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Photo of  James Tweddell, MD

James Tweddell, MD

Surgical Director of Heart Institute at CCHMC

Contact Information
Research Interests

Congenital heart surgery in neonates, infants, children, teenagers and adults; heart transplantation and mechanical circulatory support.

Peer Reviewed Publications

Brothers, Julie A; Frommelt, Michele A; Jaquiss, Robert D B; Myerburg, Robert J; Fraser, Charles D; Tweddell, James S 2017. Expert consensus guidelines: Anomalous aortic origin of a coronary artery. The Journal of thoracic and cardiovascular surgery, 153 6, 1440-1457

Hoffman, George M; Ghanayem, Nancy S; Scott, John P; Tweddell, James S; Mitchell, Michael E; Mussatto, Kathleen A 2017. Postoperative Cerebral and Somatic Near-Infrared Spectroscopy Saturations and Outcome in Hypoplastic Left Heart Syndrome. The Annals of thoracic surgery, 103 5, 1527-1535

Jacobs, Jeffrey P; Mayer, John E; Mavroudis, Constantine; O'Brien, Sean M; Austin, Erle H; Pasquali, Sara K; Hill, Kevin D; Overman, David M; St Louis, James D; Karamlou, Tara; Pizarro, Christian; Hirsch-Romano, Jennifer C; McDonald, Donna; Han, Jane M; Becker, Susan; Tchervenkov, Christo I; Lacour-Gayet, Francois; Backer, Carl L; Fraser, Charles D; Tweddell, James S; Elliott, Martin J; Walters, Hal; Jonas, Richard A; Prager, Richard L; Shahian, David M; Jacobs, Marshall L 2017. The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2017 Update on Outcomes and Quality. The Annals of thoracic surgery, 103 3, 699-709

Morales, David L S; Khan, Muhammad S; Turek, Joseph W; Biniwale, Reshma; Tchervenkov, Christo I; Rush, Michele; Jacobs, Jeffrey P; Tweddell, James S; Jacobs, Marshall L 2017. Report of the 2015 Society of Thoracic Surgeons Congenital Heart Surgery PracticeĀ Survey. The Annals of thoracic surgery, 103 2, 622-628

Tweddell, James S 2017. What do we really know about the management of patients with congenitally corrected transposition of the great arteries? The Journal of thoracic and cardiovascular surgery, ,

Tweddell, James S 2017. Congenital Heart Surgery Subspecialty Certification: How Is It Working? The American Board of Thoracic Surgery Perspective. Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual, 20 , 67-69

Tweddell, James S; Jacobs, Jeffrey P; Austin, Erle H 2017. Are there negative consequences of public reporting? The hype and the reality. The Journal of thoracic and cardiovascular surgery, 153 4, 908-911

Zafar, Farhan; Jaquiss, Robert D; Almond, Christopher S; Lorts, Angela; Chin, Clifford; Rizwan, Raheel; Bryant, Roosevelt; Tweddell, James S; Morales, David L S 2017. Pediatric Heart Donor Assessment Tool (PH-DAT): A novel donor risk scoring system to predict 1-year mortality in pediatric heart transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, ,

Zafar, Farhan; Rizwan, Raheel; Lorts, Angela; Bryant, Roosevelt; Tweddell, James S; Chin, Clifford; Morales, David L 2017. Implications and outcomes of cardiac grafts refused by pediatric centers but transplanted by adult centers. The Journal of thoracic and cardiovascular surgery, ,

Jacobs, Jeffrey P; Mayer, John E; Mavroudis, Constantine; O'Brien, Sean M; Austin, Erle H; Pasquali, Sara K; Hill, Kevin D; He, Xia; Overman, David M; St Louis, James D; Karamlou, Tara; Pizarro, Christian; Hirsch-Romano, Jennifer C; McDonald, Donna; Han, Jane M; Dokholyan, Rachel S; Tchervenkov, Christo I; Lacour-Gayet, Francois; Backer, Carl L; Fraser, Charles D; Tweddell, James S; Elliott, Martin J; Walters, Hal; Jonas, Richard A; Prager, Richard L; Shahian, David M; Jacobs, Marshall L 2016. The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2016 Update on Outcomes and Quality. The Annals of thoracic surgery, 101 3, 850-62

Maher, Kevin O; Tweddell, James S 2016. Aortic and Mitral Valve Disease and Left Ventricular Dysfunction in Children. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 17 8 Suppl 1, S131-9

Powell, Adam W; Hanke, Samuel; Tweddell, James S; Madsen, Nicolas 2016. A 14-Year-Old Boy with Unusual Presentation of Respiratory Distress. Case reports in pediatrics, 2016 , 7313942

Tabbutt, Sarah; Tweddell, James S; Ghanayem, Nancy 2016. Hypoplastic Left Heart Syndrome and Other Shunt-Dependent Single Ventricles. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 17 8 Suppl 1, S318-22

