Contact Information Childrens Hospital Bldg R Office 513-636-4200 Email arakiki@ucmail.uc.edu Research InterestsI received my PhD from Hokkaido University, Japan. During my PhD study, I became interested in infectious diseases and T cell immunity. In my laboratory, I’ve studied CD8 T cell immunity, which is important for controlling viral infections and intracellular bacterial and parasitic infections. It is now clear that CD8 T cells are also involved in immunity against tumors. There is considerable interest in cancer immunotherapy that stimulates CD8 T cell immunity. My resear... Peer Reviewed Publications Krummey, Scott M; Morris, Anna B; Jacobs, Jesica R; McGuire, Donald J; Ando, Satomi; Tong, Katherine P; Zhang, Weiwen; Robertson, Jennifer; Guasch, Sara A; Araki, Koichi; Larsen, Christian P; Evavold, Brian D; Kissick, Haydn T; Ford, Mandy L 2020. CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence. Cell reports, 30 5, 1282-1291.e5Hashimoto, Masao; Im, Se Jin; Araki, Koichi; Ahmed, Rafi 2019. Cytokine-Mediated Regulation of CD8 T-Cell Responses During Acute and Chronic Viral Infection. Cold Spring Harbor perspectives in biology, 11 1, Ahn, Eunseon; Araki, Koichi; Hashimoto, Masao; Li, Weiyan; Riley, James L; Cheung, Jeanne; Sharpe, Arlene H; Freeman, Gordon J; Irving, Bryan A; Ahmed, Rafi 2018. Role of PD-1 during effector CD8 T cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 115 18, 4749-4754Hashimoto, Masao; Kamphorst, Alice O; Im, Se Jin; Kissick, Haydn T; Pillai, Rathi N; Ramalingam, Suresh S; Araki, Koichi; Ahmed, Rafi 2018. CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions. Annual review of medicine, 69 , 301-318Araki, Koichi; Morita, Masahiro; Bederman, Annelise G; Konieczny, Bogumila T; Kissick, Haydn T; Sonenberg, Nahum; Ahmed, Rafi 2017. Translation is actively regulated during the differentiation of CD8+ effector T cells. Nature immunology, 18 9, 1046-1057Kamphorst, Alice O; Wieland, Andreas; Nasti, Tahseen; Yang, Shu; Zhang, Ruan; Barber, Daniel L; Konieczny, Bogumila T; Daugherty, Candace Z; Koenig, Lydia; Yu, Ke; Sica, Gabriel L; Sharpe, Arlene H; Freeman, Gordon J; Blazar, Bruce R; Turka, Laurence A; Owonikoko, Taofeek K; Pillai, Rathi N; Ramalingam, Suresh S; Araki, Koichi; Ahmed, Rafi 2017. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science (New York, N.Y.), 355 6332, 1423-1427Lee, Junghwa; Hashimoto, Masao; Im, Se Jin; Araki, Koichi; Jin, Hyun-Tak; Davis, Carl W; Konieczny, Bogumila T; Spies, Gregory A; McElrath, M Juliana; Ahmed, Rafi 2017. Adenovirus Serotype 5 Vaccination Results in Suboptimal CD4 T Helper 1 Responses in Mice. Journal of virology, 91 5, Ye, Lilin; Lee, Junghwa; Xu, Lifan; Mohammed, Ata-Ur-Rasheed; Li, Weiyan; Hale, J Scott; Tan, Wendy G; Wu, Tuoqi; Davis, Carl W; Ahmed, Rafi; Araki, Koichi 2017. mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses. Journal of virology, 91 4, Youngblood, Ben; Hale, J Scott; Kissick, Haydn T; Ahn, Eunseon; Xu, Xiaojin; Wieland, Andreas; Araki, Koichi; West, Erin E; Ghoneim, Hazem E; Fan, Yiping; Dogra, Pranay; Davis, Carl W; Konieczny, Bogumila T; Antia, Rustom; Cheng, Xiaodong; Ahmed, Rafi 2017. Effector CD8 T cells dedifferentiate into long-lived memory cells. Nature, 552 7685, 404-409Kamphorst, Alice O; Araki, Koichi; Ahmed, Rafi 2015. Beyond adjuvants: immunomodulation strategies to enhance T cell immunity. Vaccine, 33 Suppl 2 , B21-8Ray, John P; Staron, Matthew M; Shyer, Justin A; Ho, Ping-Chih; Marshall, Heather D; Gray, Simon M; Laidlaw, Brian J; Araki, Koichi; Ahmed, Rafi; Kaech, Susan M; Craft, Joe 2015. