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Department of

Surgery

Photo of  Helen Jones, PhD

Helen Jones, PhD

Assistant Professor of Surgery

Education/Credentials
  • Bachelor's Degree: University of St. Andrews - Scotland
  • Doctoral Degree: University of Aberdeen - Scotland
Contact Information
  • Cincinnati Children's Hospital Medical Center
  • Department of Pediatric Surgery
  • 3333 Burnet Avenue
  • Cincinnati, Ohio 45229
  • Office 513-636-6259
  • Email helen.jones@cchmc.org

Peer Reviewed Publications

Abd Ellah NH, Taylor L, Ayres N, Elmahdy MM, Fetih GN, Jones HN, Ibrahim EA, Pauletti GM 2016. NF-κB decoy polyplexes decrease P-glycoprotein-mediated multidrug resistance in colorectal cancer cells Cancer Gene Therapy, 23 5, 149-55

Chaturvedi, Vandana; Ertelt, James M; Jiang, Tony T; Kinder, Jeremy M; Xin, Lijun; Owens, Kathryn J; Jones, Helen N; Way, Sing Sing 2015. CXCR3 blockade protects against Listeria monocytogenes infection-induced fetal wastage. The Journal of clinical investigation, 125 4, 1713-25

Jones, Helen N; Olbrych, Stephanie K; Smith, Kathleen L; Cnota, James F; Habli, Mounira; Ramos-Gonzales, Osniel; Owens, Kathryn J; Hinton, Andrea C; Polzin, William J; Muglia, Louis J; Hinton, Robert B 2015. Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation. Placenta, 36 10, 1078-86

Troja, Weston; Kil, Kicheol; Klanke, Charles; Jones, Helen N 2014. Interaction between human placental microvascular endothelial cells and a model of human trophoblasts: effects on growth cycle and angiogenic profile. Physiological reports, 2 3, e00244

Jansson, Nina; Rosario, Fredrick J; Gaccioli, Francesca; Lager, Susanne; Jones, Helen N; Roos, Sara; Jansson, Thomas; Powell, Theresa L 2013. Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies. The Journal of clinical endocrinology and metabolism, 98 1, 105-13

Jones, Helen N; Crombleholme, Timothy; Habli, Mounira 2013. Adenoviral-mediated placental gene transfer of IGF-1 corrects placental insufficiency via enhanced placental glucose transport mechanisms. PloS one, 8 9, e74632

Lager, Susanne; Gaccioli, Francesca; Ramirez, Vanessa I; Jones, Helen N; Jansson, Thomas; Powell, Theresa L 2013. Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4. Journal of lipid research, 54 3, 725-33

Keswani, Sundeep G; Balaji, Swathi; Le, Louis; Leung, Alice; Katz, Anna B; Lim, Foong-Yen; Habli, Mounira; Jones, Helen N; Wilson, James M; Crombleholme, Timothy M 2012. Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis. PloS one, 7 8, e43633

Wang, Kang; Dong, Hai-Qing; Wen, Hui-Yun; Xu, Meng; Li, Cao; Li, Yong-Yong; Jones, Helen N; Shi, Dong-Lu; Zhang, Xian-Zheng 2011. Novel vesicles self-assembled from amphiphilic star-armed PEG/polypeptide hybrid copolymers for drug delivery. Macromolecular bioscience, 11 1, 65-71

Jones, Helen N; Jansson, Thomas; Powell, Theresa L 2010. Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells. Diabetes, 59 5, 1161-70

Jones, H N; Jansson, T; Powell, T L 2009. IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2. American journal of physiology. Cell physiology, 297 5, C1228-35

Jones, Helen N; Woollett, Laura A; Barbour, Nicolette; Prasad, Puttur D; Powell, Theresa L; Jansson, Thomas 2009. High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23 1, 271-8

Jones, H N; Ashworth, C J; Page, K R; McArdle, H J 2006. Expression and adaptive regulation of amino acid transport system A in a placental cell line under amino acid restriction. Reproduction (Cambridge, England), 131 5, 951-60

Jones, Helen N; Ashworth, Cheryl J; Page, Ken R; McArdle, Harry J 2006. Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo). American journal of physiology. Endocrinology and metabolism, 291 3, E596-603

Adibi J.; Burton G.; Clifton V.; Collins S.; Frias A.; Gierman L.; Grigsby P.; Jones H.; Lee C.; Maloyan A.; Markert U.; Morales-Prieto D.; Murthi P.; Myatt L.; O'Tierney-Ginn P.; Pollheimer J.; Roberts V.; Robinson W.; Salafia C.; Schabel M.; Shah D.; Sled J.; Vaillancourt C.; Weber M. 12-01-2017. IFPA meeting 2016 workshop report II: Placental imaging, placenta and development of other organs, s Placenta, 60 , S10-S14

Albrecht C.; Caniggia I.; Clifton V.; Göhner C.; Harris L.; Hemmings D.; Jawerbaum A.; Johnstone E.; Jones H.; Keelan J.; Lewis R.; Mitchell M.; Murthi P.; Powell T.; Saffery R.; Salomon C.; Smith R.; Vaillancourt C.; Wadsack C. 12-01-2016. IFPA meeting 2015 workshop report III: nanomedicine applications and exosome biology, xenobiotics an Placenta, 48 , S12-S16

