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Satish K. Madala

Professor

Internal Medicine | College of Medicine

Contact Information
Research Interests

My laboratory research interests include idiopathic pulmonary fibrosis, asthma, scleroderma, cystic fibrosis, and lung injury. Our research studies aim to identify the cellular and molecular mechanisms underlying chronic lung diseases to guide the development of new therapies.

Our research on genomic comparisons of IPF and non-IPF cells revealed significant differences in cellular and molecular pathways underlying the pathogenesis in IPF. We were the first to describe an increase of WT1 pro...

Peer Reviewed Publications

Ghandikota, Sudhir; Sharma, Mihika; Ediga, Harshavardhana H; Madala, Satish K; Jegga, Anil G 2022. Consensus Gene Co-Expression Network Analysis Identifies Novel Genes Associated with Severity of Fibrotic Lung Disease. International journal of molecular sciences, 23 10,

Schuliga, Michael; Madala, Satish K 2022. ASK1ng to Delay the Progression of Pulmonary Fibrosis. American journal of respiratory cell and molecular biology, 66 5, 465-467

Gajjala, Prathibha R; Kasam, Rajesh K; Soundararajan, Divyalakshmi; Sinner, Debora; Huang, Steven K; Jegga, Anil G; Madala, Satish K 2021. Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis. JCI insight, 6 20,

Gajjala, Prathibha R; Madala, Satish K 2021. Notch3: A New Culprit in Fibrotic Lung Disease. American journal of respiratory cell and molecular biology, 64 4, 403-404

Yombo, Dan J K; Odayar, Varshini; Gupta, Nishant; Jegga, Anil G; Madala, Satish K 2021. The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis. Frontiers in immunology, 12 , 645717

Kasam, Rajesh K; Gajjala, Prathibha R; Jegga, Anil G; Courtney, Jennifer A; Randell, Scott H; Kramer, Elizabeth L; Clancy, John P; Madala, Satish K 2020. Fibrocyte accumulation in the lungs of cystic fibrosis patients. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 19 5, 815-822

Kasam, Rajesh K; Ghandikota, Sudhir; Soundararajan, Divyalakshmi; Reddy, Geereddy B; Huang, Steven K; Jegga, Anil G; Madala, Satish K 2020. Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis. EMBO molecular medicine, 12 9, e12131

Kramer, Elizabeth L; Madala, Satish K; Hudock, Kristin M; Davidson, Cynthia; Clancy, John P 2020. Subacute TGF? Exposure Drives Airway Hyperresponsiveness in Cystic Fibrosis Mice through the PI3K Pathway. American journal of respiratory cell and molecular biology, 62 5, 657-667

Guo, Jinbang; Hardie, William D; Cleveland, Zackary I; Davidson, Cynthia; Xu, Xuefeng; Madala, Satish K; Woods, Jason C 2019. Longitudinal free-breathing MRI measurement of murine lung physiology in a progressive model of lung fibrosis. Journal of applied physiology (Bethesda, Md. : 1985), 126 4, 1138-1149

Kasam, Rajesh K; Reddy, Geereddy B; Jegga, Anil G; Madala, Satish K 2019. Dysregulation of Mesenchymal Cell Survival Pathways in Severe Fibrotic Lung Disease: The Effect of Nintedanib Therapy. Frontiers in pharmacology, 10 , 532

Sontake, Vishwaraj; Gajjala, Prathibha R; Kasam, Rajesh K; Madala, Satish K 2019. New therapeutics based on emerging concepts in pulmonary fibrosis. Expert opinion on therapeutic targets, 23 1, 69-81

Yombo, Dan J K; Mentink-Kane, Margaret M; Wilson, Mark S; Wynn, Thomas A; Madala, Satish K 2019. Heat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation. The Journal of biological chemistry, 294 41, 15082-15094

Kramer, Elizabeth L; Hardie, William D; Madala, Satish K; Davidson, Cynthia; Clancy, John P 2018. Subacute TGF? expression drives inflammation, goblet cell hyperplasia, and pulmonary function abnormalities in mice with effects dependent on CFTR function. American journal of physiology. Lung cellular and molecular physiology, 315 3, L456-L465

Reddy, V Sudhakar; Madala, Satish K; Trinath, Jamma; Reddy, G Bhanuprakash 2018. Extracellular small heat shock proteins: exosomal biogenesis and function. Cell stress & chaperones, 23 3, 441-454

