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Photo of  Andrew B. Herr, PhD

Andrew B. Herr, PhD


Pediatrics | College of Medicine

  • Fellowship: California Institute of Technology (Research)
  • Doctoral Degree: Washington University (Molecular Biophysics)
  • Bachelor's Degree: Oral Roberts University (Biomedical Chemistry)
Contact Information
Research Interests

My lab studies protein-protein interactions involved in receptor signaling and bacterial pathogenesis. We use x-ray crystallography to solve the three-dimensional atomic structures of interesting proteins, combined with techniques of biophysical chemistry to understand their interactions in solution. In particular, we use analytical ultracentrifugation, calorimetry, and surface plasmon resonance to study binding and complex formation.

Peer Reviewed Publications

RT Strait, MT Posgai, A Mahler, N Barasa, CO Jacob, J Köhl, M Ehlers, K Stringer, SK Shanmukappa, D Witte, MM Hossain, M Khodoun, AB Herr, and FD Finkelman 2014. IgG1 protects against renal disease in a mouse model of cryoglobulinemia Nature, ,

Conrady, Deborah G; Wilson, Jeffrey J; Herr, Andrew B 2013. Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms. Proceedings of the National Academy of Sciences of the United States of America, 110 3, E202-11

Kachapati, Kritika; Bednar, Kyle J; Adams, David E; Wu, Yuehong; Mittler, Robert S; Jordan, Michael B; Hinerman, Jennifer M; Herr, Andrew B; Ridgway, William M 2013. Recombinant soluble CD137 prevents type one diabetes in nonobese diabetic mice. Journal of autoimmunity, 47 , 94-103

Li, Xin; Shu, Chang; Yi, Guanghui; Chaton, Catherine T; Shelton, Catherine L; Diao, Jiasheng; Zuo, Xiaobing; Kao, C Cheng; Herr, Andrew B; Li, Pingwei 2013. Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity, 39 6, 1019-31

Shu, Chang; Sankaran, Banumathi; Chaton, Catherine T; Herr, Andrew B; Mishra, Ashutosh; Peng, Junmin; Li, Pingwei 2013. Structural insights into the functions of TBK1 in innate antimicrobial immunity. Structure (London, England : 1993), 21 7, 1137-48

Gallegos, Karen M; Conrady, Deborah G; Karve, Sayali S; Gunasekera, Thusitha S; Herr, Andrew B; Weiss, Alison A 2012. Shiga toxin binding to glycolipids and glycans. PloS one, 7 2, e30368

Bahassi, El Mustapha; Yin, Moying; Robbins, Susan B; Li, Ya-Qin; Conrady, Deborah G; Yuan, Zhenyu; Kovall, Rhett A; Herr, Andrew B; Stambrook, Peter J 2011. A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis. Cell division, 6 1, 4

Hart, Benjamin R; Mishra, Pankaj K; Lintner, Robert E; Hinerman, Jennifer M; Herr, Andrew B; Blumenthal, Robert M 2011. Recognition of DNA by the helix-turn-helix global regulatory protein Lrp is modulated by the amino terminus. Journal of bacteriology, 193 15, 3794-803

Herr, Andrew B; Conrady, Deborah G 2011. Thermodynamic analysis of metal ion-induced protein assembly. Methods in enzymology, 488 , 101-21

Mani, Timmy; Hennigan, Robert F; Foster, Lauren A; Conrady, Deborah G; Herr, Andrew B; Ip, Wallace 2011. FERM domain phosphoinositide binding targets merlin to the membrane and is essential for its growth-suppressive function. Molecular and cellular biology, 31 10, 1983-96

Suzuki, Hitoshi; Kiryluk, Krzysztof; Novak, Jan; Moldoveanu, Zina; Herr, Andrew B; Renfrow, Matthew B; Wyatt, Robert J; Scolari, Francesco; Mestecky, Jiri; Gharavi, Ali G; Julian, Bruce A 2011. The pathophysiology of IgA nephropathy. Journal of the American Society of Nephrology : JASN, 22 10, 1795-803

Conrady, Deborah G; Flagler, Michael J; Friedmann, David R; Vander Wielen, Bradley D; Kovall, Rhett A; Weiss, Alison A; Herr, Andrew B 2010. Molecular basis of differential B-pentamer stability of Shiga toxins 1 and 2. PloS one, 5 12, e15153

Gomes, Michelle M; Suzuki, Hitoshi; Brooks, Monica T; Tomana, Milan; Moldoveanu, Zina; Mestecky, Jiri; Julian, Bruce A; Novak, Jan; Herr, Andrew B 2010. Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: a comparative binding study. Biochemistry, 49 27, 5671-82