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity, 43 4, 690-702Penaloza-MacMaster, Pablo; Kamphorst, Alice O; Wieland, Andreas; Araki, Koichi; Iyer, Smita S; West, Erin E; O'Mara, Leigh; Yang, Shu; Konieczny, Bogumila T; Sharpe, Arlene H; Freeman, Gordon J; Rudensky, Alexander Y; Ahmed, Rafi 2014. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. The Journal of experimental medicine, 211 9, 1905-18Xu, Xiaojin; Araki, Koichi; Li, Shuzhao; Han, Jin-Hwan; Ye, Lilin; Tan, Wendy G; Konieczny, Bogumila T; Bruinsma, Monique W; Martinez, Jennifer; Pearce, Erika L; Green, Douglas R; Jones, Dean P; Virgin, Herbert W; Ahmed, Rafi 2014. Autophagy is essential for effector CD8(+) T cell survival and memory formation. Nature immunology, 15 12, 1152-61Araki, Koichi; Ahmed, Rafi 2013. AMPK: a metabolic switch for CD8+ T-cell memory. European journal of immunology, 43 4, 878-81Araki, Koichi; Youngblood, Ben; Ahmed, Rafi 2013. Programmed cell death 1-directed immunotherapy for enhancing T-cell function. Cold Spring Harbor symposia on quantitative biology, 78 , 239-47Araki, Koichi; Konieczny, Bogumila T 2012. Utilizing a retroviral RNAi system to investigate in vivo mTOR functions in T cells. Methods in molecular biology (Clifton, N.J.), 821 , 305-16Wu, Tuoqi; Wieland, Andreas; Araki, Koichi; Davis, Carl W; Ye, Lilin; Hale, J Scott; Ahmed, Rafi 2012. Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 109 25, 9965-70Xu, Xiaojin; Ye, Lilin; Araki, Koichi; Ahmed, Rafi 2012. mTOR, linking metabolism and immunity. Seminars in immunology, 24 6, 429-35Araki, Koichi; Ellebedy, Ali H; Ahmed, Rafi 2011. TOR in the immune system. Current opinion in cell biology, 23 6, 707-15Duraiswamy, Jaikumar; Ibegbu, Chris C; Masopust, David; Miller, Joseph D; Araki, Koichi; Doho, Gregory H; Tata, Pramila; Gupta, Satish; Zilliox, Michael J; Nakaya, Helder I; Pulendran, Bali; Haining, W Nicholas; Freeman, Gordon J; Ahmed, Rafi 2011. Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults. Journal of immunology (Baltimore, Md. : 1950), 186 7, 4200-12Ferrer, I R; Araki, K; Ford, M L 2011. Paradoxical aspects of rapamycin immunobiology in transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 11 4, 654-9Takegawa, Yasuhiro; Araki, Kayo; Fujitani, Naoki; Furukawa, Jun-ichi; Sugiyama, Hiroaki; Sakai, Hideaki; Shinohara, Yasuro 2011. Simultaneous analysis of heparan sulfate, chondroitin/dermatan sulfates, and hyaluronan disaccharides by glycoblotting-assisted sample preparation followed by single-step zwitter-ionic-hydrophilic interaction chromatography. Analytical chemistry, 83 24, 9443-9Turner, A P; Shaffer, V O; Araki, K; Martens, C; Turner, P L; Gangappa, S; Ford, M L; Ahmed, R; Kirk, A D; Larsen, C P 2011. Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 11 3, 613-8West, Erin E; Youngblood, Ben; Tan, Wendy G; Jin, Hyun-Tak; Araki, Koichi; Alexe, Gabriela; Konieczny, Bogumila T; Calpe, Silvia; Freeman, Gordon J; Terhorst, Cox; Haining, W Nicholas; Ahmed, Rafi 2011. Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load. Immunity, 35 2, 285-98Araki, Koichi; Gangappa, Shivaprakash; Dillehay, Dirck L; Rouse, Barry T; Larsen, Christian P; Ahmed, Rafi 2010. Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation. The Journal of experimental medicine, 207 11, 2355-67Araki, Koichi; Youngblood, Ben; Ahmed, Rafi 2010. The role of mTOR in memory CD8 T-cell differentiation. Immunological reviews, 235 1, 234-43Ferrer, Ivana R; Wagener, Maylene E; Robertson, Jennifer M; Turner, Alexa P; Araki, Koichi; Ahmed, Rafi; Kirk, Allan D; Larsen, Christian P; Ford, Mandy L 2010. Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. Journal of immunology (Baltimore, Md. : 1950), 185 4, 2004-8Jin, Hyun-Tak; Anderson, Ana C; Tan, Wendy G; West, Erin E; Ha, Sang-Jun; Araki, Koichi; Freeman, Gordon J; Kuchroo, Vijay K; Ahmed, Rafi 2010. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proceedings of the National Academy of Sciences of the United States of America, 107 33, 14733-8Sallusto, Federica; Lanzavecchia, Antonio; Araki, Koichi; Ahmed, Rafi 2010. From vaccines to memory and back. Immunity, 33 4, 451-63Araki, Kiwako; Shimatani, Kenichiro; Ohara, Masashi 2009. Dynamics of distribution and performance of ramets constructing genets: a demographic-genetic study in a clonal plant, Convallaria keiskei. Annals of botany, 104 1, 71-9Araki, Koichi; Turner, Alexandra P; Shaffer, Virginia Oliva; Gangappa, Shivaprakash; Keller, Susanne A; Bachmann, Martin F; Larsen, Christian P; Ahmed, Rafi 2009. mTOR regulates memory CD8 T-cell differentiation. Nature, 460 7251, 108-12Truong, Thua Thang; Yoshimatsu, Kumiko; Araki, Koichi; Lee, Byoung-Hee; Nakamura, Ichiro; Endo, Rika; Shimizu, Kenta; Yasuda, Shumpei P; Koma, Takaaki; Taruishi, Midori; Okumura, Megumi; Truong, Uyen Ninh; Arikawa, Jiro 2009. Molecular epidemiological and serological studies of hantavirus infection in northern Vietnam. The Journal of veterinary medical science, 71 10, 1357-63Ha, Sang-Jun; West, Erin E; Araki, Koichi; Smith, Kendall A; Ahmed, Rafi 2008. Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections. Immunological reviews, 223 , 317-33Nakamura, Ichiro; Yoshimatsu, Kumiko; Lee, Byoung-Hee; Okumura, Megumi; Taruishi, Midori; Araki, Koichi; Kariwa, Hiroaki; Takashima, Ikuo; Arikawa, Jiro 2008. Development of a serotyping ELISA system for Thailand virus infection. Archives of virology, 153 8, 1537-42Taruishi, Midori; Yoshimatsu, Kumiko; Araki, Koichi; Okumura, Megumi; Nakamura, Ichiro; Kajino, Kiichi; Arikawa, Jiro 2007. Analysis of the immune response of Hantaan virus nucleocapsid protein-specific CD8+ T cells in mice. Virology, 365 2, 292-301Lee, Byoung-Hee; Yoshimatsu, Kumiko; Araki, Koichi; Okumura, Megumi; Nakamura, Ichiro; Arikawa, Jiro 2006. A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice. Vaccine, 24 15, 2928-34Pattamadilok, Sirima; Lee, Byoung-Hee; Kumperasart, Sanit; Yoshimatsu, Kumiko; Okumura, Megumi; Nakamura, Ichiro; Araki, Koichi; Khoprasert, Yuvaluk; Dangsupa, Prayadh; Panlar, Pornpitak; Jandrig, Burkhard; Krüger, Detlev H; Klempa, Boris; Jäkel, Thomas; Schmidt, Jonas; Ulrich, Rainer; Kariwa, Hiroaki; Arikawa, Jiro 2006. Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus. The American journal of tropical medicine and hygiene, 75 5, 994-1002Araki, K; Yoshimatsu, K; Lee, B-H; Okumura, M; Kariwa, H; Takashima, I; Arikawa, J 2004. Age-dependent hantavirus-specific CD8(+) T-cell responses in mice infected with Hantaan virus. Archives of virology, 149 7, 1373-82Araki, Koichi; Yoshimatsu, Kumiko; Lee, Byoung-Hee; Kariwa, Hiroaki; Takashima, Ikuo; Arikawa, Jiro 2004. A new model of Hantaan virus persistence in mice: the balance between HTNV infection and CD8(+) T-cell responses. Virology, 322 2, 318-27Lokugamage, Kumari; Kariwa, Hiroaki; Lokugamage, Nandadeva; Iwasa, Masahiro; Hagiya, Tomohiro; Araki, Koichi; Tachi, Atsushi; Mizutani, Tetsuya; Yoshimatsu, Kumiko; Arikawa, Jiro; Iwasaki, Takuya; Takashima, Ikuo 2004. Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model. The Japanese journal of veterinary research, 51 3-4, 143-9Lokugamage, Kumari; Kariwa, Hiroaki; Lokugamage, Nandadeva; Miyamoto, Hironobu; Iwasa, Masahiro; Hagiya, Tomohiro; Araki, Koichi; Tachi, Atsushi; Mizutani, Tetsuya; Yoshimatsu, Kumiko; Arikawa, Jiro; Takashima, Ikuo 2004. Genetic and antigenic characterization of the Amur virus associated with hemorrhagic fever with renal syndrome. Virus research, 101 2, 127-34Lokugamage, Nandadeva; Kariwa, Hiroaki; Lokugamage, Kumari; Iwasa, Masahiro A; Hagiya, Tomohiro; Yoshii, Kentaro; Tachi, Atsushi; Ando, Shuji; Fukushima, Hiroshi; Tsuchiya, Kimiyuki; Iwasaki, Takuya; Araki, Koichi; Yoshimatsu, Kumiko; Arikawa, Jiro; Mizutani, Tetsuya; Osawa, Kazutaka; Sato, Hiroshi; Takashima, Ikuo 2004. Epizootiological and epidemiological study of hantavirus infection in Japan. Microbiology and immunology, 48 11, 843-51Ogino, Michiko; Yoshimatsu, Kumiko; Ebihara, Hideki; Araki, Koichi; Lee, Byoung-Hee; Okumura, Megumi; Arikawa, Jiro 2004. Cell fusion activities of Hantaan virus envelope glycoproteins. Journal of virology, 78 19, 10776-82Okumura, M; Yoshimatsu, K; Araki, K; Lee, B-H; Asano, A; Agui, T; Arikawa, J 2004. Epitope analysis of monoclonal antibody E5/G6, which binds to a linear epitope in the nucleocapsid protein of hantaviruses. Archives of virology, 149 12, 2427-34Araki, Koichi; Yoshimatsu, Kumiko; Lee, Byoung-Hee; Kariwa, Hiroaki; Takashima, Ikuo; Arikawa, Jiro 2003. Hantavirus-specific CD8(+)-T-cell responses in newborn mice persistently infected with Hantaan virus. Journal of virology, 77 15, 8408-17Kariwa, H; Tanabe, H; Mizutani, T; Kon, Y; Lokugamage, K; Lokugamage, N; Iwasa, M A; Hagiya, T; Araki, K; Yoshimatsu, K; Arikawa, J; Takashima, I 2003. Synthesis of Seoul virus RNA and structural proteins in cultured cells. Archives of virology, 148 9, 1671-85Lee, B-H; Yoshimatsu, K; Araki, K; Ogino, M; Okumura, M; Tsuchiya, K; Kariwa, H; Arikawa, J 2003. Detection of antibody for the serodiagnosis of hantavirus infection in different rodent species. Archives of virology, 148 10, 1885-97Lee, Byoung-Hee; Yoshimatsu, Kumiko; Maeda, Akihiko; Ochiai, Kazuhiko; Morimatsu, Masami; Araki, Koichi; Ogino, Michiko; Morikawa, Shigeru; Arikawa, Jiro 2003. Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules. Virus research, 98 1, 83-91Lokugamage, Nandadeva; Kariwa, Hiroaki; Lokugamage, Kumari; Hagiya, Tomohiro; Miyamoto, Hironobu; Iwasa, Masahiro A; Araki, Koichi; Yoshimatsu, Kumiko; Arikawa, Jiro; Mizutani, Tetsuya; Takashima, Ikuo 2003. Development of an efficient method for recovery of Puumala and Puumala-related viruses by inoculation of Mongolian gerbils. The Journal of veterinary medical science, 65 11, 1189-94Miyamoto, H; Kariwa, H; Araki, K; Lokugamage, K; Hayasaka, D; Cui, B Z; Lokugamage, N; Ivanov, L I; Mizutani, T; Iwasa, M A; Yoshimatsu, K; Arikawa, J; Takashima, I 2003. Serological analysis of hemorrhagic fever with renal syndrome (HFRS) patients in Far Eastern Russia and identification of the causative hantavirus genotype. Archives of virology, 148 8, 1543-56Ogino, Michiko; Ebihara, Hideki; Lee, Byoung-Hee; Araki, Koichi; Lundkvist, Ake; Kawaoka, Yoshihiro; Yoshimatsu, Kumiko; Arikawa, Jiro 2003. Use of vesicular stomatitis virus pseudotypes bearing hantaan or seoul virus envelope proteins in a rapid and safe neutralization test. Clinical and diagnostic laboratory immunology, 10 1, 154-60Yoshii, Kentarou; Hayasaka, Daisuke; Goto, Akiko; Obara, Mayumi; Araki, Koichi; Yoshimatsu, Kumiko; Arikawa, Jiro; Ivanov, Leonoid; Mizutani, Tetsuya; Kariwa, Hiroaki; Takashima, Ikuo 2003. Enzyme-linked immunosorbent assay using recombinant antigens expressed in mammalian cells for serodiagnosis of tick-borne encephalitis. Journal of virological methods, 108 2, 171-9Yoshimatsu, Kumiko; Lee, Byoung-Hee; Araki, Koichi; Morimatsu, Masami; Ogino, Michiko; Ebihara, Hideki; Arikawa, Jiro 2003. The multimerization of hantavirus nucleocapsid protein depends on type-specific epitopes. Journal of virology, 77 2, 943-52Lokugamage, Kumari; Kariwa, Hiroaki; Hayasaka, Daisuke; Cui, Bai Zhong; Iwasaki, Takuya; Lokugamage, Nandadeva; Ivanov, Leonid I; Volkov, Vladimir I; Demenev, Vladimir A; Slonova, Raisa; Kompanets, Galina; Kushnaryova, Tatyana; Kurata, Takeshi; Maeda, Kenji; Araki, Koichi; Mizutani, Tetsuya; Yoshimatsu, Kumiko; Arikawa, Jiro; Takashima, Ikuo 2002. Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia. Emerging infectious diseases, 8 8, 768-76Araki, K; Yoshimatsu, K; Ogino, M; Ebihara, H; Lundkvist A, ; Kariwa, H; Takashima, I; Arikawa, J 2001. Truncated hantavirus nucleocapsid proteins for serotyping Hantaan, Seoul, and Dobrava hantavirus infections. Journal of clinical microbiology, 39 7, 2397-404Kariwa, H; Zhong, C B; Araki, K; Yoshimatsu, K; Lokugamage, K; Lokugamage, N; Murphy, M E; Mizutani, T; Arikawa, J; Fukushima, H; Xiong, H; Jiehua, C; Takashima, I 2001. Epizootiological survey of hantavirus among rodent species in Ningxia Hui Autonomous Province, China. The Japanese journal of veterinary research, 49 2, 105-14Ebihara, H; Yoshimatsu, K; Ogino, M; Araki, K; Ami, Y; Kariwa, H; Takashima, I; Li, D; Arikawa, J 2000. Pathogenicity of Hantaan virus in newborn mice: genetic reassortant study demonstrating that a single amino acid change in glycoprotein G1 is related to virulence. Journal of virology, 74 19, 9245-55Kariwa, H; Yoshimatsu, K; Araki, K; Chayama, K; Kumada, H; Ogino, M; Ebihara, H; Murphy, M E; Mizutani, T; Takashima, I; Arikawa, J 2000. Detection of hantaviral antibodies among patients with hepatitis of unknown etiology in Japan. Microbiology and immunology, 44 5, 357-62Wang, H; Yoshimatsu, K; Ebihara, H; Ogino, M; Araki, K; Kariwa, H; Wang, Z; Luo, Z; Li, D; Hang, C; Arikawa, J 2000. Genetic diversity of hantaviruses isolated in china and characterization of novel hantaviruses isolated from Niviventer confucianus and Rattus rattus. Virology, 278 2, 332-45Mizutani, T; Inagaki, H; Araki, K; Kariwa, H; Arikawa, J; Takashima, I 1998. Inhibition of Borna disease virus replication by ribavirin in persistently infected cells. Archives of virology, 143 10, 2039-44
