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Yi Zheng, PhD

Professor-Affiliate

Co-Director, Cincinnati Children's Cancer and Blood Diseases Institute, Director, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Affiliate Faculty Cancer Biology

Pediatrics | College of Medicine

Contact Information

Peer Reviewed Publications

Althoff, Mark; Nayak, Ramesh; Hegde, Shailaja; Wellendorf, Ashley; Bohan, Breanna; Filippi, Marie-Dominique; Xin, Mei; Lu, Richard; Geiger, Hartmut; Zheng, Yi; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A 2020. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood, ,

Florian, Maria Carolina; Leins, Hanna; Gobs, Michael; Han, Yang; Marka, Gina; Soller, Karin; Vollmer, Angelika; Sakk, Vadim; Nattamai, Kalpana J; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Mulaw, Medhanie; Wagner, Wolfgang; Zheng, Yi; Geiger, Hartmut 2020. Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Aging cell, , e13208

Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T 2020. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature immunology, 21 5, 535-545

Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2020. Author Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 11 1, 3878

Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2020. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood, ,

Sheng, Yue; Ma, Rui; Yu, Chunjie; Wu, Qiong; Zhang, Steven; Paulsen, Kimberly; Zhang, Jiwang; Ni, Hongyu; Huang, Yong; Zheng, Yi; Qian, Zhijian 2020. Role of c-Myc haploinsufficiency in the maintenance of HSCs. Blood, ,

Hochstetler, Cindy L; Feng, Yuxin; Sacma, Mehmet; Davis, Ashley K; Rao, Mahil; Kuan, Chia-Yi; You, Li-Ru; Geiger, Hartmut; Zheng, Yi 2019. KRasG12D expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals. Experimental hematology, ,

Nayak, R C; Hegde, S; Althoff, M J; Wellendorf, A M; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, M T; Moscat, J; Cancelas, J A 2019. The signaling axis atypical protein kinase C ?/?-Satb2 mediates leukemic transformation of B-cell progenitors. Nature communications, 10 1, 46

Nguyen, Phuong; Chakrabarti, Jayati; Li, Yuan; Kalim, Khalid W; Zhang, Mengnan; Zhang, Lin; Zheng, Yi; Guo, Fukun 2019. Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma. Frontiers in oncology, 9 , 958

Papaioannou, Dimitrios; Petri, Andreas; Dovey, Oliver M; Terreri, Sara; Wang, Eric; Collins, Frances A; Woodward, Lauren A; Walker, Allison E; Nicolet, Deedra; Pepe, Felice; Kumchala, Prasanthi; Bill, Marius; Walker, Christopher J; Karunasiri, Malith; Mrózek, Krzysztof; Gardner, Miranda L; Camilotto, Virginia; Zitzer, Nina; Cooper, Jonathan L; Cai, Xiongwei; Rong-Mullins, Xiaoqing; Kohlschmidt, Jessica; Archer, Kellie J; Freitas, Michael A; Zheng, Yi; Lee, Robert J; Aifantis, Iannis; Vassiliou, George; Singh, Guramrit; Kauppinen, Sakari; Bloomfield, Clara D; Dorrance, Adrienne M; Garzon, Ramiro 2019. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nature communications, 10 1, 5351

Xie, Yangyang; Gao, Li; Xu, Chunhui; Chu, Liming; Gao, Lei; Wu, Ruichi; Liu, Yu; Liu, Ting; Sun, Xiao-Jian; Ren, Ruibao; Tang, Jingyan; Zheng, Yi; Zhou, Yong; Shen, Shuhong 2019. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica, ,

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Duan, Xin; Nguyen, Phuong; Khurana Hershey, Gurjit K; Kroner, John; Ruff, Brandy; Zhang, Li; Salomonis, Nathan; Rochman, Mark; Wen, Ting; Zheng, Yi; Guo, Fukun 2019. Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 49 1, 92-107

