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Punam Malik, MD

Professor-Affiliate

Pediatrics | College of Medicine

Contact Information

Peer Reviewed Publications

Arumugam, Paritha I; Mullins, Eric S; Shanmukhappa, Shiva Kumar; Monia, Brett P; Loberg, Anastacia; Shaw, Maureen A; Rizvi, Tilat; Wansapura, Janaka; Degen, Jay L; Malik, Punam 2015. Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice. Blood, 126 15, 1844-55

Carmo, Marlene; Risma, Kimberly A; Arumugam, Paritha; Tiwari, Swati; Hontz, Adrianne E; Montiel-Equihua, Claudia A; Alonso-Ferrero, Maria E; Blundell, Michael P; Schambach, Axel; Baum, Christopher; Malik, Punam; Thrasher, Adrian J; Jordan, Michael B; Gaspar, H Bobby 2015. Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency. Molecular therapy : the journal of the American Society of Gene Therapy, 23 4, 737-45

Chang, Kyung Hee; Nayak, Ramesh C; Roy, Swarnava; Perumbeti, Ajay; Wellendorf, Ashley M; Bezold, Katie Y; Pirman, Megan; Hill, Sarah E; Starnes, Joseph; Loberg, Anastacia; Zhou, Xuan; Inagami, Tadashi; Zheng, Yi; Malik, Punam; Cancelas, Jose A 2015. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT?R and cytoskeletal dysregulation. Nature communications, 6 , 5914

Gonsalves, Caryn S; Li, Chen; Mpollo, Marthe-Sandrine Eiymo Mwa; Pullarkat, Vinod; Malik, Punam; Tahara, Stanley M; Kalra, Vijay K 2015. Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1? and post-transcriptionally by miR-214 in sickle cell disease. The Biochemical journal, 468 3, 409-23

Gonsalves, Caryn Suzanne; Li, Chen; Malik, Punam; Tahara, Stanley M; Kalra, Vijay K 2015. Peroxisome Proliferator alpha mediated transcription of miR-301a and miR-454 and their host gene SKA2 regulate Endothelin-1 and PAI-1 expression in sickle cell disease. Bioscience reports, ,

Li, Chen; Gonsalves, Caryn S; Eiymo Mwa Mpollo, Marthe-Sandrine; Malik, Punam; Tahara, Stanley M; Kalra, Vijay K 2015. MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5. Molecular and cellular biology, 35 3, 514-28

Chandrakasan, Shanmuganathan; Malik, Punam 2014. Gene therapy for hemoglobinopathies: the state of the field and the future. Hematology/oncology clinics of North America, 28 2, 199-216

Kiem, Hans-Peter; Arumugam, Paritha I; Burtner, Christopher R; Fox, Catherine F; Beard, Brian C; Dexheimer, Phillip; Adair, Jennifer E; Malik, Punam 2014. Pigtailed macaques as a model to study long-term safety of lentivirus vector-mediated gene therapy for hemoglobinopathies. Molecular therapy. Methods & clinical development, 1 , 14055

Li, Chen; Mpollo, Marthe-Sandrine Eiymo Mwa; Gonsalves, Caryn S; Tahara, Stanley M; Malik, Punam; Kalra, Vijay K 2014. Peroxisome proliferator-activated receptor-?-mediated transcription of miR-199a2 attenuates endothelin-1 expression via hypoxia-inducible factor-1?. The Journal of biological chemistry, 289 52, 36031-47

Suzuki, Takuji; Arumugam, Paritha; Sakagami, Takuro; Lachmann, Nico; Chalk, Claudia; Sallese, Anthony; Abe, Shuichi; Trapnell, Cole; Carey, Brenna; Moritz, Thomas; Malik, Punam; Lutzko, Carolyn; Wood, Robert E; Trapnell, Bruce C 2014. Pulmonary macrophage transplantation therapy. Nature, 514 7523, 450-4

