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Photo of  Kenneth Campbell, PhD

Kenneth Campbell, PhD

Professor-Affiliate

Pediatrics | College of Medicine

Education/Credentials
  • Doctoral Degree: University of Lund
Contact Information
Research Interests

The Campbell lab is working to uncover the molecular genetic mechanisms that control the normal formation of basal ganglia circuits. By disrupting or augmenting these circuits they learn how normal behaviors are altered. This knowledge will help generate mouse models of certain behaviors that characterize childhood neuropsychiatric disorders and pave the way for the development of improved therapeutics.

Peer Reviewed Publications

Del Águila, Ángela; Adam, Mike; Ullom, Kristy; Shaw, Nicholas; Qin, Shenyue; Ehrman, Jacqueline; Nardini, Diana; Salomone, Joseph; Gebelein, Brian; Lu, Q Richard; Potter, Steven S; Waclaw, Ronald; Campbell, Kenneth; Nakafuku, Masato 2022. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice. Development (Cambridge, England), 149 5,

Ehrman, Jacqueline M; Merchan-Sala, Paloma; Ehrman, Lisa A; Chen, Bin; Lim, Hee-Woong; Waclaw, Ronald R; Campbell, Kenneth 2022. Formation of the Mouse Internal Capsule and Cerebral Peduncle: A Pioneering Role for Striatonigral Axons as Revealed in Isl1 Conditional Mutants. The Journal of neuroscience : the official journal of the Society for Neuroscience, 42 16, 3344-3364

Iwasawa, Eri; Brown, Farrah N; Shula, Crystal; Kahn, Fatima; Lee, Sang Hoon; Berta, Temugin; Ladle, David R; Campbell, Kenneth; Mangano, Francesco T; Goto, June 2022. The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience, 42 9, 1820-1844

Zoubovsky, Sandra P; Williams, Michael T; Hoseus, Sarah; Tumukuntala, Shivani; Riesenberg, Amy; Schulkin, Jay; Vorhees, Charles V; Campbell, Kenneth; Lim, Hee-Woong; Muglia, Louis J 2022. Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment. Translational psychiatry, 12 1, 22

Salomone, Joseph; Qin, Shenyue; Fufa, Temesgen D; Cain, Brittany; Farrow, Edward; Guan, Bin; Hufnagel, Robert B; Nakafuku, Masato; Lim, Hee-Woong; Campbell, Kenneth; Gebelein, Brian 2021. Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice. Genes & development, 35 1-2, 157-174

Roychoudhury, Kaushik; Salomone, Joseph; Qin, Shenyue; Cain, Brittany; Adam, Mike; Potter, S Steven; Nakafuku, Masato; Gebelein, Brian; Campbell, Kenneth 2020. Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence. Development (Cambridge, England), 147 7,

Abdelhamed, Zakia; Vuong, Shawn M; Hill, Lauren; Shula, Crystal; Timms, Andrew; Beier, David; Campbell, Kenneth; Mangano, Francesco T; Stottmann, Rolf W; Goto, June 2018. A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice. Development (Cambridge, England), 145 1,

Chapman, Heather; Riesenberg, Amy; Ehrman, Lisa A; Kohli, Vikram; Nardini, Diana; Nakafuku, Masato; Campbell, Kenneth; Waclaw, Ronald R 2018. Gsx transcription factors control neuronal versus glial specification in ventricular zone progenitors of the mouse lateral ganglionic eminence. Developmental biology, 442 1, 115-126

Desmaris, Elodie; Keruzore, Marc; Saulnier, Amandine; Ratié, Leslie; Assimacopoulos, Stavroula; De Clercq, Sarah; Nan, Xinsheng; Roychoudhury, Kaushik; Qin, Shenyue; Kricha, Sadia; Chevalier, Clément; Lingner, Thomas; Henningfeld, Kristine A; Zarkower, David; Mallamaci, Antonello; Theil, Thomas; Campbell, Kenneth; Pieler, Tomas; Li, Meng; Grove, Elizabeth A; Bellefroid, Eric J 2018. DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 38 42, 9105-9121

Kuerbitz, Jeffrey; Arnett, Melinda; Ehrman, Sarah; Williams, Michael T; Vorhees, Charles V; Fisher, Simon E; Garratt, Alistair N; Muglia, Louis J; Waclaw, Ronald R; Campbell, Kenneth 2018. Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 38 5, 1160-1177

