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Syn Yeo, PhD

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Peer Reviewed Publications

Okamoto, Takako; Yeo, Syn Kok; Hao, Mingang; Copley, Mary Rose; Haas, Michael A; Chen, Song; Guan, Jun-Lin 2020. FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function. Cancer research, 80 17, 3580-3592

Paul, Ritama; Luo, Ming; Mo, Xueying; Lu, Jason; Yeo, Syn Kok; Guan, Jun-Lin 2020. Correction to: FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors. Breast cancer research : BCR, 22 1, 71

Paul, Ritama; Luo, Ming; Mo, Xueying; Lu, Jason; Yeo, Syn Kok; Guan, Jun-Lin 2020. FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors. Breast cancer research : BCR, 22 1, 59

Wu, Hsin-Jung; Hao, Mingang; Yeo, Syn Kok; Guan, Jun-Lin 2020. FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication. Oncogene, ,

Yang, Fuchun; Sun, Shaogang; Wang, Chenran; Haas, Michael; Yeo, Syn; Guan, Jun-Lin 2020. Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation. British journal of cancer, 122 12, 1791-1802

Yeo, Syn Kok; Guan, Jun-Lin 2020. Regulation of immune checkpoint blockade efficacy in breast cancer by FIP200: A canonical-autophagy-independent function. Cell stress, 4 8, 216-217

Yeo, Syn Kok; Wang, Chenran; Guan, Jun-Lin 2020. Role of FIP200 in inflammatory processes beyond its canonical autophagy function. Biochemical Society transactions, 48 4, 1599-1607

Yeo, Syn Kok; Zhu, Xiaoting; Okamoto, Takako; Hao, Mingang; Wang, Cailian; Lu, Peixin; Lu, Long Jason; Guan, Jun-Lin 2020. Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer. eLife, 9 ,

Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin 2019. Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells. Nature metabolism, 1 11, 1127-1140

Yeo, Syn Kok; Paul, Ritama; Haas, Michael; Wang, Chenran; Guan, Jun-Lin 2018. Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer. Autophagy, 14 7, 1214-1225

Wang, Chenran; Yeo, Syn; Haas, Michael A; Guan, Jun-Lin 2017. Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia. The Journal of cell biology, 216 8, 2581-2596

Yeo, Syn Kok; French, Rhiannon; Spada, Filomena; Clarkson, Richard 2017. Opposing roles of Nfkb2 gene products p100 and p52 in the regulation of breast cancer stem cells. Breast cancer research and treatment, 162 3, 465-477

Yeo, Syn Kok; Guan, Jun-Lin 2017. Breast Cancer: Multiple Subtypes within a Tumor? Trends in cancer, 3 11, 753-760

Chen, Song; Wang, Chenran; Yeo, Syn; Liang, Chun-Chi; Okamoto, Takako; Sun, Shaogang; Wen, Jian; Guan, Jun-Lin 2016. Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model. Genes & development, 30 7, 856-69

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin 2016. Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. The Journal of cell biology, 212 5, 545-60

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin 2016. Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. The Journal of cell biology, 212 7, 879

Yeo, Syn Kok; Ali, Ahmed Y; Hayward, Olivia A; Turnham, Daniel; Jackson, Troy; Bowen, Ifor D; Clarkson, Richard 2016. ?-Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines. Phytotherapy research : PTR, 30 3, 418-25

Yeo, Syn Kok; Guan, Jun-Lin 2016. Hierarchical heterogeneity in mammary tumors and its regulation by autophagy. Autophagy, 12 10, 1960-1961

Yeo, Syn Kok; Wen, Jian; Chen, Song; Guan, Jun-Lin 2016. Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgf?/Smad Signaling. Cancer research, 76 11, 3397-410

Wen, Jian; Yeo, Syn; Wang, Chenran; Chen, Song; Sun, Shaogang; Haas, Michael A; Tu, Wei; Jin, Feng; Guan, Jun-Lin 2015. Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis. Breast cancer research and treatment, 149 3, 619-29

Aydar, Ebru; Yeo, Syn; Djamgoz, Mustafa; Palmer, Christopher 2009. Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy. Cancer cell international, 9 , 23