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Photo of  David Plas, PhD

David Plas, PhD

Research Interests

The Plas lab aims to discover mechanisms that link cancer-causing mutations to oncogenic metabolism in cancers affected by mutations in PTEN and PI3K, including cancers of the blood, brain, and breast.  Current work is investigating the metaboli...

Education/Credentials
  • BS: University of Notre Dame
  • Ph.D.: Washington University
  • Postdoc: University of Pennsylvania
Contact Information
  • Vontz Center for Molecular Studies
  • 3125 Eden Avenue
  • ML 0521
  • Cincinnati, Ohio 45267
  • Office 513-558-7245
  • Email david.plas [at] uc.edu

Peer Reviewed Publications

Ren, Yan; Sivaganesan, Siva; Clark, Nicholas A; Zhang, Lixia; Biesiada, Jacek; Niu, Wen; Plas, David R; Medvedovic, Mario 2020. Predicting mechanism of action of cellular perturbations with pathway activity signatures. Bioinformatics (Oxford, England), ,

Sliz, Anna; Locker, Kathryn C S; Lampe, Kristin; Godarova, Alzbeta; Plas, David R; Janssen, Edith M; Jones, Helen; Herr, Andrew B; Hoebe, Kasper 2019. Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy. Science immunology, 4 38,

Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin 2019. Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells. Nature metabolism, 1 11, 1127-1140

Su, Rui; Dong, Lei; Li, Chenying; Nachtergaele, Sigrid; Wunderlich, Mark; Qing, Ying; Deng, Xiaolan; Wang, Yungui; Weng, Xiaocheng; Hu, Chao; Yu, Mengxia; Skibbe, Jennifer; Dai, Qing; Zou, Dongling; Wu, Tong; Yu, Kangkang; Weng, Hengyou; Huang, Huilin; Ferchen, Kyle; Qin, Xi; Zhang, Bin; Qi, Jun; Sasaki, Atsuo T; Plas, David R; Bradner, James E; Wei, Minjie; Marcucci, Guido; Jiang, Xi; Mulloy, James C; Jin, Jie; He, Chuan; Chen, Jianjun 2018. R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling. Cell, 172 1-2, 90-105.e23

Berman, Adi Y; Manna, Subrata; Schwartz, Naomi S; Katz, Yardena E; Sun, Yang; Behrmann, Catherine A; Yu, Jane J; Plas, David R; Alayev, Anya; Holz, Marina K 2017. ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism. Signal transduction and targeted therapy, 2 ,

Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kohei; Li, Na; Kopras, Elizabeth J; Kwiatkowski, David J; Borchers, Michael T; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Mays, Maxwell; Sun, Yang; Plas, David R; Sun, Julia L; Franz, David N; Capal, Jamie K; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J 2017. Tuberin Regulates Prostaglandin Receptor-mediated Viability, via Rheb, in mTORC1-hyperactive Cells. Molecular cancer research : MCR, ,

Liu, Hongqi; Feng, Xizhi; Ennis, Kelli N; Behrmann, Catherine A; Sarma, Pranjal; Jiang, Tony T; Kofuji, Satoshi; Niu, Liang; Stratton, Yiwen; Thomas, Hala Elnakat; Yoon, Sang-Oh; Sasaki, Atsuo T; Plas, David R 2017. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. Cell reports, 18 9, 2088-2095

Orr-Asman, Melissa A; Chu, Zhengtao; Jiang, Min; Worley, Mariah; LaSance, Kathleen; Koch, Sheryl E; Carreira, Vinicius S; Dahche, Hanan M; Plas, David R; Komurov, Kakajan; Qi, Xiaoyang; Mercer, Carol A; Anthony, Lowell B; Rubinstein, Jack; Thomas, Hala E 2017. mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment. Molecular cancer therapeutics, 16 11, 2432-2441