Li, Jiwen; Wang, Chunyang; Zhang, Zhuangzhi; Wen, Yan; An, Lei; Liang, Qifei; Xu, Zhejun; Wei, Song; Li, Weiwei; Guo, Teng; Liu, Guoping; Tao, Guangxu; You, Yan; Du, Heng; Fu, Zhuoning; He, Miao; Chen, Bin; Campbell, Kenneth; Alvarez-Buylla, Arturo; Rubenstein, John L; Yang, Zhengang 2018. Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development. Cerebral cortex (New York, N.Y. : 1991), 28 9, 3278-3294

Scheimann, Jessie R; Mahbod, Parinaz; Morano, Rachel; Frantz, Lindsey; Packard, Ben; Campbell, Kenneth; Herman, James P 2018. Deletion of Glucocorticoid Receptors in Forebrain GABAergic Neurons Alters Acute Stress Responding and Passive Avoidance Behavior in Female Mice. Frontiers in behavioral neuroscience, 12 , 325

Tinterri, Andrea; Menardy, Fabien; Diana, Marco A; Lokmane, Ludmilla; Keita, Maryama; Coulpier, Fanny; Lemoine, Sophie; Mailhes, Caroline; Mathieu, Benjamin; Merchan-Sala, Paloma; Campbell, Kenneth; Gyory, Ildiko; Grosschedl, Rudolf; Popa, Daniela; Garel, Sonia 2018. Active intermixing of indirect and direct neurons builds the striatal mosaic. Nature communications, 9 1, 4725

Merchan-Sala, Paloma; Nardini, Diana; Waclaw, Ronald R; Campbell, Kenneth 2017. Selective neuronal expression of the SoxE factor, Sox8, in direct pathway striatal projection neurons of the developing mouse brain. The Journal of comparative neurology, 525 13, 2805-2819

Qin, Shenyue; Ware, Stephanie M; Waclaw, Ronald R; Campbell, Kenneth 2017. Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2. Neural development, 12 1, 13

Qin, Shenyue; Madhavan, Mayur; Waclaw, Ronald R; Nakafuku, Masato; Campbell, Kenneth 2016. Characterization of a new Gsx2-cre line in the developing mouse telencephalon. Genesis (New York, N.Y. : 2000), 54 10, 542-549

Dunty, William C; Kennedy, Mark W L; Chalamalasetty, Ravindra B; Campbell, Kenneth; Yamaguchi, Terry P 2014. Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/?-catenin pathway in neuromesodermal stem cells. PloS one, 9 1, e87018

Seto, Yusuke; Nakatani, Tomoya; Masuyama, Norihisa; Taya, Shinichiro; Kumai, Minoru; Minaki, Yasuko; Hamaguchi, Akiko; Inoue, Yukiko U; Inoue, Takayoshi; Miyashita, Satoshi; Fujiyama, Tomoyuki; Yamada, Mayumi; Chapman, Heather; Campbell, Kenneth; Magnuson, Mark A; Wright, Christopher V; Kawaguchi, Yoshiya; Ikenaka, Kazuhiro; Takebayashi, Hirohide; Ishiwata, Shin'ichi; Ono, Yuichi; Hoshino, Mikio 2014. Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum. Nature communications, 5 , 3337

Chapman, Heather; Waclaw, Ronald R; Pei, Zhenglei; Nakafuku, Masato; Campbell, Kenneth 2013. The homeobox gene Gsx2 controls the timing of oligodendroglial fate specification in mouse lateral ganglionic eminence progenitors. Development (Cambridge, England), 140 11, 2289-98

Ehrman, Lisa A; Mu, Xiuqian; Waclaw, Ronald R; Yoshida, Yutaka; Vorhees, Charles V; Klein, William H; Campbell, Kenneth 2013. The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proceedings of the National Academy of Sciences of the United States of America, 110 42, E4026-35

Grande, Andrew; Sumiyoshi, Kyoko; López-Juárez, Alejandro; Howard, Jennifer; Sakthivel, Bhuvaneswari; Aronow, Bruce; Campbell, Kenneth; Nakafuku, Masato 2013. Environmental impact on direct neuronal reprogramming in vivo in the adult brain. Nature communications, 4 , 2373

Katayama, Kei-ichi; Imai, Fumiyasu; Campbell, Kenneth; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka 2013. RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration. Development (Cambridge, England), 140 15, 3139-45