Zhou, Xuan; Florian, Maria Carolina; Arumugam, Paritha; Chen, Xiaoyi; Cancelas, Jose A; Lang, Richard; Malik, Punam; Geiger, Hartmut; Zheng, Yi 2013. RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors. The Journal of experimental medicine, 210 11, 2371-85

van der Loo, J C M; Swaney, W P; Grassman, E; Terwilliger, A; Higashimoto, T; Schambach, A; Baum, C; Thrasher, A J; Williams, D A; Nordling, D L; Reeves, L; Malik, P 2012. Scale-up and manufacturing of clinical-grade self-inactivating ?-retroviral vectors by transient transfection. Gene therapy, 19 3, 246-54

van der Loo, J C M; Swaney, W P; Grassman, E; Terwilliger, A; Higashimoto, T; Schambach, A; Hacein-Bey-Abina, S; Nordling, D L; Cavazzana-Calvo, M; Thrasher, A J; Williams, D A; Reeves, L; Malik, P 2012. Critical variables affecting clinical-grade production of the self-inactivating gamma-retroviral vector for the treatment of X-linked severe combined immunodeficiency. Gene therapy, 19 8, 872-6

Sundaram, Nambirajan; Bennett, Michael; Wilhelm, Jamie; Kim, Mi-Ok; Atweh, George; Devarajan, Prasad; Malik, Punam 2011. Biomarkers for early detection of sickle nephropathy. American journal of hematology, 86 7, 559-66

Arumugam, Paritha; Malik, Punam 2010. Genetic therapy for beta-thalassemia: from the bench to the bedside. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 2010 , 445-50

Perumbeti, Ajay; Malik, Punam 2010. Therapy for beta-globinopathies: a brief review and determinants for successful and safe correction. Annals of the New York Academy of Sciences, 1202 , 36-44

Perumbeti, Ajay; Malik, Punam 2010. Genetic correction of sickle cell anemia and beta-thalassemia: progress and new perspective. TheScientificWorldJournal, 10 , 644-54

Sundaram, Nambirajan; Tailor, Anitaben; Mendelsohn, Laurel; Wansapura, Janaka; Wang, Xunde; Higashimoto, Tomoyasu; Pauciulo, Michael W; Gottliebson, William; Kalra, Vijay K; Nichols, William C; Kato, Gregory J; Malik, Punam 2010. High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension. Blood, 116 1, 109-12

Arumugam, Paritha I; Higashimoto, Tomoyasu; Urbinati, Fabrizia; Modlich, Ute; Nestheide, Shawna; Xia, Ping; Fox, Catherine; Corsinotti, Andrea; Baum, Christopher; Malik, Punam 2009. Genotoxic potential of lineage-specific lentivirus vectors carrying the beta-globin locus control region. Molecular therapy : the journal of the American Society of Gene Therapy, 17 11, 1929-37

Arumugam, Paritha I; Urbinati, Fabrizia; Velu, Chinavenmeni S; Higashimoto, Tomoyasu; Grimes, H Leighton; Malik, Punam 2009. The 3' region of the chicken hypersensitive site-4 insulator has properties similar to its core and is required for full insulator activity. PloS one, 4 9, e6995

Perumbeti, Ajay; Higashimoto, Tomoyasu; Urbinati, Fabrizia; Franco, Robert; Meiselman, Herbert J; Witte, David; Malik, Punam 2009. A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction. Blood, 114 6, 1174-85

Urbinati, Fabrizia; Arumugam, Paritha; Higashimoto, Tomoyasu; Perumbeti, Anil; Mitts, Kyle; Xia, Ping; Malik, Punam 2009. Mechanism of reduction in titers from lentivirus vectors carrying large inserts in the 3'LTR. Molecular therapy : the journal of the American Society of Gene Therapy, 17 9, 1527-36

Wang, Daren; Zhang, Wei; Kalfa, Theodosia A; Grabowski, Gregory; Davies, Stella; Malik, Punam; Pan, Dao 2009. Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome. Proceedings of the National Academy of Sciences of the United States of America, 106 47, 19958-63

Williams, Jon P; Wu, Jianqiang; Johansson, Gunnar; Rizvi, Tilat A; Miller, Shyra C; Geiger, Hartmut; Malik, Punam; Li, Wenling; Mukouyama, Yoh-suke; Cancelas, Jose A; Ratner, Nancy 2008. Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell stem cell, 3 6, 658-69