Yoon, Sang-Oh; Shin, Sejeong; Karreth, Florian A; Buel, Gwen R; Jedrychowski, Mark P; Plas, David R; Dedhar, Shoukat; Gygi, Steven P; Roux, Philippe P; Dephoure, Noah; Blenis, John 2017. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Molecular cell, ,

Ghosh, Joydeep; Kobayashi, Michihiro; Ramdas, Baskar; Chatterjee, Anindya; Ma, Peilin; Mali, Raghuveer Singh; Carlesso, Nadia; Liu, Yan; Plas, David R; Chan, Rebecca J; Kapur, Reuben 2016. S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance. The Journal of clinical investigation, 126 7, 2621-5

Shin, Sejeong; Buel, Gwen R; Wolgamott, Laura; Plas, David R; Asara, John M; Blenis, John; Yoon, Sang-Oh 2015. ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Molecular cell, 59 3, 382-98

Vallabhapurapu, Subrahmanya D; Noothi, Sunil K; Pullum, Derek A; Lawrie, Charles H; Pallapati, Rachel; Potluri, Veena; Kuntzen, Christian; Khan, Sohaib; Plas, David R; Orlowski, Robert Z; Chesi, Marta; Kuehl, W Michael; Bergsagel, P Leif; Karin, Michael; Vallabhapurapu, Sivakumar 2015. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nature communications, 6 , 8428

Hall, Daniel P; Cost, Nicholas G; Hegde, Shailaja; Kellner, Emily; Mikhaylova, Olga; Stratton, Yiwen; Ehmer, Birgit; Abplanalp, William A; Pandey, Raghav; Biesiada, Jacek; Harteneck, Christian; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F 2014. TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma. Cancer cell, 26 5, 738-53

Unruh, Dusten; Turner, Kevin; Srinivasan, Ramprasad; Kocatürk, Begüm; Qi, Xiaoyang; Chu, Zhengtao; Aronow, Bruce J; Plas, David R; Gallo, Catherine A; Kalthoff, Holger; Kirchhofer, Daniel; Ruf, Wolfram; Ahmad, Syed A; Lucas, Fred V; Versteeg, Henri H; Bogdanov, Vladimir Y 2014. Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma. International journal of cancer. Journal international du cancer, 134 1, 9-20

Barger, JF; Gallo, CA; Tandon, P; Liu, H; Sullivan, A; Grimes, HL; Plas, DR 2013. S6K1 determines the metabolic requirements for BCR-ABL survival Oncogene, 32 4, 453-61

Ma, Li; Tao, Yongzhen; Duran, Angeles; Llado, Victoria; Galvez, Anita; Barger, Jennifer F; Castilla, Elias A; Chen, Jing; Yajima, Tomoko; Porollo, Aleksey; Medvedovic, Mario; Brill, Laurence M; Plas, David R; Riedl, Stefan J; Leitges, Michael; Diaz-Meco, Maria T; Richardson, Adam D; Moscat, Jorge 2013. Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis. Cell, 152 3, 599-611

Raynor, Jana; Sholl, Allyson; Plas, David R; Bouillet, Philippe; Chougnet, Claire A; Hildeman, David A 2013. IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels. Frontiers in immunology, 4 , 161

Aksoylar H, Lampe K, Barnes M, Plas DR, Hoebe K 2012. Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo transcription factor expression in CD4+ lymphocytes Journal of Immunology, 188 1, 146

Aksoylar, H Ibrahim; Lampe, Kristin; Barnes, Michael J; Plas, David R; Hoebe, Kasper 2012. Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950), 188 1, 146-54

Czyzyk-Krzeska, Maria F; Meller, Jarek; Plas, David R 2012. Not all autophagy is equal. Autophagy, 8 7, 1155-6

Mikhaylova, Olga; Stratton, Yiwen; Hall, Daniel; Kellner, Emily; Ehmer, Birgit; Drew, Angela F; Gallo, Catherine A; Plas, David R; Biesiada, Jacek; Meller, Jarek; Czyzyk-Krzeska, Maria F 2012. VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. Cancer cell, 21 4, 532-46