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zheng, Yi; Guo, Fukun 2019. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation. Journal of leukocyte biology, ,

Zahra, Fatema Tuz; Sajib, Md Sanaullah; Ichiyama, Yusuke; Akwii, Racheal Grace; Tullar, Paul E; Cobos, Christopher; Minchew, Shelby A; Doçi, Colleen L; Zheng, Yi; Kubota, Yoshiaki; Gutkind, J Silvio; Mikelis, Constantinos M 2019. Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis. Scientific reports, 9 1, 11666

Zhang, Cuiping; Fondufe-Mittendorf, Yvonne N; Wang, Chi; Chen, Jin; Cheng, Qiang; Zhou, Daohong; Zheng, Yi; Geiger, Hartmut; Liang, Ying 2019. Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Haematologica, ,

Zhou, Wei; Yang, Yingying; Mei, Congjin; Dong, Panpan; Mu, Shasha; Wu, Hongchu; Zhou, Yonghua; Zheng, Yi; Guo, Fukun; Yang, Jun-Qi 2019. Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection. Cells, 8 10,

Akbar, H; Duan, X; Piatt, R; Saleem, S; Davis, A K; Tandon, N N; Bergmeier, W; Zheng, Y 2018. Small molecule targeting the Rac1-NOX2 interaction prevents collagen-related peptide and thrombin-induced reactive oxygen species generation and platelet activation. Journal of thrombosis and haemostasis : JTH, 16 10, 2083-2096

Cai, Xiongwei; Zheng, Yi; Speck, Nancy A 2018. A Western Blotting Protocol for Small Numbers of Hematopoietic Stem Cells. Journal of visualized experiments : JoVE, 138,

Cai, Xiongwei; Zhou, Xuan; Zheng, Yi 2018. In Vivo Rescue Assay of RhoA-Deficient Hematopoietic Stem and Progenitor Cells. Methods in molecular biology (Clifton, N.J.), 1821 , 247-256

Chadwick, Michelle L; Lane, Adam; Thomas, Dana; Smith, Amanda R; White, Angela R; Davidson, Dominique; Feng, Yuxin; Boscolo, Elisa; Zheng, Yi; Adams, Denise M; Gupta, Anita; Veillette, André; Chow, Lionel M L 2018. Combined mTOR and MEK inhibition is an effective therapy in a novel mouse model for angiosarcoma. Oncotarget, 9 37, 24750-24765

Du, Wei; Liu, Wei; Mizukawa, Benjamin; Shang, Xun; Sipple, Jared; Wunderlich, Mark; Geiger, Hartmut; Davies, Stella; Mulloy, James; Pang, Qishen; Zheng, Yi 2018. A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells. Leukemia, 32 9, 2041-2046

Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T 2018. TRAF6 Mediates Basal Activation of NF-?B Necessary for Hematopoietic Stem Cell Homeostasis. Cell reports, 22 5, 1250-1262

Florian, M Carolina; Klose, Markus; Sacma, Mehmet; Jablanovic, Jelena; Knudson, Luke; Nattamai, Kalpana J; Marka, Gina; Vollmer, Angelika; Soller, Karin; Sakk, Vadim; Cabezas-Wallscheid, Nina; Zheng, Yi; Mulaw, Medhanie A; Glauche, Ingmar; Geiger, Hartmut 2018. Aging alters the epigenetic asymmetry of HSC division. PLoS biology, 16 9, e2003389

Grigoryan, Ani; Guidi, Novella; Senger, Katharina; Liehr, Thomas; Soller, Karin; Marka, Gina; Vollmer, Angelika; Markaki, Yolanda; Leonhardt, Heinrich; Buske, Christian; Lipka, Daniel B; Plass, Christoph; Zheng, Yi; Mulaw, Medhanie A; Geiger, Hartmut; Florian, Maria Carolina 2018. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome biology, 19 1, 189

