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Tamara Tilburgs

Assistant Professor-Affiliate

Pediatrics | College of Medicine

Contact Information

Peer Reviewed Publications

Papúchová, Henrieta; Meissner, Torsten B; Li, Qin; Strominger, Jack L; Tilburgs, Tamara 2019. The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface. Frontiers in immunology, 10 , 2730

Salvany-Celades, Maria; van der Zwan, Anita; Benner, Marilen; Setrajcic-Dragos, Vita; Bougleux Gomes, Hannah Ananda; Iyer, Vidya; Norwitz, Errol R; Strominger, Jack L; Tilburgs, Tamara 2019. Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface. Cell reports, 27 9, 2537-2547.e5

van der Zwan, Anita; Bi, Kevin; Norwitz, Errol R; Crespo, Ângela C; Claas, Frans H J; Strominger, Jack L; Tilburgs, Tamara 2018. Mixed signature of activation and dysfunction allows human decidual CD8+ T cells to provide both tolerance and immunity. Proceedings of the National Academy of Sciences of the United States of America, 115 2, 385-390

Crespo, Ângela C; van der Zwan, Anita; Ramalho-Santos, João; Strominger, Jack L; Tilburgs, Tamara 2017. Cytotoxic potential of decidual NK cells and CD8+ T cells awakened by infections. Journal of reproductive immunology, 119 , 85-90

Ferreira, Leonardo M R; Meissner, Torsten B; Tilburgs, Tamara; Strominger, Jack L 2017. HLA-G: At the Interface of Maternal-Fetal Tolerance. Trends in immunology, 38 4, 272-286

Tilburgs, Tamara; Meissner, Torsten B; Ferreira, Leonardo M R; Mulder, Arend; Musunuru, Kiran; Ye, Junqiang; Strominger, Jack L 2017. NLRP2 is a suppressor of NF-?B signaling and HLA-C expression in human trophoblasts†,‡. Biology of reproduction, 96 4, 831-842

Crespo, Ângela C; Strominger, Jack L; Tilburgs, Tamara 2016. Expression of KIR2DS1 by decidual natural killer cells increases their ability to control placental HCMV infection. Proceedings of the National Academy of Sciences of the United States of America, 113 52, 15072-15077

Ferreira, Leonardo M R; Meissner, Torsten B; Mikkelsen, Tarjei S; Mallard, William; O'Donnell, Charles W; Tilburgs, Tamara; Gomes, Hannah A B; Camahort, Raymond; Sherwood, Richard I; Gifford, David K; Rinn, John L; Cowan, Chad A; Strominger, Jack L 2016. A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface. Proceedings of the National Academy of Sciences of the United States of America, 113 19, 5364-9

Tilburgs, Tamara; Strominger, Jack L 2016. Decidual endothelium, Notch1 and TGF?, gatekeepers for Treg accumulation at the maternal-fetal interface. Immunology and cell biology, 94 5, 419-20

Guerin, Leigh; Wu, Vernon; Houser, Brandy; Tilburgs, Tamara; de Jong, Annemieke; Moody, D Branch; Strominger, Jack L 2015. CD1 Antigen Presentation and Autoreactivity in the Pregnant Human Uterus. American journal of reproductive immunology (New York, N.Y. : 1989), 74 2, 126-35

Tilburgs, Tamara; Crespo, Ângela C; van der Zwan, Anita; Rybalov, Basya; Raj, Towfique; Stranger, Barbara; Gardner, Lucy; Moffett, Ashley; Strominger, Jack L 2015. Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes. Proceedings of the National Academy of Sciences of the United States of America, 112 23, 7219-24

Tilburgs, Tamara; Evans, J Henry; Crespo, Ângela C; Strominger, Jack L 2015. The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface. Proceedings of the National Academy of Sciences of the United States of America, 112 43, 13312-7

Guo, Zhenhong; Tilburgs, Tamara; Wong, Bonnie; Strominger, Jack L 2014. Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication. Proceedings of the National Academy of Sciences of the United States of America, 111 39, 14199-204

Tilburgs, Tamara; Strominger, Jack L 2013. CD8+ effector T cells at the fetal-maternal interface, balancing fetal tolerance and antiviral immunity. American journal of reproductive immunology (New York, N.Y. : 1989), 69 4, 395-407

