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George Deepe, MD

Clinical Interest

Infectious Disease

Research Interests

I have been involved in the study of the host response to the pathogenic fungus, Histoplasma capsulatum for over 25 years. I have devoted the large majority of our work on the role of the innate and adaptive immune response to this fungus. The la...

Specialties

Infectious Disease
Internal Medicine

Education/Credentials
  • Bachelor's Degree: Kenyon College
  • Medical Degree: University of Cincinnati College of Medicine
  • Residency: Southern Illinois School of Medicine
  • Fellowship : University of Kentucky College of Medicine
  • Fellowship : University of Cincinnati College of Medicine
Board Certifications & Licenses
    American Board of Internal Medicine (Infectious Disease) (Certification Date: 11/09/1982)
    American Board of Internal Medicine (Certification Date: 09/12/1979)
Contact Information
  • Medical Sciences Building
  • Room 6152
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0560
  • Office 513-558-4704
  • Fax 513-558-2089
  • Email george.deepe@uc.edu

Peer Reviewed Publications

Friedrich, Dirk; Zapf, Dorinja; Lohse, Björn; Fecher, Roger A; Deepe, George S; Rupp, Jan 2019. The HIF-1?/LC3-II-axis impacts on fungal immunity in human macrophages. Infection and immunity, ,

Bueter, Chelsea L; Deepe, George S 2018. Aeroallergens Exacerbate Histoplasma capsulatum Infection. Journal of immunology (Baltimore, Md. : 1950), 201 11, 3352-3361

Deepe, George S 2018. Outbreaks of histoplasmosis: The spores set sail. PLoS pathogens, 14 9, e1007213

Deepe, George S; Buesing, William R; Ostroff, Gary R; Abraham, Ambily; Specht, Charles A; Huang, Haibin; Levitz, Stuart M 2018. Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice. Vaccine, 36 23, 3359-3367

Kyrmizi, Irene; Ferreira, Helena; Carvalho, Agostinho; Figueroa, Julio Alberto Landero; Zarmpas, Pavlos; Cunha, Cristina; Akoumianaki, Tonia; Stylianou, Kostas; Deepe, George S; Samonis, George; Lacerda, João F; Campos, António; Kontoyiannis, Dimitrios P; Mihalopoulos, Nikolaos; Kwon-Chung, Kyung J; El-Benna, Jamel; Valsecchi, Isabel; Beauvais, Anne; Brakhage, Axel A; Neves, Nuno M; Latge, Jean-Paul; Chamilos, Georgios 2018. Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis. Nature microbiology, 3 7, 791-803

Tweedle, Jamie L; Deepe, George S 2018. Tumor Necrosis Factor Alpha Antagonism Reveals a Gut/Lung Axis That Amplifies Regulatory T Cells in a Pulmonary Fungal Infection. Infection and immunity, 86 6,

Donnell, Anna M; Lewis, Stephanie; Abraham, Sami; Subramanian, Kavitha; Figueroa, Julio Landero; Deepe, George S; Vonderheide, Anne P 2017. Investigation of an optimal cell lysis method for the study of the zinc metalloproteome of Histoplasma capsulatum. Analytical and bioanalytical chemistry, ,

Friedrich, Dirk; Fecher, Roger A; Rupp, Jan; Deepe, George S 2017. Impact of HIF-1? and hypoxia on fungal growth characteristics and fungal immunity. Microbes and infection, 19 3, 204-209

Horwath, Michael C; Bell-Horwath, Tiffany R; Lescano, Victor; Krishnan, Karthik; Merino, Edward J; Deepe, George S 2017. Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1. Chembiochem : a European journal of chemical biology, ,

Subramanian Vignesh, Kavitha; Deepe, George S 2017. Metallothioneins: Emerging Modulators in Immunity and Infection. International journal of molecular sciences, 18 10,

Dade, Jessica; DuBois, Juwen C; Pasula, Rajamouli; Donnell, Anna M; Caruso, Joseph A; Smulian, A George; Deepe, George S 2016. HcZrt2, a zinc responsive gene, is indispensable for the survival of Histoplasma capsulatum in vivo. Medical mycology, 54 8, 865-75

Fecher, Roger A; Horwath, Michael C; Friedrich, Dirk; Rupp, Jan; Deepe, George S 2016. Inverse Correlation between IL-10 and HIF-1? in Macrophages Infected with Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 197 2, 565-79

