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Photo of  Rolf Stottmann, Ph.D.

Rolf Stottmann, Ph.D.

Research Interests

Genetics, Developmental Biology, Mouse Models of Human Disease, Congenital Malformations, Neural Development, Craniofacial Development, Forward Genetics, Next Generation Sequencing, ENU Mutagenesis

  • Ph.D.: Duke University School of Medicine
  • M.S.: University of Maryland, College Park
  • B.S.: University of Maryland, College Park
Contact Information
  • CCHMC R.1033
  • MLC 7016
  • 3333 Burnet Ave
  • Cincinnati, Ohio 45229
  • Office 513-636-7136
  • Fax 513-636-4373
  • Email

Peer Reviewed Publications

Ha, Seungshin; Stottmann, Rolf W; Furley, Andrew J; Beier, David R 2013. A Forward Genetic Screen in Mice Identifies Mutants with Abnormal Cortical Patterning. Cerebral cortex (New York, N.Y. : 1991), ,

Stottmann, R W; Donlin, M; Hafner, A; Bernard, A; Sinclair, D A; Beier, D R 2013. A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse. Human molecular genetics, 22 20, 4053-63

Leshchiner, Ignaty; Alexa, Kristen; Kelsey, Peter; Adzhubei, Ivan; Austin-Tse, Christina A; Cooney, Jeffrey D; Anderson, Heidi; King, Matthew J; Stottmann, Rolf W; Garnaas, Maija K; Ha, Seungshin; Drummond, Iain A; Paw, Barry H; North, Trista E; Beier, David R; Goessling, Wolfram; Sunyaev, Shamil R 2012. Mutation mapping and identification by whole-genome sequencing. Genome research, 22 8, 1541-8

Stottmann, R W; Moran, J L; Turbe-Doan, A; Driver, E; Kelley, M; Beier, D R 2011. Focusing forward genetics: a tripartite ENU screen for neurodevelopmental mutations in the mouse. Genetics, 188 3, 615-24

Stottmann, Rolf W; Klingensmith, John 2011. Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons. Developmental dynamics : an official publication of the American Association of Anatomists, 240 4, 755-65

Stottmann, Rolf W; Turbe-Doan, Annick; Tran, Pamela; Kratz, Lisa E; Moran, Jennifer L; Kelley, Richard I; Beier, David R 2011. Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. PLoS genetics, 7 9, e1002224

Jaeger, Savina A; Chan, Esther T; Berger, Michael F; Stottmann, Rolf; Hughes, Timothy R; Bulyk, Martha L 2010. Conservation and regulatory associations of a wide affinity range of mouse transcription factor binding sites. Genomics, 95 4, 185-95

Stottmann, R W; Bjork, B C; Doyle, J B; Beier, D R 2010. Identification of a Van der Woude syndrome mutation in the cleft palate 1 mutant mouse. Genesis (New York, N.Y. : 2000), 48 5, 303-8

Stottmann, Rolf W; Beier, David R 2010. Using ENU mutagenesis for phenotype-driven analysis of the mouse. Methods in enzymology, 477 , 329-48

Stottmann, R W; Tran, P V; Turbe-Doan, A; Beier, D R 2009. Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain. Developmental biology, 335 1, 166-78

Tran, Pamela V; Haycraft, Courtney J; Besschetnova, Tatiana Y; Turbe-Doan, Annick; Stottmann, Rolf W; Herron, Bruce J; Chesebro, Allyson L; Qiu, Haiyan; Scherz, Paul J; Shah, Jagesh V; Yoder, Bradley K; Beier, David R 2008. THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nature genetics, 40 4, 403-10

Choi, Murim; Stottmann, Rolf W; Yang, Yu-Ping; Meyers, Erik N; Klingensmith, John 2007. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circulation research, 100 2, 220-8

Anderson, Ryan M; Stottmann, Rolf W; Choi, Murim; Klingensmith, John 2006. Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Developmental dynamics : an official publication of the American Association of Anatomists, 235 9, 2507-20

Stottmann, Rolf W; Berrong, Mark; Matta, Karen; Choi, Murim; Klingensmith, John 2006. The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. Developmental biology, 295 2, 647-63

Stottmann, Rolf W; Choi, Murim; Mishina, Yuji; Meyers, Erik N; Klingensmith, John 2004. BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. Development (Cambridge, England), 131 9, 2205-18

Anderson, Ryan M; Lawrence, Alison R; Stottmann, Rolf W; Bachiller, Daniel; Klingensmith, John 2002. Chordin and noggin promote organizing centers of forebrain development in the mouse. Development (Cambridge, England), 129 21, 4975-87

Stottmann, R W; Anderson, R M; Klingensmith, J 2001. The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth. Developmental biology, 240 2, 457-73

Stottmann, R W; Rivas, R J 1998. Distribution of TAG-1 and synaptophysin in the developing cerebellar cortex: relationship to Purkinje cell dendritic development. The Journal of comparative neurology, 395 1, 121-35

Bauer, Kim A; George, Timothy M; Enterline, David S; Stottmann, Rolf W; Melvin, Elizabeth C; Siegel, Deborah; Samal, Surekha; Hauser, Michael A; Klingensmith, John; Nye, Jeffery S; Speer, Marcy C . A novel mutation in the gene encoding noggin is not causative in human neural tube defects. Journal of neurogenetics, 16 1, 65-71

Beckstead, Wesley A; Bjork, Bryan C; Stottmann, Rolf W; Sunyaev, Shamil; Beier, David R . SNP2RFLP: a computational tool to facilitate genetic mapping using benchtop analysis of SNPs. Mammalian genome : official journal of the International Mammalian Genome Society, 19 10-12, 687-90

Tran, Pamela V; Lachke, Salil A; Stottmann, Rolf W . Toward a systems-level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile. Wiley interdisciplinary reviews. Systems biology and medicine, 5 1, 83-100