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Photo of  Daniel Starczynowski, Ph.D., PhD

Daniel Starczynowski, Ph.D., PhD

Professor-Affiliate

Pediatrics | College of Medicine

Contact Information
Research Interests

The Starczynowski Lab has an interest in understanding the molecular and cellular basis of hematologic malignancies, with an emphasis on Myelodysplastic Syndromes and Acute Myeloid Leukemia. 
 

Peer Reviewed Publications

Jones, LaQuita M; Melgar, Katelyn; Bolanos, Lyndsey; Hueneman, Kathleen; Walker, Morgan M; Jiang, Jian-Kang; Wilson, Kelli M; Zhang, Xiaohu; Shen, Jian; Jiang, Fan; Sutter, Patrick; Wang, Amy; Xu, Xin; Tawa, Gregory J; Hoyt, Scott B; Wunderlich, Mark; O'Brien, Eric; Perentesis, John P; Starczynowski, Daniel T; Thomas, Craig J 2020. Targeting AML-associated FLT3 mutations with a type I kinase inhibitor. The Journal of clinical investigation, ,

Muto, Tomoya; Walker, Callum S; Choi, Kwangmin; Hueneman, Kathleen; Smith, Molly A; Gul, Zartash; Garcia-Manero, Guillermo; Ma, Averil; Zheng, Yi; Starczynowski, Daniel T 2020. Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Nature immunology, 21 5, 535-545

Niederkorn, Madeline; Hueneman, Kathleen; Choi, Kwangmin; Varney, Melinda E; Romano, Laurel; Pujato, Mario A; Greis, Kenneth D; Inoue, Jun-Ichiro; Meetei, Ruhikanta; Starczynowski, Daniel T 2020. TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis. Cell reports, 30 8, 2776-2790.e6

Melgar, Katelyn; Walker, Morgan M; Jones, LaQuita M; Bolanos, Lyndsey C; Hueneman, Kathleen; Wunderlich, Mark; Jiang, Jiang-Kang; Wilson, Kelli M; Zhang, Xiaohu; Sutter, Patrick; Wang, Amy; Xu, Xin; Choi, Kwangmin; Tawa, Gregory; Lorimer, Donald; Abendroth, Jan; O'Brien, Eric; Hoyt, Scott B; Berman, Ellin; Famulare, Christopher A; Mulloy, James C; Levine, Ross L; Perentesis, John P; Thomas, Craig J; Starczynowski, Daniel T 2019. Overcoming adaptive therapy resistance in AML by targeting immune response pathways. Science translational medicine, 11 508,

Rawat, Radhika; Starczynowski, Daniel T; Ntziachristos, Panagiotis 2019. Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in disease. Current opinion in cell biology, 58 , 85-94

Sekeres, Mikkael A; Gore, Steven D; Stablein, Donald M; DiFronzo, Nancy; Abel, Gregory A; DeZern, Amy E; Troy, Jesse D; Rollison, Dana E; Thomas, John W; Waclawiw, Myron A; Liu, Jane Jijun; Al Baghdadi, Tareq; Walter, Matthew J; Bejar, Rafael; Gorak, Edward J; Starczynowski, Daniel T; Foran, James M; Cerhan, James R; Moscinski, Lynn C; Komrokji, Rami S; Deeg, H Joachim; Epling-Burnette, Pearlie K 2019. The National MDS Natural History Study: design of an integrated data and sample biorepository to promote research studies in myelodysplastic syndromes. Leukemia & lymphoma, , 1-11

Smith, Molly A; Choudhary, Gaurav S; Pellagatti, Andrea; Choi, Kwangmin; Bolanos, Lyndsey C; Bhagat, Tushar D; Gordon-Mitchell, Shanisha; Von Ahrens, Dagny; Pradhan, Kith; Steeples, Violetta; Kim, Sanghyun; Steidl, Ulrich; Walter, Matthew; Fraser, Iain D C; Kulkarni, Aishwarya; Salomonis, Nathan; Komurov, Kakajan; Boultwood, Jacqueline; Verma, Amit; Starczynowski, Daniel T 2019. U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies. Nature cell biology, ,

Barreyro, Laura; Chlon, Timothy M; Starczynowski, Daniel T 2018. Chronic immune response dysregulation in MDS pathogenesis. Blood, 132 15, 1553-1560