George, Mariam Mathew; Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Caruso, Joseph A; Deepe, George S 2016. Zinc Induces Dendritic Cell Tolerogenic Phenotype and Skews Regulatory T Cell-Th17 Balance. Journal of immunology (Baltimore, Md. : 1950), 197 5, 1864-76

Hsieh, Heidi; Vignesh, Kavitha Subramanian; Deepe, George S; Choubey, Divaker; Shertzer, Howard G; Genter, Mary Beth 2016. Mechanistic studies of the toxicity of zinc gluconate in the olfactory neuronal cell line Odora. Toxicology in vitro : an international journal published in association with BIBRA, 35 , 24-30

Sterkel, Alana K; Lorenzini, Jenna L; Fites, J Scott; Subramanian Vignesh, Kavitha; Sullivan, Thomas D; Wuthrich, Marcel; Brandhorst, Tristan; Hernandez-Santos, Nydiaris; Deepe, George S; Klein, Bruce S 2016. Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity. Cell host & microbe, 19 3, 361-74

Subramanian Vignesh, Kavitha; Deepe, George S 2016. Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses. Archives of biochemistry and biophysics, 611 , 66-78

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Divanovic, Senad; Caruso, Joseph A; Deepe, George S 2016. IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn(2+) that Promotes Pathogen Persistence in Macrophages. Cell reports, 16 12, 3232-46

Xiong, Ye; Lingrel, Jerry B; Wüthrich, Marcel; Klein, Bruce S; Vasudevan, Neelakantan T; Jain, Mukesh K; George, Mariam; Deepe, George S 2016. Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1?/Jagged2/Notch Axis. mBio, 7 3,

Horwath, Michael C; Fecher, Roger A; Deepe, George S 2015. Histoplasma capsulatum, lung infection and immunity. Future microbiology, 10 6, 967-75

Figueroa, Julio A Landero; Vignesh, Kavitha Subramanian; Deepe, George S; Caruso, Joseph 2014. Selectivity and specificity of small molecule fluorescent dyes/probes used for the detection of Zn2+ and Ca2+ in cells. Metallomics : integrated biometal science, 6 2, 301-15

Verma, A; Kroetz, D N; Tweedle, J L; Deepe, G S 2014. Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33. Mucosal immunology, ,

Verma, Akash; Wüthrich, Marcel; Deepe, George; Klein, Bruce 2014. Adaptive Immunity to Fungi. Cold Spring Harbor perspectives in medicine, ,

Cole, Garry T; Hung, Chiung-Yu; Sanderson, Sam D; Hurtgen, Brady J; Wüthrich, Marcel; Klein, Bruce S; Deepe, George S; Ostroff, Gary R; Levitz, Stuart M 2013. Novel strategies to enhance vaccine immunity against coccidioidomycosis. PLoS pathogens, 9 12, e1003768

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S 2013. Zinc sequestration: arming phagocyte defense against fungal attack. PLoS pathogens, 9 12, e1003815

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S 2013. Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. Immunity, 39 4, 697-710

Deepe, G. S., Jr.; Buesing, W. R. 2012. Deciphering the pathways of death of , 188 1 , 334-44

Deepe, George S 2012. NADPH oxidase regulates efficacy of vaccination in aspergillosis. The Journal of clinical investigation, 122 5, 1608-11

Deepe, George S; Buesing, William R 2012. Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection. Journal of immunology (Baltimore, Md. : 1950), 188 1, 334-44

Kroetz, D. N.; Deepe, G. S. 2012. The role of cytokines and chemokines in Cytokine, 58 1 , 112-7

Kroetz, D. N.; Deepe, G. S., Jr. 2012. CCR5 deficiency mitigates the deleterious effects of tumor necrosis factor J Immunol, 205 6 , 955-63

Kroetz, Danielle N; Deepe, George S 2012. The role of cytokines and chemokines in Histoplasma capsulatum infection. Cytokine, 58 1, 112-7

Kroetz, Danielle N; Deepe, George S 2012. CCR5 deficiency mitigates the deleterious effects of tumor necrosis factor ? antagonism in murine histoplasmosis. The Journal of infectious diseases, 205 6, 955-63