Sontake, Vishwaraj; Kasam, Rajesh K; Sinner, Debora; Korfhagen, Thomas R; Reddy, Geereddy B; White, Eric S; Jegga, Anil G; Madala, Satish K 2018. Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease. JCI insight, 3 16,

Singh, Brijendra; Jegga, Anil G; Shanmukhappa, Kumar S; Edukulla, Ramakrishna; Khurana Hershey, Gurjit Kaur; Medvedovic, Mario; Dillon, Stacey R; Madala, Satish K 2017. Correction: IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function. PloS one, 12 1, e0170446

Singh, Brijendra; Kasam, Rajesh K; Sontake, Vishwaraj; Wynn, Thomas A; Madala, Satish K 2017. Repetitive intradermal bleomycin injections evoke T-helper cell 2 cytokine-driven pulmonary fibrosis. American journal of physiology. Lung cellular and molecular physiology, 313 5, L796-L806

Sontake, Vishwaraj; Wang, Yunguan; Kasam, Rajesh K; Sinner, Debora; Reddy, Geereddy B; Naren, Anjaparavanda P; McCormack, Francis X; White, Eric S; Jegga, Anil G; Madala, Satish K 2017. Hsp90 regulation of fibroblast activation in pulmonary fibrosis. JCI insight, 2 4, e91454

Wang, Yunguan; Yella, Jaswanth; Chen, Jing; McCormack, Francis X; Madala, Satish K; Jegga, Anil G 2017. Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers. BMC pulmonary medicine, 17 1, 133

Glasser, Stephan W; Hagood, James S; Wong, Simon; Taype, Carmen A; Madala, Satish K; Hardie, William D 2016. Mechanisms of Lung Fibrosis Resolution. The American journal of pathology, 186 5, 1066-77

Madala, Satish K; Sontake, Vishwaraj; Edukulla, Ramakrishna; Davidson, Cynthia R; Schmidt, Stephanie; Hardie, William D 2016. Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis. American journal of respiratory cell and molecular biology, 55 6, 792-803

Madala, Satish K; Thomas, George; Edukulla, Ramakrishna; Davidson, Cynthia; Schmidt, Stephanie; Schehr, Angelica; Hardie, William D 2016. p70 ribosomal S6 kinase regulates subpleural fibrosis following transforming growth factor-? expression in the lung. American journal of physiology. Lung cellular and molecular physiology, 310 2, L175-86

Singh, Brijendra; Jegga, Anil G; Shanmukhappa, Kumar S; Edukulla, Ramakrishna; Khurana Hershey, Gurjit H; Medvedovic, Mario; Dillon, Stacey R; Madala, Satish K 2016. IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function. PloS one, 11 8, e0161877

Edukulla, Ramakrishna; Singh, Brijendra; Jegga, Anil G; Sontake, Vishwaraj; Dillon, Stacey R; Madala, Satish K 2015. Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression. The Journal of biological chemistry, 290 21, 13510-20

Huang, Yan; Powers, Corey; Madala, Satish K; Greis, Kenneth D; Haffey, Wendy D; Towbin, Jeffrey A; Purevjav, Enkhsaikhan; Javadov, Sabzali; Strauss, Arnold W; Khuchua, Zaza 2015. Cardiac metabolic pathways affected in the mouse model of barth syndrome. PloS one, 10 6, e0128561

Madala, Satish K 2015. Reply: tissue fibrocytes are a subpopulation of macrophages. American journal of respiratory cell and molecular biology, 52 1, 138

Sontake, Vishwaraj; Shanmukhappa, Shiva K; DiPasquale, Betsy A; Reddy, Geereddy B; Medvedovic, Mario; Hardie, William D; White, Eric S; Madala, Satish K 2015. Fibrocytes Regulate Wilms Tumor 1-Positive Cell Accumulation in Severe Fibrotic Lung Disease. Journal of immunology (Baltimore, Md. : 1950), 195 8, 3978-91

Madala, Satish K; Edukulla, Ramakrishna; Phatak, Mukta; Schmidt, Stephanie; Davidson, Cynthia; Acciani, Thomas H; Korfhagen, Thomas R; Medvedovic, Mario; Lecras, Timothy D; Wagner, Kimberly; Hardie, William D 2014. Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis. PloS one, 9 1, e86536

Madala, Satish K; Edukulla, Ramakrishna; Schmidt, Stephanie; Davidson, Cynthia; Ikegami, Machiko; Hardie, William D 2014. Bone marrow-derived stromal cells are invasive and hyperproliferative and alter transforming growth factor-?-induced pulmonary fibrosis. American journal of respiratory cell and molecular biology, 50 4, 777-86

