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Richard Lu, PhD

Professor-Affiliate

Pediatrics | College of Medicine

Contact Information
Research Interests

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases, Developmental Biology

Peer Reviewed Publications

Del Águila, Ángela; Adam, Mike; Ullom, Kristy; Shaw, Nicholas; Qin, Shenyue; Ehrman, Jacqueline; Nardini, Diana; Salomone, Joseph; Gebelein, Brian; Lu, Q Richard; Potter, Steven S; Waclaw, Ronald; Campbell, Kenneth; Nakafuku, Masato 2022. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Development (Cambridge, England), 149 5,

Garrett, Matthew C; Albano, Rebecca; Carnwath, Troy; Shah, Sanjit; Woo, Daniel; Lamba, Michael; Plas, David R; Paranjpe, Aditi; Roskin, Krishna; Zhao, Chuntao; Lu, Richard 2022. Chromatin structure predicts survival in glioma patients. Scientific reports, 12 1, 8221

Rao, Rohit; Han, Rong; Ogurek, Sean; Xue, Chengbin; Wu, Lai Man; Zhang, Liguo; Zhang, Li; Hu, Jian; Phoenix, Timothy N; Waggoner, Stephen N; Lu, Q Richard 2022. Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition. Neuro-oncology, 24 4, 584-597

Tu, Zhaowei; Fan, Cuiqing; Davis, Ashely K; Hu, Mengwen; Wang, Chen; Dandamudi, Akhila; Seu, Katie G; Kalfa, Theodosia A; Lu, Q Richard; Zheng, Yi 2022. Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Cell reports, 40 2, 111072

Yi, Jiaqing; Kim, BongWoo; Shi, Xuanming; Zhan, Xiaoming; Lu, Q Richard; Xuan, Zhenyu; Wu, Jiang 2022. PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma. Cancer research, ,

Zhang, Jing; Guan, Menglong; Zhou, Xianyao; Berry, Kalen; He, Xuelian; Lu, Q Richard 2022. Long Noncoding RNAs in CNS Myelination and Disease. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, , 10738584221083919

Fan, Cuiqing; Zhao, Chuntao; Zhang, Feng; Kesarwani, Meenu; Tu, Zhaowei; Cai, Xiongwei; Davis, Ashley Kuenzi; Xu, Lingli; Hochstetler, Cindy L; Chen, Xiaoyi; Guo, Fukun; Huang, Gang; Azam, Mohammad; Tian, Weidong; Lu, Q Richard; Zheng, Yi 2021. Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Proceedings of the National Academy of Sciences of the United States of America, 118 1,

Geraldo, Luiz H; Xu, Yunling; Jacob, Laurent; Pibouin-Fragner, Laurence; Rao, Rohit; Maissa, Nawal; Verreault, Maïté; Lemaire, Nolwenn; Knosp, Camille; Lesaffre, Corinne; Daubon, Thomas; Dejaegher, Joost; Solie, Lien; Rudewicz, Justine; Viel, Thomas; Tavitian, Bertrand; De Vleeschouwer, Steven; Sanson, Marc; Bikfalvi, Andreas; Idbaih, Ahmed; Lu, Q Richard; Lima, Flavia Rs; Thomas, Jean-Leon; Eichmann, Anne; Mathivet, Thomas 2021. SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia. The Journal of clinical investigation, 131 16,

Guo, Duancheng; Wang, Yuan; Cheng, Yan; Liao, Shengyou; Hu, Jian; Du, Fang; Xu, Gang; Liu, Yongqiang; Cai, Kathy Q; Cheung, Martin; Wainwright, Brandon J; Lu, Q Richard; Zhao, Yi; Yang, Zeng-Jie 2021. Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. The Journal of experimental medicine, 218 9,