Tomita-Mitchell, Aoy; Stamm, Karl D; Mahnke, Donna K; Kim, Min-Su; Hidestrand, Pip M; Liang, Huan Ling; Goetsch, Mary A; Hidestrand, Mats; Simpson, Pippa; Pelech, Andrew N; Tweddell, James S; Benson, D Woodrow; Lough, John W; Mitchell, Michael E 2016. Impact of MYH6 variants in hypoplastic left heart syndrome. Physiological genomics, 48 12, 912-921

Tweddell, James S 2016. Why doesn't the flow study work better for pulmonary atresia, ventricular septal defect, and major aortopulmonary collaterals? The Journal of thoracic and cardiovascular surgery, 152 6, 1504-1505

Tweddell, James S 2016. Historical perspectives of The American Association for Thoracic Surgery: Thomas L. Spray. The Journal of thoracic and cardiovascular surgery, 152 4, 945-9

Tweddell, James S 2016. Advances in neonatal cardiac surgery: recent advances, the low-hanging fruit, what is on the horizon and the next moonshot. Current opinion in cardiology, 31 1, 109-16

Tweddell, James S 2015. Where do we go now? The Journal of thoracic and cardiovascular surgery, 150 6, 1453-4

Tweddell, James S 2015. Are stem cells the next frontier for hypoplastic left heart syndrome? What are the promise, the reality, and the future? The Journal of thoracic and cardiovascular surgery, 150 5, 1023-5

Tweddell, James S 2015. Atrial-Level Switch Operation: Lessons Old and New. Circulation, 132 8, 619-20

Aiyagari, Ranjit; Rhodes, John F; Shrader, Peter; Radtke, Wolfgang A; Bandisode, Varsha M; Bergersen, Lisa; Gillespie, Matthew J; Gray, Robert G; Guey, Lin T; Hill, Kevin D; Hirsch, Russel; Kim, Dennis W; Lee, Kyong-Jin; Pelech, Andrew N; Ringewald, Jeremy; Takao, Cheryl; Vincent, Julie A; Ohye, Richard G 2014. Impact of pre-stage II hemodynamics and pulmonary artery anatomy on 12-month outcomes in the Pediatric Heart Network Single Ventricle Reconstruction trial. The Journal of thoracic and cardiovascular surgery, 148 4, 1467-74

Castleberry, Chesney D; Gudausky, Todd M; Berger, Stuart; Tweddell, James S; Pelech, Andrew N 2014. Stenting of the right ventricular outflow tract in the high-risk infant with cyanotic teratology of Fallot. Pediatric cardiology, 35 3, 423-30

Goldberg, Caren S; Lu, Minmin; Sleeper, Lynn A; Mahle, William T; Gaynor, J William; Williams, Ismee A; Mussatto, Kathleen A; Ohye, Richard G; Graham, Eric M; Frank, Deborah U; Jacobs, Jeffrey P; Krawczeski, Catherine; Lambert, Linda; Lewis, Alan; Pemberton, Victoria L; Sananes, Renee; Sood, Erica; Wechsler, Stephanie B; Bellinger, David C; Newburger, Jane W 2014. Factors associated with neurodevelopment for children with single ventricle lesions. The Journal of pediatrics, 165 3, 490-496.e8

Lambert, Linda M; Pike, Nancy A; Medoff-Cooper, Barbara; Zak, Victor; Pemberton, Victoria L; Young-Borkowski, Lisa; Clabby, Martha L; Nelson, Kathryn N; Ohye, Richard G; Trainor, Bethany; Uzark, Karen; Rudd, Nancy; Bannister, Louise; Korsin, Rosalind; Cooper, David S; Pizarro, Christian; Zyblewski, Sinai C; Bartle, Bronwyn H; Williams, Richard V 2014. Variation in feeding practices following the Norwood procedure. The Journal of pediatrics, 164 2, 237-42.e1

Nathan, Meena; Sleeper, Lynn A; Ohye, Richard G; Frommelt, Peter C; Caldarone, Christopher A; Tweddell, James S; Lu, Minmin; Pearson, Gail D; Gaynor, J William; Pizarro, Christian; Williams, Ismee A; Colan, Steven D; Dunbar-Masterson, Carolyn; Gruber, Peter J; Hill, Kevin; Hirsch-Romano, Jennifer; Jacobs, Jeffrey P; Kaltman, Jonathan R; Kumar, S Ram; Morales, David; Bradley, Scott M; Kanter, Kirk; Newburger, Jane W 2014. Technical performance score is associated with outcomes after the Norwood procedure. The Journal of thoracic and cardiovascular surgery, 148 5, 2208-13, 2214.e1-6

VillafaƱe, Juan; Lantin-Hermoso, M Regina; Bhatt, Ami B; Tweddell, James S; Geva, Tal; Nathan, Meena; Elliott, Martin J; Vetter, Victoria L; Paridon, Stephen M; Kochilas, Lazaros; Jenkins, Kathy J; Beekman, Robert H; Wernovsky, Gil; Towbin, Jeffrey A 2014. D-transposition of the great arteries: the current era of the arterial switch operation. Journal of the American College of Cardiology, 64 5, 498-511