Hennigan, Robert F; Foster, Lauren A; Chaiken, Mary F; Mani, Timmy; Gomes, Michelle M; Herr, Andrew B; Ip, Wallace 2010. Fluorescence resonance energy transfer analysis of merlin conformational changes. Molecular and cellular biology, 30 1, 54-67

Lu, Cheng; Xu, Hengyu; Ranjith-Kumar, C T; Brooks, Monica T; Hou, Tim Y; Hu, Fuqu; Herr, Andrew B; Strong, Roland K; Kao, C Cheng; Li, Pingwei 2010. The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain. Structure (London, England : 1993), 18 8, 1032-43

Millen, Scott H; Lewallen, Daniel M; Herr, Andrew B; Iyer, Suri S; Weiss, Alison A 2010. Identification and characterization of the carbohydrate ligands recognized by pertussis toxin via a glycan microarray and surface plasmon resonance. Biochemistry, 49 28, 5954-67

Rajan, Sudarsan; Jagatheesan, Ganapathy; Karam, Chehade N; Alves, Marco L; Bodi, Ilona; Schwartz, Arnold; Bulcao, Christian F; D'Souza, Karen M; Akhter, Shahab A; Boivin, Greg P; Dube, Dipak K; Petrashevskaya, Natalia; Herr, Andrew B; Hullin, Roger; Liggett, Stephen B; Wolska, Beata M; Solaro, R John; Wieczorek, David F 2010. Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation, 121 3, 410-8

Hassett, Daniel J; Sutton, Mark D; Schurr, Michael J; Herr, Andrew B; Caldwell, Charles C; Matu, Joseph O 2009. Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways. Trends in microbiology, 17 3, 130-8

Herr, A B 2009. Direct evidence of a native GPVI dimer at the platelet surface. Journal of thrombosis and haemostasis : JTH, 7 8, 1344-6

Herr, Andrew B; Farndale, Richard W 2009. Structural insights into the interactions between platelet receptors and fibrillar collagen. The Journal of biological chemistry, 284 30, 19781-5

Horii, Katsunori; Brooks, Monica T; Herr, Andrew B 2009. Convulxin forms a dimer in solution and can bind eight copies of glycoprotein VI: implications for platelet activation. Biochemistry, 48 13, 2907-14

Li, Xiaojun; Ranjith-Kumar, C T; Brooks, Monica T; Dharmaiah, S; Herr, Andrew B; Kao, Cheng; Li, Pingwei 2009. The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. The Journal of biological chemistry, 284 20, 13881-91

Okano-Kosugi, Hitomi; Matsushita, Osamu; Asada, Shinichi; Herr, Andrew B; Kitagawa, Kouki; Koide, Takaki 2009. Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions. Analytical biochemistry, 394 1, 125-31

Urrea Moreno, Ramon; Gil, Juana; Rodriguez-Sainz, Carmen; Cela, Elena; LaFay, Victor; Oloizia, Brian; Herr, Andrew B; Sumegi, Janos; Jordan, Michael B; Risma, Kimberly A 2009. Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function. Blood, 113 2, 338-46

Zhang, Jinjin; Xing, Xu; Herr, Andrew B; Bell, Charles E 2009. Crystal structure of E. coli RecE protein reveals a toroidal tetramer for processing double-stranded DNA breaks. Structure (London, England : 1993), 17 5, 690-702

Conrady, Deborah G; Brescia, Cristin C; Horii, Katsunori; Weiss, Alison A; Hassett, Daniel J; Herr, Andrew B 2008. A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms. Proceedings of the National Academy of Sciences of the United States of America, 105 49, 19456-61

Gomes, Michelle M; Wall, Stephanie B; Takahashi, Kazuo; Novak, Jan; Renfrow, Matthew B; Herr, Andrew B 2008. Analysis of IgA1 N-glycosylation and its contribution to FcalphaRI binding. Biochemistry, 47 43, 11285-99

Jing, Peng; Rudra, Jai S; Herr, Andrew B; Collier, Joel H 2008. Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin. Biomacromolecules, 9 9, 2438-46

Xu, Zhen; Page, Richard C; Gomes, Michelle M; Kohli, Ekta; Nix, Jay C; Herr, Andrew B; Patterson, Cam; Misra, Saurav 2008. Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2. Nature structural & molecular biology, 15 12, 1309-17