Luo, Zaili; Dong, Xinran; Yu, Jianzhong; Xia, Yong; Berry, Kalen P; Rao, Rohit; Xu, Lingli; Xue, Ping; Chen, Tong; Lin, Yifeng; Yu, Jiyang; Huang, Guoying; Li, Hao; Zhou, Wenhao; Lu, Q Richard 2021. Genomic and Transcriptomic Analyses Reveals ZNF124 as a Critical Regulator in Highly Aggressive Medulloblastomas. Frontiers in cell and developmental biology, 9 , 634056

Tu, Zhaowei; Wang, Chen; Davis, Ashley K; Hu, Mengwen; Zhao, Chuntao; Xin, Mei; Lu, Q Richard; Zheng, Yi 2021. The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood, 138 3, 221-233

Zhang, Ming; Wang, Jian; Zhang, Kaixiang; Lu, Guozhen; Liu, Yuming; Ren, Keke; Wang, Wenting; Xin, Dazhuan; Xu, Lingli; Mao, Honghui; Xing, Junlin; Gao, Xingchun; Jin, Weilin; Berry, Kalen; Mikoshiba, Katsuhiko; Wu, Shengxi; Lu, Q Richard; Zhao, Xianghui 2021. Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain. Nature communications, 12 1, 5091

Althoff, Mark J; Nayak, Ramesh C; Hegde, Shailaja; Wellendorf, Ashley M; Bohan, Breanna; Filippi, Marie-Dominique; Xin, Mei; Lu, Q Richard; Geiger, Hartmut; Zheng, Yi; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A 2020. Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood, 136 16, 1824-1836

Berry, Kalen P; Lu, Q Richard 2020. Chromatin modification and epigenetic control in functional nerve regeneration. Seminars in cell & developmental biology, 97 , 74-83

Berry, Kalen; Wang, Jiajia; Lu, Q Richard 2020. Epigenetic regulation of oligodendrocyte myelination in developmental disorders and neurodegenerative diseases. F1000Research, 9 ,

Wang, Jiajia; Lu, Q Richard 2020. Convergent epigenetic regulation of glial plasticity in myelin repair and brain tumorigenesis: A focus on histone modifying enzymes. Neurobiology of disease, 144 , 105040

Wang, Jiajia; Yang, Lijun; Dong, Chen; Wang, Jincheng; Xu, Lingli; Qiu, Yueping; Weng, Qinjie; Zhao, Chuntao; Xin, Mei; Lu, Q Richard 2020. EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways. Science advances, 6 33, eaaz6477

Wang, Jincheng; Wang, Jiajia; Yang, Lijun; Zhao, Chuntao; Wu, Laiman Natalie; Xu, Lingli; Zhang, Feng; Weng, Qinjie; Wegner, Michael; Lu, Q Richard 2020. CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair. Nature communications, 11 1, 4133

Wang, Jing; He, Xuelian; Meng, Huyan; Li, Yi; Dmitriev, Phillip; Tian, Feng; Page, Jessica C; Lu, Q Richard; He, Zhigang 2020. Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia. Neuron, 108 5, 876-886.e4

Weng, Qinjie; Wang, Jiaying; Wang, Jiajia; Wang, Jing; Sattar, Fahmida; Zhang, Zhikang; Zheng, Jiahuan; Xu, Zijie; Zhao, Mengting; Liu, Xuan; Yang, Lijun; Hao, Guifeng; Fang, Liang; Lu, Q Richard; Yang, Bo; He, Qiaojun 2020. Correction: Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization. Cell death & disease, 11 2, 108

Weng, Qinjie; Zhao, Mengting; Zheng, Jiahuan; Yang, Lijun; Xu, Zijie; Zhang, Zhikang; Wang, Jincheng; Wang, Jiajia; Yang, Bo; Richard Lu, Q; Ying, Meidan; He, Qiaojun 2020. STAT3 dictates ?-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation, 27 1, 130-145

Boshans, Linda L; Factor, Daniel C; Singh, Vijender; Liu, Jia; Zhao, Chuntao; Mandoiu, Ion; Lu, Q Richard; Casaccia, Patrizia; Tesar, Paul J; Nishiyama, Akiko 2019. The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming. Frontiers in neuroscience, 13 , 829