Wüthrich, Marcel; Deepe, George S; Klein, Bruce 2012. Adaptive immunity to fungi. Annual review of immunology, 30 , 115-48

Kroetz, D. N.; Deepe, G. S., Jr. 2011. An aberrant thymus in CCR5 J Immunol, 186 10 , 5949-55

Kroetz, Danielle N; Deepe, George S 2011. An Aberrant Thymus in CCR5-/- Mice Is Coupled with an Enhanced Adaptive Immune Response in Fungal Infection. Journal of immunology (Baltimore, Md. : 1950), 186 10, 5949-55

Mora-Montes, Héctor M; Netea, Mihai G; Ferwerda, Gerben; Lenardon, Megan D; Brown, Gordon D; Mistry, Anita R; Kullberg, Bart Jan; O'Callaghan, Chris A; Sheth, Chirag C; Odds, Frank C; Brown, Alistair J P; Munro, Carol A; Gow, Neil A R; Deepe, G S 2011. Recognition and Blocking of Innate Immunity Cells by Candida albicans Chitin. Infection and immunity, 79 5, 1961-70

Deepe, G. S., Jr. 2010. Histoplasma capsulatum , 2 , 3305-3318

Kroetz, D. N.; Deepe, G. S., Jr. 2010. CCR5 dictates the equilibrium of proinflammatory IL-17 J Immunol, 184 9 , 5224-31

Kroetz, Danielle N; Deepe, George S 2010. CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection. Journal of immunology (Baltimore, Md. : 1950), 184 9, 5224-31

Szymczak, W. A.; Deepe, G. S., Jr. 2010. Antigen-presenting dendritic cells rescue CD4-depleted CCR2 Infect Immun, 78 5 , 2125-37

Szymczak, Wendy A; Deepe, George S 2010. Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection. Infection and immunity, 78 5, 2125-37

Winters, M. S.; Chan, Q.; Caruso, J. A.; Deepe, G. S., Jr. 2010. Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses J Infect Dis, 202 7 , 1136-45

Winters, Michael S; Chan, Qilin; Caruso, Joseph A; Deepe, George S 2010. Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses. The Journal of infectious diseases, 202 7, 1136-45

Deepe, George S; Gibbons, Reta S 2009. Interleukins 17 and 23 influence the host response to Histoplasma capsulatum. The Journal of infectious diseases, 200 1, 142-51

Szymczak, W. A.; Deepe, G. S., Jr. 2009. The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity J Immunol, 183 3 , 1964-74

Szymczak, Wendy A; Deepe, George S 2009. The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity. Journal of immunology (Baltimore, Md. : 1950), 183 3, 1964-74

Chagas, Ronney Fernandes; Bailão, Alexandre Melo; Pereira, Maristela; Winters, Michael S; Smullian, Alan George; Deepe, George S; de Almeida Soares, Célia Maria 2008. The catalases of Paracoccidioides brasiliensis are differentially regulated: protein activity and transcript analysis. Fungal genetics and biology : FG & B, 45 11, 1470-8

de Bastos Ascenço Soares, Renata; Gomez, Francisco J; de Almeida Soares, Célia Maria; Deepe, George S 2008. Vaccination with heat shock protein 60 induces a protective immune response against experimental Paracoccidioides brasiliensis pulmonary infection. Infection and immunity, 76 9, 4214-21

Deepe, George S; Gibbons, Reta S 2008. TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), 180 2, 1088-97

Deepe, George S; Gibbons, Reta S; Smulian, A George 2008. Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs. Journal of leukocyte biology, 84 3, 669-78

Medeiros, Alexandra I; Sá-Nunes, Anderson; Turato, Walter M; Secatto, Adriana; Frantz, Fabiani G; Sorgi, Carlos A; Serezani, Carlos H; Deepe, George S; Faccioli, Lúcia H 2008. Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells. Journal of immunology (Baltimore, Md. : 1950), 181 12, 8544-51

Winters, Michael S; Spellman, Daniel S; Chan, Qilin; Gomez, Francisco J; Hernandez, Margarita; Catron, Brittany; Smulian, Alan G; Neubert, Thomas A; Deepe, George S 2008. Histoplasma capsulatum proteome response to decreased iron availability. Proteome science, 6 , 36

