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Photo of  Manoj K. Pandey, BS,MS,PhD

Manoj K. Pandey, BS,MS,PhD

Research Assistant Professor-Affiliate

Pediatrics | College of Medicine

Education/Credentials
  • PhD: Sanjay Gandhi Post Graduate Institute of Medical Sciences, (Maternal immunoregulation and foetal survival")
Contact Information
Research Interests

Using mouse model and human patients with Gaucher disease, the major focus of investigation in the Dr. Pandey laboratory is to study the 1) Role of immunological cells i.e.,dendritic cells, macrophages, neutrophils, T,  and B lymphocytes and their competence for glucosylceramide (GC) accumulation. 2) Using these cells to evaluate the impact of GC in induction of several innate and adaptive immune responses. 3) Uncovering downstream signaling critical for immunological inflammation in Gaucher and othe...

Peer Reviewed Publications

Pandey, Manoj Kumar; Jabre, Nicholas A; Xu, You-Hai; Zhang, Wujuan; Setchell, Kenneth D R; Grabowski, Gregory A 2014. Gaucher disease: Chemotactic factors and immunological cell invasion in a mouse model. Molecular genetics and metabolism, 111 2, 163-71

Pandey, Manoj Kumar 2013. Molecular basis for downregulation of C5a-mediated inflammation by IgG1 immune complexes in allergy and asthma. Current allergy and asthma reports, 13 6, 596-606

Pandey, Manoj Kumar; Grabowski, Gregory A 2013. Immunological cells and functions in Gaucher disease. Critical reviews in oncogenesis, 18 3, 197-220

Stemerding, Annette M; Köhl, Jörg; Pandey, Manoj K; Kuipers, Annemarie; Leusen, Jeanette H; Boross, Peter; Nederend, Maaike; Vidarsson, Gestur; Weersink, Annemarie Y L; van de Winkel, Jan G J; van Kessel, Kok P M; van Strijp, Jos A G 2013. Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent Fc?R antagonists that inhibit IgG-mediated effector functions. Journal of immunology (Baltimore, Md. : 1950), 191 1, 353-62

Karsten, Christian M; Pandey, Manoj K; Figge, Julia; Kilchenstein, Regina; Taylor, Philip R; Rosas, Marcela; McDonald, Jacqueline U; Orr, Selinda J; Berger, Markus; Petzold, Dominique; Blanchard, Veroniqué; Winkler, André; Hess, Constanze; Reid, Delyth M; Majoul, Irina V; Strait, Richard T; Harris, Nathaniel L; Köhl, Gabriele; Wex, Eva; Ludwig, Ralf; Zillikens, Detlef; Nimmerjahn, Falk; Finkelman, Fred D; Brown, Gordon D; Ehlers, Marc; Köhl, Jörg 2012. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of Fc?RIIB and dectin-1. Nature medicine, 18 9, 1401-6

Pandey, Manoj Kumar; Rani, Reena; Zhang, Wujuan; Setchell, Kenneth; Grabowski, Gregory A 2012. Immunological cell type characterization and Th1-Th17 cytokine production in a mouse model of Gaucher disease. Molecular genetics and metabolism, 106 3, 310-22

Bestebroer, Jovanka; Aerts, Piet C; Rooijakkers, Suzan H M; Pandey, Manoj K; Köhl, Jörg; van Strijp, Jos A G; de Haas, Carla J C 2010. Functional basis for complement evasion by staphylococcal superantigen-like 7. Cellular microbiology, 12 10, 1506-16

Fritsche, Lars G; Lauer, Nadine; Hartmann, Andrea; Stippa, Selina; Keilhauer, Claudia N; Oppermann, Martin; Pandey, Manoj K; Köhl, Jörg; Zipfel, Peter F; Weber, Bernhard H F; Skerka, Christine 2010. An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD). Human molecular genetics, 19 23, 4694-704

Weaver, Donald J; Reis, Edimara S; Pandey, Manoj K; Köhl, Gabriele; Harris, Nathaniel; Gerard, Craig; Köhl, Jörg 2010. C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. European journal of immunology, 40 3, 710-21

