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Photo of  Wenhai Shao, PhD

Wenhai Shao, PhD

Associate Professor

Internal Medicine | College of Medicine

  • Fellow: University of Pennsylvania
  • PhD: University of Lousiville (Immunology)
  • Master of Science: Chinese Academy of Sciences, Wuhan Institute of Virology
  • Bachelor of Science: Jiangsu Normal University (Biology)
Contact Information

Peer Reviewed Publications

Adams, David E; Shao, Wen-Hai 2022. Epigenetic Alterations in Immune Cells of Systemic Lupus Erythematosus and Therapeutic Implications. Cells, 11 3,

Adams, David E; Zhen, Yuxuan; Qi, Xiaoyang; Shao, Wen-Hai 2022. Axl Expression in Renal Mesangial Cells Is Regulated by Sp1, Ap1, MZF1, and Ep300, and the IL-6/miR-34a Pathway. Cells, 11 12,

Zhen, Yuxuan; McGaha, Tracy L; Finkelman, Fred D; Shao, Wen-Hai 2022. The Akt-mTORC1 pathway mediates Axl receptor tyrosine kinase-induced mesangial cell proliferation. Journal of leukocyte biology, 111 3, 563-571

Zhen, Yuxuan; Ren, Yan; Medvedovic, Mario; Adams, David E; Wang, Diping; Shao, Wen-Hai 2022. Axl regulated survival/proliferation network and its therapeutic intervention in mouse models of glomerulonephritis. Arthritis research & therapy, 24 1, 284

Khodoun, Marat V; Morris, Suzanne C; Shao, Wen-Hai; Potter, Crystal; Angerman, Elizabeth; Kiselev, Artem; Yarawsky, Alexander E; Herr, Andrew B; Klausz, Katja; Otte, Anna; Peipp, Matthias; Finkelman, Fred D 2021. Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs. The Journal of allergy and clinical immunology, 147 5, 1838-1854.e4

Zhen, Yuxuan; Smith, Roger D; Finkelman, Fred D; Shao, Wen-Hai 2020. Ezh2-mediated epigenetic modification is required for allogeneic T cell-induced lupus disease. Arthritis research & therapy, 22 1, 133

Cohen, Philip L; Shao, Wen-Hai 2019. Gas6/TAM Receptors in Systemic Lupus Erythematosus. Disease markers, 2019 , 7838195

Zhen, Yuxuan; Finkelman, Fred D; Shao, Wen-Hai 2018. Mechanism of Mer receptor tyrosine kinase inhibition of glomerular endothelial cell inflammation. Journal of leukocyte biology, 103 4, 709-717

Zhen, Yuxuan; Lee, Iris J; Finkelman, Fred D; Shao, Wen-Hai 2018. Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis. Journal of autoimmunity, ,

Shao, Wen-Hai 2016. The Role of Microparticles in Rheumatic Diseases and their Potentials as Therapeutic Tools. Journal of molecular immunology, 1 1,

Shao, Wen-Hai; Shu, Daniel H; Zhen, Yuxuan; Hilliard, Brendan; Priest, Stephen O; Cesaroni, Matteo; Ting, Jenny P-Y; Cohen, Philip L 2016. Prion-like MAVS aggregation in lupus patients associates with increased interferon-I. Arthritis & rheumatology (Hoboken, N.J.), ,

Zhen, Yuxuan; Priest, Stephen O; Shao, Wen-Hai 2016. Opposing Roles of Tyrosine Kinase Receptors Mer and Axl Determine Clinical Outcomes in Experimental Immune-Mediated Nephritis. Journal of immunology (Baltimore, Md. : 1950), ,

Shao, Wen-Hai; Gamero, Ana M; Zhen, Yuxuan; Lobue, Monica J; Priest, Stephen O; Albandar, Hazem J; Cohen, Philip L 2015. Stat1 Regulates Lupus-like Chronic Graft-versus-Host Disease Severity via Interactions with Stat3. Journal of immunology (Baltimore, Md. : 1950), 195 9, 4136-43

Shao, Wen-Hai; Cohen, Philip L 2014. The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets. Expert review of clinical immunology, 10 5, 573-82

Shao, Wen-Hai; Zhen, Yuxuan; Finkelman, Fred D; Cohen, Philip L 2014. The Mertk receptor tyrosine kinase promotes T-B interaction stimulated by IgD B-cell receptor cross-linking. Journal of autoimmunity, 53 , 78-84

Hong, Cynthia; Kidani, Yoko; A-Gonzalez, Noelia; Phung, Tram; Ito, Ayaka; Rong, Xin; Ericson, Katrin; Mikkola, Hanna; Beaven, Simon W; Miller, Lloyd S; Shao, Wen-Hai; Cohen, Philip L; Castrillo, Antonio; Tontonoz, Peter; Bensinger, Steven J 2012. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. The Journal of clinical investigation, 122 1, 337-47

