Skip to main content
Photo of  Shao-Chun Wang, PhD

Shao-Chun Wang, PhD

Research Interests

My laboratory uses molecular, cellular, and genetic approaches to study the following projects:
(1) Proliferating Cell Nuclear Antigen (PCNA): PCNA is an indispensable protein forming the platform on the chromatin to coordinate cell proliferation a...

Education/Credentials
  • Doctoral Degree: University of Minnesota
  • Bachelor's Degree: Taipei Medical University
  • Fellowship: M. D. Anderson Cancer Center
Contact Information
  • Vontz Center for Molecular Studies
  • 3125 Eden Avenue
  • ML 0521
  • Cincinnati, Ohio 45267
  • Office 513-558-4259
  • Email shao-chun.wang@uc.edu
  • UC Institute Member Seal

Peer Reviewed Publications

Hung, Yu; Wang, Yuan-Liang; Lin, You-Zhe; Chiang, Shu-Fen; Wu, Wan-Rong; Wang, Shao-Chun 2019. The exosomal compartment protects epidermal growth factor receptor from small molecule inhibitors. Biochemical and biophysical research communications, 510 1, 42-47

Liu, Liang-Chih; Wang, Yuan-Liang; Lin, Pei-Le; Zhang, Xiang; Cheng, Wei-Chung; Liu, Shu-Hsuan; Chen, Chih-Jung; Hung, Yu; Jan, Chia-Ing; Chang, Ling-Chu; Qi, Xiaoyang; Hsieh-Wilson, Linda C; Wang, Shao-Chun 2019. Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15. International journal of cancer, 145 9, 2478-2487

Hunt, Brian G; Wang, Yuan-Liang; Chen, Min-Shan; Wang, Shao-Chun; Waltz, Susan E 2017. Maternal diethylhexyl phthalate exposure affects adiposity and insulin tolerance in offspring in a PCNA-dependent manner. Environmental research, 159 , 588-594

De Toni, Enrico N; Ziesch, Andreas; Rizzani, Antonia; Török, Helga-Paula; Hocke, Sandra; Lü, Shuai; Wang, Shao-Chun; Hucl, Tomas; Göke, Burkhard; Bruns, Christiane; Gallmeier, Eike 2016. Inactivation of BRCA2 in human cancer cells identifies a subset of tumors with enhanced sensitivity towards death receptor-mediated apoptosis. Oncotarget, 7 8, 9477-90

Broering, Tyler J; Wang, Yuan-Liang; Pandey, Ram Naresh; Hegde, Rashmi S; Wang, Shao-Chun; Namekawa, Satoshi H 2015. BAZ1B is dispensable for H2AX phosphorylation on Tyrosine 142 during spermatogenesis. Biology open, ,

Chou, Lien-Yang; Hu, Pan; Zhuang, Jia; Morabito, Joseph V; Ng, Ka Chon; Kao, Ya-Chuan; Wang, Shao-Chun; Shieh, Fa-Kuen; Kuo, Chun-Hong; Tsung, Chia-Kuang 2015. Formation of hollow and mesoporous structures in single-crystalline microcrystals of metal-organic frameworks via double-solvent mediated overgrowth. Nanoscale, 7 46, 19408-12

Hu, Jun-Li; Li, Xian; Wang, Xi-Ming; Cheng, Zhao-Ping; Chen, Dong-Feng; Wang, Shao-Chun; Kong, Qing-Xia 2015. Comparison of Elastic Properties of Bilateral Carotid Arteries in Relation to Site of Acute Ischemic Stroke Using Velocity Vector Imaging. Chinese medical journal, 128 21, 2960-3

Wang, Yuan-Liang; Overstreet, Anne-Marie; Chen, Min-Shan; Wang, Jiang; Zhao, Hua-Jun; Ho, Po-Chun; Smith, Molly; Wang, Shao-Chun 2015. Combined inhibition of EGFR and c-ABL suppresses the growth of triple-negative breast cancer growth through inhibition of HOTAIR. Oncotarget, 6 13, 11150-61

