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Photo of  Kotagal S. Kant, MD

Kotagal S. Kant, MD

Professor of Clinical

Internal Medicine | College of Medicine

  • Fellowship: University of Cincinnati (Nephrology)
  • Residency: Michael Reese Hospital and Medical Center (Internal Medicine)
  • Medical Degree: All India Institute of Medical Sciences
Board Certifications & Licenses

American Board of Internal Medicine (Certification Date: 1974-06-19)
American Board of Internal Medicine (Nephrology) (Certification Date: 1976-10-19)


Internal Medicine

Contact Information
Research Interests

Calcium, Phosphorus and Bone Metabolism, Acid Base Changes in Hemodialysis, Glomerular Disease, Vascular Disease in CKD/ESRD: Role of Dialysis Adequacy, Thrombophilia and Mineral Metabolism Abnormalities

Clinical Interests


Acute Kidney Injury (AKI)

Acute Renal failure (Acute kidney failure)

Peer Reviewed Publications

Kant, K Shashi; Gonzalez, Alejandro R; Hariachar, Srinivas; Bernardo, Marializa; Duggal, Ajay; Engstrand, Sara; Hunter, John; Plone, Melissa; Hertel, Joachim 2011. Converting to Doxercalciferol Capsules From Intravenous Paricalcitol or Doxercalciferol Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, ,

Nicolaou, Stella A; Neumeier, Lisa; Takimoto, Koichi; Lee, Susan Molleran; Duncan, Heather J; Kant, Shashi K; Mongey, Anne Barbara; Filipovich, Alexandra H; Conforti, Laura 2010. Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus. Cell calcium, 47 1, 19-28

Duncan, Heather J; Pittman, Susan; Govil, Amit; Sorn, Lisa; Bissler, Gloria; Schultz, Tersea; Faith, J; Kant, Shashi; Roy-Chaudhury, Prabir 2007. Alternative medicine use in dialysis patients: potential for good and bad! Nephron. Clinical practice, 105 3, c108-13

Nicolaou, Stella A; Szigligeti, Peter; Neumeier, Lisa; Lee, Susan Molleran; Duncan, Heather J; Kant, Shashi K; Mongey, Anne Barbara; Filipovich, Alexandra H; Conforti, Laura 2007. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. Journal of immunology (Baltimore, Md. : 1950), 179 1, 346-56

El-Khatib, Mahmoud; Duncan, Heather J; Kant, K Shashi 2006. Role of C-reactive protein, reticulocyte haemoglobin content and inflammatory markers in iron and erythropoietin administration in dialysis patients. Nephrology (Carlton, Vic.), 11 5, 400-4

Kant, K Shashi; Cook, E Francis; Duncan, Heather; Freyberg, Ron 2002. Parathyroid hormone suppression by intravenous calcitriol: role of phosphate, calcium, race and diabetes. The American journal of the medical sciences, 323 4, 210-5

Bleyer AJ, Burke SK, Dillon M, Garrett B, Kant KS, Lynch D, Rodman SN, Schoenfeld P, Teitelbaum I, Zeig S, Slatopolsky E 1999. A comparison of the calcium free-phosphate binder sevelamer hydrocholoride with calcium acetate in the treatment of hyperphosphatemia in hemodialysis patients Am J Kidney Disease, 33 , 694-701

Peddi VR, Kant KS 1998. Catastrophic secondary antiphospholipid syndrome with concomitant antithrombin III deficiency J Am Soc Nephrol, 5 , 1882-1887

Kant KS 1994. Intradialytic cardiac arrhythmias: II Seminars in Dialysis, 7 , 58-60

Padilla B, Pollak VE, Pesce A, Kant KS, Gilinsky NH, Deddens JA 1994. Pancreatitis in patients with end-stage renal disease Medicine (Baltimore), 73 , 8-20

Asherson RA, Kant KS 1993. Antiphospholipid antibodies and the kidney J of Rheumat, 20 , 1267-1272