Hayashi, Yoshihiro; Zhang, Yue; Yokota, Asumi; Yan, Xiaomei; Liu, Jinqin; Choi, Kwangmin; Li, Bing; Sashida, Goro; Peng, Yanyan; Xu, Zefeng; Huang, Rui; Zhang, Lulu; Freudiger, George M; Wang, Jingya; Dong, Yunzhu; Zhou, Yile; Wang, Jieyu; Wu, Lingyun; Bu, Jiachen; Chen, Aili; Zhao, Xinghui; Sun, Xiujuan; Chetal, Kashish; Olsson, Andre; Watanabe, Miki; Romick-Rosendale, Lindsey E; Harada, Hironori; Shih, Lee-Yung; Tse, William; Bridges, James P; Caligiuri, Michael A; Huang, Taosheng; Zheng, Yi; Witte, David P; Wang, Qian-Fei; Qu, Cheng-Kui; Salomonis, Nathan; Grimes, H Leighton; Nimer, Stephen D; Xiao, Zhijian; Huang, Gang 2018. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer discovery, 8 11, 1438-1457

Hegde, Shailaja; Akbar, Huzoor; Zheng, Yi; Cancelas, Jose A 2018. Towards increasing shelf life and haemostatic potency of stored platelet concentrates. Current opinion in hematology, 25 6, 500-508

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun 2018. Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 9 1, 670

Kalim, Khalid W; Yang, Jun-Qi; Li, Yuan; Meng, Yan; Zheng, Yi; Guo, Fukun 2018. Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42. Journal of immunology (Baltimore, Md. : 1950), 200 7, 2313-2326

Liu, Wei; Du, Wei; Shang, Xun; Wang, Lei; Evelyn, Chris; Florian, Maria Carolina; A Ryan, Marnie; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Meller, Jarek; Guo, Fukun; Nassar, Nicolas; Geiger, Hartmut; Pang, Qishen; Zheng, Yi 2018. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia, ,

Lv, Jiawen; Zeng, Junchao; Guo, Fukun; Li, Yiran; Xu, Mengying; Cheng, Yuanxiong; Zhang, Lin; Cai, Shaoxi; Chen, Yinghua; Zheng, Yi; Hu, Guodong 2018. Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury. Respiratory research, 19 1, 27

Maliken, Bryan D; Kanisicak, Onur; Karch, Jason; Khalil, Hadi; Fu, Xing; Boyer, Justin G; Prasad, Vikram; Zheng, Yi; Molkentin, Jeffery D 2018. Gata4-Dependent Differentiation of c-Kit+ Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation, ,

Mizukawa, Benjamin; O'Brien, Eric; Mulloy, James C; Zheng, Yi 2018. Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells. Methods in molecular biology (Clifton, N.J.), 1821 , 257-266

Sertorio, Mathieu; Perentesis, John P; Vatner, Ralph E; Mascia, Anthony E; Zheng, Yi; Wells, Susanne I 2018. Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. International journal of particle therapy, 5 1, 40-48

Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard 2018. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer cell, 33 2, 292-308.e7

Yang, Yingying; Dong, Panpan; Zhao, Jing; Zhou, Wei; Zhou, Yonghua; Xu, Yongliang; Mei, Congjin; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi 2018. PKC?/? regulates Th17 differentiation and house dust mite-induced allergic airway inflammation. Biochimica et biophysica acta, 1864 3, 934-941

Chen, Xiaoyi; Clark, Jason; Wunderlich, Mark; Fan, Cuiqing; Davis, Ashley; Chen, Song; Guan, Jun-Lin; Mulloy, James C; Kumar, Ashish; Zheng, Yi 2017. Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy, 13 5, 955-966

El Zowalaty, Ahmed E; Li, Rong; Zheng, Yi; Lydon, John P; DeMayo, Francesco J; Ye, Xiaoqin 2017. Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice. Endocrinology, 158 7, 2168-2178

Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T 2017. Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nature immunology, 18 2, 236-245

Guo, Fukun; Zheng, Yi 2017. Vav1: Friend and Foe of Cancer. Trends in cell biology, 27 12, 879-880

Hato, Takashi; Winfree, Seth; Day, Richard; Sandoval, Ruben M; Molitoris, Bruce A; Yoder, Mervin C; Wiggins, Roger C; Zheng, Yi; Dunn, Kenneth W; Dagher, Pierre C 2017. Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures. Journal of the American Society of Nephrology : JASN, 28 8, 2420-2430

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun 2017. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nature communications, 8 1, 2099

Kalim, Khalid W; Zhang, Shuangmin; Chen, Xiaoyi; Li, Yuan; Yang, Jun-Qi; Zheng, Yi; Guo, Fukun 2017. mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity. PloS one, 12 8, e0183266

Li, Jingjing; Miao, Lianjie; Zhao, Chen; Shaikh Qureshi, Wasay Mohiuddin; Shieh, David; Guo, Hua; Lu, Yangyang; Hu, Saiyang; Huang, Alice; Zhang, Lu; Cai, Chen-Leng; Wan, Leo Q; Xin, Hongbo; Vincent, Peter; Singer, Harold A; Zheng, Yi; Cleaver, Ondine; Fan, Zhen-Chuan; Wu, Mingfu 2017. CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane. Development (Cambridge, England), 144 9, 1635-1647

Liu, Ming; Zhang, Zheng; Sampson, Leesa; Zhou, Xuan; Nalapareddy, Kodandaramireddy; Feng, Yuxin; Akunuru, Shailaja; Melendez, Jaime; Davis, Ashley Kuenzi; Bi, Feng; Geiger, Hartmut; Xin, Mei; Zheng, Yi 2017. RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance. Stem cell reports, 9 6, 1961-1975

Mizukawa, Benjamin; O'Brien, Eric; Moreira, Daniel C; Wunderlich, Mark; Hochstetler, Cindy L; Duan, Xin; Liu, Wei; Orr, Emily; Grimes, H Leighton; Mulloy, James C; Zheng, Yi 2017. The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation. Blood, 130 11, 1336-1346

Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut 2017. Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell reports, 18 11, 2608-2621

Qiu, Sugan; Fan, Xiaolin; Yang, Yingying; Dong, Panpan; Zhou, Wei; Xu, Yongliang; Zhou, Yonghua; Guo, Fukun; Zheng, Yi; Yang, Jun-Qi 2017. Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice. PloS one, 12 6, e0179565

Sakabe, Masahide; Fan, Jieqing; Odaka, Yoshinobu; Liu, Ning; Hassan, Aishlin; Duan, Xin; Stump, Paige; Byerly, Luke; Donaldson, Megan; Hao, Jiukuan; Fruttiger, Marcus; Lu, Qing Richard; Zheng, Yi; Lang, Richard A; Xin, Mei 2017. YAP/TAZ-CDC42 signaling regulates vascular tip cell migration. Proceedings of the National Academy of Sciences of the United States of America, 114 41, 10918-10923

Sinagoga, Katie L; Stone, William J; Schiesser, Jacqueline V; Schweitzer, Jamie I; Sampson, Leesa; Zheng, Yi; Wells, James M 2017. Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development (Cambridge, England), 144 13, 2402-2414

Zandvakili, I; Lin, Y; Morris, J C; Zheng, Y 2017. Rho GTPases: Anti- or pro-neoplastic targets? Oncogene, 36 23, 3213-3222

Barry, David M; Koo, Yeon; Norden, Pieter R; Wylie, Lyndsay A; Xu, Ke; Wichaidit, Chonlarat; Azizoglu, D Berfin; Zheng, Yi; Cobb, Melanie H; Davis, George E; Cleaver, Ondine 2016. Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II. Circulation research, 119 7, 810-26