Ackerman, W E; Bulmer, J N; Carter, A M; Chaillet, J R; Chamley, L; Chen, C P; Chuong, E B; Coleman, S J; Collet, G P; Croy, B A; de Mestre, A M; Dickinson, H; Ducray, J; Enders, A C; Fogarty, N M E; Gauster, M; Golos, T; Haider, S; Heazell, A E; Holland, O J; Huppertz, B; Husebekk, A; John, R M; Johnsen, G M; Jones, C J P; Kalionis, B; König, J; Lorenzon, A R; Moffett, A; Moreira de Mello, J C; Nuzzo, A M; Parham, P; Parolini, O; Petroff, M G; Pidoux, G; Ramírez-Pinilla, M P; Robinson, W P; Rolfo, A; Sadovsky, Y; Soma, H; Southcombe, J H; Tilburgs, T; Lash, G E 2012. IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells. Placenta, 33 Suppl , S15-22

Houser, Brandy L; Tilburgs, Tamara; Hill, Jonathan; Nicotra, Matthew L; Strominger, Jack L 2011. Two unique human decidual macrophage populations. Journal of immunology (Baltimore, Md. : 1950), 186 4, 2633-42

Lashley, Lisa E E L O; van der Hoorn, Marie-Louise P; van der Mast, Barbara J; Tilburgs, Tamara; van der Lee, Nadine; van der Keur, Carin; van Beelen, Els; Roelen, Dave L; Claas, Frans H J; Scherjon, Sicco A 2011. Changes in cytokine production and composition of peripheral blood leukocytes during pregnancy are not associated with a difference in the proliferative immune response to the fetus. Human immunology, 72 10, 805-11

Tilburgs, T; Claas, F H J; Scherjon, S A 2010. Elsevier Trophoblast Research Award Lecture: Unique properties of decidual T cells and their role in immune regulation during human pregnancy. Placenta, 31 Suppl , S82-6

Tilburgs, Tamara; Scherjon, Sicco A; Claas, Frans H J 2010. Major histocompatibility complex (MHC)-mediated immune regulation of decidual leukocytes at the fetal-maternal interface. Journal of reproductive immunology, 85 1, 58-62

Tilburgs, Tamara; Schonkeren, Dorrith; Eikmans, Michael; Nagtzaam, Nicole M; Datema, Gert; Swings, Godelieve M; Prins, Frans; van Lith, Jan M; van der Mast, Barbara J; Roelen, Dave L; Scherjon, Sicco A; Claas, Frans H 2010. Human decidual tissue contains differentiated CD8+ effector-memory T cells with unique properties. Journal of immunology (Baltimore, Md. : 1950), 185 7, 4470-7

Tilburgs, Tamara; Scherjon, Sicco A; Roelen, Dave L; Claas, Frans H J 2009. Decidual CD8+CD28- T cells express CD103 but not perforin. Human immunology, 70 2, 96-100

Tilburgs, Tamara; Scherjon, Sicco A; van der Mast, Barbara J; Haasnoot, Geert W; Versteeg-V D Voort-Maarschalk, Minke; Roelen, Dave L; van Rood, Johannes J; Claas, Frans H J 2009. Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells. Journal of reproductive immunology, 82 2, 148-57

Tilburgs, Tamara; van der Mast, Barbara J; Nagtzaam, Nicole M A; Roelen, Dave L; Scherjon, Sicco A; Claas, Frans H J 2009. Expression of NK cell receptors on decidual T cells in human pregnancy. Journal of reproductive immunology, 80 1-2, 22-32

Repnik, U; Tilburgs, T; Roelen, D L; van der Mast, B J; Kanhai, H H H; Scherjon, S; Claas, F H J 2008. Comparison of macrophage phenotype between decidua basalis and decidua parietalis by flow cytometry. Placenta, 29 5, 405-12

Tilburgs, Tamara; Roelen, Dave L; van der Mast, Barbara J; de Groot-Swings, Godelieve M; Kleijburg, Carin; Scherjon, Sicco A; Claas, Frans H 2008. Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. Journal of immunology (Baltimore, Md. : 1950), 180 8, 5737-45

Tilburgs, T; Roelen, D L; van der Mast, B J; van Schip, J J; Kleijburg, C; de Groot-Swings, G M; Kanhai, H H H; Claas, F H J; Scherjon, S A 2006. Differential distribution of CD4(+)CD25(bright) and CD8(+)CD28(-) T-cells in decidua and maternal blood during human pregnancy. Placenta, 27 Suppl A , S47-53

Gredmark, Sara; Tilburgs, Tamara; Söderberg-Nauclér, Cecilia 2004. Human cytomegalovirus inhibits cytokine-induced macrophage differentiation. Journal of virology, 78 19, 10378-89