López-Juárez, Alejandro; Howard, Jennifer; Ullom, Kristy; Howard, Lindsey; Grande, Andrew; Pardo, Andrea; Waclaw, Ronald; Sun, Yu-Yo; Yang, Dianer; Kuan, Chia-Yi; Campbell, Kenneth; Nakafuku, Masato 2013. Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone. Genes & development, 27 11, 1272-87

Pei, Zhenglei; Wang, Bei; Chen, Gang; Nagao, Motoshi; Nakafuku, Masato; Campbell, Kenneth 2011. Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation. Proceedings of the National Academy of Sciences of the United States of America, 108 4, 1675-80

Carpenter, April C; Rao, Sujata; Wells, James M; Campbell, Kenneth; Lang, Richard A 2010. Generation of mice with a conditional null allele for Wntless. Genesis (New York, N.Y. : 2000), 48 9, 554-8

Waclaw, Ronald R; Ehrman, Lisa A; Pierani, Alessandra; Campbell, Kenneth 2010. Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30 20, 6944-53

Chen, Lei; Melendez, Jaime; Campbell, Kenneth; Kuan, Chia-Yi; Zheng, Yi 2009. Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Developmental biology, 325 1, 162-70

Waclaw, Ronald R; Campbell, Kenneth 2009. Regional control of cortical lamination. Nature neuroscience, 12 10, 1211-2

Waclaw, Ronald R; Wang, Bei; Pei, Zhenglei; Ehrman, Lisa A; Campbell, Kenneth 2009. Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates. Neuron, 63 4, 451-65

Wang, Bei; Waclaw, Ronald R; Allen, Zegary J; Guillemot, Francois; Campbell, Kenneth 2009. Ascl1 is a required downstream effector of Gsx gene function in the embryonic mouse telencephalon. Neural development, 4 , 5

Nagao, Motoshi; Campbell, Kenneth; Burns, Kevin; Kuan, Chia-Yi; Trumpp, Andreas; Nakafuku, Masato 2008. Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway. The Journal of cell biology, 183 7, 1243-57

Allen, Zegary J; Waclaw, Ronald R; Colbert, Melissa C; Campbell, Kenneth 2007. Molecular identity of olfactory bulb interneurons: transcriptional codes of periglomerular neuron subtypes. Journal of molecular histology, 38 6, 517-25

Chen, Lei; Liao, Guanghong; Waclaw, Ronald R; Burns, Kevin A; Linquist, Diana; Campbell, Kenneth; Zheng, Yi; Kuan, Chia-Yi 2007. Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 14, 3884-93

Chen, Lei; Liao, Guanghong; Yang, Linda; Campbell, Kenneth; Nakafuku, Masato; Kuan, Chia-Yi; Zheng, Yi 2006. Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proceedings of the National Academy of Sciences of the United States of America, 103 44, 16520-5

Waclaw, Ronald R; Allen, Zegary J; Bell, Sheila M; Erdélyi, Ferenc; Szabó, Gábor; Potter, S Steven; Campbell, Kenneth 2006. The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons. Neuron, 49 4, 503-16

Campbell, Kenneth 2005. Cortical neuron specification: it has its time and place. Neuron, 46 3, 373-6

Waclaw, Ronald R; Wang, Bei; Campbell, Kenneth 2004. The homeobox gene Gsh2 is required for retinoid production in the embryonic mouse telencephalon. Development (Cambridge, England), 131 16, 4013-20

Bell, Sheila M; Schreiner, Claire M; Waclaw, Ronald R; Campbell, Kenneth; Potter, S Steven; Scott, William J 2003. Sp8 is crucial for limb outgrowth and neuropore closure. Proceedings of the National Academy of Sciences of the United States of America, 100 21, 12195-200

Campbell, Kenneth 2003. Signaling to and from radial glia. Glia, 43 1, 44-6

Campbell, Kenneth 2003. Dorsal-ventral patterning in the mammalian telencephalon. Current opinion in neurobiology, 13 1, 50-6

Stenman, Jan M; Wang, Bei; Campbell, Kenneth 2003. Tlx controls proliferation and patterning of lateral telencephalic progenitor domains. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 33, 10568-76

Stenman, Jan; Toresson, Hakan; Campbell, Kenneth 2003. Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 1, 167-74

Stenman, Jan; Yu, Ruth T; Evans, Ronald M; Campbell, Kenneth 2003. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development (Cambridge, England), 130 6, 1113-22

Campbell, Kenneth; Götz, Magdalena 2002. Radial glia: multi-purpose cells for vertebrate brain development. Trends in neurosciences, 25 5, 235-8