Madala, Satish K; Korfhagen, Thomas R; Schmidt, Stephanie; Davidson, Cynthia; Edukulla, Ramakrishna; Ikegami, Machiko; Violette, Shelia M; Weinreb, Paul H; Sheppard, Dean; Hardie, William D 2014. Inhibition of the ?v?6 integrin leads to limited alteration of TGF-?-induced pulmonary fibrosis. American journal of physiology. Lung cellular and molecular physiology, 306 8, L726-35

Madala, Satish K; Edukulla, Ramakrishna; Davis, Katy R; Schmidt, Stephanie; Davidson, Cynthia; Kitzmiller, Joseph A; Hardie, William D; Korfhagen, Thomas R 2012. Resistin-like molecule ?1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis. Respiratory research, 13 , 51

Madala, Satish K; Schmidt, Stephanie; Davidson, Cynthia; Ikegami, Machiko; Wert, Susan; Hardie, William D 2012. MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation. American journal of respiratory cell and molecular biology, 46 3, 380-8

Madala, Satish K; Dolan, Michael A; Sharma, Deepak; Ramalingam, Thirumalai R; Wilson, Mark S; Mentink-Kane, Margaret M; Masison, Daniel C; Wynn, Thomas A 2011. Mapping mouse IL-13 binding regions using structure modeling, molecular docking, and high-density peptide microarray analysis. Proteins, 79 1, 282-93

Madala, Satish K; Maxfield, Melissa D; Davidson, Cynthia R; Schmidt, Stephanie M; Garry, Daniel; Ikegami, Machiko; Hardie, William D; Glasser, Stephan W 2011. Rapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient Mice. Pulmonary medicine, 2011 , 653524

Mentink-Kane, Margaret M; Cheever, Allen W; Wilson, Mark S; Madala, Satish K; Beers, Lara Megan; Ramalingam, Thirumalai R; Wynn, Thomas A 2011. Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13R?2. Gastroenterology, 141 6, 2200-9

Wilson, Mark S; Ramalingam, Thirumalai R; Rivollier, Aymeric; Shenderov, Kevin; Mentink-Kane, Margaret M; Madala, Satish K; Cheever, Allen W; Artis, David; Kelsall, Brian L; Wynn, Thomas A 2011. Colitis and intestinal inflammation in IL10-/- mice results from IL-13R?2-mediated attenuation of IL-13 activity. Gastroenterology, 140 1, 254-64

Wynn, Thomas A; Barron, Luke; Thompson, Robert W; Madala, Satish K; Wilson, Mark S; Cheever, Allen W; Ramalingam, Thirumalai 2011. Quantitative assessment of macrophage functions in repair and fibrosis. Current protocols in immunology, Chapter 14 , Unit14.22

Madala, Satish K; Pesce, John T; Ramalingam, Thirumalai R; Wilson, Mark S; Minnicozzi, Samantha; Cheever, Allen W; Thompson, Robert W; Mentink-Kane, Margaret M; Wynn, Thomas A 2010. Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis. Journal of immunology (Baltimore, Md. : 1950), 184 7, 3955-63

Nemeth, Krisztian; Keane-Myers, Andrea; Brown, Jared M; Metcalfe, Dean D; Gorham, James D; Gorham, Jared D; Bundoc, Virgilio G; Bundoc, Victor G; Hodges, Marcus G; Jelinek, Ivett; Madala, Satish; Karpati, Sarolta; Mezey, Eva 2010. Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proceedings of the National Academy of Sciences of the United States of America, 107 12, 5652-7

Wilson, Mark S; Madala, Satish K; Ramalingam, Thirumalai R; Gochuico, Bernadette R; Rosas, Ivan O; Cheever, Allen W; Wynn, Thomas A 2010. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. The Journal of experimental medicine, 207 3, 535-52

Ramalingam, Thirumalai R; Pesce, John T; Mentink-Kane, Margaret M; Madala, Satish; Cheever, Allen W; Comeau, Michael R; Ziegler, Steven F; Wynn, Thomas A 2009. Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin. Journal of immunology (Baltimore, Md. : 1950), 182 10, 6452-9

Wang, Yunguan; Yella, Jaswanth K; Ghandikota, Sudhir; Cherukuri, Tejaswini C; Ediga, Harshavardhana H; Madala, Satish K; Jegga, Anil G . Pan-transcriptome-based candidate therapeutic discovery for idiopathic pulmonary fibrosis. Therapeutic advances in respiratory disease, 14 , 1753466620971143