Hsieh, Tsung-Hua; Hsu, Chia-Yi; Tsai, Cheng-Fang; Long, Cheng-Yu; Chai, Chee-Yin; Hou, Ming-Feng; Lee, Jau-Nan; Wu, Deng-Chyang; Wang, Shao-Chun; Tsai, Eing-Mei 2014. miR-125a-5p is a prognostic biomarker that targets HDAC4 to suppress breast tumorigenesis. Oncotarget, ,

Wang, Shao-Chun 2014. PCNA: a silent housekeeper or a potential therapeutic target? Trends in pharmacological sciences, 35 4, 178-86

Lo, Yuan-Hung; Ho, Po-Chun; Chen, Min-Shan; Hugo, Eric; Ben-Jonathan, Nira; Wang, Shao-Chun 2013. Phosphorylation at tyrosine 114 of Proliferating Cell Nuclear Antigen (PCNA) is required for adipogenesis in response to high fat diet. Biochemical and biophysical research communications, 430 1, 43-8

Yu, Yung-Luen; Chou, Ruey-Hwang; Liang, Jia-Hong; Chang, Wei-Jung; Su, Kuo-Jung; Tseng, Yen-Ju; Huang, Wei-Chien; Wang, Shao-Chun; Hung, Mien-Chie 2013. Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides. PloS one, 8 4, e61362

Cui, Jiajun; Germer, Katherine; Wu, Tianying; Wang, Jiang; Luo, Jia; Wang, Shao-chun; Wang, Qianben; Zhang, Xiaoting 2012. Cross-talk between HER2 and MED1 regulates tamoxifen resistance of human breast cancer cells. Cancer research, 72 21, 5625-34

Hsieh, Tsung-Hua; Tsai, Cheng-Fang; Hsu, Chia-Yi; Kuo, Po-Lin; Hsi, Edward; Suen, Jau-Ling; Hung, Chih-Hsing; Lee, Jau-Nan; Chai, Chee-Yin; Wang, Shao-Chun; Tsai, Eing-Mei 2012. n-Butyl benzyl phthalate promotes breast cancer progression by inducing expression of lymphoid enhancer factor 1. PloS one, 7 8, e42750

Hsieh, Tsung-Hua; Tsai, Cheng-Fang; Hsu, Chia-Yi; Kuo, Po-Lin; Lee, Jau-Nan; Chai, Chee-Yin; Wang, Shao-Chun; Tsai, Eing-Mei 2012. Phthalates induce proliferation and invasiveness of estrogen receptor-negative breast cancer through the AhR/HDAC6/c-Myc signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26 2, 778-87

Lo, Yuan-Hung; Ho, Po-Chun; Wang, Shao-Chun 2012. Epidermal growth factor receptor protects proliferating cell nuclear antigen from cullin 4A protein-mediated proteolysis. The Journal of biological chemistry, 287 32, 27148-57

Zhao, Huajun; Ho, Po-Chun; Lo, Yuan-Hung; Espejo, Alexsandra; Bedford, Mark T; Hung, Mien-Chie; Wang, Shao-Chun 2012. Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. PloS one, 7 1, e29416

Ding, Qingqing; Chang, Chun-Ju; Xie, Xiaoming; Xia, Weiya; Yang, Jer-Yen; Wang, Shao-Chun; Wang, Yan; Xia, Jiahong; Chen, Libo; Cai, Changchun; Li, Huabin; Yen, Chia-Jui; Kuo, Hsu-Ping; Lee, Dung-Fang; Lang, Jingyu; Huo, Longfei; Cheng, Xiaoyun; Chen, Yun-Ju; Li, Chia-Wei; Jeng, Long-Bin; Hsu, Jennifer L; Li, Long-Yuan; Tan, Alai; Curley, Steven A; Ellis, Lee M; Dubois, Raymond N; Hung, Mien-Chie 2011. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. The Journal of clinical investigation, 121 11, 4526-36