Pollak VE, Thornley-Brown D, kant KS, Pesce A, Deddens JA 1993. A case study of a recent decline in the dalysis fatality rate Contrib Nephrol, 102 , 59-72

Kant KS, Glueck HI, Coots MC, Tonne VA, Brubaker R, Penn I 1992. Protein S deficiency and skin necrosis associated with continuous ambulatory peritoneal dialysis Am J Kidney Disease, 19 , 264-271

Padilla B, Weiss M, Kant KS 1992. Henoch-Schonlein purpura in a patient with diabetic nephropathy: Case report and a review of the literature Am J Kidney Disease, 20 , 191-194

Pollak VE, Kant KS, Pesce A, Cathey M 1992. Continous quality improvement in chronic disease: Early detection of a mini-cluster of pyrogenic reactions during hemodialysis and the effect of on-line monitoring Dialysis and Transplantation, 21 , 330-339

Pollak VE, Pesce A, Kant KS 1992. Continuous quality improvement in chronic disease: a computerized medical record enables description of a severity index to evaluate outcomes in end-stage renal disease Am J Kidney Disease, 19 , 514-522

Thornley-Brown D, Galla JH, Williams PD, Kant KS, Rashkin M 1992. Lithium toxicity associated with trichobezoar Ann Intern Med, 116 , 739-740

Pollak VE, Kant KS, Hariharan S 1991. Diffuse and focal proliferative lupus nephritis: Treatment approaches and results Nephron, 59 , 177-193

Hariharan S, Pollak VE, Kant KS, Weiss MA, Wadhwa NK 1990. Diffuse proliferative lupus nephritis: long-term observations in patients treated with ancrod Clin Nephrol, 34 , 61-69

Sridhar NR, Thornley-Brown D, Kant K 1990. Peritonitis due to Aspergillus niger: diagnostic importance of peritoneal eosinophilia Perit Dial Int, 10 , 100-101

First MR, Smith RD, Weiss, MA, Schroeder TJ, Kant KS, Minda R, Stephens GW, Penn I, Alexander JW 1989. Cyclosporine-associated glomerular and arteriolar thrombosis following renal transplantation Transplant Proc, 21 , 1567-1570

Kant, KS 1989. Treatment of recurrent peritonitis Perit Dial Int, 9 , 355

Kant KS, Goetz D, Marzluff C, Motz D 1988. Relapsing peritonitis in continuous ambulatory peritoneal dialysis (CAPD): Treatment by interruption of CAPD and prolonged antibiotic therapy Perit Dial Int, 8 , 155-157

Kim S, Washwa NK, Kant KS, Pollak VE, Glas-Greenwalt P, Weiss MA, Hong CG 1988. Fibrinolysis in glomerulonephritis treated with ancrod: Renal functional, immunologic and histopathologic effects Q J Med, 69 , 879-905

Pollak VE, Charoenpanich R, Robson M, Kant KS 1988. Dialyzer membranes: syndromes associated with first use and effects of multiple use Kindey Int, Suppl 24 , S49-S52

Charoenpanich R, Pollak VE, Kant KS, Robson MD, Cathey M, 1987. Effect of first and subsequent use of hemodialyzers on patient well-being: The rise and fall of a syndrome associated with new dialyzer use Artif Organs, 11 , 123-127

Pollak VE, Kant KS 1987. Autoimmune glomerulonephritis: An approach to certain pathogenetic factors and their relation to treatment Clin Aspect of Autoimmunity, 1 , 2-11

Glas-Greenwalt P, Hall JM, Panke TW, Kant KS, Allen CM, Pollak VE 1986. Fibrinolysis in health and disease: abnormal levels of plasminogen activator, plasminogen inhibitor, and protein C in thrombotic thrombocytopenic purpura J Lab Clin Med, 108 , 415-422

Pollak VE, Kant KS, Parnell SL, Levin NW 1986. Repeated use of dialyzers is safe: Long-term observations on morbidity and mortality in patients with end-stage renal disease Nephron, 42 , 217-223

