, Jeffery D 2019. CARdiac Immunotherapy: T Cells Engineered to Treat the Fibrotic Heart. Molecular therapy : the journal of the American Society of Gene Therapy, 27 11, 1869-1871

Wang, Yuhua; Pandey, Ram Naresh; York, Allen J; Mallela, Jaya; Nichols, William C; Hu, Yueh-Chiang; Molkentin, Jeffery D; Wikenheiser-Brokamp, Kathryn A; Hegde, Rashmi S 2019. The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Nature communications, 10 1, 4143

Bhandary, Bidur; Meng, Qinghang; James, Jeanne; Osinska, Hanna; Gulick, James; Valiente-Alandi, Iñigo; Sargent, Michelle A; Bhuiyan, Md Shenuarin; Blaxall, Burns C; Molkentin, Jeffery D; Robbins, Jeffrey 2018. Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF -? Signaling. Journal of the American Heart Association, 7 20, e010013

Brody, Matthew J; Vanhoutte, Davy; Schips, Tobias G; Boyer, Justin G; Bakshi, Chinmay V; Sargent, Michelle A; York, Allen J; Molkentin, Jeffery D 2018. Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy. Molecular and cellular biology, 38 14,

Fu, Xing; Khalil, Hadi; Kanisicak, Onur; Boyer, Justin G; Vagnozzi, Ronald J; Maliken, Bryan D; Sargent, Michelle A; Prasad, Vikram; Valiente-Alandi, Iñigo; Blaxall, Burns C; Molkentin, Jeffery D 2018. Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. The Journal of clinical investigation, 128 5, 2127-2143

Galluzzi, Lorenzo; Vitale, Ilio; Aaronson, Stuart A; Abrams, John M; Adam, Dieter; Agostinis, Patrizia; Alnemri, Emad S; Altucci, Lucia; Amelio, Ivano; Andrews, David W; Annicchiarico-Petruzzelli, Margherita; Antonov, Alexey V; Arama, Eli; Baehrecke, Eric H; Barlev, Nickolai A; Bazan, Nicolas G; Bernassola, Francesca; Bertrand, Mathieu J M; Bianchi, Katiuscia; Blagosklonny, Mikhail V; Blomgren, Klas; Borner, Christoph; Boya, Patricia; Brenner, Catherine; Campanella, Michelangelo; Candi, Eleonora; Carmona-Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K-M; Chandel, Navdeep S; Cheng, Emily H; Chipuk, Jerry E; Cidlowski, John A; Ciechanover, Aaron; Cohen, Gerald M; Conrad, Marcus; Cubillos-Ruiz, Juan R; Czabotar, Peter E; D'Angiolella, Vincenzo; Dawson, Ted M; Dawson, Valina L; De Laurenzi, Vincenzo; De Maria, Ruggero; Debatin, Klaus-Michael; DeBerardinis, Ralph J; Deshmukh, Mohanish; Di Daniele, Nicola; Di Virgilio, Francesco; Dixit, Vishva M; Dixon, Scott J; Duckett, Colin S; Dynlacht, Brian D; El-Deiry, Wafik S; Elrod, John W; Fimia, Gian Maria; Fulda, Simone; García-Sáez, Ana J; Garg, Abhishek D; Garrido, Carmen; Gavathiotis, Evripidis; Golstein, Pierre; Gottlieb, Eyal; Green, Douglas R; Greene, Lloyd A; Gronemeyer, Hinrich; Gross, Atan; Hajnoczky, Gyorgy; Hardwick, J Marie; Harris, Isaac S; Hengartner, Michael O; Hetz, Claudio; Ichijo, Hidenori; Jäättelä, Marja; Joseph, Bertrand; Jost, Philipp J; Juin, Philippe P; Kaiser, William J; Karin, Michael; Kaufmann, Thomas; Kepp, Oliver; Kimchi, Adi; Kitsis, Richard N; Klionsky, Daniel J; Knight, Richard A; Kumar, Sharad; Lee, Sam W; Lemasters, John J; Levine, Beth; Linkermann, Andreas; Lipton, Stuart A; Lockshin, Richard A; López-Otín, Carlos; Lowe, Scott W; Luedde, Tom; Lugli, Enrico; MacFarlane, Marion; Madeo, Frank; Malewicz, Michal; Malorni, Walter; Manic, Gwenola; Marine, Jean-Christophe; Martin, Seamus J; Martinou, Jean-Claude; Medema, Jan Paul; Mehlen, Patrick; Meier, Pascal; Melino, Sonia; Miao, Edward A; Molkentin, Jeffery D; Moll, Ute M; Muñoz-Pinedo, Cristina; Nagata, Shigekazu; Nuñez, Gabriel; Oberst, Andrew; Oren, Moshe; Overholtzer, Michael; Pagano, Michele; Panaretakis, Theocharis; Pasparakis, Manolis; Penninger, Josef M; Pereira, David M; Pervaiz, Shazib; Peter, Marcus E; Piacentini, Mauro; Pinton, Paolo; Prehn, Jochen H M; Puthalakath, Hamsa; Rabinovich, Gabriel A; Rehm, Markus; Rizzuto, Rosario; Rodrigues, Cecilia M P; Rubinsztein, David C; Rudel, Thomas; Ryan, Kevin M; Sayan, Emre; Scorrano, Luca; Shao, Feng; Shi, Yufang; Silke, John; Simon, Hans-Uwe; Sistigu, Antonella; Stockwell, Brent R; Strasser, Andreas; Szabadkai, Gyorgy; Tait, Stephen W G; Tang, Daolin; Tavernarakis, Nektarios; Thorburn, Andrew; Tsujimoto, Yoshihide; Turk, Boris; Vanden Berghe, Tom; Vandenabeele, Peter; Vander Heiden, Matthew G; Villunger, Andreas; Virgin, Herbert W; Vousden, Karen H; Vucic, Domagoj; Wagner, Erwin F; Walczak, Henning; Wallach, David; Wang, Ying; Wells, James A; Wood, Will; Yuan, Junying; Zakeri, Zahra; Zhivotovsky, Boris; Zitvogel, Laurence; Melino, Gerry; Kroemer, Guido 2018. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell death and differentiation, 25 3, 486-541

Hu, Ray; Morley, Michael P; Brandimarto, Jeffrey; Tucker, Nathan R; Parsons, Victoria A; Zhao, Sihai D; Meder, Benjamin; Katus, Hugo A; Rühle, Frank; Stoll, Monika; Villard, Eric; Cambien, François; Lin, Honghuang; Smith, Nicholas L; Felix, Janine F; Vasan, Ramachandran S; van der Harst, Pim; Newton-Cheh, Christopher; Li, Jin; Kim, Cecilia E; Hakonarson, Hakon; Hannenhalli, Sridhar; Ashley, Euan A; Moravec, Christine S; Tang, W H Wilson; Maillet, Marjorie; Molkentin, Jeffery D; Ellinor, Patrick T; Margulies, Kenneth B; Cappola, Thomas P 2018. Genetic Reduction in Left Ventricular Protein Kinase C-? and Adverse Ventricular Remodeling in Human Subjects. Circulation. Genomic and precision medicine, 11 3, e001901

Kwong, Jennifer Q; Huo, Jiuzhou; Bround, Michael J; Boyer, Justin G; Schwanekamp, Jennifer A; Ghazal, Nasab; Maxwell, Joshua T; Jang, Young C; Khuchua, Zaza; Shi, Kevin; Bers, Donald M; Davis, Jennifer; Molkentin, Jeffery D 2018. The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. JCI insight, 3 22,

Li, Yingxin; Zhang, Xiaoxiao; Zhang, Chen; Zhang, Xiaoying; Li, Ying; Qi, Zhao; Szeto, Christopher; Tang, Mingxin; Peng, Yizhi; Molkentin, Jeffery D; Houser, Steven R; Xie, Mingxing; Chen, Xiongwen 2018. Increasing T-type calcium channel activity by ?-adrenergic stimulation contributes to ?-adrenergic regulation of heart rates. The Journal of physiology, 596 7, 1137-1151

Maliken, Bryan D; Kanisicak, Onur; Karch, Jason; Khalil, Hadi; Fu, Xing; Boyer, Justin G; Prasad, Vikram; Zheng, Yi; Molkentin, Jeffery D 2018. Gata4-Dependent Differentiation of c-Kit+-Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation, 138 10, 1012-1024

Maliken, Bryan D; Molkentin, Jeffery D 2018. Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell. Circulation, 138 8, 806-808

Melfsen, Andreas; Holstermann, Max; Haeussermann, Angelika; Molkentin, Joachim; Susenbeth, Andreas; Hartung, Eberhard 2018. Accuracy and application of milk fatty acid estimation with diffuse reflectance near-infrared spectroscopy. The Journal of dairy research, 85 2, 212-221

Meng, Qinghang; Bhandary, Bidur; Bhuiyan, Md Shenuarin; James, Jeanne; Osinska, Hanna; Valiente-Alandi, Iñigo; Shay-Winkler, Kritton; Gulick, James; Molkentin, Jeffery D; Blaxall, Burns C; Robbins, Jeffrey 2018. Myofibroblast-Specific TGF? Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy. Circulation research, 123 12, 1285-1297

Nayak, Gowri; Odaka, Yoshinobu; Prasad, Vikram; Solano, Alyssa F; Yeo, Eun-Jin; Vemaraju, Shruti; Molkentin, Jeffery D; Trumpp, Andreas; Williams, Bart; Rao, Sujata; Lang, Richard A 2018. Developmental vascular regression is regulated by a Wnt/?-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death. Development (Cambridge, England), 145 12,

Neidig, Lauren E; Weinberger, Florian; Palpant, Nathan J; Mignone, John; Martinson, Amy M; Sorensen, Daniel W; Bender, Ingrid; Nemoto, Natsumi; Reinecke, Hans; Pabon, Lil; Molkentin, Jeffery D; Murry, Charles E; van Berlo, Jop H 2018. Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart. Circulation, 138 25, 2960-2962

Olivares-Florez, Silvana; Czolbe, Martin; Riediger, Fabian; Seidlmayer, Lea; Williams, Tatjana; Nordbeck, Peter; Strasen, Jörn; Glocker, Cristina; Jänsch, Monique; Eder-Negrin, Petra; Arias-Loza, Paula; Mühlfelder, Melanie; Pla?ki?, Jelena; Heinze, Katrin G; Molkentin, Jeffery D; Engelhardt, Stefan; Kockskämper, Jens; Ritter, Oliver 2018. Nuclear calcineurin is a sensor for detecting Ca2+ release from the nuclear envelope via IP3R. Journal of molecular medicine (Berlin, Germany), 96 11, 1239-1249

Schulz, Franziska; Westreicher-Kristen, Edwin; Knappstein, Karin; Molkentin, Joachim; Susenbeth, Andreas 2018. Replacing maize silage plus soybean meal with red clover silage plus wheat in diets for lactating dairy cows. Journal of dairy science, 101 2, 1216-1226

Schulz, Franziska; Westreicher-Kristen, Edwin; Molkentin, Joachim; Knappstein, Karin; Susenbeth, Andreas 2018. Effect of replacing maize silage with red clover silage in the diet on milk fatty acid composition in cows. Journal of dairy science, 101 8, 7156-7167

Stremmel, C; Schuchert, R; Wagner, F; Thaler, R; Weinberger, T; Pick, R; Mass, E; Ishikawa-Ankerhold, H C; Margraf, A; Hutter, S; Vagnozzi, R; Klapproth, S; Frampton, J; Yona, S; Scheiermann, C; Molkentin, J D; Jeschke, U; Moser, M; Sperandio, M; Massberg, S; Geissmann, F; Schulz, C 2018. Author Correction: Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. Nature communications, 9 1, 3699

Stremmel, C; Schuchert, R; Wagner, F; Thaler, R; Weinberger, T; Pick, R; Mass, E; Ishikawa-Ankerhold, H C; Margraf, A; Hutter, S; Vagnozzi, R; Klapproth, S; Frampton, J; Yona, S; Scheiermann, C; Molkentin, J D; Jeschke, U; Moser, M; Sperandio, M; Massberg, S; Geissmann, F; Schulz, C 2018. Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. Nature communications, 9 1, 75

Vagnozzi, Ronald J; Molkentin, Jeffery D; Houser, Steven R 2018. New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications. Circulation research, 123 2, 159-176

Vagnozzi, Ronald J; Sargent, Michelle A; Lin, Suh-Chin J; Palpant, Nathan J; Murry, Charles E; Molkentin, Jeffery D 2018. Genetic Lineage Tracing of Sca-1+ Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart. Circulation, 138 25, 2931-2939

Valiente-Alandi, Iñigo; Potter, Sarah J; Salvador, Ane M; Schafer, Allison E; Schips, Tobias; Carrillo-Salinas, Francisco; Gibson, Aaron M; Nieman, Michelle L; Perkins, Charles; Sargent, Michelle A; Huo, Jiuzhou; Lorenz, John N; DeFalco, Tony; Molkentin, Jeffery D; Alcaide, Pilar; Blaxall, Burns C 2018. Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure. Circulation, 138 12, 1236-1252

van Berlo, Jop H; Kanisicak, Onur; Maillet, Marjorie; Vagnozzi, Ronald J; Karch, Jason; Lin, Suh-Chin J; Middleton, Ryan C; Marbán, Eduardo; Molkentin, Jeffery D 2018. van Berlo et al. reply. Nature, 555 7697, E18

Accornero, Federica; Schips, Tobias G; Petrosino, Jennifer M; Gu, Shan-Qing; Kanisicak, Onur; van Berlo, Jop H; Molkentin, Jeffery D 2017. BEX1 is an RNA-dependent mediator of cardiomyopathy. Nature communications, 8 1, 1875

Cai, Chen-Leng; Molkentin, Jeffery D 2017. The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away. Circulation research, 120 2, 400-406

Correll, Robert N; Lynch, Jeffrey M; Schips, Tobias G; Prasad, Vikram; York, Allen J; Sargent, Michelle A; Brochet, Didier X P; Ma, Jianjie; Molkentin, Jeffery D 2017. Mitsugumin 29 regulates t-tubule architecture in the failing heart. Scientific reports, 7 1, 5328

Correll, Robert N; Makarewich, Catherine A; Zhang, Hongyu; Zhang, Chen; Sargent, Michelle A; York, Allen J; Berretta, Remus M; Chen, Xiongwen; Houser, Steven R; Molkentin, Jeffery D 2017. Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart. Cardiovascular research, 113 7, 749-759

Eschenhagen, Thomas; Bolli, Roberto; Braun, Thomas; Field, Loren J; Fleischmann, Bernd K; Frisén, Jonas; Giacca, Mauro; Hare, Joshua M; Houser, Steven; Lee, Richard T; Marbán, Eduardo; Martin, James F; Molkentin, Jeffery D; Murry, Charles E; Riley, Paul R; Ruiz-Lozano, Pilar; Sadek, Hesham A; Sussman, Mark A; Hill, Joseph A 2017. Cardiomyocyte Regeneration: A Consensus Statement. Circulation, 136 7, 680-686

He, Lingjuan; Huang, Xiuzhen; Kanisicak, Onur; Li, Yi; Wang, Yue; Li, Yan; Pu, Wenjuan; Liu, Qiaozhen; Zhang, Hui; Tian, Xueying; Zhao, Huan; Liu, Xiuxiu; Zhang, Shaohua; Nie, Yu; Hu, Shengshou; Miao, Xiang; Wang, Qing-Dong; Wang, Fengchao; Chen, Ting; Xu, Qingbo; Lui, Kathy O; Molkentin, Jeffery D; Zhou, Bin 2017. Preexisting endothelial cells mediate cardiac neovascularization after injury. The Journal of clinical investigation, 127 8, 2968-2981