Cutler, Jim E; Deepe, George S; Klein, Bruce S 2007. Advances in combating fungal diseases: vaccines on the threshold. Nature reviews. Microbiology, 5 1, 13-28

Dann, Frank J; Gottlieb, Alice B; Deepe, George S; Flynn, JoAnne L; Wallis, Robert S; Thompson, Elizabeth H Z; Louie, James S 2007. Structural-functional relationships of TNF-alpha antagonists: next steps. The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, 12 1, 46-7

Deepe, George S 2007. Tumor necrosis factor-alpha antagonism by the murine tumor necrosis factor-alpha receptor 2-Fc fusion protein exacerbates histoplasmosis in mice. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 27 6, 471-80

Deepe, George S 2007. Tumor necrosis factor-alpha and host resistance to the pathogenic fungus, Histoplasma capsulatum. The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, 12 1, 34-7

Smulian, A George; Gibbons, Reta S; Demland, Jeffery A; Spaulding, Deborah T; Deepe, George S 2007. Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum. Eukaryotic cell, 6 11, 2066-71

Wüthrich, Marcel; Filutowicz, Hanna I; Allen, Holly L; Deepe, George S; Klein, Bruce S 2007. V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis. Infection and immunity, 75 1, 193-200

Allen, Holly L; Deepe, George S 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), 177 3, 1763-71

Deepe, George S; Gibbons, Reta S 2006. T cells require tumor necrosis factor-alpha to provide protective immunity in mice infected with Histoplasma capsulatum. The Journal of infectious diseases, 193 2, 322-30

Deepe, George S; McGuinness, Michael 2006. Interleukin-1 and host control of pulmonary histoplasmosis. The Journal of infectious diseases, 194 6, 855-64

Scheckelhoff, Mark R; Deepe, George S 2006. Pulmonary V beta 4+ T cells from Histoplasma capsulatum-infected mice respond to a homologue of Sec31 that confers a protective response. The Journal of infectious diseases, 193 6, 888-97

Allen, Holly L; Deepe, George S 2005. Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. The Journal of clinical investigation, 115 10, 2875-85

Borges, Clayton L; Pereira, Maristela; Felipe, Maria S S; de Faria, Fabrícia P; Gomez, Francisco J; Deepe, George S; Soares, Célia M A 2005. The antigenic and catalytically active formamidase of Paracoccidioides brasiliensis: protein characterization, cDNA and gene cloning, heterologous expression and functional analysis of the recombinant protein. Microbes and infection / Institut Pasteur, 7 1, 66-77

Deepe, George S 2005. Modulation of infection with Histoplasma capsulatum by inhibition of tumor necrosis factor-alpha activity. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 41 Suppl 3 , S204-7

Deepe, George S; Smelt, Sara; Louie, James S 2005. Tumor necrosis factor inhibition and opportunistic infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 41 Suppl 3 , S187-8

Deepe, George S; Wüthrich, Marcel; Klein, Bruce S 2005. Progress in vaccination for histoplasmosis and blastomycosis: coping with cellular immunity. Medical mycology : official publication of the International Society for Human and Animal Mycology, 43 5, 381-9

Scheckelhoff, Mark; Deepe, George S 2005. A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatum. Infection and immunity, 73 4, 2129-34

Barton, Lance F; Runnels, Herbert A; Schell, Todd D; Cho, Yunjung; Gibbons, Reta; Tevethia, Satvir S; Deepe, George S; Monaco, John J 2004. Immune defects in 28-kDa proteasome activator gamma-deficient mice. Journal of immunology (Baltimore, Md. : 1950), 172 6, 3948-54

Deepe, George S 2004. Preventative and therapeutic vaccines for fungal infections: from concept to implementation. Expert review of vaccines, 3 6, 701-9

Deepe, George S; Gibbons, Reta S 2003. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. Journal of immunology (Baltimore, Md. : 1950), 171 10, 5353-62

Gildea, Lucy A; Gibbons, Reta; Finkelman, Fred D; Deepe, George S 2003. Overexpression of interleukin-4 in lungs of mice impairs elimination of Histoplasma capsulatum. Infection and immunity, 71 7, 3787-93