Research InterestsI received my PhD from Hokkaido University, Japan. During my PhD study, I became interested in infectious diseases and T cell immunity. In my laboratory, I’ve studied CD8 T cell immunity, which is important for controlling viral infections and intracellular bacterial and parasitic infections. It is now clear that CD8 T cells are also involved in immunity against tumors. There is considerable interest in cancer immunotherapy that stimulates CD8 T cell immunity. My resear...
Peer Reviewed Publications Krummey, Scott M; Morris, Anna B; Jacobs, Jesica R; McGuire, Donald J; Ando, Satomi; Tong, Katherine P; Zhang, Weiwen; Robertson, Jennifer; Guasch, Sara A; Araki, Koichi; Larsen, Christian P; Evavold, Brian D; Kissick, Haydn T; Ford, Mandy L 2020. CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence. Cell reports, 30 5, 1282-1291.e5Hashimoto, Masao; Im, Se Jin; Araki, Koichi; Ahmed, Rafi 2019. Cytokine-Mediated Regulation of CD8 T-Cell Responses During Acute and Chronic Viral Infection. Cold Spring Harbor perspectives in biology, 11 1, Ahn, Eunseon; Araki, Koichi; Hashimoto, Masao; Li, Weiyan; Riley, James L; Cheung, Jeanne; Sharpe, Arlene H; Freeman, Gordon J; Irving, Bryan A; Ahmed, Rafi 2018. Role of PD-1 during effector CD8 T cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 115 18, 4749-4754Hashimoto, Masao; Kamphorst, Alice O; Im, Se Jin; Kissick, Haydn T; Pillai, Rathi N; Ramalingam, Suresh S; Araki, Koichi; Ahmed, Rafi 2018. CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions. Annual review of medicine, 69 , 301-318Araki, Koichi; Morita, Masahiro; Bederman, Annelise G; Konieczny, Bogumila T; Kissick, Haydn T; Sonenberg, Nahum; Ahmed, Rafi 2017. Translation is actively regulated during the differentiation of CD8+ effector T cells. Nature immunology, 18 9, 1046-1057Kamphorst, Alice O; Wieland, Andreas; Nasti, Tahseen; Yang, Shu; Zhang, Ruan; Barber, Daniel L; Konieczny, Bogumila T; Daugherty, Candace Z; Koenig, Lydia; Yu, Ke; Sica, Gabriel L; Sharpe, Arlene H; Freeman, Gordon J; Blazar, Bruce R; Turka, Laurence A; Owonikoko, Taofeek K; Pillai, Rathi N; Ramalingam, Suresh S; Araki, Koichi; Ahmed, Rafi 2017. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science (New York, N.Y.), 355 6332, 1423-1427Lee, Junghwa; Hashimoto, Masao; Im, Se Jin; Araki, Koichi; Jin, Hyun-Tak; Davis, Carl W; Konieczny, Bogumila T; Spies, Gregory A; McElrath, M Juliana; Ahmed, Rafi 2017. Adenovirus Serotype 5 Vaccination Results in Suboptimal CD4 T Helper 1 Responses in Mice. Journal of virology, 91 5, Ye, Lilin; Lee, Junghwa; Xu, Lifan; Mohammed, Ata-Ur-Rasheed; Li, Weiyan; Hale, J Scott; Tan, Wendy G; Wu, Tuoqi; Davis, Carl W; Ahmed, Rafi; Araki, Koichi 2017. mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses. Journal of virology, 91 4, Youngblood, Ben; Hale, J Scott; Kissick, Haydn T; Ahn, Eunseon; Xu, Xiaojin; Wieland, Andreas; Araki, Koichi; West, Erin E; Ghoneim, Hazem E; Fan, Yiping; Dogra, Pranay; Davis, Carl W; Konieczny, Bogumila T; Antia, Rustom; Cheng, Xiaodong; Ahmed, Rafi 2017. Effector CD8 T cells dedifferentiate into long-lived memory cells. Nature, 552 7685, 404-409Kamphorst, Alice O; Araki, Koichi; Ahmed, Rafi 2015. Beyond adjuvants: immunomodulation strategies to enhance T cell immunity. Vaccine, 33 Suppl 2 , B21-8Ray, John P; Staron, Matthew M; Shyer, Justin A; Ho, Ping-Chih; Marshall, Heather D; Gray, Simon M; Laidlaw, Brian J; Araki, Koichi; Ahmed, Rafi; Kaech, Susan M; Craft, Joe 2015. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity, 43 4, 690-702Penaloza-MacMaster, Pablo; Kamphorst, Alice O; Wieland, Andreas; Araki, Koichi; Iyer, Smita S; West, Erin E; O'Mara, Leigh; Yang, Shu; Konieczny, Bogumila T; Sharpe, Arlene H; Freeman, Gordon J; Rudensky, Alexander Y; Ahmed, Rafi 2014. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. The Journal of experimental medicine, 211 9, 1905-18Xu, Xiaojin; Araki, Koichi; Li, Shuzhao; Han, Jin-Hwan; Ye, Lilin; Tan, Wendy G; Konieczny, Bogumila T; Bruinsma, Monique W; Martinez, Jennifer; Pearce, Erika L; Green, Douglas R; Jones, Dean P; Virgin, Herbert W; Ahmed, Rafi 2014. Autophagy is essential for effector CD8(+) T cell survival and memory formation. Nature immunology, 15 12, 1152-61Araki, Koichi; Ahmed, Rafi 2013. AMPK: a metabolic switch for CD8+ T-cell memory. European journal of immunology, 43 4, 878-81Araki, Koichi; Youngblood, Ben; Ahmed, Rafi 2013. Programmed cell death 1-directed immunotherapy for enhancing T-cell function. Cold Spring Harbor symposia on quantitative biology, 78 , 239-47Araki, Koichi; Konieczny, Bogumila T 2012. Utilizing a retroviral RNAi system to investigate in vivo mTOR functions in T cells. Methods in molecular biology (Clifton, N.J.), 821 , 305-16Wu, Tuoqi; Wieland, Andreas; Araki, Koichi; Davis, Carl W; Ye, Lilin; Hale, J Scott; Ahmed, Rafi 2012. Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 109 25, 9965-70Xu, Xiaojin; Ye, Lilin; Araki, Koichi; Ahmed, Rafi 2012. mTOR, linking metabolism and immunity. Seminars in immunology, 24 6, 429-35Araki, Koichi; Ellebedy, Ali H; Ahmed, Rafi 2011. TOR in the immune system. Current opinion in cell biology, 23 6, 707-15Duraiswamy, Jaikumar; Ibegbu, Chris C; Masopust, David; Miller, Joseph D; Araki, Koichi; Doho, Gregory H; Tata, Pramila; Gupta, Satish; Zilliox, Michael J; Nakaya, Helder I; Pulendran, Bali; Haining, W Nicholas; Freeman, Gordon J; Ahmed, Rafi 2011. Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults. Journal of immunology (Baltimore, Md. : 1950), 186 7, 4200-12Ferrer, I R; Araki, K; Ford, M L 2011. Paradoxical aspects of rapamycin immunobiology in transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 11 4, 654-9Takegawa, Yasuhiro; Araki, Kayo; Fujitani, Naoki; Furukawa, Jun-ichi; Sugiyama, Hiroaki; Sakai, Hideaki; Shinohara, Yasuro 2011. Simultaneous analysis of heparan sulfate, chondroitin/dermatan sulfates, and hyaluronan disaccharides by glycoblotting-assisted sample preparation followed by single-step zwitter-ionic-hydrophilic interaction chromatography. Analytical chemistry, 83 24, 9443-9Turner, A P; Shaffer, V O; Araki, K; Martens, C; Turner, P L; Gangappa, S; Ford, M L; Ahmed, R; Kirk, A D; Larsen, C P 2011. Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques. 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