Henke, Anika; Dickhoefer, Uta; Westreicher-Kristen, Edwin; Knappstein, Karin; Molkentin, Joachim; Hasler, Mario; Susenbeth, Andreas 2017. Effect of dietary Quebracho tannin extract on feed intake, digestibility, excretion of urinary purine derivatives and milk production in dairy cows. Archives of animal nutrition, 71 1, 37-53

Henke, Anika; Westreicher-Kristen, Edwin; Molkentin, Joachim; Dickhoefer, Uta; Knappstein, Karin; Hasler, Mario; Susenbeth, Andreas 2017. Effect of dietary quebracho tannin extract on milk fatty acid composition in cows. Journal of dairy science, 100 8, 6229-6238

Kanisicak, Onur; Vagnozzi, Ronald J; Molkentin, Jeffery D 2017. Identity Crisis for Regenerative Cardiac cKit+ Cells. Circulation research, 121 10, 1130-1132

Karch, Jason; Schips, Tobias G; Maliken, Bryan D; Brody, Matthew J; Sargent, Michelle A; Kanisicak, Onur; Molkentin, Jeffery D 2017. Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak. eLife, 6 ,

Khalil, Hadi; Kanisicak, Onur; Prasad, Vikram; Correll, Robert N; Fu, Xing; Schips, Tobias; Vagnozzi, Ronald J; Liu, Ruijie; Huynh, Thanh; Lee, Se-Jin; Karch, Jason; Molkentin, Jeffery D 2017. Fibroblast-specific TGF-?-Smad2/3 signaling underlies cardiac fibrosis. The Journal of clinical investigation, 127 10, 3770-3783

Khalil, Hadi; Maillet, Marjorie; Molkentin, Jeffery D 2017. Spatial Gene Profiling in the Ischemic Heart: Fibroblasts Put on Their SOX. Circulation, 136 15, 1410-1411

Klir, Z; Castro-Montoya, J M; Novoselec, J; Molkentin, J; Domacinovic, M; Mioc, B; Dickhoefer, U; Antunovic, Z 2017. Influence of pumpkin seed cake and extruded linseed on milk production and milk fatty acid profile in Alpine goats. Animal : an international journal of animal bioscience, 11 10, 1772-1778

Luongo, Timothy S; Lambert, Jonathan P; Gross, Polina; Nwokedi, Mary; Lombardi, Alyssa A; Shanmughapriya, Santhanam; Carpenter, April C; Kolmetzky, Devin; Gao, Erhe; van Berlo, Jop H; Tsai, Emily J; Molkentin, Jeffery D; Chen, Xiongwen; Madesh, Muniswamy; Houser, Steven R; Elrod, John W 2017. The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability. Nature, 545 7652, 93-97

McLendon, Patrick M; Davis, Gregory; Gulick, James; Singh, Sonia R; Xu, Na; Salomonis, Nathan; Molkentin, Jeffery D; Robbins, Jeffrey 2017. An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels. Circulation research, 121 6, 604-616

Molkentin, Jan-Philip; Nägele, Matthias P; Frank, Michelle; Sudano, Isabella; Enseleit, Frank; Wilhelm, Markus J; Lüscher, Thomas F; Maisano, Francesco; Ruschitzka, Frank; Flammer, Andreas J 2017. Prognostic value of mean pulmonary artery pressure in the stable phase after heart transplantation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 52 4, 775-780

Molkentin, Jeffery D; Bugg, Darrian; Ghearing, Natasha; Dorn, Lisa E; Kim, Peter; Sargent, Michelle A; Gunaje, Jagadambika; Otsu, Kinya; Davis, Jennifer 2017. Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis. Circulation, 136 6, 549-561

Schwanekamp, Jennifer A; Lorts, Angela; Sargent, Michelle A; York, Allen J; Grimes, Kelly M; Fischesser, Demetria M; Gokey, Jason J; Whitsett, Jeffrey A; Conway, Simon J; Molkentin, Jeffery D 2017. TGFBI functions similar to periostin but is uniquely dispensable during cardiac injury. PloS one, 12 7, e0181945

Sharp, Thomas E; Kubo, Hajime; Berretta, Remus M; Starosta, Timothy; Wallner, Markus; Schena, Giana J; Hobby, Alexander R; Yu, Daohai; Trappanese, Danielle M; George, Jon C; Molkentin, Jeffery D; Houser, Steven R 2017. Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction. JACC. Basic to translational science, 2 6, 669-683

Tallquist, Michelle D; Molkentin, Jeffery D 2017. Redefining the identity of cardiac fibroblasts. Nature reviews. Cardiology, 14 8, 484-491

Travers, Joshua G; Kamal, Fadia A; Valiente-Alandi, Iñigo; Nieman, Michelle L; Sargent, Michelle A; Lorenz, John N; Molkentin, Jeffery D; Blaxall, Burns C 2017. Pharmacological and Activated Fibroblast Targeting of G??-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression. Journal of the American College of Cardiology, 70 8, 958-971

Brody, Matthew J; Schips, Tobias G; Vanhoutte, Davy; Kanisicak, Onur; Karch, Jason; Maliken, Bryan D; Blair, N Scott; Sargent, Michelle A; Prasad, Vikram; Molkentin, Jeffery D 2016. Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling. Molecular and cellular biology, 36 1, 2-12

Cunha, Daniel A; Cito, Monia; Carlsson, Per-Ola; Vanderwinden, Jean-Marie; Molkentin, Jeffery D; Bugliani, Marco; Marchetti, Piero; Eizirik, Décio L; Cnop, Miriam 2016. Thrombospondin 1 protects pancreatic ?-cells from lipotoxicity via the PERK-NRF2 pathway. Cell death and differentiation, 23 12, 1995-2006

Davis, Jennifer; Davis, L Craig; Correll, Robert N; Makarewich, Catherine A; Schwanekamp, Jennifer A; Moussavi-Harami, Farid; Wang, Dan; York, Allen J; Wu, Haodi; Houser, Steven R; Seidman, Christine E; Seidman, Jonathan G; Regnier, Michael; Metzger, Joseph M; Wu, Joseph C; Molkentin, Jeffery D 2016. A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell, 165 5, 1147-1159

Kanisicak, Onur; Khalil, Hadi; Ivey, Malina J; Karch, Jason; Maliken, Bryan D; Correll, Robert N; Brody, Matthew J; J Lin, Suh-Chin; Aronow, Bruce J; Tallquist, Michelle D; Molkentin, Jeffery D 2016. Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nature communications, 7 , 12260

Kanisicak, Onur; Molkentin, Jeffery D 2016. Applying Modern Transcriptomics to Interrogate the Human Cardiac Fibroblast. JACC. Basic to translational science, 1 7, 603-605

Kim, Jung Ha; Kim, Kabsun; Kim, Inyoung; Seong, Semun; Jeong, Byung-Chul; Nam, Kwang-Il; Kim, Kyung Keun; Molkentin, Jeffery D; Kim, Nacksung 2016. RCANs regulate the convergent roles of NFATc1 in bone homeostasis. Scientific reports, 6 , 38526

Lamar, Kay-Marie; Bogdanovich, Sasha; Gardner, Brandon B; Gao, Quan Q; Miller, Tamari; Earley, Judy U; Hadhazy, Michele; Vo, Andy H; Wren, Lisa; Molkentin, Jeffery D; McNally, Elizabeth M 2016. Overexpression of Latent TGF? Binding Protein 4 in Muscle Ameliorates Muscular Dystrophy through Myostatin and TGF?. PLoS genetics, 12 5, e1006019

Liu, Ruijie; Khalil, Hadi; Lin, Suh-Chin J; Sargent, Michelle A; York, Allen J; Molkentin, Jeffery D 2016. Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart. PloS one, 11 10, e0164897

Liu, Ruijie; Molkentin, Jeffery D 2016. Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs). Journal of molecular and cellular cardiology, 101 , 44-49

Liu, Ruijie; van Berlo, Jop H; York, Allen J; Vagnozzi, Ronald J; Maillet, Marjorie; Molkentin, Jeffery D 2016. DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Circulation research, 119 2, 249-60

Lu, Xiyuan; Kwong, Jennifer Q; Molkentin, Jeffery D; Bers, Donald M 2016. Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings. Circulation research, 118 5, 834-41

Mukherjee, Rajarshi; Mareninova, Olga A; Odinokova, Irina V; Huang, Wei; Murphy, John; Chvanov, Michael; Javed, Muhammad A; Wen, Li; Booth, David M; Cane, Matthew C; Awais, Muhammad; Gavillet, Bruno; Pruss, Rebecca M; Schaller, Sophie; Molkentin, Jeffery D; Tepikin, Alexei V; Petersen, Ole H; Pandol, Stephen J; Gukovsky, Ilya; Criddle, David N; Gukovskaya, Anna S; Sutton, Robert 2016. Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. Gut, 65 8, 1333-46

Schwanekamp, Jennifer A; Lorts, Angela; Vagnozzi, Ronald J; Vanhoutte, Davy; Molkentin, Jeffery D 2016. Deletion of Periostin Protects Against Atherosclerosis in Mice by Altering Inflammation and Extracellular Matrix Remodeling. Arteriosclerosis, thrombosis, and vascular biology, 36 1, 60-8

Seidlmayer, Lea K; Kuhn, Johannes; Berbner, Annette; Arias-Loza, Paula-Anahi; Williams, Tatjana; Kaspar, Mathias; Czolbe, Martin; Kwong, Jennifer Q; Molkentin, Jeffery D; Heinze, Katrin Gertrud; Dedkova, Elena N; Ritter, Oliver 2016. Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes. Cardiovascular research, 112 1, 491-501

Tjondrokoesoemo, Andoria; Schips, Tobias G; Sargent, Michelle A; Vanhoutte, Davy; Kanisicak, Onur; Prasad, Vikram; Lin, Suh-Chin J; Maillet, Marjorie; Molkentin, Jeffery D 2016. Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice. The Journal of biological chemistry, 291 19, 9920-8

Tjondrokoesoemo, Andoria; Schips, Tobias; Kanisicak, Onur; Sargent, Michelle A; Molkentin, Jeffery D 2016. Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Human molecular genetics, 25 6, 1192-202

van Berlo, Jop H; Molkentin, Jeffery D 2016. Most of the Dust Has Settled: cKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo. Circulation research, 118 1, 17-9

Vanhoutte, Davy; Schips, Tobias G; Kwong, Jennifer Q; Davis, Jennifer; Tjondrokoesoemo, Andoria; Brody, Matthew J; Sargent, Michelle A; Kanisicak, Onur; Yi, Hong; Gao, Quan Q; Rabinowitz, Joseph E; Volk, Talila; McNally, Elizabeth M; Molkentin, Jeffery D 2016. Thrombospondin expression in myofibers stabilizes muscle membranes. eLife, 5 ,

Wallner, Markus; Duran, Jason M; Mohsin, Sadia; Troupes, Constantine D; Vanhoutte, Davy; Borghetti, Giulia; Vagnozzi, Ronald J; Gross, Polina; Yu, Daohai; Trappanese, Danielle M; Kubo, Hajime; Toib, Amir; Sharp, Thomas E; Harper, Shavonn C; Volkert, Michael A; Starosta, Timothy; Feldsott, Eric A; Berretta, Remus M; Wang, Tao; Barbe, Mary F; Molkentin, Jeffrey D; Houser, Steven R 2016. Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration. Circulation research, 119 7, 865-79

Zhang, Xiaoying; Ai, Xiaojie; Nakayama, Hiroyuki; Chen, Biyi; Harris, David M; Tang, Mingxin; Xie, Yuping; Szeto, Christopher; Li, Yingxin; Li, Ying; Zhang, Hongyu; Eckhart, Andrea D; Koch, Walter J; Molkentin, Jeffery D; Chen, Xiongwen 2016. Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias. Basic research in cardiology, 111 1, 4

Zhu, Xiang; Hogan, Simon P; Molkentin, Jeffery D; Zimmermann, Nives 2016. Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils. American journal of physiology. Gastrointestinal and liver physiology, 310 8, G609-17

Accornero, Federica; van Berlo, Jop H; Correll, Robert N; Elrod, John W; Sargent, Michelle A; York, Allen; Rabinowitz, Joseph E; Leask, Andrew; Molkentin, Jeffery D 2015. Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor ? Signaling and Cardiac Remodeling. Molecular and cellular biology, 35 12, 2154-64

Burr, A R; Molkentin, J D 2015. Genetic evidence in the mouse solidifies the calcium hypothesis of myofiber death in muscular dystrophy. Cell death and differentiation, 22 9, 1402-12

Correll, Robert N; Goonasekera, Sanjeewa A; van Berlo, Jop H; Burr, Adam R; Accornero, Federica; Zhang, Hongyu; Makarewich, Catherine A; York, Allen J; Sargent, Michelle A; Chen, Xiongwen; Houser, Steven R; Molkentin, Jeffery D 2015. STIM1 elevation in the heart results in aberrant Ca²? handling and cardiomyopathy. Journal of molecular and cellular cardiology, 87 , 38-47

Davis, Jennifer; Salomonis, Nathan; Ghearing, Natasha; Lin, Suh-Chin J; Kwong, Jennifer Q; Mohan, Apoorva; Swanson, Maurice S; Molkentin, Jeffery D 2015. MBNL1-mediated regulation of differentiation RNAs promotes myofibroblast transformation and the fibrotic response. Nature communications, 6 , 10084

Gainutdinov, T; Molkentin, J D; Siemen, D; Ziemer, M; Debska-Vielhaber, G; Vielhaber, S; Gizatullina, Z; Orynbayeva, Z; Gellerich, F N 2015. Knockout of cyclophilin D in Ppif?/? mice increases stability of brain mitochondria against Ca²? stress. Archives of biochemistry and biophysics, 579 , 40-6

Jin, Shunqian; Orabi, Abrahim I; Le, Tianming; Javed, Tanveer A; Sah, Swati; Eisses, John F; Bottino, Rita; Molkentin, Jeffery D; Husain, Sohail Z 2015. Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-?B, Calcium Signaling, and Calcineurin. Gastroenterology, 149 3, 753-64.e11

Karch, Jason; Kanisicak, Onur; Brody, Matthew J; Sargent, Michelle A; Michael, Demetria M; Molkentin, Jeffery D 2015. Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death. PloS one, 10 6, e0130520

Karch, Jason; Molkentin, Jeffery D 2015. Regulated necrotic cell death: the passive aggressive side of Bax and Bak. Circulation research, 116 11, 1800-9

Kwong, Jennifer Q; Lu, Xiyuan; Correll, Robert N; Schwanekamp, Jennifer A; Vagnozzi, Ronald J; Sargent, Michelle A; York, Allen J; Zhang, Jianyi; Bers, Donald M; Molkentin, Jeffery D 2015. The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart. Cell reports, 12 1, 15-22

Kwong, Jennifer Q; Molkentin, Jeffery D 2015. Physiological and pathological roles of the mitochondrial permeability transition pore in the heart. Cell metabolism, 21 2, 206-214

Li, Lei; Chen, Yi; Li, Jing; Yin, Haifeng; Guo, Xiaoyun; Doan, Jessica; Molkentin, Jeffery D; Liu, Qinghang 2015. TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NF?B, and Bnip3 Pathways. Scientific reports, 5 , 16626

Liu, Ruijie; Correll, Robert N; Davis, Jennifer; Vagnozzi, Ronald J; York, Allen J; Sargent, Michelle A; Nairn, Angus C; Molkentin, Jeffery D 2015. Cardiac-specific deletion of protein phosphatase 1? promotes increased myofilament protein phosphorylation and contractile alterations. Journal of molecular and cellular cardiology, 87 , 204-13

Mázala, Davi A G; Pratt, Stephen J P; Chen, Dapeng; Molkentin, Jeffery D; Lovering, Richard M; Chin, Eva R 2015. SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models. American journal of physiology. Cell physiology, 308 9, C699-709