Hall, Ashley; Choi, Kwangmin; Liu, Wei; Rose, Jonathan; Zhao, Chuntao; Yu, Yanan; Na, Youjin; Cai, Yuqi; Coover, Robert A; Lin, Yi; Dombi, Eva; Kim, MiOk; Levanon, Ditsa; Groner, Yoram; Boscolo, Elisa; Pan, Dao; Liu, P Paul; Lu, Q Richard; Ratner, Nancy; Huang, Gang; Wu, Jianqiang 2019. RUNX represses Pmp22 to drive neurofibromagenesis. Science advances, 5 4, eaau8389

Lu, Q Richard; Qian, Lily; Zhou, Xianyao 2019. Developmental origins and oncogenic pathways in malignant brain tumors. Wiley interdisciplinary reviews. Developmental biology, 8 4, e342

Ou, Zhimin; Ma, Yanchen; Sun, Yuxia; Zheng, Gege; Wang, Shiyun; Xing, Rui; Chen, Xiang; Han, Ying; Wang, Jiajia; Lu, Q Richard; Zhao, Tong-Jin; Chen, Ying 2019. A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism. Cell reports, 26 11, 2984-2997.e4

Weng, Qinjie; Wang, Jincheng; Wang, Jiajia; He, Danyang; Cheng, Zuolin; Zhang, Feng; Verma, Ravinder; Xu, Lingli; Dong, Xinran; Liao, Yunfei; He, Xuelian; Potter, Andrew; Zhang, Liguo; Zhao, Chuntao; Xin, Mei; Zhou, Qian; Aronow, Bruce J; Blackshear, Perry J; Rich, Jeremy N; He, Qiaojun; Zhou, Wenhao; Suvà, Mario L; Waclaw, Ronald R; Potter, S Steven; Yu, Guoqiang; Lu, Q Richard 2019. Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Cell stem cell, 24 5, 707-723.e8

Yang, Lin; Kong, Yanting; Dong, Xinran; Hu, Liyuan; Lin, Yifeng; Chen, Xiang; Ni, Qi; Lu, Yulan; Wu, Bingbing; Wang, Huijun; Lu, Q Richard; Zhou, Wenhao 2019. Clinical and genetic spectrum of a large cohort of children with epilepsy in China. Genetics in medicine : official journal of the American College of Medical Genetics, 21 3, 564-571

Zhang, Liguo; He, Xuelian; Liu, Xuezhao; Zhang, Feng; Huang, L Frank; Potter, Andrew S; Xu, Lingli; Zhou, Wenhao; Zheng, Tao; Luo, Zaili; Berry, Kalen P; Pribnow, Allison; Smith, Stephanie M; Fuller, Christine; Jones, Blaise V; Fouladi, Maryam; Drissi, Rachid; Yang, Zeng-Jie; Gustafson, W Clay; Remke, Marc; Pomeroy, Scott L; Girard, Emily J; Olson, James M; Morrissy, A Sorana; Vladoiu, Maria C; Zhang, Jiao; Tian, Weidong; Xin, Mei; Taylor, Michael D; Potter, S Steven; Roussel, Martine F; Weiss, William A; Lu, Q Richard 2019. Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer cell, 36 3, 302-318.e7

He, Li; Yu, Kun; Lu, Fanghui; Wang, Jiajia; Wu, Laiman N; Zhao, Chuntao; Li, Qianmei; Zhou, Xianyao; Liu, Hanmin; Mu, Dezhi; Xin, Mei; Qiu, Mengsheng; Lu, Q Richard 2018. Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development. The Journal of neuroscience : the official journal of the Society for Neuroscience, 38 6, 1575-1587