Lo, Yuan-Hung; Ho, Po-Chun; Zhao, Huajun; Wang, Shao-Chun 2011. Inhibition of c-ABL sensitizes breast cancer cells to the dual ErbB receptor tyrosine kinase inhibitor lapatinib (GW572016). Anticancer research, 31 3, 789-95

Zhao, Huajun; Lo, Yuan-Hung; Ma, Li; Waltz, Susan E; Gray, Jerilyn K; Hung, Mien-Chie; Wang, Shao-Chun 2011. Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth. Molecular cancer therapeutics, 10 1, 29-36

Zhao, Huajun; Lo, Yuan-Hung; Yu, Ling; Wang, Shao-Chun 2011. Overcoming resistance to fulvestrant (ICI182,780) by downregulating the c-ABL proto-oncogene in breast cancer. Molecular carcinogenesis, 50 5, 383-9

Zhao, Huajun; Ou-Yang, Fu; Chen, I-Fen; Hou, Ming-Feng; Yuan, Shyng-Shiou F; Chang, Hsueh-Ling; Lee, Yi-Chen; Plattner, Rina; Waltz, Susan E; Ho, Shuk-Mei; Sims, Jonathan; Wang, Shao-Chun 2010. Enhanced resistance to tamoxifen by the c-ABL proto-oncogene in breast cancer. Neoplasia (New York, N.Y.), 12 3, 214-23

Wang, Shao-Chun; Hung, Mien-Chie 2009. Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors. Clinical cancer research : an official journal of the American Association for Cancer Research, 15 21, 6484-9

Nakagawa-Goto, Kyoko; Yamada, Koji; Nakamura, Seikou; Chen, Tzu-Hsuan; Chiang, Po-Cheng; Bastow, Kenneth F; Wang, Shao-Chun; Spohn, Bill; Hung, Mien-Chie; Lee, Fang-Yu; Lee, Fang-Chen; Lee, Kuo-Hsiung 2007. Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents. Bioorganic & medicinal chemistry letters, 17 18, 5204-9

Chen, I. F.; Ou-Yang, F.; Hung, J. Y.; Liu, J. C.; Wang, H.; Wang, S. C.; Hou, M. F.; Hortobagyi, G. N.; Hung, M. C. 2006. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model Mol Cancer Ther, 5 1 , 1-7

Chen, I-Fen; Ou-Yang, Fu; Hung, Jen-Yu; Liu, Jaw-Ching; Wang, Hongying; Wang, Shao-Chun; Hou, Ming-Feng; Hortobagyi, Gabriel N; Hung, Mien-Chie 2006. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Molecular cancer therapeutics, 5 1, 1-7

Wang, Shao-Chun; Nakajima, Yusuke; Yu, Yung-Luen; Xia, Weiya; Chen, Chun-Te; Yang, Cheng-Chieh; McIntush, Eric W; Li, Long-Yuan; Hawke, David H; Kobayashi, Ryuji; Hung, Mien-Chie 2006. Tyrosine phosphorylation controls PCNA function through protein stability. Nature cell biology, 8 12, 1359-68

Xia, W. Y.; Lien, H. C.; Wang, S. C.; Pan, Y.; Sahin, A.; Kuo, Y. H.; Chang, K. J.; Zhou, X.; Wang, H.; Yu, Z.; Hortobagyi, G.; Shi, D. R.; Hung, M. C. 2006. Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer Breast Cancer Res Treat, 98 3 , 295-301

Xia, Wei-Ya; Lien, Huang-Chun; Wang, Shao-Chun; Pan, Yung; Sahin, Aysegul; Kuo, Yau-Hung; Chang, King-Jeng; Zhou, Xin; Wang, Hongying; Yu, Zhengming; Hortobagyi, Gabriel; Shi, Dar-Ren; Hung, Mien-Chie 2006. Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer. Breast cancer research and treatment, 98 3, 295-301

Yu, Zhenming; Xia, Weiya; Wang, Hong-Ying; Wang, Shao-Chun; Pan, Yong; Kwong, Ka Yin; Hortobagyi, Gabriel N; Hung, Mien-Chie 2006. Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1. Molecular carcinogenesis, 45 9, 667-75