Pfluger, Paul T; Kabra, Dhiraj G; Aichler, Michaela; Schriever, Sonja C; Pfuhlmann, Katrin; García, Verónica Casquero; Lehti, Maarit; Weber, Jon; Kutschke, Maria; Rozman, Jan; Elrod, John W; Hevener, Andrea L; Feuchtinger, Annette; Hrab? de Angelis, Martin; Walch, Axel; Rollmann, Stephanie M; Aronow, Bruce J; Müller, Timo D; Perez-Tilve, Diego; Jastroch, Martin; De Luca, Maria; Molkentin, Jeffery D; Tschöp, Matthias H 2015. Calcineurin Links Mitochondrial Elongation with Energy Metabolism. Cell metabolism, 22 5, 838-50

Shojaee, Seyedmehdi; Caeser, Rebecca; Buchner, Maike; Park, Eugene; Swaminathan, Srividya; Hurtz, Christian; Geng, Huimin; Chan, Lai N; Klemm, Lars; Hofmann, Wolf-Karsten; Qiu, Yi Hua; Zhang, Nianxiang; Coombes, Kevin R; Paietta, Elisabeth; Molkentin, Jeffery; Koeffler, H Phillip; Willman, Cheryl L; Hunger, Stephen P; Melnick, Ari; Kornblau, Steven M; Müschen, Markus 2015. Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer cell, 28 1, 114-28

Sopariwala, Danesh H; Pant, Meghna; Shaikh, Sana A; Goonasekera, Sanjeewa A; Molkentin, Jeffery D; Weisleder, Noah; Ma, Jianjie; Pan, Zui; Periasamy, Muthu 2015. Sarcolipin overexpression improves muscle energetics and reduces fatigue. Journal of applied physiology (Bethesda, Md. : 1985), 118 8, 1050-8

Accornero, Federica; Kanisicak, Onur; Tjondrokoesoemo, Andoria; Attia, Aria C; McNally, Elizabeth M; Molkentin, Jeffery D 2014. Myofiber-specific inhibition of TGF? signaling protects skeletal muscle from injury and dystrophic disease in mice. Human molecular genetics, 23 25, 6903-15

Burr, Adam R; Millay, Douglas P; Goonasekera, Sanjeewa A; Park, Ki Ho; Sargent, Michelle A; Collins, James; Altamirano, Francisco; Philipson, Kenneth D; Allen, Paul D; Ma, Jianjie; López, José Rafael; Molkentin, Jeffery D 2014. Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice. Molecular and cellular biology, 34 11, 1991-2002

Ceco, Ermelinda; Bogdanovich, Sasha; Gardner, Brandon; Miller, Tamari; DeJesus, Adam; Earley, Judy U; Hadhazy, Michele; Smith, Lucas R; Barton, Elisabeth R; Molkentin, Jeffery D; McNally, Elizabeth M 2014. Targeting latent TGF? release in muscular dystrophy. Science translational medicine, 6 259, 259ra144

Correll, Robert N; Eder, Petra; Burr, Adam R; Despa, Sanda; Davis, Jennifer; Bers, Donald M; Molkentin, Jeffery D 2014. Overexpression of the Na+/K+ ATPase ?2 but not ?1 isoform attenuates pathological cardiac hypertrophy and remodeling. Circulation research, 114 2, 249-256

Davis, Jennifer; Molkentin, Jeffery D 2014. Myofibroblasts: trust your heart and let fate decide. Journal of molecular and cellular cardiology, 70 , 9-18

Goldstein, Jeffery A; Bogdanovich, Sasha; Beiriger, Anastasia; Wren, Lisa M; Rossi, Ann E; Gao, Quan Q; Gardner, Brandon B; Earley, Judy U; Molkentin, Jeffery D; McNally, Elizabeth M 2014. Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy. Human molecular genetics, 23 25, 6722-31

Goonasekera, Sanjeewa A; Davis, Jennifer; Kwong, Jennifer Q; Accornero, Federica; Wei-LaPierre, Lan; Sargent, Michelle A; Dirksen, Robert T; Molkentin, Jeffery D 2014. Enhanced Ca²? influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Human molecular genetics, 23 14, 3706-15

Gupta, Manish K; Gulick, James; Liu, Ruijie; Wang, Xuejun; Molkentin, Jeffery D; Robbins, Jeffrey 2014. Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes. Circulation research, 115 8, 721-9

Gutiérrez-Aguilar, Manuel; Douglas, Diana L; Gibson, Anne K; Domeier, Timothy L; Molkentin, Jeffery D; Baines, Christopher P 2014. Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition. Journal of molecular and cellular cardiology, 72 , 316-25

Karch, Jason; Molkentin, Jeffery D 2014. Identifying the components of the elusive mitochondrial permeability transition pore. Proceedings of the National Academy of Sciences of the United States of America, 111 29, 10396-7

Khatlani, T; Pradhan, S; Da, Q; Gushiken, F C; Bergeron, A L; Langlois, K W; Molkentin, J D; Rumbaut, R E; Vijayan, K V 2014. The ? isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in ?II b ?3 integrin signaling. Journal of thrombosis and haemostasis : JTH, 12 12, 2089-101

Kwong, J Q; Davis, J; Baines, C P; Sargent, M A; Karch, J; Wang, X; Huang, T; Molkentin, J D 2014. Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy. Cell death and differentiation, 21 8, 1209-17

Lauriol, Jessica; Keith, Kimberly; Jaffré, Fabrice; Couvillon, Anthony; Saci, Abdel; Goonasekera, Sanjeewa A; McCarthy, Jason R; Kessinger, Chase W; Wang, Jianxun; Ke, Qingen; Kang, Peter M; Molkentin, Jeffery D; Carpenter, Christopher; Kontaridis, Maria I 2014. RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis. Science signaling, 7 348, ra100

Li, Lei; Chen, Yi; Doan, Jessica; Murray, Jason; Molkentin, Jeffery D; Liu, Qinghang 2014. Transforming growth factor ?-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling. Circulation, 130 24, 2162-72

Makarewich, Catherine A; Zhang, Hongyu; Davis, Jennifer; Correll, Robert N; Trappanese, Danielle M; Hoffman, Nicholas E; Troupes, Constantine D; Berretta, Remus M; Kubo, Hajime; Madesh, Muniswamy; Chen, Xiongwen; Gao, Erhe; Molkentin, Jeffery D; Houser, Steven R 2014. Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction. Circulation research, 115 6, 567-580

Molkentin, Jeffery D 2014. Letter by Molkentin regarding article, "The absence of evidence is not evidence of absence: the pitfalls of Cre Knock-Ins in the c-Kit Locus". Circulation research, 115 8, e21-3

Molkentin, Jeffery D; Houser, Steven R 2014. Response to Torella et al. Circulation research, 114 4, e27

Molkentin, Jeffrey; Williams, Ruth 2014. Jeffery Molkentin: delves into cell death. Interview by Ruth Williams. Circulation research, 114 2, 239-41

Rainer, Peter P; Hao, Scarlett; Vanhoutte, Davy; Lee, Dong Ik; Koitabashi, Norimichi; Molkentin, Jeffery D; Kass, David A 2014. Cardiomyocyte-specific transforming growth factor ? suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction. Circulation research, 114 8, 1246-57

Taddeo, E P; Laker, R C; Breen, D S; Akhtar, Y N; Kenwood, B M; Liao, J A; Zhang, M; Fazakerley, D J; Tomsig, J L; Harris, T E; Keller, S R; Chow, J D; Lynch, K R; Chokki, M; Molkentin, J D; Turner, N; James, D E; Yan, Z; Hoehn, K L 2014. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Molecular metabolism, 3 2, 124-34

Tane, Shoji; Kubota, Misae; Okayama, Hitomi; Ikenishi, Aiko; Yoshitome, Satoshi; Iwamoto, Noriko; Satoh, Yukio; Kusakabe, Aoi; Ogawa, Satoko; Kanai, Ayumi; Molkentin, Jeffery D; Nakamura, Kazuomi; Ohbayashi, Tetsuya; Takeuchi, Takashi 2014. Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes. The Journal of biological chemistry, 289 26, 18033-44

van Berlo, Jop H; Kanisicak, Onur; Maillet, Marjorie; Vagnozzi, Ronald J; Karch, Jason; Lin, Suh-Chin J; Middleton, Ryan C; Marbán, Eduardo; Molkentin, Jeffery D 2014. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature, 509 7500, 337-41

van Berlo, Jop H; Molkentin, Jeffery D 2014. An emerging consensus on cardiac regeneration. Nature medicine, 20 12, 1386-93

Wissing, Erin R; Boyer, Justin G; Kwong, Jennifer Q; Sargent, Michelle A; Karch, Jason; McNally, Elizabeth M; Otsu, Kinya; Molkentin, Jeffery D 2014. P38? MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism. Human molecular genetics, 23 20, 5452-63

Auger-Messier, Mannix; Accornero, Federica; Goonasekera, Sanjeewa A; Bueno, Orlando F; Lorenz, John N; van Berlo, Jop H; Willette, Robert N; Molkentin, Jeffery D 2013. Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy. Circulation research, 112 1, 48-56

Braitsch, Caitlin M; Kanisicak, Onur; van Berlo, Jop H; Molkentin, Jeffery D; Yutzey, Katherine E 2013. Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease. Journal of molecular and cellular cardiology, 65 , 108-19

Correll, Robert N; Molkentin, Jeffery D 2013. CaMKII does it again: even the mitochondria cannot escape its influence. Circulation research, 112 9, 1208-11

Davis, Jennifer; Kwong, Jennifer Q; Kitsis, Richard N; Molkentin, Jeffery D 2013. Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle. PloS one, 8 12, e82053

Elrod, John W; Molkentin, Jeffery D 2013. Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore. Circulation journal : official journal of the Japanese Circulation Society, 77 5, 1111-22

Karch, Jason; Kwong, Jennifer Q; Burr, Adam R; Sargent, Michelle A; Elrod, John W; Peixoto, Pablo M; Martinez-Caballero, Sonia; Osinska, Hanna; Cheng, Emily H-Y; Robbins, Jeffrey; Kinnally, Kathleen W; Molkentin, Jeffery D 2013. Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. eLife, 2 , e00772

Maillet, Marjorie; van Berlo, Jop H; Molkentin, Jeffery D 2013. Molecular basis of physiological heart growth: fundamental concepts and new players. Nature reviews. Molecular cell biology, 14 1, 38-48

Molkentin, Jeffery D 2013. Parsing good versus bad signaling pathways in the heart: role of calcineurin-nuclear factor of activated T-cells. Circulation research, 113 1, 16-9

Molkentin, Jeffery D; Houser, Steven R 2013. Are resident c-Kit+ cardiac stem cells really all that are needed to mend a broken heart? Circulation research, 113 9, 1037-9

Molkentin, Joachim 2013. Applicability of organic milk indicators to the authentication of processed products. Food chemistry, 137 1-4, 25-30

Muili, Kamaldeen A; Wang, Dong; Orabi, Abrahim I; Sarwar, Sheharyar; Luo, Yuhuan; Javed, Tanveer A; Eisses, John F; Mahmood, Syeda M; Jin, Shunqian; Singh, Vijay P; Ananthanaravanan, Meena; Perides, George; Williams, John A; Molkentin, Jeffery D; Husain, Sohail Z 2013. Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin. The Journal of biological chemistry, 288 1, 570-80

Nicholson, Chad K; Lambert, Jonathan P; Molkentin, Jeffery D; Sadoshima, Junichi; Calvert, John W 2013. Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure. Arteriosclerosis, thrombosis, and vascular biology, 33 4, 744-51

Suk, Hee Yun; Zhou, Chen; Yang, Teddy T C; Zhu, Hong; Yu, Raymond Y L; Olabisi, Opeyemi; Yang, XiaoYong; Brancho, Deborah; Kim, Ja-Young; Scherer, Philipp E; Frank, Philippe G; Lisanti, Michael P; Calvert, John W; Lefer, David J; Molkentin, Jeffery D; Ghigo, Alessandra; Hirsch, Emilio; Jin, Jianping; Chow, Chi-Wing 2013. Ablation of calcineurin A? reveals hyperlipidemia and signaling cross-talks with phosphodiesterases. The Journal of biological chemistry, 288 5, 3477-88

van Berlo, Jop H; Aronow, Bruce J; Molkentin, Jeffery D 2013. Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response. PloS one, 8 12, e84591

van Berlo, Jop H; Maillet, Marjorie; Molkentin, Jeffery D 2013. Signaling effectors underlying pathologic growth and remodeling of the heart. The Journal of clinical investigation, 123 1, 37-45

Wang, Fang; Gao, Hui; Kubo, Hajime; Fan, Xiaoxuan; Zhang, Hongyu; Berretta, Remus; Chen, Xiongwen; Sharp, Thomas; Starosta, Timothy; Makarewich, Catherine; Li, Ying; Molkentin, Jeffrey D; Houser, Steven R 2013. T-type Ca²? channels regulate the exit of cardiac myocytes from the cell cycle after birth. Journal of molecular and cellular cardiology, 62 , 122-30

Bal, Naresh C; Maurya, Santosh K; Sopariwala, Danesh H; Sahoo, Sanjaya K; Gupta, Subash C; Shaikh, Sana A; Pant, Meghna; Rowland, Leslie A; Bombardier, Eric; Goonasekera, Sanjeewa A; Tupling, A Russell; Molkentin, Jeffery D; Periasamy, Muthu 2012. Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Nature medicine, 18 10, 1575-9

Bolte, Craig; Zhang, Yufang; York, Allen; Kalin, Tanya V; Schultz, Jo El J; Molkentin, Jeffery D; Kalinichenko, Vladimir V 2012. Postnatal ablation of Foxm1 from cardiomyocytes causes late onset cardiac hypertrophy and fibrosis without exacerbating pressure overload-induced cardiac remodeling. PloS one, 7 11, e48713

Davis, Jennifer; Burr, Adam R; Davis, Gregory F; Birnbaumer, Lutz; Molkentin, Jeffery D 2012. A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo. Developmental cell, 23 4, 705-15

Davis, Jennifer; Maillet, Marjorie; Miano, Joseph M; Molkentin, Jeffery D 2012. Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research. Circulation research, 111 6, 761-77

Drawnel, Faye M; Wachten, Dagmar; Molkentin, Jeffery D; Maillet, Marjorie; Aronsen, Jan Magnus; Swift, Fredrik; Sjaastad, Ivar; Liu, Ning; Catalucci, Daniele; Mikoshiba, Katsuhiko; Hisatsune, Chihiro; Okkenhaug, Hanneke; Andrews, Simon R; Bootman, Martin D; Roderick, H Llewelyn 2012. Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy. The Journal of cell biology, 199 5, 783-98

Gao, Hui; Wang, Fang; Wang, Wei; Makarewich, Catherine A; Zhang, Hongyu; Kubo, Hajime; Berretta, Remus M; Barr, Larry A; Molkentin, Jeffery D; Houser, Steven R 2012. Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling. Journal of molecular and cellular cardiology, 53 5, 657-67

Goonasekera, Sanjeewa A; Hammer, Karin; Auger-Messier, Mannix; Bodi, Ilona; Chen, Xiongwen; Zhang, Hongyu; Reiken, Steven; Elrod, John W; Correll, Robert N; York, Allen J; Sargent, Michelle A; Hofmann, Franz; Moosmang, Sven; Marks, Andrew R; Houser, Steven R; Bers, Donald M; Molkentin, Jeffery D 2012. Decreased cardiac L-type Ca²? channel activity induces hypertrophy and heart failure in mice. The Journal of clinical investigation, 122 1, 280-90

Goonasekera, Sanjeewa A; Molkentin, Jeffery D 2012. Unraveling the secrets of a double life: contractile versus signaling Ca2+ in a cardiac myocyte. Journal of molecular and cellular cardiology, 52 2, 317-22

Houser, Steven R; Margulies, Kenneth B; Murphy, Anne M; Spinale, Francis G; Francis, Gary S; Prabhu, Sumanth D; Rockman, Howard A; Kass, David A; Molkentin, Jeffery D; Sussman, Mark A; Koch, Walter J; Koch, Walter 2012. Animal models of heart failure: a scientific statement from the American Heart Association. Circulation research, 111 1, 131-50