Guedes, Herbert Leonel de Matos; Guimarães, Allan Jefferson; Muniz, Mauro de Medeiros; Pizzini, Claudia Vera; Hamilton, Andrew John; Peralta, José Mauro; Deepe, George S; Zancopé-Oliveira, Rosely M 2003. PCR assay for identification of histoplasma capsulatum based on the nucleotide sequence of the M antigen. Journal of clinical microbiology, 41 2, 535-9

Huffnagle, Gary B; Deepe, George S 2003. Innate and adaptive determinants of host susceptibility to medically important fungi. Current opinion in microbiology, 6 4, 344-50

McCormack, Francis X; Gibbons, Reta; Ward, Susan R; Kuzmenko, Alexander; Wu, Huixing; Deepe, George S 2003. Macrophage-independent fungicidal action of the pulmonary collectins. The Journal of biological chemistry, 278 38, 36250-6

Nosanchuk, Joshua D; Steenbergen, Judith N; Shi, Li; Deepe, George S; Casadevall, Arturo 2003. Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum. The Journal of clinical investigation, 112 8, 1164-75

Wuthrich, Marcel; Filutowicz, Hanna I; Warner, Tom; Deepe, George S; Klein, Bruce S 2003. Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts. The Journal of experimental medicine, 197 11, 1405-16

Barton, Lance F; Cruz, Miguel; Rangwala, Reshma; Deepe, George S; Monaco, John J 2002. Regulation of immunoproteasome subunit expression in vivo following pathogenic fungal infection. Journal of immunology (Baltimore, Md. : 1950), 169 6, 3046-52

Costa, Alessandra A; Gómez, Francisco J; Pereira, Maristela; Felipe, M Sueli S; Jesuino, Rosália S A; Deepe, George S; de Almeida Soares, Célia M 2002. Characterization of a gene which encodes a mannosyltransferase homolog of Paracoccidioides brasiliensis. Microbes and infection / Institut Pasteur, 4 10, 1027-34

Cunha, Daniela A; Zancopé-Oliveira, Roseli M; Sueli, M; Felipe, S; Salem-Izacc, Silvia M; Deepe, George S; Soares, Célia M A 2002. Heterologous expression, purification, and immunological reactivity of a recombinant HSP60 from Paracoccidioides brasiliensis. Clinical and diagnostic laboratory immunology, 9 2, 374-7

Deepe, George S; Gibbons, Reta S 2002. Functional properties of the T cell receptor repertoire in responding to the protective domain of heat-shock protein 60 from Histoplasma capsulatum. The Journal of infectious diseases, 186 6, 815-22

Deepe, George S; Gibbons, Reta S 2002. Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum. Infection and immunity, 70 7, 3759-67

Deepe, George S; Gibbons, Reta S; Ward, Susan R 2002. Discordance between T-cell receptor expression and effector function in mice infected with Histoplasma capsulatum. Infection and immunity, 70 3, 1648-52

Scheckelhoff, Mark; Deepe, George S 2002. The protective immune response to heat shock protein 60 of Histoplasma capsulatum is mediated by a subset of V beta 8.1/8.2+ T cells. Journal of immunology (Baltimore, Md. : 1950), 169 10, 5818-26

Deepe, G S; Gibbons, R 2001. V beta 6+ T cells are obligatory for vaccine-induced immunity to Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 167 4, 2219-26

Deepe, G S; Gibbons, R 2001. Protective efficacy of H antigen from Histoplasma capsulatum in a murine model of pulmonary histoplasmosis. Infection and immunity, 69 5, 3128-34

Gomez, F J; Woodward, E O; Pilcher-Roberts, R; Gibbons, R S; Deepe, G S 2001. V beta 6+ and V beta 4+ T cells exert cooperative activity in clearance of secondary infection with Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 166 4, 2855-62

Izacc, S M; Gomez, F J; Jesuino, R S; Fonseca, C A; Felipe, M S; Deepe, G S; Soares, C M 2001. Molecular cloning, characterization and expression of the heat shock protein 60 gene from the human pathogenic fungus Paracoccidioides brasiliensis. Medical mycology : official publication of the International Society for Human and Animal Mycology, 39 5, 445-55

Allendoerfer, R; Deepe, G S 2000. Regulation of infection with Histoplasma capsulatum by TNFR1 and -2. Journal of immunology (Baltimore, Md. : 1950), 165 5, 2657-64