Culver-Cochran, Ashley E; Starczynowski, Daniel T 2018. Chronic innate immune signaling results in ubiquitination of splicing machinery. Cell cycle (Georgetown, Tex.), , 1-4

Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T 2018. TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis. Cell reports, 22 5, 1250-1262

Wei, Yue; Zheng, Hong; Bao, Naran; Jiang, Shan; Bueso-Ramos, Carlos E; Khoury, Joseph; Class, Caleb; Lu, Yue; Lin, Kevin; Yang, Hui; Ganan-Gomez, Irene; Starczynowski, Daniel T; Do, Kim-Anh; Colla, Simona; Garcia-Manero, Guillermo 2018. KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice. Blood advances, 2 19, 2491-2504

Fang, Jing; Bolanos, Lyndsey C; Choi, Kwangmin; Liu, Xiaona; Christie, Susanne; Akunuru, Shailaja; Kumar, Rupali; Wang, Dehua; Chen, Xiaoting; Greis, Kenneth D; Stoilov, Peter; Filippi, Marie-Dominique; Maciejewski, Jaroslaw P; Garcia-Manero, Guillermo; Weirauch, Matthew T; Salomonis, Nathan; Geiger, Hartmut; Zheng, Yi; Starczynowski, Daniel T 2017. Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia. Nature Immunology, 18 2, 236-245

Kong, Fansheng; Liu, Zhiwei; Jain, Viral G; Shima, Kenjiro; Suzuki, Takuji; Muglia, Louis J; Starczynowski, Daniel T; Pasare, Chandrashekhar; Bhattacharyya, Sandip 2017. Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages. Journal of immunology (Baltimore, Md. : 1950), 199 10, 3654-3667

Varney, M E; Choi, K; Bolanos, L; Christie, S; Fang, J; Grimes, H L; Maciejewski, J P; Inoue, J-I; Starczynowski, D T 2017. Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome. Leukemia, 31 2, 491-495

Fang J, Liu X, Bolanos L, Barker B, Rigolino C, Cortelezzi A, Oliva EN, Cuzzola M, Grimes HL, Fontanillo C, Komurov K, MacBeth K, Starczynowski DT 2016. A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes Nature Medicine, 22 7, 727

Varney ME, Choi K, Bolanos L, Christie S, Fang J, Grimes HL, Maciejewski JP, Inoue JI, Starczynowski DT 2016. Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome Leukemia, 50 , 85

Adams AK, Bolanos LC, Dexheimer PJ, Karns RA, Aronow BJ, Komurov K, Jegga AG, Casper KA, Patil YJ, Wilson KM, Starczynowski DT, Wells SI 2015. IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival Oncotarget, 6 41, 43395

Gañán-Gómez, I; Wei, Y; Starczynowski, D T; Colla, S; Yang, H; Cabrero-Calvo, M; Bohannan, Z S; Verma, A; Steidl, U; Garcia-Manero, G 2015. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes. Leukemia, 29 7, 1458-69

Rhyasen, G W; Starczynowski, D T 2015. IRAK signalling in cancer. British journal of cancer, 112 2, 232-7

Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, Starczynowski DT 2015. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling Journal of Experimental Medicine, 212 11, 1967

Beverly, Levil J; Starczynowski, Daniel T 2014. IRAK1: oncotarget in MDS and AML. Oncotarget, 5 7, 1699-700

Chang, Kyung Hee; Sengupta, Amitava; Nayak, Ramesh C; Duran, Angeles; Lee, Sang Jun; Pratt, Ronald G; Wellendorf, Ashley M; Hill, Sarah E; Watkins, Marcus; Gonzalez-Nieto, Daniel; Aronow, Bruce J; Starczynowski, Daniel T; Civitelli, Roberto; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A 2014. p62 Is Required for Stem Cell/Progenitor Retention through Inhibition of IKK/NF-kappaB/Ccl4 Signaling at the Bone Marrow Macrophage-Osteoblast Niche. Cell reports, 9 6, 2084-97

Fang, Jing; Barker, Brenden; Bolanos, Lyndsey; Liu, Xiaona; Jerez, Andres; Makishima, Hideki; Christie, Susanne; Chen, Xiaoting; Rao, Dinesh S; Grimes, H Leighton; Komurov, Kakajan; Weirauch, Matthew T; Cancelas, Jose A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T 2014. Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-kappaB gene network Cell reports, 8 5, 1328-38