Karch, Jason; Molkentin, Jeffery D 2012. Is p53 the long-sought molecular trigger for cyclophilin D-regulated mitochondrial permeability transition pore formation and necrosis? Circulation research, 111 10, 1258-60

Liu, Qinghang; Chen, Yi; Auger-Messier, Mannix; Molkentin, Jeffery D 2012. Interaction between NF?B and NFAT coordinates cardiac hypertrophy and pathological remodeling. Circulation research, 110 8, 1077-86

Lorts, Angela; Schwanekamp, Jennifer A; Baudino, Troy A; McNally, Elizabeth M; Molkentin, Jeffery D 2012. Deletion of periostin reduces muscular dystrophy and fibrosis in mice by modulating the transforming growth factor-? pathway. Proceedings of the National Academy of Sciences of the United States of America, 109 27, 10978-83

Lynch, Jeffrey M; Maillet, Marjorie; Vanhoutte, Davy; Schloemer, Aryn; Sargent, Michelle A; Blair, N Scott; Lynch, Kaari A; Okada, Tetsuya; Aronow, Bruce J; Osinska, Hanna; Prywes, Ron; Lorenz, John N; Mori, Kazutoshi; Lawler, Jack; Robbins, Jeffrey; Molkentin, Jeffery D 2012. A thrombospondin-dependent pathway for a protective ER stress response. Cell, 149 6, 1257-68

Maejima, Yasuhiro; Galeotti, Jonathan; Molkentin, Jeffery D; Sadoshima, Junichi; Zhai, Peiyong 2012. Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3? during aging and hemodynamic pressure overload. American journal of physiology. Heart and circulatory physiology, 303 8, H979-88

Makarewich, Catherine A; Correll, Robert N; Gao, Hui; Zhang, Hongyu; Yang, Baohua; Berretta, Remus M; Rizzo, Victor; Molkentin, Jeffery D; Houser, Steven R 2012. A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility. Circulation research, 110 5, 669-74

Muili, Kamaldeen A; Ahmad, Mahwish; Orabi, Abrahim I; Mahmood, Syeda M; Shah, Ahsan U; Molkentin, Jeffery D; Husain, Sohail Z 2012. Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury. American journal of physiology. Gastrointestinal and liver physiology, 302 8, G898-905

Quadrato, Giorgia; Benevento, Marco; Alber, Stefanie; Jacob, Carolin; Floriddia, Elisa M; Nguyen, Tuan; Elnaggar, Mohamed Y; Pedroarena, Christine M; Molkentin, Jeffrey D; Di Giovanni, Simone 2012. Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America, 109 23, E1499-508

Schulz, Emily M; Correll, Richard N; Sheikh, Hajer N; Lofrano-Alves, Marco S; Engel, Patti L; Newman, Gilbert; Schultz, Jo El J; Molkentin, Jeffery D; Wolska, Beata M; Solaro, R John; Wieczorek, David F 2012. Tropomyosin dephosphorylation results in compensated cardiac hypertrophy. The Journal of biological chemistry, 287 53, 44478-89

Accornero, Federica; Molkentin, Jeffery D 2011. Placental growth factor as a protective paracrine effector in the heart. Trends in cardiovascular medicine, 21 8, 220-4

Accornero, Federica; van Berlo, Jop H; Benard, Matthew J; Lorenz, John N; Carmeliet, Peter; Molkentin, Jeffery D 2011. Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism. Circulation research, 109 3, 272-80

Bolli, Roberto; Stein, Adam B; Guo, Yiru; Wang, Ou-Li; Rokosh, Gregg; Dawn, Buddhadeb; Molkentin, Jeffery D; Sanganalmath, Santosh K; Zhu, Yanqing; Xuan, Yu-Ting 2011. A murine model of inducible, cardiac-specific deletion of STAT3: its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning. Journal of molecular and cellular cardiology, 50 4, 589-97

Bolte, Craig; Zhang, Yufang; Wang, I-Ching; Kalin, Tanya V; Molkentin, Jeffrey D; Kalinichenko, Vladimir V 2011. Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development. PloS one, 6 7, e22217

Breitbart, Astrid; Auger-Messier, Mannix; Molkentin, Jeffery D; Heineke, Joerg 2011. Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting. American journal of physiology. Heart and circulatory physiology, 300 6, H1973-82

Ch'en, Irene L; Tsau, Jennifer S; Molkentin, Jeffery D; Komatsu, Masaaki; Hedrick, Stephen M 2011. Mechanisms of necroptosis in T cells. The Journal of experimental medicine, 208 4, 633-41

Chen, Xiongwen; Nakayama, Hiroyuki; Zhang, Xiaoying; Ai, Xiaojie; Harris, David M; Tang, Mingxin; Zhang, Hongyu; Szeto, Christopher; Stockbower, Kathryn; Berretta, Remus M; Eckhart, Andrea D; Koch, Walter J; Molkentin, Jeffery D; Houser, Steven R 2011. Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. Journal of molecular and cellular cardiology, 50 3, 460-70

Eder, Petra; Molkentin, Jeffery D 2011. TRPC channels as effectors of cardiac hypertrophy. Circulation research, 108 2, 265-72

Froese, Natali; Kattih, Badder; Breitbart, Astrid; Grund, Andrea; Geffers, Robert; Molkentin, Jeffery D; Kispert, Andreas; Wollert, Kai C; Drexler, Helmut; Heineke, Joerg 2011. GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/activin receptor-like kinase 5 signaling. The Journal of biological chemistry, 286 7, 5680-90

Goonasekera, Sanjeewa A; Lam, Chi K; Millay, Douglas P; Sargent, Michelle A; Hajjar, Roger J; Kranias, Evangelia G; Molkentin, Jeffery D 2011. Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle. The Journal of clinical investigation, 121 3, 1044-52

Hom, Jennifer R; Quintanilla, Rodrigo A; Hoffman, David L; de Mesy Bentley, Karen L; Molkentin, Jeffery D; Sheu, Shey-Shing; Porter, George A 2011. The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Developmental cell, 21 3, 469-78

Kehat, Izhak; Accornero, Federica; Aronow, Bruce J; Molkentin, Jeffery D 2011. Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins. The Journal of cell biology, 193 1, 21-9

Kehat, Izhak; Davis, Jennifer; Tiburcy, Malte; Accornero, Federica; Saba-El-Leil, Marc K; Maillet, Marjorie; York, Allen J; Lorenz, John N; Zimmermann, Wolfram H; Meloche, Sylvain; Molkentin, Jeffery D 2011. Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. Circulation research, 108 2, 176-83

Korf-Klingebiel, Mortimer; Kempf, Tibor; Schlüter, Klaus-Dieter; Willenbockel, Christian; Brod, Torben; Heineke, Jörg; Schmidt, Volker J; Jantzen, Franziska; Brandes, Ralf P; Sugden, Peter H; Drexler, Helmut; Molkentin, Jeffery D; Wollert, Kai C 2011. Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction. Circulation, 123 5, 504-14

Ladage, Dennis; Tilemann, Lisa; Ishikawa, Kiyotake; Correll, Robert N; Kawase, Yoshiaki; Houser, Steven R; Molkentin, Jeffery D; Hajjar, Roger J 2011. Inhibition of PKC?/? with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. Circulation research, 109 12, 1396-400

Liu, Qinghang; Molkentin, Jeffery D 2011. Protein kinase C? as a heart failure therapeutic target. Journal of molecular and cellular cardiology, 51 4, 474-8

Meissner, Marcel; Weissgerber, Petra; Londoño, Juan E Camacho; Prenen, Jean; Link, Sabine; Ruppenthal, Sandra; Molkentin, Jeffery D; Lipp, Peter; Nilius, Bernd; Freichel, Marc; Flockerzi, Veit 2011. Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene. The Journal of biological chemistry, 286 18, 15875-82

Molkentin, Jeffery D 2011. The transcription factor C/EBPbeta serves as a master regulator of physiologic cardiac hypertrophy. Circulation research, 108 3, 277-8

Qian, Li; Wythe, Joshua D; Liu, Jiandong; Cartry, Jerome; Vogler, Georg; Mohapatra, Bhagyalaxmi; Otway, Robyn T; Huang, Yu; King, Isabelle N; Maillet, Marjorie; Zheng, Yi; Crawley, Timothy; Taghli-Lamallem, Ouarda; Semsarian, Christopher; Dunwoodie, Sally; Winlaw, David; Harvey, Richard P; Fatkin, Diane; Towbin, Jeffrey A; Molkentin, Jeffery D; Srivastava, Deepak; Ocorr, Karen; Bruneau, Benoit G; Bodmer, Rolf 2011. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. The Journal of cell biology, 193 7, 1181-96

Reddy, Ramesh N; Knotts, Taylor L; Roberts, Brian R; Molkentin, Jeffery D; Price, S Russ; Gooch, Jennifer L 2011. Calcineurin A-? is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine, 15 2, 414-22

Sadayappan, Sakthivel; Gulick, James; Osinska, Hanna; Barefield, David; Cuello, Friederike; Avkiran, Metin; Lasko, Valerie M; Lorenz, John N; Maillet, Marjorie; Martin, Jody L; Brown, Joan Heller; Bers, Donald M; Molkentin, Jeffery D; James, Jeanne; Robbins, Jeffrey 2011. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circulation research, 109 2, 141-50

Sengupta, Arunima; Molkentin, Jeffery D; Paik, Ji-Hye; DePinho, Ronald A; Yutzey, Katherine E 2011. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. The Journal of biological chemistry, 286 9, 7468-78

Stefater, James A; Lewkowich, Ian; Rao, Sujata; Mariggi, Giovanni; Carpenter, April C; Burr, Adam R; Fan, Jieqing; Ajima, Rieko; Molkentin, Jeffery D; Williams, Bart O; Wills-Karp, Marsha; Pollard, Jeffrey W; Yamaguchi, Terry; Ferrara, Napoleone; Gerhardt, Holger; Lang, Richard A 2011. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature, 474 7352, 511-5

Sugden, Peter H; Markou, Thomais; Fuller, Stephen J; Tham, El Li; Molkentin, Jeffery D; Paterson, Hugh F; Clerk, Angela 2011. Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active. Cellular signalling, 23 2, 468-77

van Berlo, Jop H; Elrod, John W; Aronow, Bruce J; Pu, William T; Molkentin, Jeffery D 2011. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America, 108 30, 12331-6

Wansapura, Janaka P; Millay, Douglas P; Dunn, R Scott; Molkentin, Jeffery D; Benson, D Woodrow 2011. Magnetic resonance imaging assessment of cardiac dysfunction in ?-sarcoglycan null mice. Neuromuscular disorders : NMD, 21 1, 68-73

Xiang, Sunny Yang; Vanhoutte, Davy; Del Re, Dominic P; Purcell, Nicole H; Ling, Haiyun; Banerjee, Indroneal; Bossuyt, Julie; Lang, Richard A; Zheng, Yi; Matkovich, Scot J; Miyamoto, Shigeki; Molkentin, Jeffery D; Dorn, Gerald W; Brown, Joan Heller 2011. RhoA protects the mouse heart against ischemia/reperfusion injury. The Journal of clinical investigation, 121 8, 3269-76

Yamaguchi, Naohiro; Chakraborty, Asima; Pasek, Daniel A; Molkentin, Jeffery D; Meissner, Gerhard 2011. Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules. American journal of physiology. Heart and circulatory physiology, 300 6, H2187-95

Andersson, Kristin B; Winer, Lisbeth H; Mørk, Halvor K; Molkentin, Jeffery D; Jaisser, Frédéric 2010. Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts. Transgenic research, 19 4, 715-25

Elrod, John W; Wong, Renee; Mishra, Shikha; Vagnozzi, Ronald J; Sakthievel, Bhuvana; Goonasekera, Sanjeewa A; Karch, Jason; Gabel, Scott; Farber, John; Force, Thomas; Brown, Joan Heller; Murphy, Elizabeth; Molkentin, Jeffery D 2010. Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. The Journal of clinical investigation, 120 10, 3680-7

Force, Thomas; Bonow, Robert O; Houser, Steven R; Solaro, R John; Hershberger, Ray E; Adhikari, Bishow; Anderson, Mark E; Boineau, Robin; Byrne, Barry J; Cappola, Thomas P; Kalluri, Raghu; LeWinter, Martin M; Maron, Martin S; Molkentin, Jeffery D; Ommen, Steve R; Regnier, Michael; Tang, W H Wilson; Tian, Rong; Konstam, Marvin A; Maron, Barry J; Seidman, Christine E 2010. Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation, 122 11, 1130-3

Gilio, Karen; Harper, Matthew T; Cosemans, Judith M E M; Konopatskaya, Olga; Munnix, Imke C A; Prinzen, Lenneke; Leitges, Michael; Liu, Qinghang; Molkentin, Jeffery D; Heemskerk, Johan W M; Poole, Alastair W 2010. Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen. The Journal of biological chemistry, 285 30, 23410-9

Harper, Matthew T; Molkentin, Jeffery D; Poole, Alastair W 2010. Protein kinase C alpha enhances sodium-calcium exchange during store-operated calcium entry in mouse platelets. Cell calcium, 48 6, 333-40

Heineke, Joerg; Auger-Messier, Mannix; Correll, Robert N; Xu, Jian; Benard, Matthew J; Yuan, Weiping; Drexler, Helmut; Parise, Leslie V; Molkentin, Jeffery D 2010. CIB1 is a regulator of pathological cardiac hypertrophy. Nature medicine, 16 8, 872-9

Heineke, Joerg; Auger-Messier, Mannix; Xu, Jian; Sargent, Michelle; York, Allen; Welle, Stephen; Molkentin, Jeffery D 2010. Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation, 121 3, 419-25

Heineke, Joerg; Wollert, Kai C; Osinska, Hanna; Sargent, Michelle A; York, Allen J; Robbins, Jeffrey; Molkentin, Jeffery D 2010. Calcineurin protects the heart in a murine model of dilated cardiomyopathy. Journal of molecular and cellular cardiology, 48 6, 1080-7

Kehat, Izhak; Molkentin, Jeffery D 2010. Molecular pathways underlying cardiac remodeling during pathophysiological stimulation. Circulation, 122 25, 2727-35

Kehat, Izhak; Molkentin, Jeffery D 2010. Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy. Annals of the New York Academy of Sciences, 1188 , 96-102

Kitsis, Richard N; Molkentin, Jeffery D 2010. Apoptotic cell death "Nixed" by an ER-mitochondrial necrotic pathway. Proceedings of the National Academy of Sciences of the United States of America, 107 20, 9031-2

Maillet, Marjorie; Davis, Jennifer; Auger-Messier, Mannix; York, Allen; Osinska, Hanna; Piquereau, Jérôme; Lorenz, John N; Robbins, Jeffrey; Ventura-Clapier, Renée; Molkentin, Jeffery D 2010. Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function. The Journal of biological chemistry, 285 9, 6716-24

Marber, Michael S; Molkentin, Jeffery D; Force, Thomas 2010. Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point. Drug discovery today. Disease mechanisms, 7 2, e123-e127

Molkentin, Joachim; Giesemann, Anette 2010. Follow-up of stable isotope analysis of organic versus conventional milk. Analytical and bioanalytical chemistry, 398 3, 1493-500

Nakayama, Hiroyuki; Bodi, Ilona; Maillet, Marjorie; DeSantiago, Jaime; Domeier, Timothy L; Mikoshiba, Katsuhiko; Lorenz, John N; Blatter, Lothar A; Bers, Donald M; Molkentin, Jeffery D 2010. The IP3 receptor regulates cardiac hypertrophy in response to select stimuli. Circulation research, 107 5, 659-66