Giri, Dipak K.; Ali-Seyed, Mohamed; Li, Long-Yuan; Lee, Dung-Fang; Ling, Pin; Bartholomeusz, Geoffrey; Wang, Shao-Chun; Hung, Mien-Chie 2005. Endosomal Transport of ErbB-2: Mechanism for Nuclear Entry of the Cell Surface Receptor Mol. Cell. Biol., 25 24 , 11005-11018

Giri, Dipak K; Ali-Seyed, Mohamed; Li, Long-Yuan; Lee, Dung-Fang; Ling, Pin; Bartholomeusz, Geoffrey; Wang, Shao-Chun; Hung, Mien-Chie 2005. Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. Molecular and cellular biology, 25 24, 11005-18

Wang, S. C.; Hung, M. C. 2005. Cytoplasmic/nuclear shuttling and tumor progression Ann N Y Acad Sci, 1059 24 , 11-5

Wang, Shao-Chun; Hung, Mien-Chie 2005. Cytoplasmic/nuclear shuttling and tumor progression. Annals of the New York Academy of Sciences, 1059 , 11-5

Lee, C. M.; Lo, H. W.; Shao, R. P.; Wang, S. C.; Xia, W.; Gershenson, D. M.; Hung, M. C. 2004. Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy Cancer Res, 64 5 , 1788-93

Lee, Christine M; Lo, Hui-Wen; Shao, Ru-Ping; Wang, Shao-Chun; Xia, Weiya; Gershenson, David M; Hung, Mien-Chie 2004. Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy. Cancer research, 64 5, 1788-93

Makino, Keishi; Day, Chi-Ping; Wang, Shao-Chun; Li, Yan M; Hung, Mien-Chie 2004. Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway. Oncogene, 23 21, 3883-7

Wang, S. C.; Hung, M. C. 2004. Finding the bEST routes to cancer Cancer Biol Ther, 3 11 , 1090-1

Wang, Shao-Chun; Lien, Huang-Chun; Xia, Weiya; Chen, I. -Fen; Lo, Hui-Wen; Wang, Zhiqin; Ali-Seyed, Mohamed; Lee, Dung-Fang; Bartholomeusz, Geoffrey; Ou-Yang, Fu; Hung, Mien-Chie 2004. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2 Cancer Cell, 6 3 , 251-261

Wang, Shao-Chun; Hung, Mien-Chie 2004. Finding the bEST routes to cancer. Cancer biology & therapy, 3 11, 1090-1

Wang, Shao-Chun; Lien, Huang-Chun; Xia, Weiya; Chen, I-Fen; Lo, Hui-Wen; Wang, Zhiqin; Ali-Seyed, Mohamed; Lee, Dung-Fang; Bartholomeusz, Geoffrey; Ou-Yang, Fu; Giri, Dipak K; Hung, Mien-Chie 2004. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer cell, 6 3, 251-61

Yan, D. H.; Wen, Y.; Su, L. K.; Xia, W.; Wang, S. C.; Zhang, S.; Gan, L.; Lee, D. F.; Spohn, B.; Frey, J. A.; Hortobagyi, G. N.; Hung, M. C. 2004. A delayed chemically induced tumorigenesis in Brca2 mutant mice Oncogene, 23 10 , 1896-901

Yan, Duen-Hwa; Wen, Yong; Su, Li-Kuo; Xia, Weiya; Wang, Shao-Chun; Zhang, Su; Gan, Lin; Lee, Dung-Fang; Spohn, Bill; Frey, Jennifer A; Hortobagyi, Gabriel N; Hung, Mien-Chie 2004. A delayed chemically induced tumorigenesis in Brca2 mutant mice. Oncogene, 23 10, 1896-901

Lee, C. M.; Shvartsman, H.; Deavers, M. T.; Wang, S. C.; Xia, W.; Schmandt, R.; Bodurka, D. C.; Atkinson, E. N.; Malpica, A.; Gershenson, D. M.; Hung, M. C.; Lu, K. H. 2003. beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma Gynecol Oncol, 88 3 , 363-8