Rhyasen, G W; Wunderlich, M; Tohyama, K; Garcia-Manero, G; Mulloy, J C; Starczynowski, D T 2014. An MDS xenograft model utilizing a patient-derived cell line. Leukemia, 28 5, 1142-5

Starczynowski, Daniel T 2014. Errant innate immune signaling in del(5q) MDS. Blood, 124 5, 669-71

Wilson, I M; Vucic, E A; Enfield, K S S; Thu, K L; Zhang, Y A; Chari, R; Lockwood, W W; Radulovich, N; Starczynowski, D T; Banáth, J P; Zhang, M; Pusic, A; Fuller, M; Lonergan, K M; Rowbotham, D; Yee, J; English, J C; Buys, T P H; Selamat, S A; Laird-Offringa, I A; Liu, P; Anderson, M; You, M; Tsao, M S; Brown, C J; Bennewith, K L; MacAulay, C E; Karsan, A; Gazdar, A F; Lam, S; Lam, W L 2014. EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk. Oncogene, 33 36, 4464-73

Zhao, Jimmy L; Starczynowski, Daniel T 2014. Role of microRNA-146a in normal and malignant hematopoietic stem cell function. Frontiers in genetics, 5 , 219

Guo, Fukun; Zhang, Shuangmin; Grogg, Matthew; Cancelas, Jose A; Varney, Melinda E; Starczynowski, Daniel T; Du, Wei; Yang, Jun-Qi; Liu, Wei; Thomas, George; Kozma, Sara; Pang, Qishen; Zheng, Yi 2013. Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica, 98 9, 1353-8

Rhyasen, Garrett W; Bolanos, Lyndsey; Fang, Jing; Jerez, Andres; Wunderlich, Mark; Rigolino, Carmela; Mathews, Lesley; Ferrer, Marc; Southall, Noel; Guha, Rajarshi; Keller, Jonathan; Thomas, Craig; Beverly, Levi J; Cortelezzi, Agostino; Oliva, Esther N; Cuzzola, Maria; Maciejewski, Jaroslaw P; Mulloy, James C; Starczynowski, Daniel T 2013. Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome. Cancer cell, 24 1, 90-104

Rhyasen, Garrett W; Bolanos, Lyndsey; Starczynowski, Daniel T 2013. Differential IRAK signaling in hematologic malignancies. Experimental hematology, 41 12, 1005-7

Fang, Jing; Rhyasen, Garrett; Bolanos, Lyndsey; Rasch, Christopher; Varney, Melinda; Wunderlich, Mark; Goyama, Susumu; Jansen, Gerrit; Cloos, Jacqueline; Rigolino, Carmela; Cortelezzi, Agostino; Mulloy, James C; Oliva, Esther N; Cuzzola, Maria; Starczynowski, Daniel T 2012. Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. Blood, 120 4, 858-67

Fang, Jing; Varney, Melinda; Starczynowski, Daniel T 2012. Implication of microRNAs in the pathogenesis of MDS. Current pharmaceutical design, 18 22, 3170-9

Rhyasen, G W; Starczynowski, D T 2012. Deregulation of microRNAs in myelodysplastic syndrome. Leukemia, 26 1, 13-22

Vercauteren, Suzanne M; Starczynowski, Daniel T; Sung, Sandy; McNeil, Kelly; Salski, Chris; Jensen, Clara-Lynn; Bruyere, Helene; Lam, Wan L; Karsan, Aly 2012. T cells of patients with myelodysplastic syndrome are frequently derived from the malignant clone. British journal of haematology, 156 3, 409-12

Kuchenbauer, Florian; Mah, Sarah M; Heuser, Michael; McPherson, Andrew; Rüschmann, Jens; Rouhi, Arefeh; Berg, Tobias; Bullinger, Lars; Argiropoulos, Bob; Morin, Ryan D; Lai, David; Starczynowski, Daniel T; Karsan, Aly; Eaves, Connie J; Watahiki, Akira; Wang, Yuzhuo; Aparicio, Samuel A; Ganser, Arnold; Krauter, Jürgen; Döhner, Hartmut; Döhner, Konstanze; Marra, Marco A; Camargo, Fernando D; Palmqvist, Lars; Buske, Christian; Humphries, R Keith 2011. Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood, 118 12, 3350-8

