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Photo of  Tongli Zhang, PhD

Tongli Zhang, PhD

Associate Professor

Pharmacology & Systems Physiology | College of Medicine

  • Postdoctoral Research Associate: University of Oxford
  • Doctoral Degree: Virginia Polytechnic Institute & State University (Genetics)
Contact Information
Research Interests

Cells, working machines in our body, respond to environmental signals (e.g. food, hormone, and infection, etc.) and make critical decisions such as proliferation, differentiation, defense, or even death. 

The decision makings of cells are carried out by their molecular control networks. Although no single molecule is directing the cellular behaviors by itself, the dynamical properties emerging from the interaction between the control molecules serve as clear commands to the cells. ...

Peer Reviewed Publications

Kalantzaki M, Kitamura E, Zhang T, Mino A, Novak B, Tanaka T 2015. Kinetochore microtubule error correction is driven by differentially regulated interaction modes Nat Cell Biol, online,

Sero J, Sailem H, Ardy R, Almuttaqi H, Zhang T, Bakal C 2015. Cell shape and the microenvironment regulate nuclear translocation of NF-kB in breast epithelial and tumor cells. Mol Syst Biol, online,

Cundell MJ, Bastos RN, Zhang T, Holder J, Gruneberg U, Novak B, Barr FA 2013. The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation. Mol Cell, 52 , 393-405

Tuck C, Zhang T, Potapova T, Malumbres M, Novak B 2013. Robust mitotic entry is ensured by a latching switch. Biol Open, 2 , 924-31

Zhang T, Oliveira RA, Schmierer B, Novak B 2013. Dynamical scenarios for chromosome bi-orientation. Biophys J, 104 , 2595-606

Zhang T, TYson JJ, Novak B 2013. Role for regulated phosphatase activity in generating mitotic oscillations in Xenopus cell-free extracts Proc Natl Acad Sci USA, 110 , 20539-44

Barr A, Zhang T, Novak B, Bakal C . Systemic characterization of G1/S transition. , ,

Lossaint G, Bacevic K, Zhang T, Fraillery D, Charrier-Savournin F, Piette J, Fisher D, Dulic V. . Output of a reciprocally regulated Chk1-p21 network controls cell fate after DNA damage-induced G2 arrest. , ,

Zhang T, Kalantzaki M, Kitamura E, Novak B, Tanaka T . An improved dynamical model of chromosome bi-orientation. , ,

Zhang T, Novak B, Tyson JJ . Integrative analysis of cell cycle control in mammalian cells. , ,