Zhang, Xun; Schmudde, Inken; Laumonnier, Yves; Pandey, Manoj K; Clark, Jennifer R; König, Peter; Gerard, Norma P; Gerard, Craig; Wills-Karp, Marsha; Köhl, Jörg 2010. A critical role for C5L2 in the pathogenesis of experimental allergic asthma. Journal of immunology (Baltimore, Md. : 1950), 185 11, 6741-52

Jongerius, Ilse; Köhl, Jörg; Pandey, Manoj K; Ruyken, Maartje; van Kessel, Kok P M; van Strijp, Jos A G; Rooijakkers, Suzan H M 2007. Staphylococcal complement evasion by various convertase-blocking molecules. The Journal of experimental medicine, 204 10, 2461-71

Iankov, Ianko D; Pandey, Manoj; Harvey, Mary; Griesmann, Guy E; Federspiel, Mark J; Russell, Stephen J 2006. Immunoglobulin g antibody-mediated enhancement of measles virus infection can bypass the protective antiviral immune response. Journal of virology, 80 17, 8530-40

Köhl, Jörg; Baelder, Ralf; Lewkowich, Ian P; Pandey, Manoj K; Hawlisch, Heiko; Wang, Lihua; Best, Jennifer; Herman, Nancy S; Sproles, Alyssa A; Zwirner, Jörg; Whitsett, Jeffrey A; Gerard, Craig; Sfyroera, Georgia; Lambris, John D; Wills-Karp, Marsha 2006. A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. The Journal of clinical investigation, 116 3, 783-96

Pandey, Manoj Kumar; Rani, Reena; Agrawal, Suraksha 2005. An update in recurrent spontaneous abortion. Archives of gynecology and obstetrics, 272 2, 95-108

Pandey, Manoj Kumar; Agrawal, Suraksha 2004. Induction of MLR-Bf and protection of fetal loss: a current double blind randomized trial of paternal lymphocyte immunization for women with recurrent spontaneous abortion. International immunopharmacology, 4 2, 289-98

Pandey, Manoj Kumar; Thakur, Seema; Agrawal, Suraksha 2004. Lymphocyte immunotherapy and its probable mechanism in the maintenance of pregnancy in women with recurrent spontaneous abortion. Archives of gynecology and obstetrics, 269 3, 161-72

Agrawal, Suraksha; Pandey, Manoj Kumar 2003. The potential role of HLA-G polymorphism in maternal tolerance to the developing fetus. Journal of hematotherapy & stem cell research, 12 6, 749-56

Pandey MK, Agrawal S. 2003. Is Allogenic immunization before and during pregnancy more effective?. The Internet Journal of Gynecology and Obstetrics , 2 1,

Pandey MK, Halder A, Agarwal S, Srivastava M, Agarwal SS, Agrawal S. 2003. Immuno therapy in recurrent spontaneous abortion: randomized and non-randomized trials. The Internet Journal of Gynecology and Obstetrics , 2 1,

Pandey MK, Mishra LC, Agrawal S. 2003. Is mother immunologically suppressed during pregnancy? Asian Journal Obs & Gynae Practice , 7 5, 17

Pandey, Manoj Kumar; Saxena, Vijay; Agrawal, Suraksha 2003. Characterization of mixed lymphocyte reaction blocking antibodies (MLR-Bf) in human pregnancy. BMC pregnancy and childbirth, 3 1, 2

Agrawal, Suraksha; Pandey, Manoj K; Mandal, SK; Mishra, LC; Agarwal, SS 2002. Humoral immune response to an allogenic foetus in normal fertile women and recurrent aborters. BMC pregnancy and childbirth, 2 1, 6

Pandey MK, Agrawal S. 2002. Prevalence of MLR blocking antibodies before and after immunotherapy. Obs & Gynae Today , 10 , 574

Abstract Publications

Pandey MK, Tinch SL, Jabre, NA, Grabowski GA. 2014. Gaucher disease: glucosylceramide-mediated TLR4-MyD88 induction causes enhanced CXCL-13 secretion and increased B cell trafficking in a mouse model. Molecular Genetics and Metabolism , 111 2, S84