Navedo, Manuel F; Cheng, Edward P; Yuan, Can; Votaw, Scott; Molkentin, Jeffery D; Scott, John D; Santana, Luis F 2010. Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circulation research, 106 4, 748-56

Navedo, Manuel F; Takeda, Yukari; Nieves-Cintrón, Madeline; Molkentin, Jeffery D; Santana, Luis F 2010. Elevated Ca2+ sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells. American journal of physiology. Cell physiology, 298 2, C211-20

Quinsay, Melissa N; Lee, Youngil; Rikka, Shivaji; Sayen, M Richard; Molkentin, Jeffery D; Gottlieb, Roberta A; Gustafsson, Asa B 2010. Bnip3 mediates permeabilization of mitochondria and release of cytochrome c via a novel mechanism. Journal of molecular and cellular cardiology, 48 6, 1146-56

Rinne, Andreas; Kapur, Nidhi; Molkentin, Jeffery D; Pogwizd, Steven M; Bers, Donald M; Banach, Kathrin; Blatter, Lothar A 2010. Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure. American journal of physiology. Heart and circulatory physiology, 298 6, H2001-9

Sun, Tao; Wu, Xin-Sheng; Xu, Jianhua; McNeil, Benjamin D; Pang, Zhiping P; Yang, Wanjun; Bai, Li; Qadri, Syed; Molkentin, Jeffery D; Yue, David T; Wu, Ling-Gang 2010. The role of calcium/calmodulin-activated calcineurin in rapid and slow endocytosis at central synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30 35, 11838-47

Tang, Mingxin; Li, Jie; Huang, Wei; Su, Huabo; Liang, Qiangrong; Tian, Zongwen; Horak, Kathleen M; Molkentin, Jeffery D; Wang, Xuejun 2010. Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts. Cardiovascular research, 88 3, 424-33

Tang, Mingxin; Zhang, Xiaoying; Li, Yingxin; Guan, Yinzheng; Ai, Xiaojie; Szeto, Christopher; Nakayama, Hiroyuki; Zhang, Hongyu; Ge, Shuping; Molkentin, Jeffery D; Houser, Steven R; Chen, Xiongwen 2010. Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity. American journal of physiology. Heart and circulatory physiology, 299 2, H519-28

Teekakirikul, Polakit; Eminaga, Seda; Toka, Okan; Alcalai, Ronny; Wang, Libin; Wakimoto, Hiroko; Nayor, Matthew; Konno, Tetsuo; Gorham, Joshua M; Wolf, Cordula M; Kim, Jae B; Schmitt, Joachim P; Molkentin, Jefferey D; Norris, Russell A; Tager, Andrew M; Hoffman, Stanley R; Markwald, Roger R; Seidman, Christine E; Seidman, Jonathan G 2010. Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-?. The Journal of clinical investigation, 120 10, 3520-9

Tsika, Richard W; Ma, Lixin; Kehat, Izhak; Schramm, Christine; Simmer, Gretchen; Morgan, Brandon; Fine, Deborah M; Hanft, Laurin M; McDonald, Kerry S; Molkentin, Jeffery D; Krenz, Maike; Yang, Steve; Ji, Juan 2010. TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. The Journal of biological chemistry, 285 18, 13721-35

van Berlo, Jop H; Elrod, John W; van den Hoogenhof, Maarten M G; York, Allen J; Aronow, Bruce J; Duncan, Stephen A; Molkentin, Jeffery D 2010. The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circulation research, 107 8, 1032-40

Wissing, Erin R; Millay, Douglas P; Vuagniaux, Grégoire; Molkentin, Jeffery D 2010. Debio-025 is more effective than prednisone in reducing muscular pathology in mdx mice. Neuromuscular disorders : NMD, 20 11, 753-60

Wu, Xu; Eder, Petra; Chang, Baojun; Molkentin, Jeffery D 2010. TRPC channels are necessary mediators of pathologic cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America, 107 15, 7000-5

Zhang, Hongyu; Chen, Xiongwen; Gao, Erhe; MacDonnell, Scott M; Wang, Wei; Kolpakov, Mikhail; Nakayama, Hiroyuki; Zhang, Xiaoying; Jaleel, Naser; Harris, David M; Li, Yingxin; Tang, Mingxin; Berretta, Remus; Leri, Annarosa; Kajstura, Jan; Sabri, Abdelkarim; Koch, Walter J; Molkentin, Jeffery D; Houser, Steven R 2010. Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction. Circulation research, 107 6, 800-9

Zhu, Hong; Suk, Hee Yun; Yu, Raymond Y L; Brancho, Deborah; Olabisi, Opeyemi; Yang, Teddy T C; Yang, XiaoYong; Zhang, Jialin; Moussaif, Mustapha; Durand, Jorge L; Jelicks, Linda A; Kim, Ja-Young; Scherer, Philipp E; Frank, Philippe G; Lisanti, Michael P; Calvert, John W; Duranski, Mark R; Lefer, David J; Huston, Elaine; Baillie, George S; Houslay, Miles D; Molkentin, Jeffrey D; Jin, Jianping; Chow, Chi-Wing 2010. Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D. Molecular and cellular biology, 30 18, 4379-90

Andersson, Kristin Brevik; Birkeland, Jon Arne Kro; Finsen, Alexandra Vanessa; Louch, William E; Sjaastad, Ivar; Wang, Yibin; Chen, Ju; Molkentin, Jeffery D; Chien, Kenneth R; Sejersted, Ole M; Christensen, Geir 2009. Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. Journal of molecular and cellular cardiology, 47 2, 180-7

Baines, Christopher P; Molkentin, Jeffery D 2009. Adenine nucleotide translocase-1 induces cardiomyocyte death through upregulation of the pro-apoptotic protein Bax. Journal of molecular and cellular cardiology, 46 6, 969-77

Bommireddy, R; Bueno, O F; Martin, J; Ormsby, I; Chen, H; Gard, C; Molkentin, J D; Boivin, G P; Babcock, G F; Doetschman, T 2009. Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice. Clinical and experimental immunology, 158 3, 317-24

Carneiro, Leticia A M; Travassos, Leonardo H; Soares, Fraser; Tattoli, Ivan; Magalhaes, Joao G; Bozza, Marcelo T; Plotkowski, Maria C; Sansonetti, Philippe J; Molkentin, Jeffery D; Philpott, Dana J; Girardin, Stephen E 2009. Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell host & microbe, 5 2, 123-36

Diwan, Abhinav; Matkovich, Scot J; Yuan, Qunying; Zhao, Wen; Yatani, Atsuko; Brown, Joan Heller; Molkentin, Jeffery D; Kranias, Evangelia G; Dorn, Gerald W 2009. Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. The Journal of clinical investigation, 119 1, 203-12

Donaldson, Cameron; Eder, Sarah; Baker, Corey; Aronovitz, Mark J; Weiss, Alexandra Dabreo; Hall-Porter, Monica; Wang, Feng; Ackerman, Adam; Karas, Richard H; Molkentin, Jeffery D; Patten, Richard D 2009. Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation. Circulation research, 104 2, 265-75, 11p followin

Dzau, Victor J; Molkentin, Jeffery D 2009. Helmut Drexler, MD, 1951-2009. Circulation, 120 23, 2402-3

Gelpi, Ricardo J; Gao, Shumin; Zhai, Peiyong; Yan, Lin; Hong, Chull; Danridge, Lauren M A; Ge, Hui; Maejima, Yasahiro; Donato, Martin; Yokota, Mitsuhiro; Molkentin, Jeffery D; Vatner, Dorothy E; Vatner, Stephen F; Sadoshima, Junichi 2009. Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload. American journal of physiology. Heart and circulatory physiology, 297 5, H1814-9

Hsu, Steven; Nagayama, Takahiro; Koitabashi, Norimichi; Zhang, Manling; Zhou, Liye; Bedja, Djahida; Gabrielson, Kathleen L; Molkentin, Jeffery D; Kass, David A; Takimoto, Eiki 2009. Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway. Cardiovascular research, 81 2, 301-9

Ito, Kaoru; Akazawa, Hiroshi; Tamagawa, Masaji; Furukawa, Kensuke; Ogawa, Wataru; Yasuda, Noritaka; Kudo, Yoko; Liao, Chien-hui; Yamamoto, Rie; Sato, Toshiaki; Molkentin, Jeffery D; Kasuga, Masato; Noda, Tetsuo; Nakaya, Haruaki; Komuro, Issei 2009. PDK1 coordinates survival pathways and beta-adrenergic response in the heart. Proceedings of the National Academy of Sciences of the United States of America, 106 21, 8689-94

Konopatskaya, Olga; Gilio, Karen; Harper, Matthew T; Zhao, Yan; Cosemans, Judith M E M; Karim, Zubair A; Whiteheart, Sidney W; Molkentin, Jeffery D; Verkade, Paul; Watson, Steve P; Heemskerk, Johan W M; Poole, Alastair W 2009. PKCalpha regulates platelet granule secretion and thrombus formation in mice. The Journal of clinical investigation, 119 2, 399-407

Liu, Qinghang; Busby, Jennifer Caldwell; Molkentin, Jeffery D 2009. Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nature cell biology, 11 2, 154-61

Liu, Qinghang; Chen, Xiongwen; Macdonnell, Scott M; Kranias, Evangelia G; Lorenz, John N; Leitges, Michael; Houser, Steven R; Molkentin, Jeffery D 2009. Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circulation research, 105 2, 194-200

Liu, Qinghang; Sargent, Michelle A; York, Allen J; Molkentin, Jeffery D 2009. ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice. Circulation research, 105 11, 1110-7

Lorts, Angela; Schwanekamp, Jennifer A; Elrod, John W; Sargent, Michelle A; Molkentin, Jeffery D 2009. Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair. Circulation research, 104 1, e1-7

MacDonnell, Scott M; Weisser-Thomas, Jutta; Kubo, Hajime; Hanscome, Marie; Liu, Qinghang; Jaleel, Naser; Berretta, Remus; Chen, Xiongwen; Brown, Joan H; Sabri, Abdel-Karim; Molkentin, Jeffery D; Houser, Steven R 2009. CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circulation research, 105 4, 316-25

Maillet, Marjorie; Lynch, Jeffrey M; Sanna, Bastiano; York, Allen J; Zheng, Yi; Molkentin, Jeffery D 2009. Cdc42 is an antihypertrophic molecular switch in the mouse heart. The Journal of clinical investigation, 119 10, 3079-88

Martin, Lee J; Gertz, Barry; Pan, Yan; Price, Ann C; Molkentin, Jeffery D; Chang, Qing 2009. The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice. Experimental neurology, 218 2, 333-46

Millay, Douglas P; Goonasekera, Sanjeewa A; Sargent, Michelle A; Maillet, Marjorie; Aronow, Bruce J; Molkentin, Jeffery D 2009. Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America, 106 45, 19023-8

Millay, Douglas P; Maillet, Marjorie; Roche, Joseph A; Sargent, Michelle A; McNally, Elizabeth M; Bloch, Robert J; Molkentin, Jeffery D 2009. Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy. The American journal of pathology, 175 5, 1817-23

Molkentin, Jeffery D; Robbins, Jeffrey 2009. With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure. Journal of molecular and cellular cardiology, 46 2, 130-6

Molkentin, Joachim 2009. Authentication of organic milk using delta13C and the alpha-linolenic acid content of milk fat. Journal of agricultural and food chemistry, 57 3, 785-90

Nakayama, Hiroyuki; Bodi, Ilona; Correll, Robert N; Chen, Xiongwen; Lorenz, John; Houser, Steven R; Robbins, Jeffrey; Schwartz, Arnold; Molkentin, Jeffery D 2009. alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. The Journal of clinical investigation, 119 12, 3787-96

Qian, Jiang; Ren, Xiaoping; Wang, Xiaohong; Zhang, Pengyuan; Jones, W Keith; Molkentin, Jeffery D; Fan, Guo-Chang; Kranias, Evangelia G 2009. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circulation research, 105 12, 1223-31

Sadayappan, Sakthivel; Gulick, James; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffery D; Robbins, Jeffrey 2009. Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background. Circulation, 119 9, 1253-62

Sengupta, Arunima; Molkentin, Jeffery D; Yutzey, Katherine E 2009. FoxO transcription factors promote autophagy in cardiomyocytes. The Journal of biological chemistry, 284 41, 28319-31

Tkatchenko, Tatiana V; Moreno-Rodriguez, Ricardo A; Conway, Simon J; Molkentin, Jeffery D; Markwald, Roger R; Tkatchenko, Andrei V 2009. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Physiological genomics, 39 3, 160-8

Wu, Xu; Chang, Baojun; Blair, N Scott; Sargent, Michelle; York, Allen J; Robbins, Jeffrey; Shull, Gary E; Molkentin, Jeffery D 2009. Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. The Journal of clinical investigation, 119 4, 976-85

Yang, Yong Jun; Chen, Wei; Edgar, Alexander; Li, Bo; Molkentin, Jeffery D; Berman, Jason N; Lin, Tong-Jun 2009. Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function. The Journal of experimental medicine, 206 1, 195-207

Ago, Tetsuro; Liu, Tong; Zhai, Peiyong; Chen, Wei; Li, Hong; Molkentin, Jeffery D; Vatner, Stephen F; Sadoshima, Junichi 2008. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell, 133 6, 978-93

Blanchard, C; Mingler, M K; McBride, M; Putnam, P E; Collins, M H; Chang, G; Stringer, K; Abonia, J P; Molkentin, J D; Rothenberg, M E 2008. Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. Mucosal immunology, 1 4, 289-96

Conway, Simon J; Molkentin, Jeffery D 2008. Periostin as a heterofunctional regulator of cardiac development and disease. Current genomics, 9 8, 548-55

da Costa Martins, Paula A; Bourajjaj, Meriem; Gladka, Monika; Kortland, Mara; van Oort, Ralph J; Pinto, Yigal M; Molkentin, Jeffery D; De Windt, Leon J 2008. Conditional dicer gene deletion in the postnatal myocardium provokes spontaneous cardiac remodeling. Circulation, 118 15, 1567-76

Du, Heng; Guo, Lan; Fang, Fang; Chen, Doris; Sosunov, Alexander A; McKhann, Guy M; Yan, Yilin; Wang, Chunyu; Zhang, Hong; Molkentin, Jeffery D; Gunn-Moore, Frank J; Vonsattel, Jean Paul; Arancio, Ottavio; Chen, John Xi; Yan, Shi Du 2008. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nature medicine, 14 10, 1097-105

Fuller, Stephen J; Pikkarainen, Sampsa; Tham, El Li; Cullingford, Timothy E; Molkentin, Jeffery D; Cornils, Hauke; Hergovich, Alexander; Hemmings, Brian A; Clerk, Angela; Sugden, Peter H 2008. Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors. Cellular signalling, 20 8, 1564-77

Gurda, Grzegorz T; Guo, LiLi; Lee, Sae-Hong; Molkentin, Jeffery D; Williams, John A 2008. Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo. Molecular biology of the cell, 19 1, 198-206

Houser, Steven R; Molkentin, Jeffery D 2008. Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes? Science signaling, 1 25, pe31

Jaleel, Naser; Nakayama, Hiroyuki; Chen, Xiongwen; Kubo, Hajime; MacDonnell, Scott; Zhang, Hongyu; Berretta, Remus; Robbins, Jeffrey; Cribbs, Leanne; Molkentin, Jeffery D; Houser, Steven R 2008. Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes. Circulation research, 103 10, 1109-19

Jobe, Shawn M; Wilson, Katina M; Leo, Lorie; Raimondi, Alejandro; Molkentin, Jeffery D; Lentz, Steven R; Di Paola, Jorge 2008. Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis. Blood, 111 3, 1257-65

Krenz, Maike; Gulick, James; Osinska, Hanna E; Colbert, Melissa C; Molkentin, Jeffery D; Robbins, Jeffrey 2008. Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proceedings of the National Academy of Sciences of the United States of America, 105 48, 18930-5