Shao, Wen-Hai; Zhen, Yuxuan; Finkelman, Fred D; Eisenberg, Robert A; Cohen, Philip L 2012. Intrinsic unresponsiveness of Mertk-/- B cells to chronic graft-versus-host disease is associated with unmodulated CD1d expression. Journal of autoimmunity, 39 4, 412-9

Zheng, Peng; Gao, Hong C; Li, Qi; Shao, Wei H; Zhang, Mei L; Cheng, Ke; Yang, De Y; Fan, Song H; Chen, Liang; Fang, Liang; Xie, Peng 2012. Plasma metabonomics as a novel diagnostic approach for major depressive disorder. Journal of proteome research, 11 3, 1741-8

Otvos, Laszlo; Shao, Wen-Hai; Vanniasinghe, Anne S; Amon, Michael A; Holub, Marianna Csilla; Kovalszky, Ilona; Wade, John D; Doll, Michelle; Cohen, Philip L; Manolios, Nicholas; Surmacz, Eva 2011. Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis. Peptides, 32 8, 1567-74

Shao, Wen-Hai; Cohen, Philip L 2011. Disturbances of apoptotic cell clearance in systemic lupus erythematosus. Arthritis research & therapy, 13 1, 202

Rahman, Ziaur S M; Shao, Wen-Hai; Khan, Tahsin N; Zhen, Yuxuan; Cohen, Philip L 2010. Impaired apoptotic cell clearance in the germinal center by Mer-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses. Journal of immunology (Baltimore, Md. : 1950), 185 10, 5859-68

Shao, Wen-Hai; Kuan, Anita P; Wang, Charlie; Abraham, Valsamma; Waldman, Meryl A; Vogelgesang, Antje; Wittenburg, Gretel; Choudhury, Arpita; Tsao, Patricia Y; Miwa, Takashi; Eisenberg, Robert A; Cohen, Philip L 2010. Disrupted Mer receptor tyrosine kinase expression leads to enhanced MZ B-cell responses. Journal of autoimmunity, 35 4, 368-74

Shao, Wen-Hai; Zhen, Yuxuan; Rosenbaum, Joshua; Eisenberg, Robert A; McGaha, Tracy L; Birkenbach, Mark; Cohen, Philip L 2010. A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis. Clinical immunology (Orlando, Fla.), 136 2, 236-44

Shao, Wen-Hai; Zhen, Yuxuan; Eisenberg, Robert A; Cohen, Philip L 2009. The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells. Clinical immunology (Orlando, Fla.), 133 1, 138-44

Shao, Wen-Hai; Eisenberg, Robert A; Cohen, Philip L 2008. The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus. Journal of immunology (Baltimore, Md. : 1950), 180 11, 7728-35

Del Prete, Annalisa; Shao, Wen-Hai; Mitola, Stefania; Santoro, Giuseppe; Sozzani, Silvano; Haribabu, Bodduluri 2007. Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors: a role for LTB4 in up-regulation of CCR7 expression and function. Blood, 109 2, 626-31

Liao, Tianjiang; Ke, Yan; Shao, Wen-Hai; Haribabu, Bodduluri; Kaplan, Henry J; Sun, Deming; Shao, Hui 2006. Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis. Investigative ophthalmology & visual science, 47 4, 1543-9

Shao, Wen-Hai; Del Prete, Annalisa; Bock, Cheryl B; Haribabu, Bodduluri 2006. Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: a critical role for BLT1 in collagen-induced arthritis in mice. Journal of immunology (Baltimore, Md. : 1950), 176 10, 6254-61

Jala, Venkatakrishna R; Shao, Wen-Hai; Haribabu, Bodduluri 2005. Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors. The Journal of biological chemistry, 280 6, 4880-7

Scott, Melanie J; Cheadle, William G; Hoth, J Jason; Peyton, James C; Subbarao, Krishnaprasad; Shao, Wen-Hai; Haribabu, Bodduluri 2004. Leukotriene B4 receptor (BLT-1) modulates neutrophil influx into the peritoneum but not the lung and liver during surgically induced bacterial peritonitis in mice. Clinical and diagnostic laboratory immunology, 11 5, 936-41

Zhen Y.;Shao W.H. 05-24-2019. Experimental Analysis of Apoptotic Thymocyte Engulfment by Macrophages Journal of visualized experiments : JoVE, 147,

Shao, W H; Zhang, X E; Liu, H; Zhang, Z P; Cass, A E . Anchor-chain molecular system for orientation control in enzyme immobilization. Bioconjugate chemistry, 11 6, 822-6