He, Xuelian; Zhang, Liguo; Queme, Luis F; Liu, Xuezhao; Lu, Andrew; Waclaw, Ronald R; Dong, Xinran; Zhou, Wenhao; Kidd, Grahame; Yoon, Sung-Ok; Buonanno, Andres; Rubin, Joshua B; Xin, Mei; Nave, Klaus-Armin; Trapp, Bruce D; Jankowski, Michael P; Lu, Q Richard 2018. A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nature medicine, 24 3, 338-351

Jiang, Minqing; Rao, Rohit; Wang, Jincheng; Wang, Jiajia; Xu, Lingli; Wu, Lai Man; Chan, Jonah R; Wang, Huimin; Lu, Q Richard 2018. The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner. Glia, 66 9, 1947-1959

Koreman, Elijah; Sun, Xiaowei; Lu, Q Richard 2018. Chromatin remodeling and epigenetic regulation of oligodendrocyte myelination and myelin repair. Molecular and cellular neurosciences, 87 , 18-26

Marie, Corentine; Clavairoly, Adrien; Frah, Magali; Hmidan, Hatem; Yan, Jun; Zhao, Chuntao; Van Steenwinckel, Juliette; Daveau, Romain; Zalc, Bernard; Hassan, Bassem; Thomas, Jean-Léon; Gressens, Pierre; Ravassard, Philippe; Moszer, Ivan; Martin, Donna M; Lu, Q Richard; Parras, Carlos 2018. Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8. Proceedings of the National Academy of Sciences of the United States of America, 115 35, E8246-E8255

Moyano, Ana Lis; Steplowski, Jeffrey; Wang, Haibo; Son, Kyung-No; Rapolti, Diana I; Marshall, Jeffrey; Elackattu, Vince; Marshall, Michael S; Hebert, Amy K; Reiter, Cory R; Ulloa, Viviana; Pituch, Katarzyna C; Givogri, Maria I; Lu, Q Richard; Lipton, Howard L; Bongarzone, Ernesto R 2018. microRNA-219 Reduces Viral Load and Pathologic Changes in Theiler's Virus-Induced Demyelinating Disease. Molecular therapy : the journal of the American Society of Gene Therapy, 26 3, 730-743

Weng, Qinjie; Wang, Jiaying; Wang, Jiajia; Wang, Jing; Sattar, Fahmida; Zhang, Zhikang; Zheng, Jiahuan; Xu, Zijie; Zhao, Mengting; Liu, Xuan; Yang, Lijun; Hao, Guifeng; Fang, Liang; Lu, Q Richard; Yang, Bo; He, Qiaojun 2018. Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization. Cell death & disease, 9 2, 251

Wu, Lai Man Natalie; Deng, Yaqi; Wang, Jincheng; Zhao, Chuntao; Wang, Jiajia; Rao, Rohit; Xu, Lingli; Zhou, Wenhao; Choi, Kwangmin; Rizvi, Tilat A; Remke, Marc; Rubin, Joshua B; Johnson, Randy L; Carroll, Thomas J; Stemmer-Rachamimov, Anat O; Wu, Jianqiang; Zheng, Yi; Xin, Mei; Ratner, Nancy; Lu, Q Richard 2018. Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis. Cancer cell, 33 2, 292-308.e7

Zhao, Chuntao; Dong, Chen; Frah, Magali; Deng, Yaqi; Marie, Corentine; Zhang, Feng; Xu, Lingli; Ma, Zhixing; Dong, Xinran; Lin, Yifeng; Koenig, Scott; Nait-Oumesmar, Brahim; Martin, Donna M; Wu, Laiman N; Xin, Mei; Zhou, Wenhao; Parras, Carlos; Lu, Q Richard 2018. Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Developmental cell, 45 6, 753-768.e8

Zuo, Hao; Wood, William M; Sherafat, Amin; Hill, Robert A; Lu, Q Richard; Nishiyama, Akiko 2018. Age-Dependent Decline in Fate Switch from NG2 Cells to Astrocytes After Olig2 Deletion. The Journal of neuroscience : the official journal of the Society for Neuroscience, 38 9, 2359-2371