Maillet, Marjorie; Purcell, Nicole H; Sargent, Michelle A; York, Allen J; Bueno, Orlando F; Molkentin, Jeffery D 2008. DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. The Journal of biological chemistry, 283 45, 31246-55

Manicassamy, Santhakumar; Gupta, Sonal; Huang, Zhaofeng; Molkentin, Jeffery D; Shang, Weirong; Sun, Zuoming 2008. Requirement of calcineurin a beta for the survival of naive T cells. Journal of immunology (Baltimore, Md. : 1950), 180 1, 106-12

Millay, Douglas P; Sargent, Michelle A; Osinska, Hanna; Baines, Christopher P; Barton, Elisabeth R; Vuagniaux, Grégoire; Sweeney, H Lee; Robbins, Jeffrey; Molkentin, Jeffery D 2008. Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nature medicine, 14 4, 442-7

Morancho, Beatriz; Minguillón, Jordi; Molkentin, Jeffery D; López-Rodríguez, Cristina; Aramburu, Jose 2008. Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice. BMC molecular biology, 9 , 13

Nieves-Cintrón, Madeline; Amberg, Gregory C; Navedo, Manuel F; Molkentin, Jeffery D; Santana, Luis F 2008. The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension. Proceedings of the National Academy of Sciences of the United States of America, 105 40, 15623-8

Pinz, Ilka; Ostroy, Sanford E; Hoyer, Kirsten; Osinska, Hanna; Robbins, Jeffrey; Molkentin, Jeffery D; Ingwall, Joanne S 2008. Calcineurin-induced energy wasting in a transgenic mouse model of heart failure. American journal of physiology. Heart and circulatory physiology, 294 3, H1459-66

Ramesh, Sneha; Qi, Xiao-Jun; Wildey, Gary M; Robinson, Janet; Molkentin, Jeffery; Letterio, John; Howe, Philip H 2008. TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. EMBO reports, 9 10, 990-7

Sahin, Bogachan; Hawasli, Ammar H; Greene, Robert W; Molkentin, Jeffery D; Bibb, James A 2008. Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C. European journal of pharmacology, 581 3, 270-5

Snider, Paige; Hinton, Robert B; Moreno-Rodriguez, Ricardo A; Wang, Jian; Rogers, Rhonda; Lindsley, Andrew; Li, Fang; Ingram, David A; Menick, Donald; Field, Loren; Firulli, Anthony B; Molkentin, Jeffery D; Markwald, Roger; Conway, Simon J 2008. Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circulation research, 102 7, 752-60

Amberg, Gregory C; Navedo, Manuel F; Nieves-Cintrón, Madeline; Molkentin, Jeffery D; Santana, Luis F 2007. Calcium sparklets regulate local and global calcium in murine arterial smooth muscle. The Journal of physiology, 579 Pt 1, 187-201

Baines, Christopher P; Kaiser, Robert A; Sheiko, Tatiana; Craigen, William J; Molkentin, Jeffery D 2007. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nature cell biology, 9 5, 550-5

Davies, Kelvin J A; Ermak, Gennady; Rothermel, Beverley A; Pritchard, Melanie; Heitman, Joseph; Ahnn, Joohong; Henrique-Silva, Flavio; Crawford, Dana; Canaider, Silvia; Strippoli, Pierluigi; Carinci, Paolo; Min, Kyung-Tai; Fox, Deborah S; Cunningham, Kyle W; Bassel-Duby, Rhonda; Olson, Eric N; Zhang, Zhuohua; Williams, R Sanders; Gerber, Hans-Peter; Pérez-Riba, Mercè; Seo, Hisao; Cao, Xia; Klee, Claude B; Redondo, Juan Miguel; Maltais, Lois J; Bruford, Elspeth A; Povey, Sue; Molkentin, Jeffery D; McKeon, Frank D; Duh, Elia J; Crabtree, Gerald R; Cyert, Martha S; de la Luna, Susana; Estivill, Xavier 2007. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 21 12, 3023-8

Diwan, Abhinav; Koesters, Andrew G; Odley, Amy M; Pushkaran, Suvarnamala; Baines, Christopher P; Spike, Benjamin T; Daria, Diedre; Jegga, Anil G; Geiger, Hartmut; Aronow, Bruce J; Molkentin, Jeffery D; Macleod, Kay F; Kalfa, Theodosia A; Dorn, Gerald W 2007. Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proceedings of the National Academy of Sciences of the United States of America, 104 16, 6794-9

Hambleton, Michael; York, Allen; Sargent, Michelle A; Kaiser, Robert A; Lorenz, John N; Robbins, Jeffrey; Molkentin, Jeffery D 2007. Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure. American journal of physiology. Heart and circulatory physiology, 293 6, H3768-71

Heineke, Joerg; Auger-Messier, Mannix; Xu, Jian; Oka, Toru; Sargent, Michelle A; York, Allen; Klevitsky, Raisa; Vaikunth, Sachin; Duncan, Stephen A; Aronow, Bruce J; Robbins, Jeffrey; Crombleholme, Timothy M; Cromblehol, Timothy M; Molkentin, Jeffery D 2007. Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. The Journal of clinical investigation, 117 11, 3198-210

Hsieh, Patrick C H; Segers, Vincent F M; Davis, Michael E; MacGillivray, Catherine; Gannon, Joseph; Molkentin, Jeffery D; Robbins, Jeffrey; Lee, Richard T 2007. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nature medicine, 13 8, 970-4

Molkentin, Joachim; Giesemann, Anette 2007. Differentiation of organically and conventionally produced milk by stable isotope and fatty acid analysis. Analytical and bioanalytical chemistry, 388 1, 297-305

Nakamura, Tomoki; Colbert, Melissa; Krenz, Maike; Molkentin, Jeffery D; Hahn, Harvey S; Dorn, Gerald W; Robbins, Jeffrey 2007. Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. The Journal of clinical investigation, 117 8, 2123-32

Nakayama, Hiroyuki; Chen, Xiongwen; Baines, Christopher P; Klevitsky, Raisa; Zhang, Xiaoying; Zhang, Hongyu; Jaleel, Naser; Chua, Balvin H L; Hewett, Timothy E; Robbins, Jeffrey; Houser, Steven R; Molkentin, Jeffery D 2007. Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. The Journal of clinical investigation, 117 9, 2431-44

Nieves-Cintrón, Madeline; Amberg, Gregory C; Nichols, C Blake; Molkentin, Jeffery D; Santana, Luis F 2007. Activation of NFATc3 down-regulates the beta1 subunit of large conductance, calcium-activated K+ channels in arterial smooth muscle and contributes to hypertension. The Journal of biological chemistry, 282 5, 3231-40

Nilsson, Lisa M; Sun, Zheng-Wu; Nilsson, Jenny; Nordström, Ina; Chen, Yung-Wu; Molkentin, Jeffery D; Wide-Swensson, Dag; Hellstrand, Per; Lydrup, Marie-Louise; Gomez, Maria F 2007. Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation. American journal of physiology. Cell physiology, 292 3, C1167-78

Norris, Russell A; Damon, Brook; Mironov, Vladimir; Kasyanov, Vladimir; Ramamurthi, Anand; Moreno-Rodriguez, Ricardo; Trusk, Thomas; Potts, Jay D; Goodwin, Richard L; Davis, Jeff; Hoffman, Stanley; Wen, Xuejun; Sugi, Yukiko; Kern, Christine B; Mjaatvedt, Corey H; Turner, Debi K; Oka, Toru; Conway, Simon J; Molkentin, Jeffery D; Forgacs, Gabor; Markwald, Roger R 2007. Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. Journal of cellular biochemistry, 101 3, 695-711

Oka, Toru; Xu, Jian; Kaiser, Robert A; Melendez, Jaime; Hambleton, Michael; Sargent, Michelle A; Lorts, Angela; Brunskill, Eric W; Dorn, Gerald W; Conway, Simon J; Aronow, Bruce J; Robbins, Jeffrey; Molkentin, Jeffery D 2007. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circulation research, 101 3, 313-21

Oka, Toru; Xu, Jian; Molkentin, Jeffery D 2007. Re-employment of developmental transcription factors in adult heart disease. Seminars in cell & developmental biology, 18 1, 117-31

Parsons, Stephanie A; Millay, Douglas P; Sargent, Michelle A; Naya, Francisco J; McNally, Elizabeth M; Sweeney, H Lee; Molkentin, Jeffery D 2007. Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. The Journal of biological chemistry, 282 13, 10068-78

Peng, Jun; Raddatz, Katy; Molkentin, Jeffery D; Wu, Yiming; Labeit, Siegfried; Granzier, Henk; Gotthardt, Michael 2007. Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region. Circulation, 115 6, 743-51

Purcell, Nicole H; Wilkins, Benjamin J; York, Allen; Saba-El-Leil, Marc K; Meloche, Sylvain; Robbins, Jeffrey; Molkentin, Jeffery D 2007. Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America, 104 35, 14074-9

Sano, Masanori; Minamino, Tohru; Toko, Haruhiro; Miyauchi, Hideyuki; Orimo, Masayuki; Qin, Yingjie; Akazawa, Hiroshi; Tateno, Kaoru; Kayama, Yosuke; Harada, Mutsuo; Shimizu, Ippei; Asahara, Takayuki; Hamada, Hirofumi; Tomita, Shuhei; Molkentin, Jeffrey D; Zou, Yunzeng; Komuro, Issei 2007. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature, 446 7134, 444-8

Xiong, Dingding; Yajima, Toshitaka; Lim, Byung-Kwan; Stenbit, Antine; Dublin, Andrew; Dalton, Nancy D; Summers-Torres, Daphne; Molkentin, Jeffery D; Duplain, Herve; Wessely, Rainer; Chen, Ju; Knowlton, Kirk U 2007. Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy. Circulation, 115 1, 94-102

Chen, Xin; Shevtsov, Sergei P; Hsich, Eileen; Cui, Lei; Haq, Syed; Aronovitz, Mark; Kerkelä, Risto; Molkentin, Jeffery D; Liao, Ronglih; Salomon, Robert N; Patten, Richard; Force, Thomas 2006. The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. Molecular and cellular biology, 26 12, 4462-73

Gong, Nanling; Bodi, Ilona; Zobel, Carsten; Schwartz, Arnold; Molkentin, Jeffery D; Backx, Peter H 2006. Calcineurin increases cardiac transient outward K+ currents via transcriptional up-regulation of Kv4.2 channel subunits. The Journal of biological chemistry, 281 50, 38498-506

Hambleton, Michael; Hahn, Harvey; Pleger, Sven T; Kuhn, Matthew C; Klevitsky, Raisa; Carr, Andrew N; Kimball, Thomas F; Hewett, Timothy E; Dorn, Gerald W; Koch, Walter J; Molkentin, Jeffery D 2006. Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. Circulation, 114 6, 574-82

Heineke, Joerg; Molkentin, Jeffery D 2006. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nature reviews. Molecular cell biology, 7 8, 589-600

Kempf, Tibor; Eden, Matthias; Strelau, Jens; Naguib, Marian; Willenbockel, Christian; Tongers, Jörn; Heineke, Jörg; Kotlarz, Daniel; Xu, Jian; Molkentin, Jeffery D; Niessen, Hans W; Drexler, Helmut; Wollert, Kai C 2006. The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circulation research, 98 3, 351-60

Liu, Qinghang; Wilkins, Benjamin J; Lee, Yong J; Ichijo, Hidenori; Molkentin, Jeffery D 2006. Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. Molecular and cellular biology, 26 10, 3785-97

Molkentin, Jeffery D 2006. Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling. The Journal of clinical investigation, 116 3, 623-6

Nakayama, Hiroyuki; Wilkin, Benjamin J; Bodi, Ilona; Molkentin, Jeffery D 2006. Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20 10, 1660-70

Navedo, Manuel F; Amberg, Gregory C; Nieves, Madeline; Molkentin, Jeffery D; Santana, Luis F 2006. Mechanisms underlying heterogeneous Ca2+ sparklet activity in arterial smooth muscle. The Journal of general physiology, 127 6, 611-22

Nilsson, Jenny; Nilsson, Lisa M; Chen, Yung-Wu; Molkentin, Jeffery D; Erlinge, David; Gomez, Maria F 2006. High glucose activates nuclear factor of activated T cells in native vascular smooth muscle. Arteriosclerosis, thrombosis, and vascular biology, 26 4, 794-800

Noh, Hye-Lim; Okajima, Kazue; Molkentin, Jeffery D; Homma, Shunichi; Homma, Sunichi; Goldberg, Ira J 2006. Acute lipoprotein lipase deletion in adult mice leads to dyslipidemia and cardiac dysfunction. American journal of physiology. Endocrinology and metabolism, 291 4, E755-60

Obasanjo-Blackshire, Kofo; Mesquita, Rui; Jabr, Rita I; Molkentin, Jeffery D; Hart, Stephen L; Marber, Michael S; Xia, Yang; Heads, Richard J 2006. Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: co-operation with Src tyrosine kinase. Cardiovascular research, 71 4, 672-83

Oka, Toru; Maillet, Marjorie; Watt, Alistair J; Schwartz, Robert J; Aronow, Bruce J; Duncan, Stephen A; Molkentin, Jeffery D 2006. Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circulation research, 98 6, 837-45

Parsons, Stephanie A; Millay, Douglas P; Sargent, Michelle A; McNally, Elizabeth M; Molkentin, Jeffery D 2006. Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy. The American journal of pathology, 168 6, 1975-85

Sadayappan, Sakthivel; Osinska, Hanna; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffrey D; Seidman, Christine E; Seidman, Jonathan G; Robbins, Jeffrey 2006. Cardiac myosin binding protein C phosphorylation is cardioprotective. Proceedings of the National Academy of Sciences of the United States of America, 103 45, 16918-23

Sahin, Bogachan; Shu, Hongjun; Fernandez, Joseph; El-Armouche, Ali; Molkentin, Jeffery D; Nairn, Angus C; Bibb, James A 2006. Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C. The Journal of biological chemistry, 281 34, 24322-35

Sanna, Bastiano; Brandt, Eric B; Kaiser, Robert A; Pfluger, Paul; Witt, Sandy A; Kimball, Thomas R; van Rooij, Eva; De Windt, Leon J; Rothenberg, Marc E; Tschop, Matthias H; Benoit, Stephen C; Molkentin, Jeffery D 2006. Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proceedings of the National Academy of Sciences of the United States of America, 103 19, 7327-32

Xin, Mei; Davis, Christopher A; Molkentin, Jeffery D; Lien, Ching-Ling; Duncan, Stephen A; Richardson, James A; Olson, Eric N 2006. A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proceedings of the National Academy of Sciences of the United States of America, 103 30, 11189-94

Xu, Jian; Gong, Nanling L; Bodi, Ilona; Aronow, Bruce J; Backx, Peter H; Molkentin, Jeffery D 2006. Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. The Journal of biological chemistry, 281 14, 9152-62

Xu, Jian; Kimball, Thomas R; Lorenz, John N; Brown, David A; Bauskin, Asne R; Klevitsky, Raisa; Hewett, Timothy E; Breit, Samuel N; Molkentin, Jeffery D 2006. GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circulation research, 98 3, 342-50

Zhao, Wen; Yuan, Qunying; Qian, Jiang; Waggoner, Jason R; Pathak, Anand; Chu, Guoxiang; Mitton, Bryan; Sun, Xiaoyin; Jin, Jay; Braz, Julian C; Hahn, Harvey S; Marreez, Yehia; Syed, Faisal; Pollesello, Piero; Annila, Arto; Wang, Hong-Sheng; Schultz, Jo El J; Molkentin, Jeffery D; Liggett, Stephen B; Dorn, Gerald W; Kranias, Evangelia G 2006. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation, 113 7, 995-1004

Baines, Christopher P; Kaiser, Robert A; Purcell, Nicole H; Blair, N Scott; Osinska, Hanna; Hambleton, Michael A; Brunskill, Eric W; Sayen, M Richard; Gottlieb, Roberta A; Dorn, Gerald W; Robbins, Jeffrey; Molkentin, Jeffery D 2005. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature, 434 7033, 658-62