Starczynowski, Daniel T; Kuchenbauer, Florian; Wegrzyn, Joanna; Rouhi, Arefeh; Petriv, Oleh; Hansen, Carl L; Humphries, R Keith; Karsan, Aly 2011. MicroRNA-146a disrupts hematopoietic differentiation and survival. Experimental hematology, 39 2, 167-178.e4

Starczynowski, Daniel T; Lockwood, William W; Deléhouzée, Sophie; Chari, Raj; Wegrzyn, Joanna; Fuller, Megan; Tsao, Ming-Sound; Lam, Stephen; Gazdar, Adi F; Lam, Wan L; Karsan, Aly 2011. TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer. The Journal of clinical investigation, 121 10, 4095-105

Starczynowski, Daniel T; Morin, Ryan; McPherson, Andrew; Lam, Jeff; Chari, Raj; Wegrzyn, Joanna; Kuchenbauer, Florian; Hirst, Martin; Tohyama, Kaoru; Humphries, R Keith; Lam, Wan L; Marra, Marco; Karsan, Aly 2011. Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood, 117 2, 595-607

Starczynowski, Daniel T; Vercauteren, Suzanne; Sung, Sandy; Brooks-Wilson, Angela; Lam, Wan L; Karsan, Aly 2011. Copy number alterations at polymorphic loci may be acquired somatically in patients with myelodysplastic syndromes. Leukemia research, 35 4, 444-7

Starczynowski, Daniel T; Karsan, Aly 2010. Innate immune signaling in the myelodysplastic syndromes. Hematology/oncology clinics of North America, 24 2, 343-59

Starczynowski, Daniel T; Karsan, Aly 2010. Deregulation of innate immune signaling in myelodysplastic syndromes is associated with deletion of chromosome arm 5q. Cell cycle (Georgetown, Tex.), 9 5, 855-6

Starczynowski, Daniel T; Kuchenbauer, Florian; Argiropoulos, Bob; Sung, Sandy; Morin, Ryan; Muranyi, Andrew; Hirst, Martin; Hogge, Donna; Marra, Marco; Wells, Richard A; Buckstein, Rena; Lam, Wan; Humphries, R Keith; Karsan, Aly 2010. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nature medicine, 16 1, 49-58

Vercauteren, Suzanne M; Sung, Sandy; Starczynowski, Daniel T; Lam, Wan L; Bruyere, Helene; Horsman, Douglas E; Tsang, Peter; Leitch, Heather; Karsan, Aly 2010. Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities. American journal of clinical pathology, 134 1, 119-26

Starczynowski, Daniel T; Vercauteren, Suzanne; Telenius, Adele; Sung, Sandy; Tohyama, Kaoru; Brooks-Wilson, Angela; Spinelli, John J; Eaves, Connie J; Eaves, Allen C; Horsman, Douglas E; Lam, Wan L; Karsan, Aly 2008. High-resolution whole genome tiling path array CGH analysis of CD34+ cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival. Blood, 112 8, 3412-24

Starczynowski, Daniel T; Reynolds, Joseph G; Gilmore, Thomas D 2005. Mutations of tumor necrosis factor alpha-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability. Oncogene, 24 49, 7355-68

Gilmore, Thomas D; Kalaitzidis, Demetrios; Liang, Mei-Chih; Starczynowski, Daniel T 2004. The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene, 23 13, 2275-86

Gilmore, Thomas D; Starczynowski, Daniel T; Kalaitzidis, Demetrios 2004. RELevant gene amplification in B-cell lymphomas? Blood, 103 8, 3243-4; author reply

Kalaitzidis, Demetrios; Ok, John; Sulak, Lawrence; Starczynowski, Daniel T; Gilmore, Thomas D 2004. Characterization of a human REL-estrogen receptor fusion protein with a reverse conditional transforming activity in chicken spleen cells. Oncogene, 23 45, 7580-7

Leonida, Mihaela D; Starczynowski, Daniel T; Waldman, Riva; Aurian-Blajeni, Benedict 2003. Polymeric FAD used as enzyme-friendly mediator in lactate detection. Analytical and bioanalytical chemistry, 376 6, 832-7

Starczynowski, Daniel T; Reynolds, Joseph G; Gilmore, Thomas D 2003. Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells. Oncogene, 22 44, 6928-36

Gilmore, Thomas; Gapuzan, Maria-Emily; Kalaitzidis, Demetrios; Starczynowski, Daniel 2002. Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer. Cancer letters, 181 1, 1-9