Aronow B.; Crombleholme T.; Habli M.; Jones H.; Omar K. 12-01-2013. Recapitulation of characteristics of human placental vascular insufficiency in a novel mouse model Placenta, 34 12, 1150-1158

Jansson T.; Jones H. 11-01-2017. Preface Placenta, 59 , S1

Ayres N.; Ellah N.; Jones H.; Owens K.; Pauletti G.; Taylor L.; Troja W. 10-16-2015. Development of non-viral, trophoblast-specific gene delivery for placental therapy PLoS ONE, 10 10,

Dunn-Fletcher C.; Hu Y.; Huffman E.; Jones H.; Lamm K.; Macfarlan T.; Muglia L.; Mukherjee A.; Pavlicev M.; Sun M.; Swaggart K.; Thiele K.; Tumukuntala S.; Wolf G.; Zhang X.; Zoubovsky S. 09-01-2018. Anthropoid primate–specific retroviral element THE1B controls expression of CRH in placenta and alte PLoS Biology, 16 9,

Constancia M.; Detmar J.; Ferguson-Smith A.; Hemberger M.; Jammes H.; Jones H.; Kelsey G.; Lewis A.; Moore T.; Roberts C. 09-01-2006. Erratum to "Epigenetics and Imprinting of the Trophoblast - A Workshop Report" [Placenta 27, supplem Placenta, 27 9-10, 1036

Cnota J.; Courtney J.; Jones H. 08-07-2018. The role of abnormal placentation in congenital heart disease; Cause, correlate, or consequence? Frontiers in Physiology, 9 AUG,

Godarova A.; Herr A.; Hoebe K.; Janssen E.; Jones H.; Lampe K.; Locker K.; Plas D.; Sliz A. 08-02-2019. Gab3 is required for IL-2- And IL-15-induced NK cell expansion and limits trophoblast invasion durin Science Immunology, 4 38,

Carrillo M.; Chuecos M.; Fry M.V.; Jones H.N.; Owens K.; Schlabritz-Loutsevitch N.; Stephens K.K.; Sumser E.K.; Wilson R.L. 04-01-2020. Nanoparticle mediated increased insulin-like growth factor 1 expression enhances human placenta sync Placenta, 93 , 1-7

Andersen H.; Gambling L.; Jones H.; McArdle H. 04-01-2008. Copper and iron transport across the placenta: Regulation and interactions Journal of Neuroendocrinology, 20 4, 427-431

Andersen H.; Gambling L.; Jones H.; McArdle H. 04-01-2006. Fetal Programming: Causes and Consequences as Revealed by Studies of Dietary Manipulation in Rats - Placenta, 27 SUPPL., 56-60

Chavan A.; Dunn-Fletcher C.; Jones H.; Kallapur S.; Maziarz J.; Muglia L.; Owens K.; Pavli?ev M.; Wagner G. 03-01-2017. Single-cell transcriptomics of the human placenta: Inferring the cell communication network of the m Genome Research, 27 3, 349-361

Jones H.N.; Muglia L.J.; Pavlicev M.; Zhang X. 02-01-2020. Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation Molecular Biology and Evolution, 37 2, 507-523

Davidson W.; Jones H.; Melchior J.; Moore S.; Prentice A.; Rebholz S.; Welge J.; Woollett L. 02-01-2018. Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth FASEB Journal, 32 2, 717-727

Crombleholme T.; Habli M.; Jones H. 02-01-2014. Regulation of amino acid transporters by adenoviral-mediated human insulin-like growth factor-1 in a Placenta, 35 2, 132-138

James J.; Johnson M.; Jones H.; Lamm K.; Muglia L.; Muntifering M.; Phillips J.; Redline R.; Rokas A. 01-08-2018. Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome eLife, 7 ,

Ackerman W.E.; Brockway H.M.; Buhimschi C.S.; Buhimschi I.A.; Jones H.N.; Kallapur S.G.; Muglia L.J. 01-01-2019. Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm PLoS ONE, 14 11,

Jones H.; Kil K.; Klanke C.; Troja W. 01-01-2014. Interaction between human placental microvascular endothelial cells and a model of human trophoblast Physiological Reports, 2 3,

Constancia M.; Detmar J.; Ferguson-Smith A.; Hemberger M.; Jammes H.; Jones H.; Kelsey G.; Lewis A.; Moore T.; Roberts C. 01-01-2006. Epigenetics and Imprinting of the Trophoblast - A Workshop Report Placenta, 27 SUPPL., 122-126

Jones, H N; Powell, T L; Jansson, T . Regulation of placental nutrient transport--a review. Placenta, 28 8-9, 763-74

Keswani, Sundeep G; Balaji, Swathi; Le, Louis; Leung, Alice; Lim, Foong-Yen; Habli, Mounira; Jones, Helen N; Wilson, James M; Crombleholme, Timothy M . Pseudotyped adeno-associated viral vector tropism and transduction efficiencies in murine wound healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 20 4, 592-600