Lee, Christine M; Shvartsman, Hyun; Deavers, Michael T; Wang, Shao-Chun; Xia, Weiya; Schmandt, Rosemarie; Bodurka, Diane C; Atkinson, E Neely; Malpica, Anais; Gershenson, David M; Hung, Mien-Chie; Lu, Karen H 2003. beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma. Gynecologic oncology, 88 3, 363-8

Asada, Shinichi; Choi, Yongmun; Yamada, Masaki; Wang, Shao-Chun; Hung, Mien-Chie; Qin, Jun; Uesugi, Motonari 2002. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proceedings of the National Academy of Sciences of the United States of America, 99 20, 12747-52

Wang, Shao-Chun; Shao, Ruping; Pao, Annie Y; Zhang, Su; Hung, Mien-Chie; Su, Li-Kuo 2002. Inhibition of cancer cell growth by BRCA2. Cancer research, 62 5, 1311-4

Zou, Y.; Peng, H.; Zhou, B.; Wen, Y.; Wang, S. C.; Tsai, E. M.; Hung, M. C. 2002. Systemic tumor suppression by the proapoptotic gene bik Cancer Res, 62 1 , 8-12

Zou, Yiyu; Peng, Hua; Zhou, Binhua; Wen, Yong; Wang, Shao-Chun; Tsai, Eing-Mei; Hung, Mien-Chie 2002. Systemic tumor suppression by the proapoptotic gene bik. Cancer research, 62 1, 8-12

Tsai, E. M.; Wang, S. C.; Lee, J. N.; Hung, M. C. 2001. Akt activation by estrogen in estrogen receptor-negative breast cancer cells Cancer Res, 61 23 , 8390-2

Wang, S. C.; Makino, K.; Xia, W.; Kim, J. S.; Im, S. A.; Peng, H.; Mok, S. C.; Singletary, S. E.; Hung, M. C. 2001. DOC-2/hDab-2 inhibits ILK activity and induces anoikis in breast cancer cells through an Akt-independent pathway Oncogene, 20 47 , 6960-4

Wang, S. C.; Hung, M. C. 2001. HER2 overexpression and cancer targeting Semin Oncol, 28 5 Suppl 16 , 115-24

Wang, S. C.; Makino, K.; Su, L. K.; Pao, A. Y.; Kim, J. S.; Hung, M. C. 2001. Ultraviolet irradiation induces BRCA2 protein depletion through a p53-independent and protein synthesis-dependent pathway Cancer Res, 61 7 , 2838-42

Wang, S. C.; Zhang, L.; Hortobagyi, G. N.; Hung, M. C. 2001. Targeting HER2: recent developments and future directions for breast cancer patients Semin Oncol, 28 6 Suppl 18 , 21-9

Hung, M. C.; Wang, S. C. 2000. Suppressing HER2/neu-mediated cell transformation by transcriptional repressors Breast Dis, 11 2 , 133-44

Wang, S. C.; Hung, M. C. 2000. Transcriptional targeting of the HER-2/neu oncogene Drugs Today (Barc), 36 12 , 835-43

Xing, X.; Wang, S. C.; Xia, W.; Zou, Y.; Shao, R.; Kwong, K. Y.; Yu, Z.; Zhang, S.; Miller, S.; Huang, L.; Hung, M. C. 2000. The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis Nat Med, 6 2 , 189-95

Lo, S. S.; Lo, S. H.; Wang, S. C.; Hung, M. C. 1999. Inhibition of focal contact formation in cells transformed by p185neu Mol Carcinog, 25 2 , 150-4

Su, L. K.; Wang, S. C.; Qi, Y.; Luo, W.; Hung, M. C.; Lin, S. H. 1998. Characterization of BRCA2: temperature sensitivity of detection and cell-cycle regulated expression Oncogene, 17 18 , 2377-81

Wang, Shao-Chun; Lin, Sue-Hwa; Su, Li-Kuo; Hung, Mien-Chie 1997. Changes in BRCA2 Expression during Progression of the Cell Cycle Biochemical and Biophysical Research Communications, 234 1 , 247-251