Barger JF, Gallo CA, Torni KA, Merk L, Seibel WL, Nelson S, Plas DR 2011. Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin Cancer Biology & Therapy, 10 12, 1256

Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA 2011. A major role for Bim in regulatory T cell homeostasis Journal of Immunology, 186 1, 156

Chougnet, Claire A; Tripathi, Pulak; Lages, Celine S; Raynor, Jana; Sholl, Allyson; Fink, Pamela; Plas, David R; Hildeman, David A 2011. A major role for Bim in regulatory T cell homeostasis. Journal of immunology (Baltimore, Md. : 1950), 186 1, 156-63

Coloff JL, MacIntyre AN, Nichols AN, Liu T, Gallo CA, Plas DR, Rathmell JC 2011. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition Cancer Research, 71 15, 5204

Coloff, Jonathan L; Macintyre, Andrew N; Nichols, Amanda G; Liu, Tingyu; Gallo, Catherine A; Plas, David R; Rathmell, Jeffrey C 2011. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer research, 71 15, 5204-13

Giridhar PV, Funk HM, Gallo CA, Porollo A, Mercer CA, Plas DR, Drew AF 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells Clinical and Experimental Metastasis, 28 8, 887

Giridhar, Premkumar Vummidi; Funk, Holly M; Gallo, Catherine A; Porollo, Aleksey; Mercer, Carol A; Plas, David R; Drew, Angela F 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & experimental metastasis, 28 8, 887-97

Sommermann T, O’Neill , Plas DR, and Cahir-McFarland E 2011. IKKβ and NFκB transcription govern AKT-induced GLUT1 plasma membrane trafficking in B-lymphocytes Cancer Research, 71 23, 7291

Sommermann, Thomas G; O'Neill, Kathleen; Plas, David R; Cahir-McFarland, Ellen 2011. IKK? and NF-?B transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1. Cancer research, 71 23, 7291-300

Tandon P, Gallo CA, Khatri S, Barger, JF, Yepiskoposyan H, Plas DR 2011. Requirement for S6K1 to mediate glycolysis and apoptosis resistance induced by Pten-deficiency Proceedings of the National Academy of Sciences (USA), 108 6, 2361

Tandon, Preeti; Gallo, Catherine A; Khatri, Shikha; Barger, Jennifer F; Yepiskoposyan, Hasmik; Plas, David R 2011. Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency. Proceedings of the National Academy of Sciences of the United States of America, 108 6, 2361-5

Zhang Y, Johansson E, Miller ML, Jänicke RU, Ferguson DJ, Plas D, Meller J, Anderson MW 2011. Identification of a Conserved Anti-apoptotic Protein that Modulates the Mitochondrial Apoptosis Pathway Plos One, 6 9, e25284

Barger JF, Plas DR 2010. Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis Endocrine-related cancer, ,

Barger, Jennifer F; Gallo, Catherine A; Torni, Kyle A; Merk, Lisa; Seibel, William L; Nelson, Sandra; Plas, David R 2010. Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin. Cancer biology & therapy, 10 12, 1256-61

Khatri S, Yepiskoposyan H, Gallo CA, Tandon P, Plas DR 2010. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1 The Journal of biological chemistry, 285 21, 15960-5

Khatri S, Plas DR 2009. Targeting bioenergetics to enhance cancer chemotherapy: mitochondria SLP into apoptosis Cancer biology & therapy, 8 17, 1659-61

Plas DR, Thomas G 2009. Tubers and tumors: rapamycin therapy for benign and malignant tumors Current opinion in cell biology, 21 2, 230-6

Jones, Russell G; Plas, David R; Kubek, Sara; Buzzai, Monica; Mu, James; Xu, Yang; Birnbaum, Morris J; Thompson, Craig B 2005. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Molecular cell, 18 3, 283-93

Plas, David R; Thompson, Craig B 2005. Akt-dependent transformation: there is more to growth than just surviving. Oncogene, 24 50, 7435-42

Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste 2004. Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer research, 64 10, 3500-7

Bauer, Daniel E; Harris, Marian H; Plas, David R; Lum, Julian J; Hammerman, Peter S; Rathmell, Jeffrey C; Riley, James L; Thompson, Craig B 2004. Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18 11, 1303-5

Elstrom, Rebecca L; Bauer, Daniel E; Buzzai, Monica; Karnauskas, Robyn; Harris, Marian H; Plas, David R; Zhuang, Hongming; Cinalli, Ryan M; Alavi, Abass; Rudin, Charles M; Thompson, Craig B 2004. Akt stimulates aerobic glycolysis in cancer cells. Cancer research, 64 11, 3892-9

Karnauskas, Robyn; Niu, Qun; Talapatra, Sunit; Plas, David R; Greene, Marianne E; Crispino, John D; Rudin, Charles M 2003. Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo. Oncogene, 22 5, 688-98

Plas, David R; Thompson, Craig B 2003. Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. The Journal of biological chemistry, 278 14, 12361-6

Rathmell, Jeffrey C; Fox, Casey J; Plas, David R; Hammerman, Peter S; Cinalli, Ryan M; Thompson, Craig B 2003. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and cellular biology, 23 20, 7315-28

Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste 2002. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. The Journal of biological chemistry, 277 17, 15162-70

Frauwirth, Kenneth A; Riley, James L; Harris, Marian H; Parry, Richard V; Rathmell, Jeffrey C; Plas, David R; Elstrom, Rebecca L; June, Carl H; Thompson, Craig B 2002. The CD28 signaling pathway regulates glucose metabolism. Immunity, 16 6, 769-77

Plas, David R; Rathmell, Jeffrey C; Thompson, Craig B 2002. Homeostatic control of lymphocyte survival: potential origins and implications. Nature immunology, 3 6, 515-21

Plas, David R; Thompson, Craig B 2002. Cell metabolism in the regulation of programmed cell death. Trends in endocrinology and metabolism: TEM, 13 2, 75-8

Plas, D R; Talapatra, S; Edinger, A L; Rathmell, J C; Thompson, C B 2001. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. The Journal of biological chemistry, 276 15, 12041-8

Vander Heiden, M G; Plas, D R; Rathmell, J C; Fox, C J; Harris, M H; Thompson, C B 2001. Growth factors can influence cell growth and survival through effects on glucose metabolism. Molecular and cellular biology, 21 17, 5899-912

Dustin, L B; Plas, D R; Wong, J; Hu, Y T; Soto, C; Chan, A C; Thomas, M L 1999. Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. Journal of immunology (Baltimore, Md. : 1950), 162 5, 2717-24

Plas, D R; Williams, C B; Kersh, G J; White, L S; White, J M; Paust, S; Ulyanova, T; Allen, P M; Thomas, M L 1999. Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection. Journal of immunology (Baltimore, Md. : 1950), 162 10, 5680-4

Wang, L L; Blasioli, J; Plas, D R; Thomas, M L; Yokoyama, W M 1999. Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B. Journal of immunology (Baltimore, Md. : 1950), 162 3, 1318-23

Plas, D R; Thomas, M L 1998. Negative regulation of antigen receptor signaling in lymphocytes. Journal of molecular medicine (Berlin, Germany), 76 8, 589-95

Matsumoto, M; Lo, S F; Carruthers, C J; Min, J; Mariathasan, S; Huang, G; Plas, D R; Martin, S M; Geha, R S; Nahm, M H; Chaplin, D D 1996. Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice. Nature, 382 6590, 462-6

Plas, D R; Johnson, R; Pingel, J T; Matthews, R J; Dalton, M; Roy, G; Chan, A C; Thomas, M L 1996. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science (New York, N.Y.), 272 5265, 1173-6

Moe, A J; Plas, D R; Powell, K A; Smith, C H . Riboflavin uptake in microvillous and basal membrane vesicles isolated from full-term human placentas. Placenta, 15 2, 137-46