Cain, J A; Deepe, G S 2000. Interleukin-12 neutralization alters lung inflammation and leukocyte expression of CD80, CD86, and major histocompatibility complex class II in mice infected with Histoplasma capsulatum. Infection and immunity, 68 4, 2069-76

Deepe, G S 2000. Immune response to early and late Histoplasma capsulatum infections. Current opinion in microbiology, 3 4, 359-62

Deepe, G S; Gibbons, R 2000. Recombinant murine granulocyte-macrophage colony-stimulating factor modulates the course of pulmonary histoplasmosis in immunocompetent and immunodeficient mice. Antimicrobial agents and chemotherapy, 44 12, 3328-36

Deepe, G S; Romani, L; Calich, V L; Huffnagle, G; Arruda, C; Molinari-Madlum, E E; Perfect, J R 2000. Knockout mice as experimental models of virulence. Medical mycology : official publication of the International Society for Human and Animal Mycology, 38 Suppl 1 , 87-98

Retallack, D M; Deepe, G S; Woods, J P 2000. Applying in vivo expression technology (IVET) to the fungal pathogen Histoplasma capsulatum. Microbial pathogenesis, 28 3, 169-82

Allendörfer, R; Brunner, G D; Deepe, G S 1999. Complex requirements for nascent and memory immunity in pulmonary histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), 162 12, 7389-96

Deepe, G S; Gibbons, R; Woodward, E 1999. Neutralization of endogenous granulocyte-macrophage colony-stimulating factor subverts the protective immune response to Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 163 9, 4985-93

Fisher, K L; Deepe, G S; Woods, J P 1999. Histoplasma capsulatum strain variation in both H antigen production and beta-glucosidase activity and overexpression of HAG1 from a telomeric linear plasmid. Infection and immunity, 67 7, 3312-6

Retallack, D M; Heinecke, E L; Gibbons, R; Deepe, G S; Woods, J P 1999. The URA5 gene is necessary for histoplasma capsulatum growth during infection of mouse and human cells. Infection and immunity, 67 2, 624-9

Zancopé-Oliveira, R M; Reiss, E; Lott, T J; Mayer, L W; Deepe, G S 1999. Molecular cloning, characterization, and expression of the M antigen of Histoplasma capsulatum. Infection and immunity, 67 4, 1947-53

Allendoerfer, R; Deepe, G S 1998. Infection with Histoplasma capsulatum: Host-fungus interface. Revista iberoamericana de micología : órgano de la Asociación Española de Especialistas en Micología, 15 4, 256-60

Allendoerfer, R; Deepe, G S 1998. Blockade of endogenous TNF-alpha exacerbates primary and secondary pulmonary histoplasmosis by differential mechanisms. Journal of immunology (Baltimore, Md. : 1950), 160 12, 6072-82

Batanghari, J W; Deepe, G S; Di Cera, E; Goldman, W E 1998. Histoplasma acquisition of calcium and expression of CBP1 during intracellular parasitism. Molecular microbiology, 27 3, 531-9

Cain, J A; Deepe, G S 1998. Evolution of the primary immune response to Histoplasma capsulatum in murine lung. Infection and immunity, 66 4, 1473-81

Dixon, D M; Casadevall, A; Klein, B; Mendoza, L; Travassos, L; Deepe, G S 1998. Development of vaccines and their use in the prevention of fungal infections. Medical mycology : official publication of the International Society for Human and Animal Mycology, 36 Suppl 1 , 57-67

Gomez, F J; Cain, J A; Gibbons, R; Allendoerfer, R; Deepe, G S 1998. Vbeta4(+) T cells promote clearance of infection in murine pulmonary histoplasmosis. The Journal of clinical investigation, 102 5, 984-95

Matthews, R C; Maresca, B; Burnie, J P; Cardona, A; Carratu, L; Conti, S; Deepe, G S; Florez, A M; Franceschelli, S; Garcia, E; Gargano, L S; Kobayashi, G S; McEwen, J G; Ortiz, B L; Oviedo, A M; Polonelli, L; Ponton, J; Restrepos, A; Storlazzi, A 1998. Stress proteins in fungal diseases. Medical mycology : official publication of the International Society for Human and Animal Mycology, 36 Suppl 1 , 45-51

Mounts, A; Deepe, G S 1998. Simultaneous infection with Blastomyces dermatitidis and Cryptococcus neoformans. Medical mycology : official publication of the International Society for Human and Animal Mycology, 36 1, 47-50