Baines, Christopher P; Molkentin, Jeffery D 2005. STRESS signaling pathways that modulate cardiac myocyte apoptosis. Journal of molecular and cellular cardiology, 38 1, 47-62

Bell, Osnat; Gaberman, Elena; Kilav, Rachel; Levi, Ronen; Cox, Keith B; Molkentin, Jeffery D; Silver, Justin; Naveh-Many, Tally 2005. The protein phosphatase calcineurin determines basal parathyroid hormone gene expression. Molecular endocrinology (Baltimore, Md.), 19 2, 516-26

Dai, Yan-Shan; Xu, Jian; Molkentin, Jeffery D 2005. The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Molecular and cellular biology, 25 22, 9936-48

Heineke, Joerg; Ruetten, Hartmut; Willenbockel, Christian; Gross, Sandra C; Naguib, Marian; Schaefer, Arnd; Kempf, Tibor; Hilfiker-Kleiner, Denise; Caroni, Pico; Kraft, Theresia; Kaiser, Robert A; Molkentin, Jeffery D; Drexler, Helmut; Wollert, Kai C 2005. Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc. Proceedings of the National Academy of Sciences of the United States of America, 102 5, 1655-60

Kaiser, Robert A; Liang, Qiangrong; Bueno, Orlando; Huang, Yuan; Lackey, Troy; Klevitsky, Raisa; Hewett, Timothy E; Molkentin, Jeffery D 2005. Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. The Journal of biological chemistry, 280 38, 32602-8

Kaiser, Robert A; Lyons, Jefferson M; Duffy, Jodie Y; Wagner, Connie J; McLean, Kelly M; O'Neill, Timothy P; Pearl, Jeffrey M; Molkentin, Jeffery D 2005. Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion. American journal of physiology. Heart and circulatory physiology, 289 6, H2747-51

Kostetskii, Igor; Li, Jifen; Xiong, Yanming; Zhou, Rong; Ferrari, Victor A; Patel, Vickas V; Molkentin, Jeffery D; Radice, Glenn L 2005. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circulation research, 96 3, 346-54

Li, Jifen; Patel, Vickas V; Kostetskii, Igor; Xiong, Yanming; Chu, Antony F; Jacobson, Jason T; Yu, Cindy; Morley, Gregory E; Molkentin, Jeffery D; Radice, Glenn L 2005. Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circulation research, 97 5, 474-81

Lynch, Jeffrey; Guo, Lei; Gelebart, Pascal; Chilibeck, Kaari; Xu, Jian; Molkentin, Jeffery D; Agellon, Luis B; Michalak, Marek 2005. Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. The Journal of cell biology, 170 1, 37-47

Molkentin, Jeffery D 2005. Locating heart failure. Nature medicine, 11 12, 1284-5

Nimah, Marianne; Zhao, Bin; Denenberg, Alvin G; Bueno, Orlando; Molkentin, Jeffery; Wong, Hector R; Shanley, Thomas P 2005. Contribution of MKP-1 regulation of p38 to endotoxin tolerance. Shock (Augusta, Ga.), 23 1, 80-7

Oka, Toru; Dai, Yan-Shan; Molkentin, Jeffery D 2005. Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo. Molecular and cellular biology, 25 15, 6649-59

Parlakian, Ara; Charvet, Claude; Escoubet, Brigitte; Mericskay, Mathias; Molkentin, Jeffery D; Gary-Bobo, Guillaume; De Windt, Leon J; Ludosky, Marie-Aline; Paulin, Denise; Daegelen, Dominique; Tuil, David; Li, Zhenlin 2005. Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart. Circulation, 112 19, 2930-9

Pope, Samuel M; Fulkerson, Patricia C; Blanchard, Carine; Akei, Hiroko Saito; Nikolaidis, Nikolaos M; Zimmermann, Nives; Molkentin, Jeffery D; Rothenberg, Marc E 2005. Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. The Journal of biological chemistry, 280 14, 13952-61

Sanna, Bastiano; Bueno, Orlando F; Dai, Yan-Shan; Wilkins, Benjamin J; Molkentin, Jeffery D 2005. Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Molecular and cellular biology, 25 3, 865-78

Zhang, Lin; Deng, Maoxian; Parthasarathy, Ranjani; Wang, Lei; Mongan, Maureen; Molkentin, Jeffery D; Zheng, Yi; Xia, Ying 2005. MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Molecular and cellular biology, 25 1, 60-5

Aliahmad, Parinaz; O'Flaherty, Emmett; Han, Peggy; Goularte, Olivia D; Wilkinson, Beverley; Satake, Masanobu; Molkentin, Jeffery D; Kaye, Jonathan 2004. TOX provides a link between calcineurin activation and CD8 lineage commitment. The Journal of experimental medicine, 199 8, 1089-99

Braz, Julian C; Gregory, Kimberly; Pathak, Anand; Zhao, Wen; Sahin, Bogachan; Klevitsky, Raisa; Kimball, Thomas F; Lorenz, John N; Nairn, Angus C; Liggett, Stephen B; Bodi, Ilona; Wang, Su; Schwartz, Arnold; Lakatta, Edward G; DePaoli-Roach, Anna A; Robbins, Jeffrey; Hewett, Timothy E; Bibb, James A; Westfall, Margaret V; Kranias, Evangelia G; Molkentin, Jeffery D 2004. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature medicine, 10 3, 248-54

Bueno, Orlando F; Lips, Daniel J; Kaiser, Robert A; Wilkins, Benjamin J; Dai, Yan-Shan; Glascock, Betty J; Klevitsky, Raisa; Hewett, Timothy E; Kimball, Thomas R; Aronow, Bruce J; Doevendans, Pieter A; Molkentin, Jeffery D 2004. Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction. Circulation research, 94 1, 91-9

Dorn, Gerald W; Molkentin, Jeffery D 2004. Manipulating cardiac contractility in heart failure: data from mice and men. Circulation, 109 2, 150-8

Kaiser, Robert A; Bueno, Orlando F; Lips, Daniel J; Doevendans, Pieter A; Jones, Fred; Kimball, Thomas F; Molkentin, Jeffery D 2004. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. The Journal of biological chemistry, 279 15, 15524-30

Lange, Alexander W; Molkentin, Jeffery D; Yutzey, Katherine E 2004. DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. Developmental biology, 266 2, 346-60

Lips, Daniel J; Bueno, Orlando F; Wilkins, Benjamin J; Purcell, Nicole H; Kaiser, Robert A; Lorenz, John N; Voisin, Laure; Saba-El-Leil, Marc K; Meloche, Sylvain; Pouysségur, Jacques; Pagès, Gilles; De Windt, Leon J; Doevendans, Pieter A; Molkentin, Jeffery D 2004. MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo. Circulation, 109 16, 1938-41

Matsuura, Katsuhisa; Wada, Hiroshi; Nagai, Toshio; Iijima, Yoshihiro; Minamino, Tohru; Sano, Masanori; Akazawa, Hiroshi; Molkentin, Jeffery D; Kasanuki, Hiroshi; Komuro, Issei 2004. Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle. The Journal of cell biology, 167 2, 351-63

Michael, Ashour; Haq, Syed; Chen, Xin; Hsich, Eileen; Cui, Lei; Walters, Brian; Shao, Zhili; Bhattacharya, Kausik; Kilter, Heiko; Huggins, Gordon; Andreucci, Michele; Periasamy, Muthu; Solomon, Robert N; Liao, Ronglih; Patten, Richard; Molkentin, Jeffery D; Force, Thomas 2004. Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart. The Journal of biological chemistry, 279 20, 21383-93

Molkentin, Jeffery D 2004. Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs. Cardiovascular research, 63 3, 467-75

Moz, Yulia; Levi, Ronen; Lavi-Moshayoff, Vardit; Cox, Keith B; Molkentin, Jeffery D; Silver, Justin; Naveh-Many, Tally 2004. Calcineurin Abeta is central to the expression of the renal type II Na/Pi co-transporter gene and to the regulation of renal phosphate transport. Journal of the American Society of Nephrology : JASN, 15 12, 2972-80

Parsons, Stephanie A; Millay, Douglas P; Wilkins, Benjamin J; Bueno, Orlando F; Tsika, Gretchen L; Neilson, Joel R; Liberatore, Christine M; Yutzey, Katherine E; Crabtree, Gerald R; Tsika, Richard W; Molkentin, Jeffery D 2004. Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy. The Journal of biological chemistry, 279 25, 26192-200

Purcell, Nicole H; Darwis, Dina; Bueno, Orlando F; Müller, Judith M; Schüle, Roland; Molkentin, Jeffery D 2004. Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. Molecular and cellular biology, 24 3, 1081-95

Wilkins, Benjamin J; Dai, Yan-Shan; Bueno, Orlando F; Parsons, Stephanie A; Xu, Jian; Plank, David M; Jones, Fred; Kimball, Thomas R; Molkentin, Jeffery D 2004. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circulation research, 94 1, 110-8

Wilkins, Benjamin J; Molkentin, Jeffery D 2004. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochemical and biophysical research communications, 322 4, 1178-91

Braz, Julian C; Bueno, Orlando F; Liang, Qiangrong; Wilkins, Benjamin J; Dai, Yan-Shan; Parsons, Stephanie; Braunwart, Joseph; Glascock, Betty J; Klevitsky, Raisa; Kimball, Thomas F; Hewett, Timothy E; Molkentin, Jeffery D 2003. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. The Journal of clinical investigation, 111 10, 1475-86

Bushdid, Paul B; Osinska, Hanna; Waclaw, Ronald R; Molkentin, Jeffery D; Yutzey, Katherine E 2003. NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circulation research, 92 12, 1305-13

Dong, Deli; Duan, Yanjun; Guo, Jiqing; Roach, Dan E; Swirp, Shauni L; Wang, Li; Lees-Miller, J P; Sheldon, R S; Molkentin, Jeffery D; Duff, Henry J 2003. Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels. Cardiovascular research, 57 2, 320-32

Gajewski, Kathleen; Wang, Jianbo; Molkentin, Jeffery D; Chen, Elizabeth H; Olson, Eric N; Schulz, Robert A 2003. Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 100 3, 1040-5

Haq, Syed; Kilter, Heiko; Michael, Ashour; Tao, Jingzang; O'Leary, Eileen; Sun, Xio Ming; Walters, Brian; Bhattacharya, Kausik; Chen, Xin; Cui, Lei; Andreucci, Michele; Rosenzweig, Anthony; Guerrero, J Luis; Patten, Richard; Liao, Ronglih; Molkentin, Jeffery; Picard, Michael; Bonventre, Joseph V; Force, Thomas 2003. Deletion of cytosolic phospholipase A2 promotes striated muscle growth. Nature medicine, 9 7, 944-51

Liang, Qiangrong; Bueno, Orlando F; Wilkins, Benjamin J; Kuan, Chia-Yi; Xia, Ying; Molkentin, Jeffery D 2003. c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. The EMBO journal, 22 19, 5079-89

Liang, Qiangrong; Molkentin, Jeffery D 2003. Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models. Journal of molecular and cellular cardiology, 35 12, 1385-94

Molkentin, Jeffery D 2003. A friend within the heart: natriuretic peptide receptor signaling. The Journal of clinical investigation, 111 9, 1275-7

Parsons, Stephanie A; Wilkins, Benjamin J; Bueno, Orlando F; Molkentin, Jeffery D 2003. Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice. Molecular and cellular biology, 23 12, 4331-43

Petrich, Brian G; Molkentin, Jeffery D; Wang, Yibin 2003. Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17 6, 749-51

Prabhakar, Rethinasamy; Petrashevskaya, Natalia; Schwartz, Arnold; Aronow, Bruce; Boivin, Greg P; Molkentin, Jeffery D; Wieczorek, David F 2003. A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation. Molecular and cellular biochemistry, 251 1-2, 33-42

Purcell, Nicole H; Molkentin, Jeffery D 2003. Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy? Circulation, 108 6, 638-40

Rybin, Vitalyi O; Sabri, Abdelkarim; Short, Jacob; Braz, Julian C; Molkentin, Jeffery D; Steinberg, Susan F 2003. Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations. The Journal of biological chemistry, 278 16, 14555-64

Sayen, M R; Gustafsson, Asa B; Sussman, Mark A; Molkentin, Jeffery D; Gottlieb, Roberta A 2003. Calcineurin transgenic mice have mitochondrial dysfunction and elevated superoxide production. American journal of physiology. Cell physiology, 284 2, C562-70

Schubert, William; Yang, Xiao Yong; Yang, Teddy T C; Factor, Stephen M; Lisanti, Michael P; Molkentin, Jeffery D; Rincon, Mercedes; Chow, Chi-Wing 2003. Requirement of transcription factor NFAT in developing atrial myocardium. The Journal of cell biology, 161 5, 861-74

Semeniuk, L M; Severson, D L; Kryski, A J; Swirp, S L; Molkentin, J D; Duff, H J 2003. Time-dependent systolic and diastolic function in mice overexpressing calcineurin. American journal of physiology. Heart and circulatory physiology, 284 2, H425-30

Suzuki, Yuichiro J; Day, Regina M; Tan, Chia Chi; Sandven, Tor H; Liang, Qiangrong; Molkentin, Jeffery D; Fanburg, Barry L 2003. Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells. The Journal of biological chemistry, 278 19, 17525-31

Braz, Julian C; Bueno, Orlando F; De Windt, Leon J; Molkentin, Jeffery D 2002. PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2). The Journal of cell biology, 156 5, 905-19

Bueno, Orlando F; Brandt, Eric B; Rothenberg, Marc E; Molkentin, Jeffery D 2002. Defective T cell development and function in calcineurin A beta -deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 99 14, 9398-403

Bueno, Orlando F; Molkentin, Jeffery D 2002. Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circulation research, 91 9, 776-81

Bueno, Orlando F; van Rooij, Eva; Molkentin, Jeffery D; Doevendans, Pieter A; De Windt, Leon J 2002. Calcineurin and hypertrophic heart disease: novel insights and remaining questions. Cardiovascular research, 53 4, 806-21

Bueno, Orlando F; Wilkins, Benjamin J; Tymitz, Kevin M; Glascock, Betty J; Kimball, Thomas F; Lorenz, John N; Molkentin, Jeffery D 2002. Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 99 7, 4586-91

Chu, Guoxiang; Carr, Andrew N; Young, Karen B; Lester, J William; Yatani, Atsuko; Sanbe, Atsushi; Colbert, Melissa C; Schwartz, Steven M; Frank, Konrad F; Lampe, Paul D; Robbins, Jeffrey; Molkentin, Jeffery D; Kranias, Evangelia G 2002. Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure. Cardiovascular research, 54 1, 105-16

Dai, Yan-Shan; Cserjesi, Peter; Markham, Bruce E; Molkentin, Jeffery D 2002. The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. The Journal of biological chemistry, 277 27, 24390-8

Donelan, Matthew J; Morfini, Gerardo; Julyan, Richard; Sommers, Scott; Hays, Lori; Kajio, Hiroshi; Briaud, Isabelle; Easom, Richard A; Molkentin, Jeffery D; Brady, Scott T; Rhodes, Christopher J 2002. Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis. The Journal of biological chemistry, 277 27, 24232-42

Fiedler, Beate; Lohmann, Suzanne M; Smolenski, Albert; Linnemuller, Stephan; Pieske, Burkert; Schroder, Frank; Molkentin, Jeffery D; Drexler, Helmut; Wollert, Kai C 2002. Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America, 99 17, 11363-8

Jacob, Asha; Molkentin, Jeffery D; Smolenski, Albert; Lohmann, Suzanne M; Begum, Najma 2002. Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKs. American journal of physiology. Cell physiology, 283 3, C704-13

Kassiri, Zamaneh; Zobel, Carsten; Nguyen, The-Tin T; Molkentin, Jeffery D; Backx, Peter H 2002. Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes. Circulation research, 90 5, 578-85

