Education/CredentialsPhD: University of Cincinnati, College of Medicine (Cancer and Cell Biology Graduate Program) Contact Information Email dashaa@ucmail.uc.edu Research InterestsRegulate PRPS1 (rate limiting protein for nucleotide biosynthesis) expression with single base mutations using CRISPR-Cas9 to treat developmental and metabolic disorders. Investigate cellular senescence and mitochondrial dysfunction caused by disrupted PRPS1-bound YY1 signaling as a consequence of these mutations. Technique/Experimental expertise: CRISPR-Cas9 (Adenine/Cytosine Base-Editing, ssODN based HDR, Prime Editing, NHEJ) to create ...
Research InterestsRegulate PRPS1 (rate limiting protein for nucleotide biosynthesis) expression with single base mutations using CRISPR-Cas9 to treat developmental and metabolic disorders. Investigate cellular senescence and mitochondrial dysfunction caused by disrupted PRPS1-bound YY1 signaling as a consequence of these mutations. Technique/Experimental expertise: CRISPR-Cas9 (Adenine/Cytosine Base-Editing, ssODN based HDR, Prime Editing, NHEJ) to create ...