Murphy, J W; Bistoni, F; Deepe, G S; Blackstock, R A; Buchanan, K; Ashman, R B; Romani, L; Mencacci, A; Cenci, E; Fè d'Ostiani, C; Del Sero, G; Calich, V L; Kashino, S S 1998. Type 1 and type 2 cytokines: from basic science to fungal infections. Medical mycology : official publication of the International Society for Human and Animal Mycology, 36 Suppl 1 , 109-18

Allendoerfer, R; Biovin, G P; Deepe, G S 1997. Modulation of immune responses in murine pulmonary histoplasmosis. The Journal of infectious diseases, 175 4, 905-14

Allendoerfer, R; Deepe, G S 1997. Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice. Infection and immunity, 65 7, 2564-9

Deepe, G S 1997. Prospects for the development of fungal vaccines. Clinical microbiology reviews, 10 4, 585-96

Healy, D P; Dansereau, R J; Dunn, A B; Clendening, C E; Mounts, A W; Deepe, G S 1997. Reduced tetracycline bioavailability caused by magnesium aluminum silicate in liquid formulations of bismuth subsalicylate. The Annals of pharmacotherapy, 31 12, 1460-4

Allendoerfer, R; Maresca, B; Deepe, G S 1996. Cellular immune responses to recombinant heat shock protein 70 from Histoplasma capsulatum. Infection and immunity, 64 10, 4123-8

Deepe, G S; Gibbons, R; Brunner, G D; Gomez, F J 1996. A protective domain of heat-shock protein 60 from Histoplasma capsulatum. The Journal of infectious diseases, 174 4, 828-34

Deepe, G S; Durose, G G 1995. Immunobiological activity of recombinant H antigen from Histoplasma capsulatum. Infection and immunity, 63 8, 3151-7

Gomez, F J; Allendoerfer, R; Deepe, G S 1995. Vaccination with recombinant heat shock protein 60 from Histoplasma capsulatum protects mice against pulmonary histoplasmosis. Infection and immunity, 63 7, 2587-95

Deepe, G S 1994. Role of CD8+ T cells in host resistance to systemic infection with Histoplasma capsulatum in mice. Journal of immunology (Baltimore, Md. : 1950), 152 7, 3491-500

Deepe, G S 1994. The immune response to Histoplasma capsulatum: unearthing its secrets. The Journal of laboratory and clinical medicine, 123 2, 201-5

Newman, S L; Gootee, L; Brunner, G; Deepe, G S 1994. Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis. The Journal of clinical investigation, 93 4, 1422-9

Allendoerfer, R; Magee, D M; Deepe, G S; Graybill, J R 1993. Transfer of protective immunity in murine histoplasmosis by a CD4+ T-cell clone. Infection and immunity, 61 2, 714-8

Deepe, G S 1993. Histoplasma capsulatum and V beta a mice: cellular immune responses and susceptibility patterns. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 31 3, 181-8

Rossi, S J; Healy, D P; Savani, D V; Deepe, G 1993. High-dose ciprofloxacin in the treatment of a renal cyst infection. The Annals of pharmacotherapy, 27 1, 38-9

Domer, J E; Murphy, J W; Deepe, G S; Franco, M 1992. Immunomodulation in the mycoses. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 30 Suppl 1 , 157-66

Gomez, F J; Gomez, A M; Deepe, G S 1992. An 80-kilodalton antigen from Histoplasma capsulatum that has homology to heat shock protein 70 induces cell-mediated immune responses and protection in mice. Infection and immunity, 60 7, 2565-71

Henderson, H M; Deepe, G S 1992. Recognition of Histoplasma capsulatum yeast-cell antigens by human lymphocytes and human T-cell clones. Journal of leukocyte biology, 51 5, 432-6

Gómez, A M; Rhodes, J C; Deepe, G S 1991. Antigenicity and immunogenicity of an extract from the cell wall and cell membrane of Histoplasma capsulatum yeast cells. Infection and immunity, 59 1, 330-6

Gomez, F J; Gomez, A M; Deepe, G S 1991. Protective efficacy of a 62-kilodalton antigen, HIS-62, from the cell wall and cell membrane of Histoplasma capsulatum yeast cells. Infection and immunity, 59 12, 4459-64