Robson MD, Charoenpanich R, Kant KS, Peterson DW, Flynn J, Cathey M, Pollak VE 1986. Effect of first ans subsequent use of hemodialyzers on patient well-being: Analysis of the incidence of symptoms and events and description of a syndrome associate with new dialyzer use Am J Nephrol, 6 , 101-106

Du X-H, Glas-Greenwalt P, Kant KS, Allen CM, Hayes S, Pollak VE 1985. Nephrotic syndrome with renal vein thrombosis: Pathogenetic importance of a plasmin inhibitor (alpha 2-antiplasmin) Clin Nephrol, 24 , 186-191

Garcia G, Deddens JA, D-Achiardi-Rey R, First MR, Samuels SJ, Kant KS, Pollak VE 1985. Results of treatment in patients with end-stage renal disease: A multivariate analysis of risk factors and survival in 341 successive patients Am J Kidney Disease, 5 , 10-18

Glas-Greenwalt P, Kant KS, Dosekun A, Frazier J, Allen C, Pollak VE 1985. Ancros: Normalization of fibrinolyti enzyme abnormalities in patients with systemic lupus erythematous and lupus nephritis J Lab Clin Med, 105 , 99-107

Glueck HI, Kant KS, Weiss MA, :Pollak VE, Miller MA, Coots M 1985. Thrombosis in systemic lupus erythematosus: Relation to the presence of circulating anicoagulants Arch Intern Med, 145 , 1389-1395

Kant KS, Pollak VE, Dosekun A, Glas-Greenwalt P, Weiss MA, Glueck HI 1985. Lupus nephritis with thrombosis and abnormal fibrinolysis: Effect of ancrod J Lab Clin Med, 105 , 77-88

Dosekun AK, Pollak VE, Glas-Greenwalt P, Kant KS, Penovich P, Lebron-Berges A, Weiss MA, Levinson JE 1984. Ancrod in systemic lupus erythematosus and with thrombosis: clinical and fibrinolysis effects Arch Intern Med, 44 , 37-42

Glas-Greenwalt P, Kant KS, Allen C, Pollak VE 1984. Fibrinolysis in health and disease: severe abnormalities in systemic lupus erythematosus J Lab Clin Med, 104 , 962-976

Dosekun AK, First MR, Chandran PK, Kant KS, Glas-Greenwalt P, Weiss MA, Alexander JW, Pollak VE 1982. Successful treatment by defibrination with ancrod in a patient with hyperacute renal allograft failure and a deficiency of plasma prostacyclin stimulating factor Clin Nephrol, 18 , 101-105

Grant KD, Kant KS, Pollak VE, Weiss MA, Hess EV 1982. Thrombosis in the lupus kidney Arthritis Rheum, 25 , 117

Kant KS, Dosekun AK, Chandran KG, Glas-Greenwalt P, Weiss MA, Pollak VE 1982. Deficiency of a plasma factor stimulating vascular prostacyclin generation in patients with lupus nephritis and glomerular thrombi and its correction by ancrod: Ino-vivo and in-vitro observations Thromb Res, 27 , 641-658

First MR, Munda R, Kant KS, Fidler JP, Alexander JW 1981. Steroid withdrawal following HLA-identical related donor transplantation Transplant Proc, 13 , 319-322

Kant KS, Pollak VE, Cathey M, Goetz D, Berlin R 1981. Multiple use of dialyzers: Safety and efficacy Kindey Int, 19 , 728-138

Kant KS, Pollak VE, Weiss MA, Glueck HI, Miller AN, Hess EV 1981. Glomerular thrombosis in systemic lupus erythematosus: Prevalence and significance Medicine (Baltimore), 60 , 71-86

Ooi BS, Weiss MA, Kant KS, Hong CF, Pollak VE, Andriole VT 1981. Antibody to Tamm-Horsfall protein after acute tubular necrosis Am J Nephrol, 1 , 48-51

Pollak VE, Kant KS 1981. Nephritis in systemic lupus erythematosus (natural history, treatment and pathogenesis) Ric Clin Lab, 11 , 1-10