Deng, Yaqi; Wu, Lai Man Natalie; Bai, Shujun; Zhao, Chuntao; Wang, Haibo; Wang, Jincheng; Xu, Lingli; Sakabe, Masahide; Zhou, Wenhao; Xin, Mei; Lu, Q Richard 2017. A reciprocal regulatory loop between TAZ/YAP and G-protein G?s regulates Schwann cell proliferation and myelination. Nature communications, 8 , 15161

He, Danyang; Wang, Jincheng; Lu, Yulan; Deng, Yaqi; Zhao, Chuntao; Xu, Lingli; Chen, Yinhuai; Hu, Yueh-Chiang; Zhou, Wenhao; Lu, Q Richard 2017. lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS. Neuron, 93 2, 362-378

Kosty, Jennifer; Lu, Fanghui; Kupp, Robert; Mehta, Shwetal; Lu, Q Richard 2017. Harnessing OLIG2 function in tumorigenicity and plasticity to target malignant gliomas. Cell cycle (Georgetown, Tex.), 16 18, 1654-1660

Li, Zhuo; Peng, Yanyan; Hufnagel, Robert B; Hu, Yueh-Chiang; Zhao, Chuntao; Queme, Luis F; Khuchua, Zaza; Driver, Ashley M; Dong, Fei; Lu, Q Richard; Lindquist, Diana M; Jankowski, Michael P; Stottmann, Rolf W; Kao, Winston W Y; Huang, Taosheng 2017. Loss of SLC25A46 causes neurodegeneration by affecting mitochondrial dynamics and energy production in mice. Human molecular genetics, 26 19, 3776-3791

Qu, Yi; Tang, Jun; Wang, Huiqing; Li, Shiping; Zhao, Fengyan; Zhang, Li; Richard Lu, Q; Mu, Dezhi 2017. RIPK3 interactions with MLKL and CaMKII mediate oligodendrocytes death in the developing brain. Cell death & disease, 8 2, e2629

Wang, Haibo; Moyano, Ana Lis; Ma, Zhangyan; Deng, Yaqi; Lin, Yifeng; Zhao, Chuntao; Zhang, Liguo; Jiang, Minqing; He, Xuelian; Ma, Zhixing; Lu, Fanghui; Xin, Mei; Zhou, Wenhao; Yoon, Sung Ok; Bongarzone, Ernesto R; Lu, Q Richard 2017. miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS. Developmental cell, 40 6, 566-582.e5

Weng, Qinjie; Wang, Jiajia; Wang, Jiaying; Tan, Biqin; Wang, Jing; Wang, Haibo; Zheng, Tao; Lu, Q Richard; Yang, Bo; He, Qiaojun 2017. Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPK? Activity. Scientific reports, 7 1, 1705

Dries, Daniel R; Zhu, Yi; Brooks, Mieu M; Forero, Diego A; Adachi, Megumi; Cenik, Basar; West, James M; Han, Yu-Hong; Yu, Cong; Arbella, Jennifer; Nordin, Annelie; Adolfsson, Rolf; Del-Favero, Jurgen; Lu, Q Richard; Callaerts, Patrick; Birnbaum, Shari G; Yu, Gang 2016. Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior. The Journal of biological chemistry, 291 22, 11647-56

He, Danyang; Marie, Corentine; Zhao, Chuntao; Kim, Bongwoo; Wang, Jincheng; Deng, Yaqi; Clavairoly, Adrien; Frah, Magali; Wang, Haibo; He, Xuelian; Hmidan, Hatem; Jones, Blaise V; Witte, David; Zalc, Bernard; Zhou, Xin; Choo, Daniel I; Martin, Donna M; Parras, Carlos; Lu, Q Richard 2016. Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination. Nature neuroscience, 19 5, 678-689