Deepe, G S; Brunner, G D 1990. Functional analysis of Histoplasma capsulatum-reactive T-cell hybridomas. Infection and immunity, 58 6, 1538-44

Deepe, G S; Bullock, W E 1990. Immunological aspects of fungal pathogenesis. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 9 8, 567-79

Deepe, G S; Bullock, W E 1989. Correlative studies of blastogenic responses and interleukin 1 production by mononuclear cells from patients with zoopathogenic fungal infections. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 27 3, 159-68

Harris, J E; Deepe, G S 1989. Requirements for histoplasmin presentation by accessory cells to a Histoplasma capsulatum-reactive T-cell line. Journal of leukocyte biology, 45 2, 105-13

Deepe, G S 1988. Protective immunity in murine histoplasmosis: functional comparison of adoptively transferred T-cell clones and splenic T cells. Infection and immunity, 56 9, 2350-5

Gomez, A M; Bullock, W E; Taylor, C L; Deepe, G S 1988. Role of L3T4+ T cells in host defense against Histoplasma capsulatum. Infection and immunity, 56 7, 1685-91

Hagler, D N; Deepe, G S; Pogue, C L; Walzer, P D 1988. Blastogenic responses to Pneumocystis carinii among patients with human immunodeficiency (HIV) infection. Clinical and experimental immunology, 74 1, 7-13

Harris, J E; Deepe, G S 1988. Characterization of antigenic determinants in histoplasmin that stimulate Histoplasma capsulatum-reactive T cells in vitro. Infection and immunity, 56 9, 2343-9

Deepe, G S; Smith, J G; Sonnenfeld, G; Denman, D; Bullock, W E 1986. Development and characterization of Histoplasma capsulatum-reactive murine T-cell lines and clones. Infection and immunity, 54 3, 714-22

Deepe, G S; Taylor, C L; Harris, J E; Bullock, W E 1986. Modulation of cellular immune responses in mice with disseminated histoplasmosis by recombinant interleukin-2. Infection and immunity, 53 1, 6-12

Deepe, G S; Taylor, C L; Bullock, W E 1985. Evolution of inflammatory response and cellular immune responses in a murine model of disseminated blastomycosis. Infection and immunity, 50 1, 183-9

Deepe, G S; Taylor, C L; Srivastava, L; Bullock, W E 1985. Impairment of granulomatous inflammatory response to Histoplasma capsulatum by inhibitors of angiotensin-converting enzyme. Infection and immunity, 48 2, 395-401

Deepe, G S; Watson, S R; Bullock, W E 1984. Cellular origins and target cells of immunoregulatory factors in mice with disseminated histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), 132 4, 2064-71

Bullock, W E; Deepe, G S 1983. Medical mycology in crisis. The Journal of laboratory and clinical medicine, 102 5, 685-93

Deepe, G S; Kravitz, G R; Bullock, W E 1983. Pharmacological modulation of suppressor cell activity in mice with disseminated histoplasmosis. Infection and immunity, 41 1, 114-20

Deepe, G S; MacMillan, B G; Linnemann, C C 1982. Unexplained fever in burn patients due to cytomegalovirus infection. JAMA : the journal of the American Medical Association, 248 18, 2299-301

Deepe, G S; Watson, S R; Bullock, W E 1982. Generation of disparate immunoregulatory factors in two inbred strains of mice with disseminated histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), 129 5, 2186-91

Deepe, G S; Capparell, R; Coonrod, J D 1980. Atypical mycobacterial lymphadenitis in an adult. Chest, 78 6, 882-3

Deepe, G S; Coonrod, J D 1980. Fulminant wound infection with Aeromonas hydrophila. Southern medical journal, 73 11, 1546-7

Deepe, G S; Eagleton, L E 1980. Resolution of influenzal pneumonia. IMJ. Illinois medical journal, 158 2, 76-8

Deepe, G S; Seder, R A . Molecular and cellular determinants of immunity to Histoplasma capsulatum. Research in immunology, 149 4-5, 397-406; discussion

Huaman, Moises A; Deepe, George S; Fichtenbaum, Carl J . Elevated Circulating Concentrations of Interferon-Gamma in Latent Tuberculosis Infection. Pathogens & immunity, 1 2, 291-303