Pandey MK, Tinch SL, Grabowski GA. 2013. C5a mediated increases of CD40 and CD40L molecules on dendritic and T cells are critical to Th1-Th17 mediated inflammation in Gaucher disease model. Molecular Genetics and Metabolism , 108 2, S72


Jabre NA, Pandey MK, Grabowski GA. 2012. Elevated Inflammatory Cytokines in a mouse model of Gaucher disease. American College of Physicians 2012, 54 ,


Pandey MK, Jabre NA, Grabowski GA. 2012. Chemotactic factors critical for increased immunological cell invasion in Gaucher disease mice. American Society of Human Genetics, 62nd annual meeting of the American Society of Human Genetics, Sanfrancisco, CA, 2012. , 749F


. Karsten CM, Pandey MK, Figge J, Taylor PR, McDonald JU, Strait RT, Harris NL, Koehl G, Brown GD, Finkelman FD, Koehl J. 2011. Galactosylated IgG1 links FcRIIB and dectin 1 to suppress C5aR-mediated inflammation. Molecular Immunology , 48 14, 1669


Figge J, Pandey MK, Karsten CM, Westermann J, Madaio M, Köhl J. 2011. Synergistic roles for C5aR and C5L2 in the development of anti-GBM nephritis. Molecular Immunology , 48 14, 1690


Jabre NA, Pandey MK, Grabowski GA. 2011. Enhanced leukocyte chemotaxis into serum from a mouse model of Gaucher Disease. Journal of Investigative Medicine , 59 1, 176


Pandey MK, Figge J, Karsten CM, Madaio M, Gerard C, Köhl J. 2010. A novel role for C5a in B-cell regulation driving the pathology in immune complex nephritis. Molecular Immunology , 47 13, 2232


Eberhardt H, Lauer N, Pandey MK, Köhl J, Hartmann A, Ludwig M, Zipfel PF , Skerka K. 2009. Factor H related human plasma proteins CFHR1, CFHR2 and CFHR3 regulate complement activation and exert anti-inflammatory activities. Molecular Immunology, 46 14, 2841


PandeyMK , Köhl J. 2009. Synergistic roles for C5aR and C5L2 in Goodpasture's disease. Molecular Immunology , 46 14, 2842


Pandey MK, Madaio M, Koehl J. 2008. A critical role for C5L2 in a murine model of Goodpasture’s Disease. Autumn Immunology, 37th Annual Autumn Immunology Conference, Chicago, IL, November 19-24, 2008. 18, 13


Pandey MK, Harris NL, Köhl G, Magnusen AF, Köhl J. 2007. Aggregation of FcRIIB by IgG1 immune complexes inhibits chemoattractant receptor mediated inflammation. Molecular Immunology, 44 1-3, 3909


Pandey MK, Köhl G, Köhl J. 2007. Inhibitory FcγR receptors negatively regulate C5aR-mediated effector functions in immune complex diseases. Molecular immunology, 44 1-3, 226


Magnusen AF, Pandey MK, Köhl J. 2006. C5a receptor and toll-like receptor cross talk regulates the B1 B cell compartment. Autumn Immunology, 35th Annual Autumn Immunology Conference, Chicago, IL, November 17-20, 2006 160, 56


Pandey MK, Harris NL, Magnusen AF, Köhl G, Köhl J. 2006. The inhibitory FcγR receptor blocks chemoattractant receptor signaling as a novel pathway to regulate immune complex-mediated inflammation. Autumn Immunology, 35th Annual Autumn Immunology Conference, Chicago, IL, November 17-20, 2006 132, 48


Bauer PR, Pandey MK, Hubmayr RD. 2005. Murine alveolar epithelial cells Type II in culture and osmotic challenge. Proceedings of the American Thoracic Society , 2, A230


Pandey MK, Rasmussen DL, Hubmayr RD. 2005. Effects of stretch and transdifferentiation on caveolin-1 expression in alveolar epithelial cells. Proceedings of the American Thoracic Society , 2 , A824


Lauer N, Fritsche LG, Weber BHF, Hartmann A, Keilhauer CN, Hälbich S, Oppermann M, Pandey MK, Köhl J, Zipfel PF, Skerka C. . Imbalance of complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age related macular degeneration (AMD). Molecular Immunology , 47 13, 2211