Kant KS, Pollak VE, Goetz D, Cathey M 1980. Dialyzer reuse: a long-term study of safety and efficacy at one center Proc Clin Dial Transplant Forum, 10 , 35-38

Pesce AJ, Clyne DH, Pollak VE, Kant, KS 1980. Renal tubular interactions of proteins Clin Biochem, 13 , 209-215

Clyne DH, Kant KS, Pesce AJ, Pollak VE 1979. Nephrotoxicity of low molecular weight serum proteins: Physiochemical interactions between myoglobin, hemoglobin, Bence-Jones proteins and Tamm-Horsfall mucoprotein Curr Probl Clin Biochem, 299-308,

Pesce AJ, Kant KS, Hanenson IB, Pollak VE 1978. Autoimmunity and systemic lupus erythematosus Clinical Immunochemistry, ,

Pesce AJ, Kant KS, Ooi BS, Pollak VE 1978. The application of enzyme immunoassay in the diagnosis of autoimmune diseases Scand J Immun, 8 (suppl 7) , 91-96

Ooi BS, Kant KS, Hanenson IB, Pesce AJ, Pollak VE 1977. Lymphocytotoxins in epileptic patients receiving phenytoin Clin Exp Immunol, 30 , 56-61

Kant, Shashi . Choices of ecosystem capital without discounting and prices. Environmental monitoring and assessment, 86 1-2, 105-27

Kant, Shashi; Haldar, Partha . Is NDM-1 actually being imported to UK from India? Indian journal of public health, 54 3, 151-4

Lal, Vivek; Kant, Shashi; Dewan, Richa; Rai, Sanjay K; Biswas, Ashutosh . A two-site hospital-based study on factors associated with nonadherence to highly active antiretroviral therapy. Indian journal of public health, 54 4, 179-83

Malhotra, Sumit; Kant, Shashi . Adverse female-to-male sex ratio at birth in India: a cause for concern. The National medical journal of India, 19 3, 152-4

Pandey, Arvind; Thomas, M; Reddy, D C S; Kant, Shashi; Bhattacharya, M . Process of estimating the number of people living with HIV in India. Indian journal of public health, 51 1, 7-13

Abstract Publications

Kant KS, El-Khatib MT, Duncan HJ 2009. Use of Antibiotic-Locking Solutions to Decrease Hemodialysis Catheter Related Bacteremia: Long-Term Impact on CRB Rates and Bacterial Resistance Amer Soc Neph, ,

Kant KS, Duncan HJ, Tallarico BJ, McKinney RA, Diadato CL 2008. Does the buttonhole technique of AV fistula cannulation increase risk of bacteremia? Amer Soc Neph, 19 , 262A

Nicolaou S, Szigletti P, Duncan H, Neumeier L, Lee S, Kant K, Filipovich A, Conforti L 2006. Altered dynamics of Kv 1.3 channel compartmentalization in the immunological synapse in SLE J Clinical Immunology, 119 , 568

Du Xo-H, Glas-Greenwalt P, Kant KS, Pollak VE 1984. Nephrotic syndrome with renal vein thrombosis: Pathogenetic importance of a plasmin inhibitor Clin Res, 32 , 445A

Glas-Greenwalt P, Olinger CP, Kant KS, Healy L, Pollak VE 1984. Severe abnormalities of the fibrin-clearing in multiple sclerosis Clin Res, 32 , 496A

Kant KS, Glas-Greenwalt P, Sexton J, Pollak VE 1984. Endothelial cell plasminogen activator production: Effect of mediators of inflammation Clin Res, 32 , 349A

Glas-Greenwalt P, Kant KS, Allen C, Dosekun AK, Pollak VE 1982. Impaired fibrinolysis in systemic lupus erythematosus and thrombotic thrombocytopenic purpura Clin Res, 30 , 502A

Kant KS, Pesce AJ, Clyne DH, Pollak VE 1977. Coprecipitation of Tamm-Horsfall protein with myoglobin hemoglobin and Bence-Jones proteins Clin Res, 25 , 594A