Imai, Fumiyasu; Ladle, David R; Leslie, Jennifer R; Duan, Xin; Rizvi, Tilat A; Ciraolo, Georgianne M; Zheng, Yi; Yoshida, Yutaka 2016. Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 21, 5724-35

Nohata, Nijiro; Uchida, Yutaka; Stratman, Amber N; Adams, Ralf H; Zheng, Yi; Weinstein, Brant M; Mukouyama, Yoh-Suke; Gutkind, J Silvio 2016. Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. Developmental biology, 411 2, 183-194

O'Hayre, M; Inoue, A; Kufareva, I; Wang, Z; Mikelis, C M; Drummond, R A; Avino, S; Finkel, K; Kalim, K W; DiPasquale, G; Guo, F; Aoki, J; Zheng, Y; Lionakis, M S; Molinolo, A A; Gutkind, J S 2016. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the G?13/RhoA axis in B cells. Oncogene, 35 29, 3771-80

Palazzo, A; Bluteau, O; Messaoudi, K; Marangoni, F; Chang, Y; Souquere, S; Pierron, G; Lapierre, V; Zheng, Y; Vainchenker, W; Raslova, H; Debili, N 2016. The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation. Journal of thrombosis and haemostasis : JTH, 14 12, 2524-2535

Sampson, Leesa L; Davis, Ashley K; Grogg, Matthew W; Zheng, Yi 2016. mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30 3, 1263-75

Yang, Jun-Qi; Kalim, Khalid W; Li, Yuan; Zhang, Shuangmin; Hinge, Ashwini; Filippi, Marie-Dominique; Zheng, Yi; Guo, Fukun 2016. RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation. The Journal of allergy and clinical immunology, 137 1, 231-245.e4

Barry, David M; Xu, Ke; Meadows, Stryder M; Zheng, Yi; Norden, Pieter R; Davis, George E; Cleaver, Ondine 2015. Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice. Development (Cambridge, England), 142 17, 3058-70

Chang, Kyung Hee; Nayak, Ramesh C; Roy, Swarnava; Perumbeti, Ajay; Wellendorf, Ashley M; Bezold, Katie Y; Pirman, Megan; Hill, Sarah E; Starnes, Joseph; Loberg, Anastacia; Zhou, Xuan; Inagami, Tadashi; Zheng, Yi; Malik, Punam; Cancelas, Jose A 2015. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT?R and cytoskeletal dysregulation. Nature communications, 6 , 5914

Evelyn, Chris R; Biesiada, Jacek; Duan, Xin; Tang, Hong; Shang, Xun; Papoian, Ruben; Seibel, William L; Nelson, Sandra; Meller, Jaroslaw; Zheng, Yi 2015. Combined rational design and a high throughput screening platform for identifying chemical inhibitors of a Ras-activating enzyme. The Journal of biological chemistry, 290 20, 12879-98

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Evelyn, Chris R; Biesiada, Jacek; Rance, Mark; Thapa, Mahendra B; Shah, Neil P; Meller, Jarek; Zheng, Yi; Azam, Mohammad 2015. Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance. Scientific reports, 5 , 14538

Konstantinidis, Diamantis G; Giger, Katie M; Risinger, Mary; Pushkaran, Suvarnamala; Zhou, Ping; Dexheimer, Phillip; Yerneni, Satwica; Andreassen, Paul; Klingmüller, Ursula; Palis, James; Zheng, Yi; Kalfa, Theodosia A 2015. Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation. Blood, 126 12, 1473-82

Li, Juan; Zhang, Lei; Chen, Zhenzhong; Xie, Minjuan; Huang, Lu; Xue, Jinhua; Liu, Yutong; Liu, Nuyun; Guo, Fukun; Zheng, Yi; Kong, Jiming; Zhang, Lin; Zhang, Lu 2015. Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen. Neurobiology of disease, 75 , 159-76