Yang, Mingyan; Horii, Katsunori; Herr, Andrew B; Kirley, Terence L 2008. Characterization and importance of the dimer interface of human calcium-activated nucleotidase. Biochemistry, 47 2, 771-8

Smethurst, Peter A; Onley, David J; Jarvis, Gavin E; O'Connor, Marie N; Knight, C Graham; Herr, Andrew B; Ouwehand, Willem H; Farndale, Richard W 2007. Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets. The Journal of biological chemistry, 282 2, 1296-304

Yoon, Sang Sun; Karabulut, Ahmet C; Lipscomb, John D; Hennigan, Robert F; Lymar, Sergei V; Groce, Stephanie L; Herr, Andrew B; Howell, Michael L; Kiley, Patricia J; Schurr, Michael J; Gaston, Benjamin; Choi, Kyoung-Hee; Schweizer, Herbert P; Hassett, Daniel J 2007. Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration. The EMBO journal, 26 15, 3662-72

Gomes, Michelle M; Herr, Andrew B 2006. IgA and IgA-specific receptors in human disease: structural and functional insights into pathogenesis and therapeutic potential. Springer seminars in immunopathology, 28 4, 383-95

Hamburger, A E; Bjorkman, P J; Herr, A B 2006. Structural insights into antibody-mediated mucosal immunity. Current topics in microbiology and immunology, 308 , 173-204

Horii, Katsunori; Kahn, Mark L; Herr, Andrew B 2006. Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. Blood, 108 3, 936-42

O'Connor, Marie N; Smethurst, Peter A; Davies, Lorna W; Joutsi-Korhonen, Lotta; Onley, David J; Herr, Andrew B; Farndale, Richard W; Ouwehand, Willem H 2006. Selective blockade of glycoprotein VI clustering on collagen helices. The Journal of biological chemistry, 281 44, 33505-10

Yang, Mingyan; Horii, Katsunori; Herr, Andrew B; Kirley, Terence L 2006. Calcium-dependent dimerization of human soluble calcium activated nucleotidase: characterization of the dimer interface. The Journal of biological chemistry, 281 38, 28307-17

West, Anthony P; Herr, Andrew B; Bjorkman, Pamela J 2004. The chicken yolk sac IgY receptor, a functional equivalent of the mammalian MHC-related Fc receptor, is a phospholipase A2 receptor homolog. Immunity, 20 5, 601-10

Herr, Andrew B; Ballister, Edward R; Bjorkman, Pamela J 2003. Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc. Nature, 423 6940, 614-20

Herr, Andrew B; White, Clinton L; Milburn, Christina; Wu, Carol; Bjorkman, Pamela J 2003. Bivalent binding of IgA1 to FcalphaRI suggests a mechanism for cytokine activation of IgA phagocytosis. Journal of molecular biology, 327 3, 645-57

Bennett, Melanie J; Huey-Tubman, Kathryn E; Herr, Andrew B; West, Anthony P; Ross, Scott A; Bjorkman, Pamela J 2002. A linear lattice model for polyglutamine in CAG-expansion diseases. Proceedings of the National Academy of Sciences of the United States of America, 99 18, 11634-9

West, A P; Giannetti, A M; Herr, A B; Bennett, M J; Nangiana, J S; Pierce, J R; Weiner, L P; Snow, P M; Bjorkman, P J 2001. Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. Journal of molecular biology, 313 2, 385-97

Yeo, H J; Savvides, S N; Herr, A B; Lanka, E; Waksman, G 2000. Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system. Molecular cell, 6 6, 1461-72

Yu, K; Herr, A B; Waksman, G; Ornitz, D M 2000. Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome. Proceedings of the National Academy of Sciences of the United States of America, 97 26, 14536-41

Waksman, G; Herr, A B 1998. New insights into heparin-induced FGF oligomerization. Nature structural biology, 5 7, 527-30

Herr, A B; Ornitz, D M; Sasisekharan, R; Venkataraman, G; Waksman, G 1997. Heparin-induced self-association of fibroblast growth factor-2. Evidence for two oligomerization processes. The Journal of biological chemistry, 272 26, 16382-9

Venkataraman, G; Sasisekharan, V; Herr, A B; Ornitz, D M; Waksman, G; Cooney, C L; Langer, R; Sasisekharan, R 1996. Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation. Proceedings of the National Academy of Sciences of the United States of America, 93 2, 845-50

Ornitz, D M; Herr, A B; Nilsson, M; Westman, J; Svahn, C M; Waksman, G 1995. FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides. Science (New York, N.Y.), 268 5209, 432-6