Hoffman, Lindsey M; DeWire, Mariko; Ryall, Scott; Buczkowicz, Pawel; Leach, James; Miles, Lili; Ramani, Arun K; Brudno, Michael; Kumar, Shiva Senthil; Drissi, Rachid; Dexheimer, Phillip; Salloum, Ralph; Chow, Lionel; Hummel, Trent; Stevenson, Charles; Lu, Q Richard; Jones, Blaise; Witte, David; Aronow, Bruce; Hawkins, Cynthia E; Fouladi, Maryam 2016. Erratum: Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta neuropathologica communications, 4 , 13

Hoffman, Lindsey M; DeWire, Mariko; Ryall, Scott; Buczkowicz, Pawel; Leach, James; Miles, Lili; Ramani, Arun; Brudno, Michael; Kumar, Shiva Senthil; Drissi, Rachid; Dexheimer, Phillip; Salloum, Ralph; Chow, Lionel; Hummel, Trent; Stevenson, Charles; Lu, Q Richard; Jones, Blaise; Witte, David; Aronow, Bruce; Hawkins, Cynthia E; Fouladi, Maryam 2016. Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics. Acta neuropathologica communications, 4 , 1

Jiang, Minqing; Liu, Lei; He, Xuelian; Wang, Haibo; Lin, Wensheng; Wang, Huimin; Yoon, Sung O; Wood, Teresa L; Lu, Q Richard 2016. Regulation of PERK-eIF2? signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes. Nature communications, 7 , 12185

Ju, Jun; Liu, Qian; Zhang, Yang; Liu, Yuanxiu; Jiang, Mei; Zhang, Liguo; He, Xuelian; Peng, Chenchen; Zheng, Tao; Lu, Q Richard; Li, Hedong 2016. Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum. Scientific reports, 6 , 30711

Laitman, Benjamin M; Asp, Linnéa; Mariani, John N; Zhang, Jingya; Liu, Jia; Sawai, Setsu; Chapouly, Candice; Horng, Sam; Kramer, Elisabeth G; Mitiku, Nesanet; Loo, Hannah; Burlant, Natalie; Pedre, Xiomara; Hara, Yuko; Nudelman, German; Zaslavsky, Elena; Lee, Young-Min; Braun, David A; Lu, Q Richard; Narla, Goutham; Raine, Cedric S; Friedman, Scott L; Casaccia, Patrizia; John, Gareth R 2016. The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination. PLoS biology, 14 5, e1002467

Lopez Juarez, Alejandro; He, Danyang; Richard Lu, Q 2016. Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration. Brain research, 1638 Pt B, 209-220

Lu, Fanghui; Chen, Ying; Zhao, Chuntao; Wang, Haibo; He, Danyang; Xu, Lingli; Wang, Jincheng; He, Xuelian; Deng, Yaqi; Lu, Ellen E; Liu, Xue; Verma, Ravinder; Bu, Hong; Drissi, Rachid; Fouladi, Maryam; Stemmer-Rachamimov, Anat O; Burns, Dennis; Xin, Mei; Rubin, Joshua B; Bahassi, El Mustapha; Canoll, Peter; Holland, Eric C; Lu, Q Richard 2016. Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma. Cancer cell, 29 5, 669-683

Ou, Zhimin; Sun, Yuxia; Lin, Li; You, Nachun; Liu, Xue; Li, Hongchao; Ma, Yanchen; Cao, Lei; Han, Ying; Liu, Min; Deng, Yaqi; Yao, Luming; Lu, Q Richard; Chen, Ying 2016. Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 41, 10560-10573

Rao, Rohit; Salloum, Ralph; Xin, Mei; Lu, Q Richard 2016. The G protein G?s acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis. Cell cycle (Georgetown, Tex.), 15 10, 1325-30

Steelman, Andrew J; Zhou, Yun; Koito, Hisami; Kim, SunJa; Payne, H Ross; Lu, Q Richard; Li, Jianrong 2016. Activation of oligodendroglial Stat3 is required for efficient remyelination. Neurobiology of disease, 91 , 336-46