Lin, Yuan; Zheng, Yi 2015. Approaches of targeting Rho GTPases in cancer drug discovery. Expert opinion on drug discovery, 10 9, 991-1010

Mikelis, Constantinos M; Simaan, May; Ando, Koji; Fukuhara, Shigetomo; Sakurai, Atsuko; Amornphimoltham, Panomwat; Masedunskas, Andrius; Weigert, Roberto; Chavakis, Triantafyllos; Adams, Ralf H; Offermanns, Stefan; Mochizuki, Naoki; Zheng, Yi; Gutkind, J Silvio 2015. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nature communications, 6 , 6725

Zandvakili, Inuk; Davis, Ashley Kuenzi; Hu, Guodong; Zheng, Yi 2015. Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice. PloS one, 10 6, e0127923

Delaney, Michael Keegan; Liu, Junling; Kim, Kyungho; Shen, Bo; Stojanovic-Terpo, Aleksandra; Zheng, Yi; Cho, Jaehyung; Du, Xiaoping 2014. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood, 124 12, 1957-67

Evelyn, Chris R; Duan, Xin; Biesiada, Jacek; Seibel, William L; Meller, Jaroslaw; Zheng, Yi 2014. Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. Chemistry & biology, 21 12, 1618-28

Fabbiano, Salvatore; Menacho-Márquez, Mauricio; Sevilla, María A; Albarrán-Juárez, Julián; Zheng, Yi; Offermanns, Stefan; Montero, María J; Bustelo, Xosé R 2014. Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells. Molecular and cellular biology, 34 24, 4404-19

Geiger, Hartmut; Zheng, Yi 2014. Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42. Experimental cell research, 329 2, 214-9

Guo, F; Li, J; Zhang, S; Du, W; Amarachintha, S; Sipple, J; Phelan, J; Grimes, H L; Zheng, Y; Pang, Q 2014. mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression. Leukemia, 28 1, 203-6

Kalfa, Theodosia A; Zheng, Yi 2014. Rho GTPases in erythroid maturation. Current opinion in hematology, 21 3, 165-71

Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Giger, Katie; Manganaris, Stefanos; Zheng, Yi; Kalfa, Theodosia A 2014. Identification of a murine erythroblast subpopulation enriched in enucleating events by multi-spectral imaging flow cytometry. Journal of visualized experiments : JoVE, 88,

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Zhou, Xuan; Florian, Maria Carolina; Arumugam, Paritha; Chen, Xiaoyi; Cancelas, Jose A; Lang, Richard; Malik, Punam; Geiger, Hartmut; Zheng, Yi 2013. RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors. The Journal of experimental medicine, 210 11, 2371-85

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Katayama, Kei-ichi; Leslie, Jennifer R; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2012. Left-right locomotor circuitry depends on RhoA-driven organization of the neuroepithelium in the developing spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 30, 10396-407

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Kumar, Sachin; Xu, Juying; Perkins, Charles; Guo, Fukun; Snapper, Scott; Finkelman, Fred D; Zheng, Yi; Filippi, Marie-Dominique 2012. Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood, 120 17, 3563-74

Leslie, Jennifer R; Imai, Fumiyasu; Zhou, Xuan; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2012. RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia. Frontiers in molecular neuroscience, 5 , 67

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Mizukawa, Benjamin; Wei, Junping; Shrestha, Mahesh; Wunderlich, Mark; Chou, Fu-Sheng; Griesinger, Andrea; Harris, Chad E; Kumar, Ashish R; Zheng, Yi; Williams, David A; Mulloy, James C 2011. Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia. Blood, 118 19, 5235-45

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Wang, Xiaofang; Zhang, Fan; Chen, Fanping; Liu, Dou; Zheng, Yi; Zhang, Yongliang; Dong, Chen; Su, Bing 2011. MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades. Journal of immunology (Baltimore, Md. : 1950), 186 10, 5791-800

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