Liang, Qiangrong; Molkentin, Jeffery D 2002. Divergent signaling pathways converge on GATA4 to regulate cardiac hypertrophic gene expression. Journal of molecular and cellular cardiology, 34 6, 611-6

Lynch, Roy A; Wagoner, Lynne; Li, Shunan; Sparks, Li; Molkentin, Jeffery; Dorn, Gerald W 2002. Novel and nondetected human signaling protein polymorphisms. Physiological genomics, 10 3, 159-68

Petrashevskaya, Natalia N; Bodi, Ilona; Rubio, Marta; Molkentin, Jeffery D; Schwartz, Arnold 2002. Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouse. Cardiovascular research, 54 1, 117-32

Sah, Rajan; Oudit, Gavin Y; Nguyen, The-Tin T; Lim, Hae W; Wickenden, Alan D; Wilson, Gregory J; Molkentin, Jeffery D; Backx, Peter H 2002. Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice. Circulation, 105 15, 1850-6

Tomita, Masuhiro; Reinhold, Martina I; Molkentin, Jeffery D; Naski, Michael C 2002. Calcineurin and NFAT4 induce chondrogenesis. The Journal of biological chemistry, 277 44, 42214-8

van Rooij, Eva; Doevendans, Pieter A; de Theije, Chiel C; Babiker, Fawzi A; Molkentin, Jeffery D; de Windt, Leon J 2002. Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy. The Journal of biological chemistry, 277 50, 48617-26

Wilkins, Benjamin J; De Windt, Leon J; Bueno, Orlando F; Braz, Julian C; Glascock, Betty J; Kimball, Thomas F; Molkentin, Jeffery D 2002. Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Molecular and cellular biology, 22 21, 7603-13

Wilkins, Benjamin J; Molkentin, Jeffery D 2002. Calcineurin and cardiac hypertrophy: where have we been? Where are we going? The Journal of physiology, 541 Pt 1, 1-8

Aronow, B J; Toyokawa, T; Canning, A; Haghighi, K; Delling, U; Kranias, E; Molkentin, J D; Dorn, G W 2001. Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy. Physiological genomics, 6 1, 19-28

Bueno, O F; De Windt, L J; Lim, H W; Tymitz, K M; Witt, S A; Kimball, T R; Molkentin, J D 2001. The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo. Circulation research, 88 1, 88-96

Charron, F; Tsimiklis, G; Arcand, M; Robitaille, L; Liang, Q; Molkentin, J D; Meloche, S; Nemer, M 2001. Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes & development, 15 20, 2702-19

Crispino, J D; Lodish, M B; Thurberg, B L; Litovsky, S H; Collins, T; Molkentin, J D; Orkin, S H 2001. Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes & development, 15 7, 839-44

De Windt, L J; Lim, H W; Bueno, O F; Liang, Q; Delling, U; Braz, J C; Glascock, B J; Kimball, T F; del Monte, F; Hajjar, R J; Molkentin, J D 2001. Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America, 98 6, 3322-7

Haq, S; Choukroun, G; Lim, H; Tymitz, K M; del Monte, F; Gwathmey, J; Grazette, L; Michael, A; Hajjar, R; Force, T; Molkentin, J D 2001. Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure. Circulation, 103 5, 670-7

Li, J; Molkentin, J D; Colbert, M C 2001. Retinoic acid inhibits cardiac neural crest migration by blocking c-Jun N-terminal kinase activation. Developmental biology, 232 2, 351-61

Liang, Q; De Windt, L J; Witt, S A; Kimball, T R; Markham, B E; Molkentin, J D 2001. The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo. The Journal of biological chemistry, 276 32, 30245-53

Liang, Q; Wiese, R J; Bueno, O F; Dai, Y S; Markham, B E; Molkentin, J D 2001. The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. Molecular and cellular biology, 21 21, 7460-9

Lim, H W; New, L; Han, J; Molkentin, J D 2001. Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes. The Journal of biological chemistry, 276 19, 15913-9

Molkentin, J D 2001. Calcineurin, mitochondrial membrane potential, and cardiomyocyte apoptosis. Circulation research, 88 12, 1220-2

Molkentin, J D; Dorn, G W 2001. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annual review of physiology, 63 , 391-426

Precht, D; Molkentin, J; Destaillats, F; Wolff, R L 2001. Comparative studies on individual isomeric 18:1 acids in cow, goat, and ewe milk fats by low-temperature high-resolution capillary gas-liquid chromatography. Lipids, 36 8, 827-32

Precht, D; Molkentin, J; McGuire, M A; McGuire, M K; Jensen, R G 2001. Overestimates of oleic and linoleic acid contents in materials containing trans fatty acids and analyzed with short packed gas chromatographic columns. Lipids, 36 2, 213-6

Qiao, L; Studer, E; Leach, K; McKinstry, R; Gupta, S; Decker, R; Kukreja, R; Valerie, K; Nagarkatti, P; El Deiry, W; Molkentin, J; Schmidt-Ullrich, R; Fisher, P B; Grant, S; Hylemon, P B; Dent, P 2001. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis. Molecular biology of the cell, 12 9, 2629-45

Sohal, D S; Nghiem, M; Crackower, M A; Witt, S A; Kimball, T R; Tymitz, K M; Penninger, J M; Molkentin, J D 2001. Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circulation research, 89 1, 20-5

Yatani, A; Honda, R; Tymitz, K M; Lalli, M J; Molkentin, J D 2001. Enhanced Ca2+ channel currents in cardiac hypertrophy induced by activation of calcineurin-dependent pathway. Journal of molecular and cellular cardiology, 33 2, 249-59

Bueno, O F; De Windt, L J; Tymitz, K M; Witt, S A; Kimball, T R; Klevitsky, R; Hewett, T E; Jones, S P; Lefer, D J; Peng, C F; Kitsis, R N; Molkentin, J D 2000. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. The EMBO journal, 19 23, 6341-50

De Windt, L J; Lim, H W; Haq, S; Force, T; Molkentin, J D 2000. Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways. The Journal of biological chemistry, 275 18, 13571-9

De Windt, L J; Lim, H W; Taigen, T; Wencker, D; Condorelli, G; Dorn, G W; Kitsis, R N; Molkentin, J D 2000. Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure. Circulation research, 86 3, 255-63

Delling, U; Sussman, M A; Molkentin, J D 2000. Re-evaluating sarcoplasmic reticulum function in heart failure. Nature medicine, 6 9, 942-3

Delling, U; Tureckova, J; Lim, H W; De Windt, L J; Rotwein, P; Molkentin, J D 2000. A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression. Molecular and cellular biology, 20 17, 6600-11

Destaillats, F; Wolff, R L; Precht, D; Molkentin, J 2000. Study of individual trans- and cis-16:1 isomers in cow, goat, and ewe cheese fats by gas-liquid chromatography with emphasis on the trans-delta3 isomer. Lipids, 35 9, 1027-32

Han, J; Molkentin, J D 2000. Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology. Trends in cardiovascular medicine, 10 1, 19-22

Haq, S; Choukroun, G; Kang, Z B; Ranu, H; Matsui, T; Rosenzweig, A; Molkentin, J D; Alessandrini, A; Woodgett, J; Hajjar, R; Michael, A; Force, T 2000. Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy. The Journal of cell biology, 151 1, 117-30

Lim, ; Molkentin, 2000. Reply to revisiting calcineurin and human heart failure Nature medicine, 6 1, 3

Lim, H W; De Windt, L J; Mante, J; Kimball, T R; Witt, S A; Sussman, M A; Molkentin, J D 2000. Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition. Journal of molecular and cellular cardiology, 32 4, 697-709

Lim, H W; De Windt, L J; Steinberg, L; Taigen, T; Witt, S A; Kimball, T R; Molkentin, J D 2000. Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy. Circulation, 101 20, 2431-7

Molkentin, J 2000. Occurrence and biochemical characteristics of natural bioactive substances in bovine milk lipids. The British journal of nutrition, 84 Suppl 1 , S47-53

Molkentin, J D 2000. The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression. The Journal of biological chemistry, 275 50, 38949-52

Molkentin, J D 2000. Calcineurin and beyond: cardiac hypertrophic signaling. Circulation research, 87 9, 731-8

Molkentin, J D; Antos, C; Mercer, B; Taigen, T; Miano, J M; Olson, E N 2000. Direct activation of a GATA6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and GATA transcription factors in the developing heart. Developmental biology, 217 2, 301-9

Molkentin, J D; Tymitz, K M; Richardson, J A; Olson, E N 2000. Abnormalities of the genitourinary tract in female mice lacking GATA5. Molecular and cellular biology, 20 14, 5256-60

Precht, D; Molkentin, J 2000. Recent trends in the fatty acid composition of German sunflower margarines, shortenings and cooking fats with emphasis on individual C16:1, C18:1, C18:2, C18:3 and C20:1 trans isomers. Die Nahrung, 44 4, 222-8

Sussman, M A; Welch, S; Walker, A; Klevitsky, R; Hewett, T E; Witt, S A; Kimball, T R; Price, R; Lim, H W; Molkentin, J D 2000. Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice. Cardiovascular research, 46 1, 90-101

Taigen, T; De Windt, L J; Lim, H W; Molkentin, J D 2000. Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy. Proceedings of the National Academy of Sciences of the United States of America, 97 3, 1196-201

Wolff, R L; Combe, N A; Destaillats, F; Boué, C; Precht, D; Molkentin, J; Entressangles, B 2000. Follow-up of the delta4 to delta16 trans-18:1 isomer profile and content in French processed foods containing partially hydrogenated vegetable oils during the period 1995-1999. Analytical and nutritional implications. Lipids, 35 8, 815-25

Gajewski, K; Fossett, N; Molkentin, J D; Schulz, R A 1999. The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila. Development (Cambridge, England), 126 24, 5679-88

Lim, H W; Molkentin, J D 1999. Calcineurin and human heart failure. Nature medicine, 5 3, 246-7

Molkentin, J 1999. Bioactive lipids naturally occurring in bovine milk. Die Nahrung, 43 3, 185-9

Olson, E N; Molkentin, J D 1999. Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype? Circulation research, 84 6, 623-32

Precht, D; Molkentin, J 1999. C18:1, C18:2 and C18:3 trans and cis fatty acid isomers including conjugated cis delta 9, trans delta 11 linoleic acid (CLA) as well as total fat composition of German human milk lipids. Die Nahrung, 43 4, 233-44

Sussman, M A; Welch, S; Gude, N; Khoury, P R; Daniels, S R; Kirkpatrick, D; Walsh, R A; Price, R L; Lim, H W; Molkentin, J D 1999. Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice. The American journal of pathology, 155 6, 2101-13

Wilson-Rawls, J; Molkentin, J D; Black, B L; Olson, E N 1999. Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Molecular and cellular biology, 19 4, 2853-62

Black, B L; Molkentin, J D; Olson, E N 1998. Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2. Molecular and cellular biology, 18 1, 69-77

Katoh, Y; Molkentin, J D; Dave, V; Olson, E N; Periasamy, M 1998. MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression. The Journal of biological chemistry, 273 3, 1511-8

Molkentin, J D; Lu, J R; Antos, C L; Markham, B; Richardson, J; Robbins, J; Grant, S R; Olson, E N 1998. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell, 93 2, 215-28

Sussman, M A; Lim, H W; Gude, N; Taigen, T; Olson, E N; Robbins, J; Colbert, M C; Gualberto, A; Wieczorek, D F; Molkentin, J D 1998. Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science (New York, N.Y.), 281 5383, 1690-3

Herzig, T C; Jobe, S M; Aoki, H; Molkentin, J D; Cowley, A W; Izumo, S; Markham, B E 1997. Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proceedings of the National Academy of Sciences of the United States of America, 94 14, 7543-8

Molkentin, J D; Lin, Q; Duncan, S A; Olson, E N 1997. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes & development, 11 8, 1061-72

Molkentin, J D; Olson, E N 1997. GATA4: a novel transcriptional regulator of cardiac hypertrophy? Circulation, 96 11, 3833-5

Precht, D; Molkentin, J 1997. Effect of feeding on conjugated cis delta 9, trans delta 11-octadecadienoic acid and other isomers of linoleic acid in bovine milk fats. Die Nahrung, 41 6, 330-5

Molkentin, J D; Black, B L; Martin, J F; Olson, E N 1996. Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C. Molecular and cellular biology, 16 6, 2627-36

Molkentin, J D; Firulli, A B; Black, B L; Martin, J F; Hustad, C M; Copeland, N; Jenkins, N; Lyons, G; Olson, E N 1996. MEF2B is a potent transactivator expressed in early myogenic lineages. Molecular and cellular biology, 16 7, 3814-24

Molkentin, J D; Jobe, S M; Markham, B E 1996. Alpha-myosin heavy chain gene regulation: delineation and characterization of the cardiac muscle-specific enhancer and muscle-specific promoter. Journal of molecular and cellular cardiology, 28 6, 1211-25

Molkentin, J D; Li, L; Olson, E N 1996. Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity. The Journal of biological chemistry, 271 29, 17199-204

Molkentin, J D; Olson, E N 1996. Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors. Proceedings of the National Academy of Sciences of the United States of America, 93 18, 9366-73

Molkentin, J D; Olson, E N 1996. Defining the regulatory networks for muscle development. Current opinion in genetics & development, 6 4, 445-53

Molkentin, J D; Black, B L; Martin, J F; Olson, E N 1995. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell, 83 7, 1125-36

Molkentin, J; Precht, D 1995. Determination of trans-octadecenoic acids in German margarines, shortenings, cooking and dietary fats by Ag-TLC/GC. Zeitschrift fur Ernahrungswissenschaft, 34 4, 314-7

Precht, D; Molkentin, J 1995. Trans fatty acids: implications for health, analytical methods, incidence in edible fats and intake (a review). Die Nahrung, 39 5-6, 343-74

Ranganayakulu, G; Zhao, B; Dokidis, A; Molkentin, J D; Olson, E N; Schulz, R A 1995. A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila. Developmental biology, 171 1, 169-81

Molkentin, J D; Kalvakolanu, D V; Markham, B E 1994. Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Molecular and cellular biology, 14 7, 4947-57

Molkentin, J D; Markham, B E 1994. An M-CAT binding factor and an RSRF-related A-rich binding factor positively regulate expression of the alpha-cardiac myosin heavy-chain gene in vivo. Molecular and cellular biology, 14 8, 5056-65

Dahms, N M; Rose, P A; Molkentin, J D; Zhang, Y; Brzycki, M A 1993. The bovine mannose 6-phosphate/insulin-like growth factor II receptor. The role of arginine residues in mannose 6-phosphate binding. The Journal of biological chemistry, 268 8, 5457-63

Molkentin, J D; Brogan, R S; Jobe, S M; Markham, B E 1993. Expression of the alpha-myosin heavy chain gene in the heart is regulated in part by an E-box-dependent mechanism. The Journal of biological chemistry, 268 4, 2602-9

Molkentin, J D; Markham, B E 1993. Myocyte-specific enhancer-binding factor (MEF-2) regulates alpha-cardiac myosin heavy chain gene expression in vitro and in vivo. The Journal of biological chemistry, 268 26, 19512-20

Molkentin, J; Gregersen, P K; Lin, X; Zhu, N; Wang, Y; Wang, Y; Chen, S; Chen, S; Baxter-Lowe, L A; Silver, J 1993. Molecular analysis of HLA-DR beta and DQ beta polymorphism in Chinese with rheumatoid arthritis. Annals of the rheumatic diseases, 52 8, 610-2

Barbieri, J T; Armellini, D; Molkentin, J; Rappuoli, R 1992. Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin. Infection and immunity, 60 12, 5071-7

Molkentin, J; Gorski, J; Baxter-Lowe, L A 1991. Detection of 14 HLA-DQB1 alleles by oligotyping. Human immunology, 31 2, 114-22