Wu, Lai Man Natalie; Wang, Jincheng; Conidi, Andrea; Zhao, Chuntao; Wang, Haibo; Ford, Zachary; Zhang, Liguo; Zweier, Christiane; Ayee, Brian G; Maurel, Patrice; Zwijsen, An; Chan, Jonah R; Jankowski, Michael P; Huylebroeck, Danny; Lu, Q Richard 2016. Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nature neuroscience, 19 8, 1060-72

Zhang, Liguo; He, Xuelian; Liu, Lei; Jiang, Minqing; Zhao, Chuntao; Wang, Haibo; He, Danyang; Zheng, Tao; Zhou, Xianyao; Hassan, Aishlin; Ma, Zhixing; Xin, Mei; Sun, Zheng; Lazar, Mitchell A; Goldman, Steven A; Olson, Eric N; Lu, Q Richard 2016. Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Developmental cell, 36 3, 316-30

Zhao, Chuntao; Deng, Yaqi; Liu, Lei; Yu, Kun; Zhang, Liguo; Wang, Haibo; He, Xuelian; Wang, Jincheng; Lu, Changqing; Wu, Laiman N; Weng, Qinjie; Mao, Meng; Li, Jianrong; van Es, Johan H; Xin, Mei; Parry, Lee; Goldman, Steven A; Clevers, Hans; Lu, Q Richard 2016. Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature communications, 7 , 10883

Diao, Hua Jia; Low, Wei Ching; Lu, Q Richard; Chew, Sing Yian 2015. Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development. Biomaterials, 70 , 105-14

Diao, Hua Jia; Low, Wei Ching; Milbreta, Ulla; Lu, Q Richard; Chew, Sing Yian 2015. Nanofiber-mediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells. Journal of controlled release : official journal of the Controlled Release Society, 208 , 85-92

Emery, Ben; Lu, Q Richard 2015. Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System. Cold Spring Harbor perspectives in biology, 7 9, a020461

Gururangan, Sridharan; Robinson, Giles; Ellison, David W; Wu, Gang; He, Xuelian; Lu, Q Richard; McLendon, Roger; Grant, Gerald; Driscoll, Timothy; Neuberg, Ronnie 2015. Gorlin syndrome and desmoplastic medulloblastoma: Report of 3 cases with unfavorable clinical course and novel mutations. Pediatric blood & cancer, 62 10, 1855-8

Liu, Wei; Zhou, Hui; Liu, Lei; Zhao, Chuntao; Deng, Yaqi; Chen, Lina; Wu, Laiman; Mandrycky, Nicole; McNabb, Christopher T; Peng, Yuanbo; Fuchs, Perry N; Lu, Jie; Sheen, Volney; Qiu, Mengsheng; Mao, Meng; Lu, Q Richard 2015. Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region. Neurobiology of disease, 77 , 106-16

He, Xuelian; Zhang, Liguo; Chen, Ying; Remke, Marc; Shih, David; Lu, Fanghui; Wang, Haibo; Deng, Yaqi; Yu, Yang; Xia, Yong; Wu, Xiaochong; Ramaswamy, Vijay; Hu, Tom; Wang, Fan; Zhou, Wenhao; Burns, Dennis K; Kim, Se Hoon; Kool, Marcel; Pfister, Stefan M; Weinstein, Lee S; Pomeroy, Scott L; Gilbertson, Richard J; Rubin, Joshua B; Hou, Yiping; Wechsler-Reya, Robert; Taylor, Michael D; Lu, Q Richard 2014. The G protein ? subunit G?s is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nature medicine, 20 9, 1035-42

Shen, Yun-An A; Chen, Yan; Dao, Dang Q; Mayoral, Sonia R; Wu, Laiman; Meijer, Dies; Ullian, Erik M; Chan, Jonah R; Lu, Q Richard 2014. Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extent. Nature communications, 5 , 4991

He, Xuelian; Lu, Q Richard . G-Protein G?s controls medulloblastoma initiation by suppressing sonic hedgehog signaling. Molecular & cellular oncology, 2 2, e975070